miR-451 inhibits cell proliferation in human hepatocellular carcinoma through direct Suppression of IKK-β

Carcinogenesis

Volumn 34, Issue 11, 2013, Pages 2443-2451

  Li, He Ping ^a   Zeng, Xian Cheng ^b   Zhang, Bing ^c   Long, Jian Ting ^a   Zhou, Bo ^a   Tan, Guo Sheng ^a   Zeng, Wei Xia ^d   Chen, Wei ^a   Yang, Jian Yong ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^b People's Hospital of Zengcheng   (China)

^c Department of Nuclear Medicine ^*  (China)

^d Laura Biotech Co Ltd   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MICRORNA; MICRORNA 451; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CANCER TISSUE; CARCINOGENICITY; CARCINOMA CELL; CELL IMMORTALIZATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; EPITHELIUM CELL; G1 PHASE CELL CYCLE CHECKPOINT; GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; IKBKB GENE; LIVER; LIVER CELL; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; S PHASE CELL CYCLE CHECKPOINT; UPREGULATION;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL ADHESION; CELL CYCLE; CELL MOVEMENT; CELL PROLIFERATION; CYCLIN D1; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; I-KAPPA B KINASE; LIVER NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, NUDE; MICRORNAS; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-MYC; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TUMOR CELLS, CULTURED;

EID: 84887013658     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt206     Document Type: Article

References (49)

1. Jemal,A. et al. (2011) Global cancer statistics. CA Cancer J. Clin., 61, 69-90.
2. Brechot,C. et al .(2010) Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC): molecular mechanisms and novel paradigms. Pathol. Biol. (Paris), 58, 278-287.
3. Tong,M.J. et al. (1995) Clinical outcomes after transfusion-associated hepatitis C. N. Engl. J. Med., 332, 1463-1466.
4. Hayden,M.S. et al. (2006) NF-kappaB and the immune response. Oncogene, 25, 6758-6780.
5. Lee,S.Y. et al . (2009) Obovatol enhances docetaxel-induced prostate and colon cancer cell death through inactivation of nuclear transcription factorkappaB. J. Pharmacol. Sci., 111, 124-136.
6. Horst,D. et al. (2009) Invasion associated up-regulation of nuclear factor kappaB target genes in colorectal cancer. Cancer, 115, 4946-4958.
7. Arsura,M. et a l. (2005) Nuclear factor-kappaB and liver carcinogenesis. Cancer Lett., 229, 157-169.
8. Tai,D.I. et al. (2000) Constitutive activation of nuclear factor kappaB in hepatocellular carcinoma. Cancer, 89, 2274-2281.
9. Häcker,H. et al. (2006) Regulation and function of IKK and IKK-related kinases. Sci. STKE, 2006, re13.
10. Hayden,M.S. et al. (2004) Signaling to NF-kappaB. Genes Dev., 18, 2195-2224.
11. Lagos-Quintana,M. et al. (2001) Identification of novel genes coding for small expressed RNAs. Science, 294, 853-858.
12. Bartel,D.P. (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell, 116, 281-297.
13. Schetter,A.J. et al. (2008) MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. JAMA, 299, 425-436.
14. Petri,A. et al. (2009) MicroRNA silencing in primates: towards development of novel therapeutics. Cancer Res., 69, 393-395.
15. Stamatopoulos,B. et al. (2009) microRNA-29c and microRNA-223 downregulation has in vivo significance in chronic lymphocytic leukemia and improves disease risk stratification. Blood, 113, 5237-5245.
16. Landi,M.T. et al. (2010) MicroRNA expression differentiates histology and predicts survival of lung cancer. Clin. Cancer Res., 16, 430-441.
17. Wong,C.M. et al. (2012) Sequential alterations of microRNA expression in hepatocellular carcinoma development and venous metastasis. Hepatology, 55, 1453-1461.
18. Budhu,A. et al . (2008) Identification of metastasis-related microRNAs in hepatocellular carcinoma. Hepatology, 47, 897-907.
19. Zhang,X. et al. (2009) Up-regulated microRNA-143 transcribed by nuclear factor kappa B enhances hepatocarcinoma metastasis by repressing fibronectin expression. Hepatology, 50, 490-499.
20. Law,P.T. et al. (2012) MiR-145 modulates multiple components of the insulin-like growth factor pathway in hepatocellular carcinoma. Carcinogenesis, 33, 1134-1141.21
21. Gao,P. et al. (2011) Deregulation of microRNA expression occurs early and accumulates in early stages of HBV-associated multistep hepatocarcinogenesis. J. Hepatol., 54, 1177-1184.
22. Jiang,J. et al. (2008) Association of MicroRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival. Clin. Cancer Res., 14, 419-427.
23. Matsushime,H. et al. (1994) D-type cyclin-dependent kinase activity in mammalian cells. Mol. Cell. Biol., 14, 2066-2076.
24. Bouchard,C. et al. (1998) Control of cell proliferation by Myc. Trends Cell Biol., 8, 202-206.
25. Ahn,K.S. et al. (2005) Transcription factor NF-kappaB: a sensor for smoke and stress signals. Ann. N. Y. Acad. Sci., 1056, 218-233.
26. Dahlman,J.M. et al. (2009) The RelA/p65 subunit of NF-kappaB specifically regulates cyclin D1 protein stability: implications for cell cycle withdrawal and skeletal myogenesis. J. Cell. Biochem., 106, 42-51.
27. Qin,Z.H. et al. (1999) Nuclear factor kappaB nuclear translocation upregulates c-Myc and p53 expression during NMDA receptor-mediated apoptosis in rat striatum. J. Neurosci., 19, 4023-4033.
28. Li,Z.W. et al. (1999) The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J. Exp. Med., 189, 1839-1845.
29. Maeda,S. (2010) NF-κB, JNK, and TLR signaling pathways in hepatocarcinogenesis. Gastroenterol. Res. Pract., 2010, 367694.
30. Pikarsky,E. et al. (2004) NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature, 431, 461-466.
31. Scheidereit,C. (2006) IkappaB kinase complexes: gateways to NF-kappaB activation and transcription. Oncogene, 25, 6685-6705.
32. Maeda,S. et al. (2005) IKKbeta couples hepatocyte death to cytokinedriven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell, 121, 977-990.
33. Jiang,R. et al. (2010) High expression levels of IKKalpha and IKKbeta are necessary for the malignant properties of liver cancer. Int. J. Cancer, 126, 1263-1274.
34. Schmid,J.A. et al. (2008) IkappaB kinase beta (IKKbeta/IKK2/IKBKB)-a key molecule in signaling to the transcription factor NF-kappaB. Cytokine Growth Factor Rev., 19, 157-165.
35. Maeda,S. et al. (2009) Ikappa B kinasebeta/nuclear factor-kappaB activation controls the development of liver metastasis by way of interleukin-6 expression. Hepatology, 50, 1851-1860.
36. He,G. et al. (2010) Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. Cancer Cell, 17, 286-297.
37. Wang,W. et al. (2012) MiR-138 induces cell cycle arrest by targeting cyclin D3 in hepatocellular carcinoma. Carcinogenesis, 33, 1113-1120.
38. Zhang,W. et al. (2012) MicroRNA-520b inhibits growth of hepatoma cells by targeting MEKK2 and cyclin D1. PLoS One, 7, e31450.
39. Jia,X.Q. et al. (2012) Lentivirus-mediated overexpression of microRNA-199a inhibits cell proliferation of human hepatocellular carcinoma. Cell Biochem. Biophys., 62, 237-244.
40. Bianchi,N. et al. (2012) Involvement of miRNA in erythroid differentiation. Epigenomics, 4, 51-65.
41. Lawrie,C.H. (2010) microRNA expression in erythropoiesis and erythroid disorders. Br. J. Haematol., 150, 144-151.
42. Godlewski,J. et al . (2010) microRNA-451: a conditional switch controlling glioma cell proliferation and migration. Cell Cycle, 9, 2742-2748.
43. Bandres,E. et al. (2009) microRNA-451 regulates macrophage migration inhibitory factor production and proliferation of gastrointestinal cancer cells. Clin. Cancer Res., 15, 2281-2290.
44. Wang,R. et al. (2011) MicroRNA-451 functions as a tumor suppressor in human non-small cell lung cancer by targeting ras-related protein 14 (RAB14). Oncogene, 30, 2644-2658.
45. Heinzelmann,J. et al. (2011) Specific miRNA signatures are associated with metastasis and poor prognosis in clear cell renal cell carcinoma. World J. Urol., 29, 367-373.
46. Bitarte,N. et al. (2011) MicroRNA-451 is involved in the self-renewal, tumorigenicity, and chemoresistance of colorectal cancer stem cells. Stem Cells, 29, 1661-1671.
47. Godlewski,J. et al. (2010) MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells. Mol. Cell, 37, 620-632.
48. Zhou,P. et al. (2012) miR-301a is a candidate oncogene that targets the homeobox gene Gax in human hepatocellular carcinoma. Dig. Dis. Sci., 57, 1171-1180.
49. Scisciani,C. et al. (2012) Transcriptional regulation of miR-224 upregulated in human HCCs by NFκB inflammatory pathways. J. Hepatol., 56, 855-861.