Contributions of AMPK and p53 dependent signaling to radiation response in the presence of metformin

Radiotherapy and Oncology

Volumn 108, Issue 3, 2013, Pages 446-450

  Muaddi, Hala ^a,b   Chowdhury, Sanjana ^a,b   Vellanki, Ravi ^a   Zamiara, Paul ^a,b   Koritzinsky, Marianne ^a,b  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

AMPK; Metformin; p53; Proliferation; Radiosensitivity

Indexed keywords

ADENYLATE KINASE; METFORMIN; PROTEIN P53;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL DEATH; CELL STRAIN HCT116; CELL SURVIVAL; CONTROLLED STUDY; GENOTYPE; GROWTH INHIBITION; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RADIATION; RADIOSENSITIVITY; SIGNAL TRANSDUCTION; TOXICITY; WESTERN BLOTTING;

AMPK; METFORMIN; P53; PROLIFERATION; RADIOSENSITIVITY;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; METFORMIN; MICE; NEOPLASMS; RADIATION TOLERANCE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84887018101     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2013.06.014     Document Type: Article

References (27)

1. M.N. Pollak Investigating metformin for cancer prevention and treatment: the end of the beginning Cancer Discov 2 2012 778 790
2. R.J. Dowling, P.J. Goodwin, and V. Stambolic Understanding the benefit of metformin use in cancer treatment BMC Med 9 2011 33
3. H. Noto, A. Goto, T. Tsujimoto, and M. Noda Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis PLoS One 7 2012 e33411
4. S. Jiralerspong, S.L. Palla, and S.H. Giordano Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer J Clin Oncol 27 2009 3297 3302
5. H.A. Hirsch, D. Iliopoulos, P.N. Tsichlis, and K. Struhl Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission Cancer Res 69 2009 7507 7511
6. D. Iliopoulos, H.A. Hirsch, and K. Struhl Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types Cancer Res 71 2011 3196 3201
7. V.N. Anisimov, P.A. Egormin, and L.M. Bershtein Metformin decelerates aging and development of mammary tumors in HER-2/neu transgenic mice Bull Exp Biol Med 139 2005 721 723
8. R.M. Memmott, J.R. Mercado, C.R. Maier, S. Kawabata, S.D. Fox, and P.A. Dennis Metformin prevents tobacco carcinogen - induced lung tumorigenesis Cancer Prev Res (Phila) 3 2010 1066 1076
9. S.A. Hinke, G.A. Martens, and Y. Cai Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer Br J Pharmacol 150 2007 1031 1043
10. M.R. Owen, E. Doran, and A.P. Halestrap Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain Biochem J 348 2000 607 614
11. R.J. Shaw, K.A. Lamia, and D. Vasquez The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin Science 310 2005 1642 1646
12. G.R. Steinberg, and B.E. Kemp AMPK in health and disease Physiol Rev 89 2009 1025 1078
13. D.B. Shackelford, E. Abt, and L. Gerken LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin Cancer Cell 23 2013 143 158
14. H.D. Skinner, V.C. Sandulache, and T.J. Ow TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence Clin Cancer Res 18 2012 290 300
15. H.D. Skinner, M.R. McCurdy, and A.E. Echeverria Metformin use and improved response to therapy in esophageal adenocarcinoma Acta Oncol 52 2012 1002 1009
16. D.E. Spratt, C. Zhang, Z.S. Zumsteg, X. Pei, Z. Zhang, and M.J. Zelefsky Metformin and prostate cancer: reduced development of castration-resistant disease and prostate cancer mortality Eur Urol 63 2012 709 716
17. C.W. Song, H. Lee, and R.P. Dings Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells Sci Rep 2 2012 362
18. Y. Storozhuk, S.N. Hopmans, and T. Sanli Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK Br J Cancer 108 2013 2021 2032
19. T. Sanli, A. Rashid, and C. Liu Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells Int J Radiat Oncol Biol Phys 78 2010 221 229
20. X. Fu, S. Wan, Y.L. Lyu, L.F. Liu, and H. Qi Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation PLoS One 3 2008 e2009
21. T. Sanli, Y. Storozhuk, and K. Linher-Melville Ionizing radiation regulates the expression of AMP-activated protein kinase (AMPK) in epithelial cancer cells: modulation of cellular signals regulating cell cycle and survival Radiother Oncol 102 2012 459 465
22. V.E. Zannella, D. Cojocari, and S. Hilgendorf AMPK regulates metabolism and survival in response to ionizing radiation Radiother Oncol 99 2011 293 299
23. R.G. Jones, D.R. Plas, and S. Kubek AMP-activated protein kinase induces a p53-dependent metabolic checkpoint Mol Cell 18 2005 283 293
24. M. Buzzai, R.G. Jones, and R.K. Amaravadi Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth Cancer Res 67 2007 6745 6752
25. K.R. Laderoute, K. Amin, and J.M. Calaoagan 5′-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments Mol Cell Biol 26 2006 5336 5347
26. F. Bunz, A. Dutriaux, and C. Lengauer Requirement for p53 and p21 to sustain G2 arrest after DNA damage Science 282 1998 1497 1501
27. I. Eke, and N. Cordes Radiobiology goes 3D: how ECM and cell morphology impact on cell survival after irradiation Radiother Oncol 99 2011 271 278