IP3R1 deficiency in the cerebellum/brainstem causes basal ganglia-independent dystonia by triggering tonic Purkinje cell firings in mice

Frontiers in Neural Circuits

Volumn 7, Issue OCT, 2013, Pages

  Hisatsune, Chihiro ^a   Miyamoto, Hiroyuki ^a,b   Hirono, Moritoshi ^a   Yamaguchi, Naohide ^a   Sugawara, Takeyuki ^a   Ogawa, Naoko ^a   Ebisui, Etsuko ^a   Ohshima, Toshio ^c   Yamada, Masahisa ^a   Hensch, Takao K ^a   Hattori, Mitsuharu ^d   Mikoshiba, Katsuhiko ^a,b  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c WASEDA UNIVERSITY   (Japan)

^d NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

Basal ganglia; Cerebellum; Complex spikes; Dystonia; Inferior olive; Inositol 1,4,5 trisphosphate; Purkinje cells; SCA15

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; PLACEBO; INOSITOL 1,4,5 TRISPHOSPHATE;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; BASAL GANGLION; BRAIN DEPTH STIMULATION; BRAIN LEVEL; BRAIN REGION; BRAIN STEM; CEREBELLUM; CONTINUOUS INFUSION; CONTROLLED STUDY; DYSKINESIA; DYSTONIA; ELECTROENCEPHALOGRAM; FREQUENCY MODULATION; GENE DELETION; GENE FUNCTION; GENE IDENTIFICATION; INFERIOR OLIVE; IP3R1 GENE; KNOCKOUT MOUSE; MOTOR COORDINATION; MOUSE; MUSCLE RIGIDITY; NERVE CELL STIMULATION; NONHUMAN; OPISTHOTONUS; PROTEIN FUNCTION; PURKINJE CELL; PURKINJE FIBER MEMBRANE POTENTIAL; SYMPTOMATOLOGY; TREMOR; ACTION POTENTIAL; ANIMAL; GENETICS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; COMPLEX SPIKES; SCA15;

ACTION POTENTIALS; ANIMALS; BASAL GANGLIA; BRAIN STEM; CEREBELLUM; DYSTONIA; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; MICE, KNOCKOUT; PURKINJE CELLS;

BASAL GANGLIA; CEREBELLUM; COMPLEX SPIKES; DYSTONIA; INFERIOR OLIVE; INOSITOL 1,4,5-TRISPHOSPHATE; PURKINJE CELLS; SCA15;

EID: 84887001009     PISSN: 16625110     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncir.2013.00156     Document Type: Article

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