MicroRNA-134 activity in somatostatin interneurons regulates H-Ras localization by repressing the palmitoylation enzyme, DHHC9

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 44, 2013, Pages 17898-17903

  Chai, Sunghee ^a   Cambronne, Xiaolu A ^a   Eichhorn, Stephen W ^b   Goodman, Richard H ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BICUCULLINE; BRAIN ENZYME; DHHC9 ENZYME; MCRORNA 134; MICRORNA; SOMATOSTATIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CELLULAR DISTRIBUTION; INTERNEURON; NONHUMAN; ONCOGENE H RAS; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT;

PALMITOYLTRANSFERASE; RISC-TRAP;

ACYLTRANSFERASES; ANIMALS; BICUCULLINE; BLOTTING, WESTERN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; INTERNEURONS; MICRORNAS; MICROSCOPY, CONFOCAL; MUTAGENESIS; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SOMATOSTATIN-SECRETING CELLS; SYNAPSES;

EID: 84887033963     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1317528110     Document Type: Article

References (35)

1. Schratt GM, et al. (2006) A brain-specific microRNA regulates dendritic spine development. Nature 439(7074):283-289.
2. Kye MJ, et al. (2007) Somatodendritic microRNAs identified by laser capture and multiplex RT-PCR. RNA 13(8):1224-1234.
3. Siegel G, et al. (2009) A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. Nat Cell Biol 11(6):705-716.
4. Natera-Naranjo O, Aschrafi A, Gioio AE, Kaplan BB (2010) Identification and quantitative analyses of microRNAs located in the distal axons of sympathetic neurons. RNA 16(8):1516-1529.
5. Fiore R, et al. (2009) Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-Tuning Pumilio2 protein levels. EMBO J 28(6):697-710.
6. Hoogenraad CC, Akhmanova A, Galjart N, De Zeeuw CI (2004) LIMK1 and CLIP-115: Linking cytoskeletal defects to Williams syndrome. Bioessays 26(2):141-150.
7. Siemen H, Colas D, Heller HC, Brüstle O, Pera RA (2011) Pumilio-2 function in the mouse nervous system. PLoS ONE 6(10):e25932.
8. Gao J, et al. (2010) A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature 466(7310):1105-1109.
9. Jimenez-Mateos EM, et al. (2012) Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects. Nat Med 18(7):1087-1094.
10. Huang ZJ, Di Cristo G, Ango F (2007) Development of GABA innervation in the cerebral and cerebellar cortices. Nat Rev Neurosci 8(9):673-686.
11. He M, et al. (2012) Cell-Type-based analysis of microRNA profiles in the mouse brain. Neuron 73(1):35-48.
12. Magill ST, et al. (2010) microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus. Proc Natl Acad Sci USA 107(47): 20382-20387.
13. Cambronne XA, Shen R, Auer PL, Goodman RH (2012) Capturing microRNA targets using an RNA-induced silencing complex (RISC)-Trap approach. Proc Natl Acad Sci USA 109(50):20473-20478.
14. Huang K, El-Husseini A (2005) Modulation of neuronal protein trafficking and function by palmitoylation. Curr Opin Neurobiol 15(5):527-535.
15. Swarthout JT, et al. (2005) DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras. J Biol Chem 280(35):31141-31148.
16. Arendt T, et al. (2004) Neuronal activation of Ras regulates synaptic connectivity. Eur J Neurosci 19(11):2953-2966.
17. Vo N, et al. (2005) A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proc Natl Acad Sci USA 102(45):16426-16431.
18. Wayman GA, et al. (2008) An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP. Proc Natl Acad Sci USA 105(26):9093-9098.
19. Gonchar Y, Wang Q, Burkhalter A (2007) Multiple distinct subtypes of GABAergic neurons in mouse visual cortex identified by triple immunostaining. Front Neuroanat 1:3.
20. Fivaz M, Bandara S, Inoue T, Meyer T (2008) Robust neuronal symmetry breaking by Ras-Triggered local positive feedback. Curr Biol 18(1):44-50.
21. Hancock JF, Magee AI, Childs JE, Marshall CJ (1989) All ras proteins are polyisoprenylated but only some are palmitoylated. Cell 57(7):1167-1177.
22. Prior IA, Hancock JF (2001) Compartmentalization of Ras proteins. J Cell Sci 114(Pt 9): 1603-1608.
23. Greaves J, Chamberlain LH (2007) Palmitoylation-dependent protein sorting. J Cell Biol 176(3):249-254.
24. Rocks O, et al. (2005) An acylation cycle regulates localization and activity of palmitoylated Ras isoforms. Science 307(5716):1746-1752.
25. Fineberg SK, Kosik KS, Davidson BL (2009) MicroRNAs potentiate neural development. Neuron 64(3):303-309.
26. Banerjee S, Neveu P, Kosik KS (2009) A coordinated local translational control point at the synapse involving relief from silencing and MOV10 degradation. Neuron 64(6): 871-884.
27. Impey S, et al. (2010) An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signaling. Mol Cell Neurosci 43(1):146-156.
28. Hansen KF, Sakamoto K, Wayman GA, Impey S, Obrietan K (2010) Transgenic miR132 alters neuronal spine density and impairs novel object recognition memory. PLoS ONE 5(11):e15497.
29. Luikart BW, et al. (2011) miR-132 mediates the integration of newborn neurons into the adult dentate gyrus. PLoS ONE 6(5):e19077.
30. Lee W-C, et al. (2006) Dynamic remodeling of dendritic arbors in GABAergic interneurons of adult visual cortex. PLoS Biol 4(2):e29.
31. Ascoli GA, et al.; Petilla Interneuron Nomenclature Group (2008) Petilla terminology: Nomenclature of features of GABAergic interneurons of the cerebral cortex. Nat Rev Neurosci 9(7):557-568.
32. Markram H, et al. (2004) Interneurons of the neocortical inhibitory system. Nat Rev Neurosci 5(10):793-807.
33. Harvey CD, Yasuda R, Zhong H, Svoboda K (2008) The spread of Ras activity triggered by activation of a single dendritic spine. Science 321(5885):136-140.
34. Kushner SA, et al. (2005) Modulation of presynaptic plasticity and learning by the H-ras/extracellular signal-regulated kinase/synapsin I signaling pathway. J Neurosci 25(42):9721-9734.
35. Lugli G, Torvik VI, Larson J, Smalheiser NR (2008) Expression of microRNAs and their precursors in synaptic fractions of adult mouse forebrain. J Neurochem 106(2):650-661.