Evaluation of multifunctional polysaccharide hydrogels with varying stiffness for bone tissue engineering

Tissue Engineering - Part A

Volumn 19, Issue 21-22, 2013, Pages 2452-2463

  Pandit, Vaibhav ^a   Zuidema, Jonathan M ^a   Venuto, Kathryn N ^a   Macione, James ^a   Dai, Guohao ^a   Gilbert, Ryan J ^a   Kotha, Shiva P ^a  

^a RENSSELAER POLYTECHNIC INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION; CELL CULTURE; CHITOSAN; ENDOTHELIAL CELLS; GELATION; GELS; HYDROGELS; MINERALOGY; OSTEOBLASTS; PHOSPHATASES; TISSUE ENGINEERING;

ANTI-BACTERIAL ACTIVITY; BONE TISSUE ENGINEERING; DEGREE OF CROSS-LINKING; DIFFERENTIATION MARKERS; HUMAN DERMAL FIBROBLASTS; OSTEOBLAST DIFFERENTIATION; POLYSACCHARIDE HYDROGELS; VASCULAR ENDOTHELIAL CELLS;

STIFFNESS;

AGAROSE; ALKALINE PHOSPHATASE; BONE SIALOPROTEIN; CHITOSAN; CRYSTAL VIOLET; ENHANCED GREEN FLUORESCENT PROTEIN; GENIPIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; METHYLCELLULOSE; OSTEOCALCIN; OSTEOPONTIN; POLYSACCHARIDE; POLYSTYRENE;

ATOMIC ABSORPTION SPECTROMETRY; BONE REGENERATION; BONE TISSUE; CELL CULTURE; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; CROSS LINKING; CULTURE MEDIUM; ENZYME ACTIVITY; FIBROBLAST; GEL; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYDROGEL; LENTIVIRINAE; MINERALIZATION; OSTEOBLAST; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SCANNING ELECTRON MICROSCOPY; TISSUE CULTURE; TISSUE ENGINEERING; UMBILICAL VEIN ENDOTHELIAL CELL;

BACTERIA (MICROORGANISMS); MURINAE;

CELL PROLIFERATION; CHITOSAN; FIBROBLASTS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDROGELS; METHYLCELLULOSE; OSTEOBLASTS; REAL-TIME POLYMERASE CHAIN REACTION; SEPHAROSE; TISSUE ENGINEERING;

EID: 84887027812     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2012.0644     Document Type: Conference Paper

References (91)

1. Benoit, D.S.W., et al. Synthesis and characterization of a fluvastatin-releasing hydrogel delivery system to modulate hMSC differentiation and function for bone regeneration. Biomaterials 27, 6102, 2006
2. Lee, K.Y., Alsberg, E., and Mooney, D.J. Degradable and injectable poly (aldehyde guluronate) hydrogels for bone tissue engineering. J Biomed Mater Res 56, 228, 2001
3. Saito, A., et al. Prolonged ectopic calcification induced by BMP-2-derived synthetic peptide. J Biomed Mater Res Part A 70, 115, 2004
4. Wang, C., et al. The control of anchorage-dependent cell behavior within a hydrogel/microcarrier system in an osteogenic model. Biomaterials 30, 2259, 2009
5. Gkioni, K., et al. Mineralization of hydrogels for bone regeneration. Tissue Eng Part B Rev 16, 577, 2010
6. Park, J.B. The use of hydrogels in bone-Tissue engineering. Med Oral 16, e115, 2011
7. Slaughter, B.V., et al. Hydrogels in regenerative medicine. Adv Mater 21, 3307, 2009
8. Kim, J., et al. Potential of hydrogels based on poly (ethylene glycol) and sebacic acid as orthopedic tissue engineering scaffolds. Tissue Eng Part A 15, 2299, 2009
9. Nuttelman, C.R., et al. The effect of ethylene glycol methacrylate phosphate in PEG hydrogels on mineralization and viability of encapsulated hMSCs. Biomaterials 27, 1377, 2006
10. Di Martino, A., Sittinger, M., and Risbud, M.V. Chitosan: A versatile biopolymer for orthopaedic tissue-engineering. Biomaterials 26, 5983, 2005
11. Molinaro, G., et al. Biocompatibility of thermosensitive chitosan-based hydrogels: An in vivo experimental approach to injectable biomaterials. Biomaterials 23, 2717, 2002
12. Drury, J.L., and Mooney, D.J. Hydrogels for tissue engineering: Scaffold design variables and applications. Biomaterials 24, 4337, 2003
13. Li, Z., et al. Chitosan-Alginate hybrid scaffolds for bone tissue engineering. Biomaterials 26, 3919, 2005
14. Rouwkema, J., Boer, J.D., and Blitterswijk, C.A.V. Endothelial cells assemble into a 3-dimensional prevascular network in a bone tissue engineering construct. Tissue Eng 12, 2685, 2006
15. Burdick, J.A., et al. Delivery of osteoinductive growth factors from degradable PEG hydrogels influences osteoblast differentiation and mineralization. J Controlled Release 83, 53, 2002
16. Yamamoto, M., Tabata, Y., and Ikada, Y. Ectopic bone formation induced by biodegradable hydrogels incorporating bone morphogenetic protein. J Biomater Sci Polym Ed 9, 439, 1998
17. Gaharwar, A.K., et al. Addition of chitosan to silicate crosslinked PEO for tuning osteoblast cell adhesion and mineralization. ACS Appl Mater Interfaces 21, 22, 2010
18. Lee, Y.M., et al. Tissue engineered bone formation using chitosan/tricalcium phosphate sponges. J Periodontol 71, 410, 2000
19. Shirosaki, Y., et al. In vitro cytocompatibility of MG63 cells on chitosan-organosiloxane hybrid membranes. Biomaterials 26, 485, 2005
20. Yu, Y., et al. Novel injectable biodegradable glycol chitosanbased hydrogels crosslinked by Michael-Type addition reaction with oligo (acryloyl carbonate)-b-poly (ethylene glycol)-b-oligo (acryloyl carbonate) copolymers. J Biomed Mater Res Part A 99, 316, 2011
21. Leach, J.K. Multifunctional cell-instructive materials for tissue regeneration. Regen Med 1, 447, 2006
22. Rutherford, R.B., et al. Bone morphogenetic protein-Transduced human fibroblasts convert to osteoblasts and form bone in vivo. Tissue Eng 8, 441, 2002
23. Tabata, Y., et al. Bone regeneration by basic fibroblast growth factor complexed with biodegradable hydrogels. Biomaterials 19, 807, 1998
24. Bouletreau, P.J., et al. Hypoxia and VEGF up-regulate BMP-2 mRNA and protein expression in microvascular endothelial cells: Implications for fracture healing. Plast Reconstr Surg 109, 2384, 2002
25. Nemir, S., and West, J.L. Synthetic materials in the study of cell response to substrate rigidity. Ann Biomed Eng 38, 2, 2010
26. Engler, A.J., et al. Matrix elasticity directs stem cell lineage specification. Cell 126, 677, 2006
27. Schneider, A., et al. Polyelectrolyte multilayers with a tunable Young's modulus: Influence of film stiffness on cell adhesion. Langmuir 22, 1193, 2006
28. Kannangara, D.W., Thadepalli, H., and McQuirter, J.L. Bacteriology and treatment of dental infections. Oral Surg Oral Med Oral Pathol 50, 103, 1980
29. Solorio, L., et al. Gelatin microspheres crosslinked with genipin for local delivery of growth factors. J Tissue Eng Regen Med 4, 514, 2010
30. Pai, V., Srinivasarao, M., and Khan, S.A. Evolution of microstructure and rheology in mixed polysaccharide systems. Macromolecules 35, 1699, 2002
31. Wang, Y.H., et al. Examination of mineralized nodule formation in living osteoblastic cultures using fluorescent dyes. Biotechnol Prog 22, 1697, 2008
32. Huang, W., et al. Signaling and transcriptional regulation in osteoblast commitment and differentiation. Front Biosci 12, 92, 2007
33. Seibel, M.J. Biochemical markers of bone turnover part I: Biochemistry and variability. Clin Biochem Rev 26, 97, 2005
34. Boyce, B.F., and Xing, L. Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys 473, 139, 2008
35. Westerlund, B., and Korhonen, T. Bacterial proteins binding to the mammalian extracellular matrix. Mol Microbiol 9, 687, 2006
36. Zuidema, J.M., et al. Fabrication and characterization of tunable polysaccharide hydrogel blends for neural repair. Acta Biomater 7, 1634, 2011
37. Yan, L.P., et al. Genipin-cross-linked collagen/chitosan biomimetic scaffolds for articular cartilage tissue engineering applications. J Biomed Mater Res Part A 95, 465, 2010
38. Schweikl, H., et al. Proliferation of osteoblasts and fibroblasts on model surfaces of varying roughness and surface chemistry. J Mater Sci Mater Med 18, 1895, 2007
39. Baxter, L., et al. Fibroblast and osteoblast adhesion and morphology on calcium phosphate surfaces. Eur Cell Mater 4: 1, 2002
40. Kunzler, T.P., et al. Systematic study of osteoblast and fibroblast response to roughness by means of surfacemorphology gradients. Biomaterials 28, 2175, 2007
41. Anselme, K. Osteoblast adhesion on biomaterials. Biomaterials 21, 667, 2000
42. Kong, H.J., Smith, M.K., and Mooney, D.J. Designing alginate hydrogels to maintain viability of immobilized cells. Biomaterials 24, 4023, 2003
43. Halstenberg, S., et al. Biologically engineered protein-graftpoly (ethylene glycol) hydrogels: A cell adhesive and plasmin-degradable biosynthetic material for tissue repair. Biomacromolecules 3, 710, 2002
44. Yamada, Y., et al. Bone regeneration following injection of mesenchymal stem cells and fibrin glue with a biodegradable scaffold. J Cranio-Maxillofac Surg 31, 27, 2003
45. Di Bella, C., Farlie, P., and Penington, A.J. Bone regeneration in a rabbit critical-sized skull defect using autologous adipose-derived cells. Tissue Eng Part A 14, 483, 2008
46. Misawa, H., et al. PuraMatrixTM facilitates bone regeneration in bone defects of calvaria in mice. Cell Transplantat 15, 903, 2006
47. Sieminski, A.L., and Gooch, K.J. Salmon fibrin supports an increased number of sprouts and decreased degradation while maintaining sprout length relative to human fibrin in an in vitro angiogenesis model. J Biomater Sci Polym Ed 15, 237, 2004
48. Fedorovich, N.E., et al. Hydrogels as extracellular matrices for skeletal tissue engineering: State-of-The-Art and novel application in organ printing. Tissue Eng 13, 1905, 2007
49. Tang, Y., et al. A thermosensitive chitosan/poly (vinyl alcohol) hydrogel containing hydroxyapatite for protein delivery. J Biomed Mater Res Part A 91, 953, 2009
50. Werner, C., Pompe, T. and Salchert, K. Modulating extracellular matrix at interfaces of polymeric materials. Polym Regen Med 203, 63, 2006
51. Butler, M.F., Ng, Y.F., and Pudney, P.D.A. Mechanism and kinetics of the crosslinking reaction between biopolymers containing primary amine groups and genipin. J Polym Science Part A Polym Chem 41, 3941, 2003
52. Stewart, G., Wang, Y., and Niewiarowski, S. Methylcellulose protects the ability of anchorage-dependent cells to adhere following isolation and holding in suspension. Biotechniques 19, 598, 1995
53. Ravi Kumar, M.N.V. A review of chitin and chitosan applications. Reactive Funct Polym 46, 1, 2000
54. Zarzycki, R., and Modrzejewska, Z. [Use of chitosan in medicine and biomedical engineering]. Polim Med 33, 47, 2003
55. Martin, B.C. Agarose and methylcellulose hydrogel blends for nerve regeneration applications. J Neural Eng 5, 221, 2008
56. Francis Suh, J.K., and Matthew, H.W.T. Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: A review. Biomaterials 21, 2589, 2000
57. Mi, F.L., et al. In vitro evaluation of a chitosan membrane cross-linked with genipin. J Biomater Sci Polym Ed 12, 835, 2001
58. Jin, J., Song, M., and Hourston, D. Novel chitosan-based films cross-linked by genipin with improved physical properties. Biomacromolecules 5, 162, 2004
59. Moura, M.J., Figueiredo, M.M., and Gil, M.H. Rheological study of genipin cross-linked chitosan hydrogels. Biomacromolecules 8, 3823, 2007
60. Budtova, T., et al. Chitosan modified by poly (ethylene oxide): Film and mixture properties. J Appl Polym Sci 84, 1114, 2002
61. Alexeev, V.L., et al. Improvement of the mechanical properties of chitosan films by the addition of poly(ethylene oxide). Polym Eng Sci 40, 1211, 2002
62. Yamamura, N., et al. Effects of the mechanical properties of collagen gel on the in vitro formation of microvessel networks by endothelial cells. Tissue Eng 13, 1443, 2007
63. Thébaud, N.B., et al. Human endothelial progenitor cell attachment to polysaccharide-based hydrogels: A pre-requisite for vascular tissue engineering. J Mater Sci Mater Med 18, 339, 2007
64. Letourneur, D., et al. Heparin and non-heparin-like dextrans differentially modulate endothelial cell proliferation: In vitro evaluation with soluble and crosslinked polysaccharide matrices. J Biomed Mater Res 60, 94, 2002
65. Seidi, A., et al. Gradient biomaterials for soft-To-hard interface tissue engineering. Acta Biomater 7, 1441, 2011
66. Saunders, R.L., and Hammer, D.A. Assembly of human umbilical vein endothelial cells on compliant hydrogels. Cell Mol Bioeng 3, 60, 2010
67. Rowlands, A.S., George, P.A., and Cooper-White, J.J. Directing osteogenic and myogenic differentiation of MSCs: Interplay of stiffness and adhesive ligand presentation. Am J Physiol Cell Physiol 295, C1037, 2008
68. Yeung, T., et al. Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion. Cell Motil Cytoskeleton 60, 24, 2004
69. Kalfas, I.H. Principles of bone healing. Neurosurg Focus 10, 1, 2001
70. Kaigler, D., et al. Transplanted endothelial cells enhance orthotopic bone regeneration. J Dent Res 85, 633, 2006
71. Mitragotri, S., and Lahann, J. Physical approaches to biomaterial design. Nature Mater 8, 15, 2009
72. Dalby, M.J., et al. The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder. Nature Mater 6, 997, 2007
73. Saha, K., et al. Substrate modulus directs neural stem cell behavior. Biophys J 95, 4426, 2008
74. Chung, E.H., et al. Biomimetic artificial ECMs stimulate bone regeneration. J Biomed Mater Res Part A 79, 815, 2006
75. Khatiwala, C.B., et al. ECM compliance regulates osteogenesis by influencing MAPK signaling downstream of RhoA and ROCK. J Bone Miner Res 24, 886, 2008
76. Hsiong, S.X., et al. Differentiation stage alters matrix control of stem cells. J Biomed Mater Res Part A 85, 145, 2007
77. Wells, R.G. The role of matrix stiffness in regulating cell behavior. Hepatology 47, 1394, 2008
78. Wu, H.D., et al. Chitosan-based polyelectrolyte complex scaffolds with antibacterial properties for treating dental bone defects. Mater Sci Eng C 32, 207, 2012
79. Zhao, L., et al. Synthesis of antibacterial PVA/CM-chitosan blend hydrogels with electron beam irradiation. Carbohydr Polym 53, 439, 2003
80. Bae, K., et al. Effect of water-soluble reduced chitosan on Streptococcus mutans, plaque regrowth and biofilm vitality. Clin Oral Invest 10, 102, 2006
81. Tarsi, R., et al. Inhibition of Streptococcus mutans adsorption to hydroxyapatite by low-molecular-weight chitosans. J Dent Res 76, 665, 1997
82. Sarasam, A.R., Krishnaswamy, R.K., and Madihally, S.V. Blending chitosan with polycaprolactone: Effects on physicochemical and antibacterial properties. Biomacromolecules 7, 1131, 2006
83. Marsh, P., and Bradshaw, D. Dental plaque as a biofilm. J Ind Microbiol Biotechnol 15, 169, 1995
84. Welin, J., et al. Protein expression by Streptococcus mutans during initial stage of biofilm formation. Appl Environ Microbiol 70, 3736, 2004
85. Kreth, J., et al. Competition and coexistence between Streptococcus mutans and Streptococcus sanguinis in the dental biofilm. J Bacteriol 187, 7193, 2005
86. Beckloff, N., et al. Activity of an antimicrobial peptide mimetic against planktonic and biofilm cultures of oral pathogens. Antimicrob Agents Chemother 51, 4125, 2007
87. Wen, Z.T., and Burne, R.A. Functional genomics approach to identifying genes required for biofilm development by Streptococcus mutans. Appl Environ Microbiol 68, 1196, 2002
88. Kong, M., et al. Antimicrobial properties of chitosan and mode of action: A state of the art review. Int J Food Microbiol 144, 51, 2010
89. Roy, S., and Das, P.K. Antibacterial hydrogels of amino acidbased cationic amphiphiles. Biotechnol Bioeng 100, 756, 2008
90. Discher, D.E., Janmey, P., and Wang, Y.-l. Tissue cells feel and respond to the stiffness of their substrate. Science 310, 1139, 2005
91. Genes, N.G., et al. Effect of substrate mechanics on chondrocyte adhesion to modified alginate surfaces. Arch Biochem Biophys 422, 161, 2004