Aneuploidy facilitates oncogenic transformation via specific genetic alterations, including Twist2 upregulation

Carcinogenesis

Volumn 34, Issue 9, 2013, Pages 2000-2009

  Högnäs, Gunilla ^a,b   Hämälistö, Saara ^b   Rilla, Kirsi ^c   Laine, Jukka O ^b   Vilkki, Vesa ^d   Murumägi, Astrid ^e   Edgren, Henrik ^e   Kallioniemi, Olli ^e   Ivaska, Johanna ^a,b  

^a VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

^d TURKU UNIVERSITY HOSPITAL   (Finland)

^e UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA 10B; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TWIST2; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ANEUPLOIDY; ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL INVASION; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; CYTOKINESIS; EMBRYO; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; INTRACELLULAR SIGNALING; LIPOGENESIS; MOUSE; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE; PRIORITY JOURNAL; UPREGULATION;

ANEUPLOIDY; ANIMALS; APOPTOSIS; CELL SURVIVAL; CHROMOSOME ABERRATIONS; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTEGRINS; LIPIDS; MICE; MICRORNAS; NEOPLASM INVASIVENESS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TWIST TRANSCRIPTION FACTOR; UP-REGULATION;

EID: 84887001264     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt171     Document Type: Article

References (48)

1. Gordon, D.J. et al. (2012) Causes and consequences of aneuploidy in cancer. Nat. Rev. Genet., 13, 189-203.
2. Torres, E.M. et al. (2007) Effects of aneuploidy on cellular physiology and cell division in haploid yeast. Science, 317, 916-924.
3. Williams, B.R. et al. (2008) Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells. Science, 322, 703-709.
4. Chen, G. et al. (2012) Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy. Nature, 482, 246-250.
5. Sotillo, R. et al. (2007) Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell, 11, 9-23.
6. Weaver, B.A. et al. (2007) Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell, 11, 25-36.
7. Iwanaga, Y. et al. (2007) Heterozygous deletion of mitotic arrest-deficient protein 1 (MAD1) increases the incidence of tumors in mice. Cancer Res., 67, 160-166.
8. Pellinen, T. et al. (2008) Integrin trafficking regulated by Rab21 is necessary for cytokinesis. Dev. Cell, 15, 371-385.
9. Montagnac, G. et al. (2008) Endocytic traffic in animal cell cytokinesis. Curr. Opin. Cell Biol., 20, 454-461.
10. Margadant, C. et al. (2011) Mechanisms of integrin activation and trafficking. Curr. Opin. Cell Biol., 23, 607-614.
11. Ivaska, J. et al. (2011) Cooperation between integrins and growth factor receptors in signaling and endocytosis. Annu. Rev. Cell Dev. Biol., 27, 291-320.
12. Muller, P.A. et al. (2009) Mutant p53 drives invasion by promoting integrin recycling. Cell, 139, 1327-1341.
13. Högnäs, G. et al. (2011) Cytokinesis failure due to derailed integrin traffic induces aneuploidy and oncogenic transformation in vitro and in vivo. Oncogene, 31, 3597-3606. doi:10.1038/onc.2011.527.
14. Lanzetti, L. et al. (2008) Endocytosis and cancer: an 'insider' network with dangerous liaisons. Traffic, 9, 2011-2021.
15. Lengauer, C. et al. (1997) Genetic instability in colorectal cancers. Nature, 386, 623-627.
16. Thompson, S.L. et al. (2008) Examining the link between chromosomal instability and aneuploidy in human cells. J. Cell Biol., 180, 665-672.
17. Ricke, R.M. et al. (2008) Whole chromosome instability and cancer: a complex relationship. Trends Genet., 24, 457-466.
18. Obe, G. et al. (2010) DNA double strand breaks and chromosomal aberrations. Cytogenet. Genome Res., 128, 8-16.
19. Janssen, A. et al. (2011) Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations. Science, 333, 1895-1898.
20. Czuchra, A. et al. (2006) Genetic analysis of beta1 integrin "activation motifs" in mice. J. Cell Biol., 174, 889-899.
21. Hilvo, M. et al. (2011) Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression. Cancer Res., 71, 3236-3245.
22. Tennant, D.A. et al. (2010) Targeting metabolic transformation for cancer therapy. Nat. Rev. Cancer, 10, 267-277.
23. Bourguignon, L.Y. (2008) Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression. Semin. Cancer Biol., 18, 251-259.
24. Ansieau, S. et al. (2008) Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence. Cancer Cell, 14, 79-89.
25. Ma, L. et al. (2007) Tumour invasion and metastasis initiated by micro- RNA-10b in breast cancer. Nature, 449, 682-688.
26. Bourguignon, L.Y. et al. (2010) Hyaluronan-CD44 interaction promotes c-Src-mediated twist signaling, microRNA-10b expression and RhoA/RhoC upregulation leading to Rho-kinase-associated cytoskeleton activation and breast tumor cell invasion. J. Biol. Chem., 285, 36721-36735. doi:10.1074/jbc. M110.162305.
27. Pan, D. et al. (2009) Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism. Cell, 137, 73-86.
28. Lee, Y.S. et al. (2003) Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c. Nucleic Acids Res., 31, 7165-7174.
29. Sosic, D. et al. (2003) Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity. Cell, 112, 169-180.
30. Kamisuki, S. et al. (2009) A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem. Biol., 16, 882-892.
31. Gasparotto, D. et al. (2011) Overexpression of TWIST2 correlates with poor prognosis in head and neck squamous cell carcinomas. Oncotarget, 2, 1165-1175.
32. Li, Y. et al. (2012) Correlation of TWIST2 up-regulation and epithelialmesenchymal transition during tumorigenesis and progression of cervical carcinoma. Gynecol. Oncol., 124, 112-118.
33. Boveri, T. (2008) Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris. J. Cell Sci., 121 (suppl. 1), 1-84.
34. Toole, B.P. et al. (2002) Hyaluronan-cell interactions in cancer and vascular disease. J. Biol. Chem., 277, 4593-4596.
35. Itano, N. et al. (2004) Selective expression and functional characteristics of three mammalian hyaluronan synthases in oncogenic malignant transformation. J. Biol. Chem., 279, 18679-18687.
36. Bourguignon, L.Y. et al. (2006) Hyaluronan-CD44 interaction with leukemia- associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells. J. Biol. Chem., 281, 14026-14040.
37. Bourguignon, L.Y. et al. (2003) Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression. J. Biol. Chem., 278, 29420-29434.
38. Radotra, B. et al. (1997) Glioma invasion in vitro is mediated by CD44-hyaluronan interactions. J. Pathol., 181, 434-438.
39. Yang, J. et al. (2004) Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell, 117, 927-939.
40. Merikallio, H. et al. (2011) Zeb1 and twist are more commonly expressed in metastatic than primary lung tumours and show inverse associations with claudins. J. Clin. Pathol., 64, 136-140.
41. Soini, Y. et al. (2011) Transcription factors zeb1, twist and snai1 in breast carcinoma. BMC Cancer, 11, 73.
42. Clendening, J.W. et al. (2010) Dysregulation of the mevalonate pathway promotes transformation. Proc. Natl Acad. Sci. USA, 107, 15051-15056.
43. Kidera, Y. et al. (2010) Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rhoassociated coiled-coil-containing protein kinase pathway. J. Exp. Clin. Cancer Res., 29, 127.
44. Koyuturk, M. et al. (2007) Simvastatin induces apoptosis in human breast cancer cells: p53 and estrogen receptor independent pathway requiring signalling through JNK. Cancer Lett., 250, 220-228.
45. Freed-Pastor, W.A. et al. (2012) Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell, 148, 244-258.
46. Ros, S. et al. (2012) Functional metabolic screen identifies 6-phosphofructo- 2-kinase/fructose-2, 6-biphosphatase 4 as an important regulator of prostate cancer cell survival. Cancer Discov., 2, 328-343.
47. Menendez, J.A. et al. (2007) Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat. Rev. Cancer, 7, 763-777.
48. Chajès, V. et al. (2006) Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival. Cancer Res., 66, 5287-5294.