The influence of polymer topology on pharmacokinetics: Differences between cyclic and linear PEGylated poly(acrylic acid) comb polymers

Journal of Controlled Release

Volumn 140, Issue 3, 2009, Pages 203-209

  Chen, Bo ^a   Jerger, Katherine ^a   Fréchet, Jean M J ^b   Szoka Jr , Francis C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

ATRP; Click chemistry; Mice; Radiolabel; Tumor accumulation

Indexed keywords

BALB/C MICE; CHAIN FLEXIBILITY; CHAIN-ENDS; CHEMICAL FEATURES; CHEMOTHERAPEUTIC DRUGS; CIRCULATION TIME; CLICK CHEMISTRY; COMB POLYMERS; CYCLIC POLYMER; DRUG CARRIER; ENHANCED PERMEATION AND RETENTIONS; HYDRODYNAMIC DIAMETER; INTRAVENOUS INJECTIONS; LINEAR POLYMERS; MOLECULAR ARCHITECTURE; POLY(ACRYLIC ACID ); POLYACRYLIC ACIDS; POLYMER ARCHITECTURE; RADIOLABEL; RENAL CLEARANCE; SERUM CONCENTRATION; SOLID TUMORS; TIME CURVES; TISSUE DISTRIBUTIONS; TUMOR ACCUMULATION; WATERSOLUBLE POLYMERS;

ACRYLICS; ATOM TRANSFER RADICAL POLYMERIZATION; BIOFILTRATION; CARBOXYLIC ACIDS; FLUID DYNAMICS; MOLECULAR WEIGHT; ORGANIC ACIDS; PHARMACOKINETICS; POLYDISPERSITY; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; POLYETHYLENES; RADIOACTIVE TRACERS; TOPOLOGY; TUMORS;

POLYMERS;

DRUG CARRIER; MACROGOL; POLYLACTIC ACID; POLYMER;

ADENOCARCINOMA; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BLOOD LEVEL; CHEMICAL STRUCTURE; CONTROLLED STUDY; DISPERSION; FEMALE; HALF LIFE TIME; KIDNEY CLEARANCE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; SYNTHESIS; TISSUE DISTRIBUTION;

ACRYLAMIDES; ANIMALS; ANTINEOPLASTIC AGENTS; COLONIC NEOPLASMS; EXCIPIENTS; FEMALE; HALF-LIFE; ISOTOPE LABELING; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, INBRED BALB C; MOLECULAR WEIGHT; NEOPLASM TRANSPLANTATION; NEOPLASMS; PHARMACOKINETICS; POLYETHYLENE GLYCOLS; POLYMERS; SOLUBILITY; TISSUE DISTRIBUTION;

EID: 70449732850     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.05.021     Document Type: Article

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