-
1
-
-
80054746492
-
Exome sequencing as a tool for Mendelian disease gene discovery
-
Bamshad, M.J. et al. Exome sequencing as a tool for Mendelian disease gene discovery. Nat. Rev. Genet. 12, 745-755 (2011).
-
(2011)
Nat. Rev. Genet
, vol.12
, pp. 745-755
-
-
Bamshad, M.J.1
-
2
-
-
84876527918
-
Cancer genome-sequencing study design
-
Mwenifumbo, J.C. & Marra, M.A. Cancer genome-sequencing study design. Nat. Rev. Genet. 14, 321-332 (2013).
-
(2013)
Nat. Rev. Genet
, vol.14
, pp. 321-332
-
-
Mwenifumbo, J.C.1
Marra, M.A.2
-
3
-
-
84880063629
-
From human genome to cancer genome: The first decade
-
Wheeler, D.A. & Wang, L. From human genome to cancer genome: The first decade. Genome Res. 23, 1054-1062 (2013).
-
(2013)
Genome Res
, vol.23
, pp. 1054-1062
-
-
Wheeler, D.A.1
Wang, L.2
-
4
-
-
55549101623
-
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome
-
Ley, T.J. et al. DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature 456, 66-72 (2008).
-
(2008)
Nature
, vol.456
, pp. 66-72
-
-
Ley, T.J.1
-
5
-
-
84863393080
-
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
-
Gerlinger, M. et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N. Engl. J. Med. 366, 883-892 (2012).
-
(2012)
N. Engl. J. Med
, vol.366
, pp. 883-892
-
-
Gerlinger, M.1
-
6
-
-
34548707114
-
Laser-capture microdissection
-
Espina, V. et al. Laser-capture microdissection. Nat. Protoc. 1, 586-603 (2006).
-
(2006)
Nat. Protoc
, vol.1
, pp. 586-603
-
-
Espina, V.1
-
7
-
-
84861033754
-
Genome-wide copy number analysis of single cells
-
Baslan, T. et al. Genome-wide copy number analysis of single cells. Nat. Protoc. 7, 1024-1041 (2012).
-
(2012)
Nat. Protoc
, vol.7
, pp. 1024-1041
-
-
Baslan, T.1
-
8
-
-
79953766940
-
Tumour evolution inferred by single-cell sequencing
-
Navin, N. et al. Tumour evolution inferred by single-cell sequencing. Nature 472, 90-94 (2011).
-
(2011)
Nature
, vol.472
, pp. 90-94
-
-
Navin, N.1
-
9
-
-
78049380554
-
The patterns and dynamics of genomic instability in metastatic pancreatic cancer
-
Campbell, P.J. et al. The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature 467, 1109-1113 (2010).
-
(2010)
Nature
, vol.467
, pp. 1109-1113
-
-
Campbell, P.J.1
-
10
-
-
0028875562
-
Allelotype of pancreatic adenocarcinoma using xenograft enrichment
-
Hahn, S.A. et al. Allelotype of pancreatic adenocarcinoma using xenograft enrichment. Cancer Res. 55, 4670-4675 (1995).
-
(1995)
Cancer Res
, vol.55
, pp. 4670-4675
-
-
Hahn, S.A.1
-
11
-
-
84862988411
-
BAP1 loss defines a new class of renal cell carcinoma
-
Peña-Llopis, S. et al. BAP1 loss defines a new class of renal cell carcinoma. Nat. Genet. 44, 751-759 (2012).
-
(2012)
Nat. Genet
, vol.44
, pp. 751-759
-
-
Peña-Llopis, S.1
-
12
-
-
84862145477
-
A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma
-
Sivanand, S. et al. A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma. Sci. Transl. Med. 4, 137ra75 (2012).
-
(2012)
Sci. Transl. Med
, vol.4
-
-
Sivanand, S.1
-
13
-
-
84880967722
-
Integrated molecular analysis of clear-cell renal cell carcinoma
-
Sato, Y. et al. Integrated molecular analysis of clear-cell renal cell carcinoma. Nat. Genet. 45, 860-867 (2013).
-
(2013)
Nat. Genet
, vol.45
, pp. 860-867
-
-
Sato, Y.1
-
14
-
-
84879466482
-
Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: A report by MSKCC and the KIRC TCGA research network
-
Hakimi, A.A. et al. Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: A report by MSKCC and the KIRC TCGA research network. Clin. Cancer Res. 19, 3259-3267 (2013).
-
(2013)
Clin. Cancer Res
, vol.19
, pp. 3259-3267
-
-
Hakimi, A.A.1
-
15
-
-
84879890360
-
Comprehensive molecular characterization of clear cell renal cell carcinoma
-
Creighton, C.J. et al. Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature 499, 43-49 (2013).
-
(2013)
Nature
, vol.499
, pp. 43-49
-
-
Creighton, C.J.1
-
16
-
-
75149188170
-
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
-
Dalgliesh, G.L. et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature 463, 360-363 (2010).
-
(2010)
Nature
, vol.463
, pp. 360-363
-
-
Dalgliesh, G.L.1
-
17
-
-
79251635938
-
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
-
Varela, I. et al. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature 469, 539-542 (2011).
-
(2011)
Nature
, vol.469
, pp. 539-542
-
-
Varela, I.1
-
18
-
-
84876037266
-
Clinical and pathologic impact of select chromatin-modulating tumor suppressors in clear cell renal cell carcinoma
-
Hakimi, A.A. et al. Clinical and pathologic impact of select chromatin-modulating tumor suppressors in clear cell renal cell carcinoma. Eur. Urol. 63, 848-854 (2013).
-
(2013)
Eur. Urol
, vol.63
, pp. 848-854
-
-
Hakimi, A.A.1
-
19
-
-
84655176646
-
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma
-
Guo, G. et al. Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. Nat. Genet. 44, 17-19 (2012).
-
(2012)
Nat. Genet
, vol.44
, pp. 17-19
-
-
Guo, G.1
-
20
-
-
51049084870
-
Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors
-
Nickerson, M.L. et al. Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors. Clin. Cancer Res. 14, 4726-4734 (2008).
-
(2008)
Clin. Cancer Res
, vol.14
, pp. 4726-4734
-
-
Nickerson, M.L.1
-
21
-
-
84880898004
-
Cooperation and antagonism among cancer genes: The renal cancer paradigm
-
Peña-Llopis, S., Christie, A., Xie, X.J. & Brugarolas, J. Cooperation and antagonism among cancer genes: The renal cancer paradigm. Cancer Res. 73, 4173-4179 (2013).
-
(2013)
Cancer Res
, vol.73
, pp. 4173-4179
-
-
Peña-Llopis, S.1
Christie, A.2
Xie, X.J.3
Brugarolas, J.4
-
22
-
-
0025089978
-
Rapid and simple method for purification of nucleic acids
-
Boom, R. et al. Rapid and simple method for purification of nucleic acids. J. Clin. Microbiol. 28, 495-503 (1990). (Pubitemid 20078123)
-
(1990)
Journal of Clinical Microbiology
, vol.28
, Issue.3
, pp. 495-503
-
-
Boom, R.1
Sol, C.J.A.2
Salimans, M.M.M.3
Jansen, C.L.4
Wertheim-Van Dillen, P.M.E.5
Van Der Noordaa, J.6
-
23
-
-
0015834582
-
Isolation of high-molecular-weight DNA from mammalian cells
-
Gross-Bellard, M., Oudet, P. & Chambon, P. Isolation of high-molecular-weight DNA from mammalian cells. Eur. J. Biochem. 36, 32-38 (1973).
-
(1973)
Eur. J. Biochem
, vol.36
, pp. 32-38
-
-
Gross-Bellard, M.1
Oudet, P.2
Chambon, P.3
-
24
-
-
39749154750
-
Preparation of genomic DNA from mammalian tissue
-
Strauss, W.M. Preparation of genomic DNA from mammalian tissue. Curr. Protoc. Mol. Biol. 42, 2.2.1-2.2.3 (2001).
-
(2001)
Curr. Protoc. Mol. Biol
, vol.42
, pp. 221-223
-
-
Strauss, W.M.1
-
25
-
-
0023277545
-
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
-
DOI 10.1006/abio.1987.9999
-
Chomczynski, P. & Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159 (1987). (Pubitemid 17064313)
-
(1987)
Analytical Biochemistry
, vol.162
, Issue.1
, pp. 156-159
-
-
Chomczynski, P.1
Sacchi, N.2
-
26
-
-
34248663955
-
The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: Twenty-something years on
-
Chomczynski, P. & Sacchi, N. The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: Twenty-something years on. Nat. Protoc. 1, 581-585 (2006).
-
(2006)
Nat. Protoc
, vol.1
, pp. 581-585
-
-
Chomczynski, P.1
Sacchi, N.2
-
27
-
-
0027169767
-
A reagent for the single-step simultaneous isolation of RNA. DNA and proteins from cell and tissue samples
-
536-537
-
Chomczynski, P. A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. Biotechniques 15, 532-534, 536-537 (1993).
-
(1993)
Biotechniques
, vol.15
, pp. 532-534
-
-
Chomczynski, P.1
-
28
-
-
0035656688
-
Non-coding RNA genes and the modern RNA world
-
DOI 10.1038/35103511
-
Eddy, S.R. Non-coding RNA genes and the modern RNA world. Nat. Rev. Genet. 2, 919-929 (2001). (Pubitemid 33691089)
-
(2001)
Nature Reviews Genetics
, vol.2
, Issue.12
, pp. 919-929
-
-
Eddy, S.R.1
-
29
-
-
79953089167
-
PIWI-interacting small RNAs: The vanguard of genome defence
-
Siomi, M.C., Sato, K., Pezic, D. & Aravin, A.A. PIWI-interacting small RNAs: The vanguard of genome defence. Nat. Rev. Mol. Cell Biol. 12, 246-258 (2011).
-
(2011)
Nat. Rev. Mol. Cell Biol
, vol.12
, pp. 246-258
-
-
Siomi, M.C.1
Sato, K.2
Pezic, D.3
Aravin, A.A.4
-
30
-
-
77949528224
-
Structural analysis and functional implications of the negative mTORC1 regulator REDD1
-
Vega-Rubin-de-Celis, S. et al. Structural analysis and functional implications of the negative mTORC1 regulator REDD1. Biochemistry 49, 2491-2501 (2010).
-
(2010)
Biochemistry
, vol.49
, pp. 2491-2501
-
-
Vega-Rubin-De-Celis, S.1
-
31
-
-
80052837898
-
Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma
-
Kucejova, B. et al. Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma. Mol. Cancer Res. 9, 1255-1265 (2011).
-
(2011)
Mol. Cancer Res
, vol.9
, pp. 1255-1265
-
-
Kucejova, B.1
-
32
-
-
80052841665
-
Regulation of TFEB and V-ATPases by mTORC1
-
Peña-Llopis, S. et al. Regulation of TFEB and V-ATPases by mTORC1. EMBO J. 30, 3242-3258 (2011).
-
(2011)
EMBO J
, vol.30
, pp. 3242-3258
-
-
Peña-Llopis, S.1
-
33
-
-
34547528183
-
DNA methylation: Bisulphite modification and analysis
-
Clark, S.J., Statham, A., Stirzaker, C., Molloy, P.L. & Frommer, M. DNA methylation: Bisulphite modification and analysis. Nat. Protoc. 1, 2353-2364 (2006).
-
(2006)
Nat. Protoc
, vol.1
, pp. 2353-2364
-
-
Clark, S.J.1
Statham, A.2
Stirzaker, C.3
Molloy, P.L.4
Frommer, M.5
-
34
-
-
84858146301
-
Methylome analysis using MeDIP-seq with low DNA concentrations
-
Taiwo, O. et al. Methylome analysis using MeDIP-seq with low DNA concentrations. Nat. Protoc. 7, 617-636 (2012).
-
(2012)
Nat. Protoc
, vol.7
, pp. 617-636
-
-
Taiwo, O.1
-
35
-
-
34248670011
-
Southern blotting
-
Southern, E. Southern blotting. Nat. Protoc. 1, 518-525 (2006).
-
(2006)
Nat. Protoc
, vol.1
, pp. 518-525
-
-
Southern, E.1
-
36
-
-
76649101075
-
Defining transcribed regions using RNA-seq
-
Wilhelm, B.T., Marguerat, S., Goodhead, I. & Bahler, J. Defining transcribed regions using RNA-seq. Nat. Protoc. 5, 255-266 (2010).
-
(2010)
Nat. Protoc
, vol.5
, pp. 255-266
-
-
Wilhelm, B.T.1
Marguerat, S.2
Goodhead, I.3
Bahler, J.4
-
37
-
-
61449196773
-
Northern blot analysis for detection and quantification of RNA in pancreatic cancer cells and tissues
-
Streit, S., Michalski, C.W., Erkan, M., Kleeff, J. & Friess, H. Northern blot analysis for detection and quantification of RNA in pancreatic cancer cells and tissues. Nat. Protoc. 4, 37-43 (2009).
-
(2009)
Nat. Protoc
, vol.4
, pp. 37-43
-
-
Streit, S.1
Michalski, C.W.2
Erkan, M.3
Kleeff, J.4
Friess, H.5
-
38
-
-
44949098384
-
Improved northern blot method for enhanced detection of small RNA
-
DOI 10.1038/nprot.2008.67, PII NPROT.2008.67
-
Pall, G.S. & Hamilton, A.J. Improved northern blot method for enhanced detection of small RNA. Nat. Protoc. 3, 1077-1084 (2008). (Pubitemid 351818694)
-
(2008)
Nature Protocols
, vol.3
, Issue.6
, pp. 1077-1084
-
-
Pall, G.S.1
Hamilton, A.J.2
-
39
-
-
42049095870
-
MicroRNA expression profiling using microarrays
-
DOI 10.1038/nprot.2008.14, PII NPROT.2008.14
-
Liu, C.G., Calin, G.A., Volinia, S. & Croce, C.M. MicroRNA expression profiling using microarrays. Nat. Protoc. 3, 563-578 (2008). (Pubitemid 351516752)
-
(2008)
Nature Protocols
, vol.3
, Issue.4
, pp. 563-578
-
-
Liu, C.-G.1
Calin, G.A.2
Volinia, S.3
Croce, C.M.4
-
40
-
-
34547905871
-
State-of-the-art two-dimensional gel electrophoresis: A key tool of proteomics research
-
Carrette, O., Burkhard, P.R., Sanchez, J.C. & Hochstrasser, D.F. State-of-the-art two-dimensional gel electrophoresis: A key tool of proteomics research. Nat. Protoc. 1, 812-823 (2006).
-
(2006)
Nat. Protoc
, vol.1
, pp. 812-823
-
-
Carrette, O.1
Burkhard, P.R.2
Sanchez, J.C.3
Hochstrasser, D.F.4
-
41
-
-
34250657012
-
Quantitative proteome analysis using isotope-coded affinity tags and mass spectrometry
-
Shiio, Y. & Aebersold, R. Quantitative proteome analysis using isotope-coded affinity tags and mass spectrometry. Nat. Protoc. 1, 139-145 (2006).
-
(2006)
Nat. Protoc
, vol.1
, pp. 139-145
-
-
Shiio, Y.1
Aebersold, R.2
-
42
-
-
77956704233
-
Rapid in situ codetection of noncoding RNAs and proteins in cells and formalin-fixed paraffin-embedded tissue sections without protease treatment
-
de Planell-Saguer, M., Rodicio, M.C. & Mourelatos, Z. Rapid in situ codetection of noncoding RNAs and proteins in cells and formalin-fixed paraffin-embedded tissue sections without protease treatment. Nat. Protoc. 5, 1061-1073 (2010).
-
(2010)
Nat. Protoc
, vol.5
, pp. 1061-1073
-
-
De Planell-Saguer, M.1
Rodicio, M.C.2
Mourelatos, Z.3
|