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Volumn 70, Issue , 2013, Pages 579-588
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Synthesis of novel triazole based benzoxazolinones: Their TNF-α based molecular docking with in-vivo anti-inflammatory, antinociceptive activities and ulcerogenic risk evaluation
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Author keywords
Benzoxazolinone; Carrageenan cyclooxygenase; Click chemistry; Molecular docking; Triazole
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Indexed keywords
1,2,3 TRIAZOLE DERIVATIVE;
3 (1 PYRIDIN 3 YL 1H [1,2,3]TRIAZOL 4 YL METHYL) 3H BENZOOXAZOL 2 ONE;
3 [1 (2 CHLOROPHENYL) 1H [1,2,3]TRIAZOL 4 YL METHYL] 5 METHYL 3H BENZOOXAZOL 2 ONE;
3 [1 (2 CHLOROPHENYL) 1H [1,2,3]TRIAZOL 4 YL METHYL] 6 METHYL 3H BENZOOXAZOL 2 ONE;
3 [1 (2 FLUOROPHENYL) 1H [1,2,3]TRIAZOL 4 YL METHYL] 5 METHYL 3H BENZOOXAZOL 2 ONE;
3 [1 (3 NITROPHENYL) 1H [1,2,3]TRIAZOL 4 YL METHYL] 3H BENZOOXAZOL 2 ONE;
3 [1 (4 BROMOPHENYL) 1H [1,2,3]TRIAZOL 4 YL METHYL] 5 METHYL 3H BENZOOXAZOL 2 ONE;
3 [1 (4 CHLOROPHENYL) 1H [1,2,3]TRIAZOL 4 YL METHYL] 5 METHYL 3H BENZOOXAZOL 2 ONE;
3 [1 (4 CHLOROPHENYL) 1H [1,2,3]TRIAZOL 4 YL METHYL] 6 METHYL 3H BENZOOXAZOL 2 ONE;
3 [1 (4 ETHOXYPHENYL) 1H [1,2,3]TRIAZOL 4 YL METHYL] 3H BENZOOXAZOL 2 ONE;
3 [1 (4 ETHOXYPHENYL) 1H [1,2,3]TRIAZOL 4 YL METHYL] 6 METHYL 3H BENZOOXAZOL 2 ONE;
3 [1 (4 FLUOROPHENYL) 1H [1,2,3]TRIAZOL 4 YL METHYL] 5 METHYL 3H BENZOOXAZOL 2 ONE;
3 [1 (4 FLUOROPHENYL) 1H [1,2,3]TRIAZOL 4 YL METHYL] 6 METHYL 3H BENZOOXAZOL 2 ONE;
3 [1 (4 METHOXYPHENYL) 1H [1,2,3]TRIAZOL 4 YL METHYL] 3H BENZOOXAZOL 2 ONE;
5 CHLORO 3 (1 PYRIDIN 3 YL 1H [1,2,3]TRIAZOL 4 YL METHYL) 3H BENZOOXAZOL 2 ONE;
5 CHLORO 3 [1 (2 FLUOROPHENYL) 1H [1,2,3]TRIAZOL 4 YL METHYL] 3H BENZOOXAZOL 2 ONE;
5 CHLORO 3 [1 (3 NITROPHENYL) 1H [1,2,3]TRIAZOL 4 YL METHYL] 3H BENZOOXAZOL 2 ONE;
5 CHLORO 3 [1 (4 CHLOROPHENYL) 1H [1,2,3]TRIAZOL 4 YL METHYL] 3H BENZOOXAZOL 2 ONE;
5 METHYL 3 (1 PYRIDIN 3 YL 1H [1,2,3]TRIAZOL 4 YL METHYL) 3H BENZOOXAZOL 2 ONE;
5 METHYL 3 [1 (3 NITROPHENYL) 1H [1,2,3]TRIAZOL 4 YL METHYL] 3H BENZOOXAZOL 2 ONE;
5 METHYL 3 [1 (4 NITROPHENYL) 1H [1,2,3]TRIAZOL 4 YL METHYL] 3H BENZOOXAZOL 2 ONE;
6 METHYL 3 [1 (3 NITROPHENYL) 1H [1,2,3]TRIAZOL 4 YL METHYL] 3H BENZOOXAZOL 2 ONE;
6 METHYL 3 [1 (4 NITROPHENYL) 1H [1,2,3]TRIAZOL 4 YL METHYL] 3H BENZOOXAZOL 2 ONE;
ANTIINFLAMMATORY AGENT;
ANTINOCICEPTIVE AGENT;
CELECOXIB;
CYCLOOXYGENASE 2 INHIBITOR;
INDOMETACIN;
TUMOR NECROSIS FACTOR ALPHA;
UNCLASSIFIED DRUG;
UNINDEXED DRUG;
BENZOXAZOLE DERIVATIVE;
CARRAGEENAN;
CYCLOOXYGENASE 2;
NONSTEROID ANTIINFLAMMATORY AGENT;
TRIAZOLE DERIVATIVE;
ANIMAL EXPERIMENT;
ANIMAL MODEL;
ANTIINFLAMMATORY ACTIVITY;
ANTINOCICEPTION;
ARTICLE;
CLICK CHEMISTRY;
CONTROLLED STUDY;
DRUG DESIGN;
DRUG SYNTHESIS;
FEMALE;
HISTOPATHOLOGY;
IN VIVO STUDY;
MALE;
MOLECULAR DOCKING;
NONHUMAN;
PAW EDEMA;
RAT;
STOMACH ULCER;
STRUCTURE ACTIVITY RELATION;
1,2,3-TRIAZOLE;
ANIMAL;
BENZOXAZOLINONE;
CARRAGEENAN CYCLOOXYGENASE;
CHEMICAL STRUCTURE;
CHEMICALLY INDUCED DISORDER;
CHEMISTRY;
CYTOLOGY;
DOSE RESPONSE;
DRUG ANTAGONISM;
EDEMA;
EPITHELIUM CELL;
HUMAN;
METABOLISM;
RISK FACTOR;
STOMACH MUCOSA;
SYNTHESIS;
1,2,3-TRIAZOLE;
BENZOXAZOLINONE;
CARRAGEENAN CYCLOOXYGENASE;
CLICK CHEMISTRY;
MOLECULAR DOCKING;
ANIMALS;
ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL;
BENZOXAZOLES;
CARRAGEENAN;
CYCLOOXYGENASE 2;
CYCLOOXYGENASE 2 INHIBITORS;
DOSE-RESPONSE RELATIONSHIP, DRUG;
EDEMA;
EPITHELIAL CELLS;
GASTRIC MUCOSA;
HUMANS;
MODELS, MOLECULAR;
MOLECULAR STRUCTURE;
RATS;
RISK FACTORS;
STRUCTURE-ACTIVITY RELATIONSHIP;
TRIAZOLES;
TUMOR NECROSIS FACTOR-ALPHA;
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EID: 84887034973
PISSN: 02235234
EISSN: 17683254
Source Type: Journal
DOI: 10.1016/j.ejmech.2013.10.032 Document Type: Article |
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Times cited : (65)
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References (52)
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