Simple catalytic mechanism for the direct coupling of α-carbonyls with functionalized amines: A one-step synthesis of plavix

Journal of the American Chemical Society

Volumn 135, Issue 43, 2013, Pages 16074-16077

  Evans, Ryan W ^a   Zbieg, Jason R ^a   Zhu, Shaolin ^a   Li, Wei ^a   Macmillan, David W C ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE SUBSTRATES; CATALYTIC MECHANISMS; COPPER CATALYSIS; DIRECT COUPLING; FRAGMENT COUPLING; NUCLEOPHILIC DISPLACEMENT; ONE STEP SYNTHESIS; PHARMACEUTICAL AGENTS;

AMINATION; CATALYSIS; COPPER; KETONES; QUANTUM CHEMISTRY;

AMINES;

ALDEHYDE; AMINE; BROMIDE; CARBONYL DERIVATIVE; CLOPIDOGREL; COPPER; KETONE;

AMINATION; ARTICLE; CATALYSIS; DRAWING; DRUG MECHANISM; DRUG SYNTHESIS; NUCLEOPHILICITY;

ALDEHYDES; AMINES; BROMIDES; CATALYSIS; COPPER; DIETHYLPROPION; ESTERS; TICLOPIDINE;

EID: 84887037627     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja4096472     Document Type: Article

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