Somatostatin receptor sst2 reduces Akt activity and aggravates hypoxic/ischemic death in cerebral cortical neurons

Neuropharmacology

Volumn 77, Issue , 2014, Pages 249-256

  Stumm, Ralf ^a,b  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b Institut fuer Pharmakologie und Toxikologie   (Germany)

Author keywords

Akt; Apoptosis; Ischemia; Neuroprotection; PKB; Preconditioning; Somatostatin; Stroke

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BETA GALACTOSIDASE; BIM 23244; BIM 23627; GLUCOSE; OXYGEN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RECEPTOR BLOCKING AGENT; SOMATOSTATIN; SOMATOSTATIN RECEPTOR 2; SOMATOSTATIN RECEPTOR 2 ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CELL; BRAIN CELL CULTURE; CELL HYPOXIA; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE DELETION; GENE EXPRESSION; GENE TARGETING; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; INTERNALIZATION; ISCHEMIA; KNOCKOUT GENE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELL; WILD TYPE;

AKT; APOPTOSIS; BALANCED SALT SOLUTION; BSS; DAYS IN VITRO; DIV; ISCHEMIA; NEUROPROTECTION; NG; NORMOXIA/GLUCOSE; OGD; OXYGEN/GLUCOSE DEPRIVATION; PKB; PRECONDITIONING; SOMATOSTATIN; STROKE;

ANIMALS; CELL DEATH; CEREBRAL CORTEX; HYPOXIA-ISCHEMIA, BRAIN; MICE; MICE, TRANSGENIC; NEURONS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, SOMATOSTATIN;

EID: 84887001247     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.10.011     Document Type: Article

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