Functional significance of climbing-fiber synchrony: A population coding and behavioral analysis

Annals of the New York Academy of Sciences

Volumn 978, Issue , 2002, Pages 188-204

  Welsh, John P ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Cerebellum; Climbing fiber system; Delay eyeblink conditioning; Mossy fiber system

Indexed keywords

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; CELL FUNCTION; CELL SYNCHRONIZATION; CEREBELLUM; CLIMBING FIBER; CONFERENCE PAPER; CONTROLLED STUDY; EYELID REFLEX; HISTOGRAM; MOTOR NERVE; MOVEMENT (PHYSIOLOGY); NERVE CONDUCTION; NONHUMAN; OLIVARY NUCLEUS; RAT; SENSORY STIMULATION;

ANIMALIA;

EID: 0036960321     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb07567.x     Document Type: Conference Paper

References (31)

1. NICOLELIS, M.A.L. 2001. Prog. Brain Res. Adv. Neural Popul. Coding. Vol. 130.
2. THACH, W.T. 1968. Discharge of Purkinje and cerebellar nuclear neurons during rapidly alternating arm movement in the monkey. J. Neurophysiol. 31: 785-797.
3. GELLMAN, R., J.C. HOUK & A.R. GIBSON. 1983. Somatosensory properties of the inferior olive of the cat. J. Comp. Neurol. 215: 228-243.
4. BLOEDEL, J.R. & T.J. EBNER. 1984. Rhythmic discharge of climbing fibre afferents in response to natural peripheral stimuli in the cat. J. Physiol. 352: 129-146.
5. SIMPSON, J.I. 1984. The accessory optic system. Annu. Rev. Neurosci. 7: 13-41.
6. OSCARSSON, O. 1980. Functional organization of olivary projection to the cerebellar anterior lobe. In The Inferior Olivary Nucleus: Anatomy and Physiology. J. Courville, C. de Montigney & Y. Lamarre, Eds. Raven Press. New York.
7. BOWER, J.M. 1997. Is the cerebellum sensory for motor's sake, or motor for sensory's sake: The view from the whiskers of a rat? in Progress in Brain Research. The Cerebellum: From Structure to Control. C.I. DeZeeuw, P. Strata & J. Voogd, Eds.: 114: 463-496. Elsevier. Amsterdam.
8. ITO, M. 1972. Neural design of the cerebellar motor control system. Brain Res. 40: 81-84.
9. MANO, N.I. 1974. Simple and complex spike activities of the cerebellar Purkinje cell in relation to selective alternate movement in intact monkey. Brain Res. 70: 381-393.
10. FU, Q.G., C.R. MASON, D. FLAMENT, et al. 1997. Movement kinematics encoded in complex spike discharge of primate cerebellar Purkinje cells. Neuroreport 8: 523-529.
11. KITAZAWA, S., T. KIMURA & P.B. YIN. 1998. Cerebellar complex spikes encode both destinations and errors in arm movements. Nature 392: 494-497.
12. WELSH, J.P. 1998. Systemic harmaline blocks associative and motor learning by the actions of the inferior olive. Eur. J. Neurosci. 10: 3307-3320.
13. WELSH, J.P., E.J. LANG, I. SUGIHARA & R. LLINÁS. 1995. Dynamic organization of motor control within the olivocerebellar system. Nature 374: 453-457.
14. AERTSEN, A.M.H.J., G.L. GERSTEIN, M. HABIB & G. PALM. 1989. Dynamics of neuronal firing correlation: modulation of "effective connectivity." J. Neurophysiol. 61: 900-917.
15. GERSTEIN, G.L. 1999. Correlation-based analysis methods for neural ensemble data. In Methods for Neural Ensemble Recording. M.A.L. Nicolelis, Ed.: 157-177. CRC Press. Boca Raton.
16. BELL, C.C. & R.J. GRIMM. 1969. Discharge properties of Purkinje cells recorded on single and double microelectrodes. J. Neurophysiol. 32: 1044-1055.
17. BLOEDEL, J.R. & W.J. ROBERTS. 1971. Action of climbing fibers in cerebellar cortex of the cat. J. Neurophysiol. 34: 17-31.
18. EBNER, T.J. & J.R. BLOEDEL. 1981. Role of climbing fiber afferent input in determining responsiveness of Purkinje cells to mossy fiber inputs. J. Neurophysiol. 45: 962-971.
19. MCDEVITT, C.J., T.J. EBNER & J.R. BLOEDEL. 1982. The changes in Purkinje cell simple spike activity following spontaneous climbing fiber inputs. Brain Res. 237: 484-491.
20. SCHWARZ, C. & J.P. WELSH. 2001. Dynamic modulation of mossy fiber system throughput by inferior olive synchrony: A multielectrode study of cerebellar cortex activated by motor cortex. J. Neurophysiol. 86: 2489-2504.
21. WELSH, J.P. & C. SCHWARZ. 1999. Multielectrode recording from the cerebellum. In Methods for Neural Ensemble Recording. M.A.L. Nicolelis, Ed.: 79-100. CRC Press. Boca Raton.
22. SIMPSON, J.I., D.R. WYLIE & C.I. DEZEEUW. 1996. On climbing fiber signals and their consequence(s). Behav. Brain Sci. 19: 384-398.
23. LLINÁS, R. & M. MÜHLETHALER. 1988. Electrophysiology of guinea-pig cerebellar nuclear cells in the in vitro brain stem-cerebellar preparation. J. Physiol. (Lond.) 404: 241-258.
24. LLINÁS, R. 1970. Neuronal operations in cerebellar transactions. In The Neurosciences: Second Study Program. F.O. Schmitt, Ed.: 409-426. Rockefeller University Press. New York.
25. WELSH, J.P. & R. LLINÁS. 1997. Some organizing principles for the control of movement based on olivocerebellar physiology. In Progress in Brain Research. The Cerebellum: From Structure to Control. C.I. DeZeeuw, P. Strata & J. Voogd, Eds.: Vol. 114: 449-461. Elsevier. Amsterdam.
26. GOULD, S.J. & E.S. VBRA. 1982. Exaptation - a missing term in the science of form. Paleobiology 8: 4-15.
27. LLINÁS, R., K. WALTON, D.E. HILLMAN & C. SOTELO. 1975. Inferior olive: Its role in motor learning. Science 190: 1230-1232.
28. WELSH, J.P., B. CHANG, M.E. MENAKER & S.A. AICHER. 1998. Removal of the inferior olive abolishes myoclonic seizures associated with a loss of olivary serotonin. Neuroscience 82: 879-897.
29. SMITH, M.C., S.R. COLEMAN & I. GORMEZANO. 1969. Classical conditioning of the rabbit's nictitating membrane response at backward, simultaneous, and forward CS-US intervals. J. Comp. Physiol. Psychol. 69: 226-231.
30. MINTZ, M., D.G. LAVOND, A.A. ZHANG, et al. 1994. Unilateral inferior olive NMDA lesion leads to unilateral deficit in acquisition and retention of eyelid classical conditioning. Behav. Neural Biol. 61: 218-224.
31. WELSH, J.P. & J.A. HARVEY. 1998. Acute inactivation of the inferior olive blocks associative learning. Eur. J. Neurosci. 10: 3321-3332.