Magnetic nanobeads as potential contrast agents for magnetic resonance imaging

ACS Nano

Volumn 7, Issue 10, 2013, Pages 9040-9048

  Pablico Lansigan, Michele H ^a   Hickling, William J ^a   Japp, Emily A ^a   Rodriguez, Olga C ^b   Ghosh, Anup ^b   Albanese, Chris ^b   Nishida, Maki ^a   Van Keuren, Edward ^a   Fricke, Stanley ^c   Dollahon, Norman ^d   Stoll, Sarah L ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

^c GEORGE WASHINGTON UNIVERSITY   (United States)

^d VILLANOVA UNIVERSITY   (United States)

Author keywords

contrast agents; manganese oxo clusters; miniemulsion nanobeads

Indexed keywords

CONTRAST AGENT; CONTRAST ENHANCEMENT; HUMAN PROSTATE CANCER CELLS; HYBRID NANOMATERIALS; MRI CONTRAST AGENTS; NANOBEADS; OXO CLUSTERS; SURFACE FUNCTIONALIZATION;

BENZOIC ACID; BIOCOMPATIBILITY; CELL CULTURE; COPOLYMERS; MAGNETIC RESONANCE IMAGING; MANGANESE; MANGANESE REMOVAL (WATER TREATMENT); NANOSTRUCTURED MATERIALS; NUCLEAR MAGNETIC RESONANCE; POLYVINYL ACETATES; STYRENE;

MANGANESE COMPOUNDS;

CONTRAST MEDIUM; NANOPARTICLE;

ARTICLE; HUMAN; MAGNETISM; MALE; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL LINE;

CELL LINE, TUMOR; CONTRAST MEDIA; HUMANS; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MAGNETICS; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES;

EID: 84886996511     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn403647t     Document Type: Article

References (70)

1. Strijkers, G.; Mulder, W.; van Tilborg, G.; Nicolay, K. MRI Contrast Agents: Current Status and Future Perspectives Anti-Cancer Agents Med. Chem. 2007, 7, 291-305
2. Caravan, P.; Ellison, J. J.; McMurry, T. J.; Lauffer, R. B. Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications Chem. Rev. 1999, 99, 2293-2352
3. Pankhurst, Q. A.; Connolly, J.; Jones, S. K.; Dobson, J. Applications of Magnetic Nanoparticles in Biomedicine J. Phys. D: Appl. Phys. 2003, 36, R167-R181
4. Laurent, S.; Forge, D.; Port, M.; Roch, A.; Robic, C.; Vander Elst, L.; Muller, R. N. Magnetic Iron Oxide Nanoparticles: Synthesis, Stabilization, Vectorization, Physicochemical Characterizations, and Biological Applications Chem. Rev. 2008, 108, 2064-2110
5. Chavhan, G. B.; Babyn, P. S.; Thomas, B.; Shroff, M. M.; Haacke, E. M. Principles, Techniques, and Applications of T2-based MR Imaging and Its Special Applications Radiographics 2009, 29, 1433-1449
6. Kowalewski, J.; Nordenskiold, L.; Benetis, N.; Westlund, P. Theory of Nuclear Spin Relaxation in Paramagnetic Systems in Solution Prog. NMR Spectrosc. 1984, 17, 141-185
7. Lowe, M. P. MRI Contrast Agents: The Next Generation Aust. J. Chem. 2002, 55, 551
8. Wolff, S.; Balaban, R. Magnetization Transfer Contrast (MTC) and Tissue Water Proton Relaxation in Vivo Magn. Reson. Med. 1989, 10, 135-144
9. Saritas, E. U.; Goodwill, P. W.; Croft, L. R.; Konkle, J. J.; Lu, K.; Zheng, B.; Conolly, S. M. Magnetic Particle Imaging (MPI) for NMR and MRI researchers J. Magn. Reson. 2013, 229, 116-126
10. Manjunath, V.; Perazella, M. A. Imaging Patients with Kidney Disease in the Era of NSF: Can It Be Done Safely? Clin. Nephrol. 2011, 75, 279-285
11. Weinreb, J. C.; Abu-Alfa, A. K. Gadolinium-Based Contrast Agents and Nephrogenic Systemic Fibrosis: Why Did It Happen and What Have We Learned? J. Magn. Reson. Imaging 2009, 30, 1236-1239
12. Sadowski, E. A.; Bennett, L. K.; Chan, M. R.; Wentland, A. L.; Garrett, A. L.; Garrett, R. W.; Djamali, A. Nephrogenic Systemic Fibrosis: Risk Factors and Incidence Estimation Radiology 2007, 243, 148-157
13. Kuo, P. H.; Kanal, E.; Abu-Alfa, A. K.; Cowper, S. E. Gadolinium-based MR Contrast Agents and Nephrogenic Systemic Fibrosis Radiology 2007, 242, 647-649
14. Serkan, K.; Bau, M. Anthropogenic Gadolinium as a Microcontaminant in Tap Water Used As Drinking Water in Urban Areas and Megacities Appl. Geochem. 2011, 26, 1877-1885
15. Kümmerer, K.; Helmers, E. Hospital Effluents as a Source of Gadolinium in the Aquatic Environment Environ. Sci. Technol. 2000, 34, 573-577
16. Liu, Y.; Solomon, M.; Achilefu, S. Perspectives and Potential Applications of Nanomedicine In Breast And Prostate Cancer Med. Res. Rev. 2010, 33, 3-32
17. Liu, Y.; Chen, Z.; Liu, C.; Yu, D.; Lu, Z.; Zhang, N. Gadolinium-Loaded Polymeric Nanoparticles Modified with Anti-VEGF as Multifunctional MRI Contrast Agents for the Diagnosis of Liver Cancer Biomaterials 2011, 32, 5167-5176
18. Liong, M.; Lu, J.; Kovochich, M.; Xia, T.; Ruehm, S. G.; Nel, A. E.; Tamanoi, F.; Zink, J. I. Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug Delivery ACS Nano 2008, 2, 889-896
19. Holzapfel, V.; Lorenz, M.; Weiss, C. K.; Schrezenmeier, H.; Landfester, K.; Mailander, V. Synthesis and Biomedical Applications of Functionalized Fluorescent and Magnetic Dual Reporter Nanoparticles as Obtained in the Miniemulsion Process J. Phys.: Condens. Matter 2006, 18, S2581-S2594
20. Hong, G.; Yuan, R.; Liang, B.; Shen, J.; Yang, X.; Shuai, X. Folate-Functionalized Polymeric Micelle as Hepatic Carcinoma-Targeted, MRI-Ultrasensitive Delivery System of Antitumor Drug Biomed. Microdevices 2008, 10, 693-700
21. Shapiro, E. M.; Skrtic, S.; Koretsky, A. P. Sizing it up: Cellular MRI Using Micron-Sized Iron Oxide Particles Magn. Reson. Med. 2005, 53, 329-338
22. Shapiro, E. M.; Skrtic, S.; Sharer, K.; Hill, J.; Dunbar, C.; Koretsky, A. P. MRI Detection Of Single Particles For Cellular Imaging Proc. Natl. Acad. Sci. U. S. A. 2004, 101, 10901-10906
23. Rodriguez, O.; Fricke, S.; Chien, C.; Dettin, L.; VanMeter, J.; Shapiro, E. M.; Dai, H.-N.; Casimiro, M.; Ileva, L.; Dagata, J. et al. Contrast-Enhanced in Vivo Imaging of Breast and Prostate Cancer Cells By MRI Cell Cycle 2006, 5, 113-119
24. Tassa, C.; Shaw, S. Y.; Weissleder, R. Dextran-Coated Iron Oxide Nanoparticles: A Versatile Platform for Targeted Molecular Imaging, Molecular Diagnostics, and Therapy Acc. Chem. Res. 2011, 44, 842-852
25. Koretsky, A. P.; Silva, A. C. Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) NMR Biomed. 2004, 17, 527-531
26. Pan, D.; Schmieder, A. H.; Wickline, S. A.; Lanza, G. M. Manganese-Based MRI Contrast Agents: Past, Present, and Future Tetrahedron 2011, 67, 8431-8444
27. Pan, D.; Caruthers, S. D.; Senpan, A.; Schmieder, A. H.; Wickline, S. A.; Lanza, G. M. Revisiting an Old Friend: Manganese-Based MRI Contrast Agents WIREs Nanomed. Nanobiotechnol. 2010, 3, 162-173
28. Kueny-Stotz, M.; Garofalo, A.; Felder-Flesch, D. Manganese-Enhanced MRI Contrast Agents: From Small Chelates to Nanosized Hybrids Eur. J. Inorg. Chem. 2012, 1987-2005
29. Drahoš, B.; Lukeš, I.; Tóth, é. Manganese(II) Complexes as Potential Contrast Agents for MRI Eur. J. Inorg. Chem. 2012, 1975-1986
30. Lauterbur, P. Image Formation by Induced local Interactions: Examples Employing Nuclear Magnetic Resonance Nature 2004, 1-2
31. Bryant, L. H.; Hodges, M. W.; Bryant, R. G. Test of Electron Delocalization Effects on Water-Proton Spin-Lattice Relaxation by Bromination of [Tetrakis(4-sulfonatophenyl) porphine] Manganese Inorg. Chem. 1999, 38, 1002-1005
32. Krause, W. Contrast Agents I, Magnetic Resonance Imaging; Springer-Verlag: New York, 2002; p 165.
33. Federle, M.; Chezmar, J.; Rubin, D. L.; Weinreb, J.; Freeny, P.; Schmiedl, U.; Brown, J.; Borrello, J.; Lee, J. E.-H.; Semelka, R. et al. Efficacy and Safety of Mangafodipir Trisodium (MnDPDP) Injection for Hepatic MRI in Adults: Results of the U.S. Multicenter Phase III Clinical Trials. Efficacy of Early Imaging J. Magn. Reson. Imaging 2000, 12, 689-701
34. Troughton, J. S.; Greenfield, M. T.; Greenwood, J. M.; Dumas, S.; Wiethoff, A. J.; Wang, J.; Spiller, M.; McMurry, T. J.; Caravan, P. Synthesis and Evaluation of a High Relaxivity Manganese(II)-Based MRI Contrast Agent Inorg. Chem. 2004, 43, 6313-6323
35. Hernandez, G.; Bryant, R. Proton Magnetic Relaxation of Manganese(11)Tetrakis(4-sulfophenyl) Porphrine Ion in Water Bioconjugate Chem. 2001, 1-4
36. 2 as a Liver Specific Contrast Agent for Magnetic Resonance Imaging Invest. Radiol. 1990, 25, 545
37. Taylor, K. M. L.; Rieter, W. J.; Lin, W. Manganese-Based Nanoscale Metal-Organic Frameworks for Magnetic Resonance Imaging J. Am. Chem. Soc. 2008, 130, 14358-14359
38. Li, Z.; Li, W.; Li, X.; Pei, F.; Wang, X.; Lei, H. Mn(II)-Monosubstituted Polyoxometalates as Candidates for Contrast Agents In Magnetic Resonance Imaging J. Inorg. Biochem. 2007, 101, 1036-1042
39. 1 Contrast Agent for Magnetic Resonance Imaging Using MnO Nanoparticles Angew. Chem., Int. Ed. Engl. 2007, 46, 5397-5401
40. Bennewitz, M. F.; Lobo, T. L.; Nkansah, M. K.; Ulas, G.; Brudvig, G. W.; Shapiro, E. M. Biocompatible and pH-Sensitive PLGA Encapsulated MnO Nanocrystals for Molecular and Cellular MRI ACS Nano 2011, 5, 3438-3446
41. Cersosimo, M. G.; Koller, W. C. The Diagnosis of Manganese-Induced Parkinsonism Neurotoxicology 2006, 27, 340-346
42. Cage, B.; Russek, S. E.; Shoemaker, R.; Barker, A. J.; Stoldt, C.; Ramachandaran, V.; Dalal, N. S. The Utility of the Single-Molecule Magnet Fe8 as a Magnetic Resonance Imaging Contrast Agent over a Broad Range of Concentration Polyhedron 2007, 26, 2413-2419
43. Isaacman, S.; Kumar, R.; Barco, E. D.; Kent, A. D.; Canary, J. W.; Jerschow, A. Critical Examination of Fe8 as a Contrast Agent for Magnetic Resonance Imaging Polyhedron 2005, 24, 2691-2694
44. 16] Nano Lett. 2004, 4, 399-402
45. Mertzman, J. E.; Kar, S.; Lofland, S.; Fleming, T.; Van Keuren, E.; Tong, Y. Y.; Stoll, S. L. Surface Attached Manganese-Oxo Clusters as Potential Contrast Agents Chem. Commun. 2009, 788-790
46. 12 Single-Molecule Magnet Aggregates as Magnetic Resonance Imaging Contrast Agents Chem. Commun. 2011, 47, 3541
47. 4] and its Influence on the S = 10 Ground State of the Former Inorg. Chem. 1994, 33, 6020-6028
48. Pablico, M. H.; Mertzman, J. E.; Japp, E. A.; Boncher, W. L.; Nishida, M.; Van Keuren, E.; Lofland, S. E.; Dollahon, N.; Rubinson, J. F.; Holman, K. T. et al. Miniemulsion Synthesis of Metal-Oxo Cluster Containing Copolymer Nanobeads Langmuir 2011, 27, 12575-12584
49. Derfus, A. M.; Chan, W. C. W.; Bhatia, S. N. Probing the Cytotoxicity of Semiconductor Quantum Dots Nano Lett. 2004, 4, 11-18
50. Li, H.; Li, P.; Yang, Y.; Qi, W.; Sun, H.; Wu, L. Incorporation of Polyoxometalates Into Polystyrene Latex by Supramolecular Encapsulation and Miniemulsion Polymerization Macromol. Rapid Commun. 2008, 29, 431-436
51. Landfester, K.; Musyanovych, A.; Mailander, V. From Polymeric Particles to Multifunctional Nanocapsules for Biomedical Applications Using the Miniemulsion Process J. Polym. Sci., Part A: Polym. Chem. 2010, 48, 493-515
52. 16 J. Mater. Chem. 2004, 14, 1873
53. 4] Building Block New J. Chem. 2004, 28, 919
54. Elizondo, G.; Fretz, C. J.; Stark, D. D.; Rocklage, S. M.; Quay, S. C.; Worah, D.; Tsang, Y. M.; Chen, M. C.; Ferrucci, J. T. Preclinical Evaluation of MnDPDP: New Paramagnetic Hepatobiliary Contrast Agent for MR Imaging Radiology 1991, 178, 73-78
55. 8 Cluster as Potential MRI Contrast Agent NMR Biomed. 2005, 18, 300-307
56. Gupta, A. K.; Gupta, M. Synthesis and Surface Engineering of Iron Oxide Nanoparticles for Biomedical Applications Biomaterials 2005, 26, 3995-4021
57. Tromsdorf, U. I.; Bigall, N. C.; Kaul, M. G.; Bruns, O. T.; Nikolic, M. S.; Mollwitz, B.; Sperling, R. A.; Reimer, R.; Hohenberg, H.; Parak, W. J. et al. Size and Surface Effects on the MRI Relaxivity of Manganese Ferrite Nanoparticle Contrast Agents Nano Lett. 2007, 7, 2422-2427
58. Jun, Y.-W.; Seo, J.-W.; Cheon, J. Nanoscaling Laws of Magnetic Nanoparticles and Their Applicabilities in Biomedical Sciences Acc. Chem. Res. 2008, 41, 179-189
59. Jun, Y.-W.; Lee, J. E.-H.; Cheon, J. Chemical Design of Nanoparticle Probes for High-Performance Magnetic Resonance Imaging Angew. Chem., Int. Ed. 2008, 47, 5122-5135
60. Jun, Y.-W.; Huh, Y.-M.; Choi, J.-S.; Lee, J. E.-H.; Song, H.-T.; Kim; Yoon, S.; Kim, K.-S.; Shin, J.-S.; Suh, J.-S.; Cheon, J. Nanoscale Size Effect of Magnetic Nanocrystals and Their Utilization for Cancer Diagnosis via Magnetic Resonance Imaging J. Am. Chem. Soc. 2005, 127, 5732-5733
61. Lee, J. E.-H.; Huh, Y.-M.; Jun, Y.-W.; Seo, J.-W.; Jang, J.-T.; Song, H.-T.; Kim, S.; Cho, E.-J. et al. Artificially Engineered Magnetic Nanoparticles for Ultra-Sensitive Molecular Imaging Nat. Med. 2006, 13, 95-99
62. Duan, H.; Kuang, M.; Wang, X.; Wang, Y. A.; Mao, H.; Nie, S. Reexamining the Effects of Particle Size and Surface Chemistry on the Magnetic Properties of Iron Oxide Nanocrystals: New Insights into Spin Disorder and Proton Relaxivity J. Phys. Chem. C 2008, 112, 8127-8131
63. 4 Spinel Ferrite Nanoparticles J. Am. Chem. Soc. 2003, 125, 9828-9833
64. Di Marco, M.; Port, M.; Couvreur, P.; Dubernet, C.; Ballirano, P.; Sadun, C. Structural Characterization of Ultrasmall Superparamagnetic Iron Oxide (USPIO) Particles in Aqueous Suspension by Energy Dispersive X-ray Diffraction (EDXD) J. Am. Chem. Soc. 2006, 128, 10054-10059
65. Kucheryavy, P.; He, J.; John, V. T.; Maharjan, P.; Spinu, L.; Goloverda, G. Z.; Kolesnichenko, V. L. Superparamagnetic Iron Oxide Nanoparticles with Variable Size and an Iron Oxidation State as Prospective Imaging Agents Langmuir 2013, 29, 710-716
66. Daou, T. J.; Grenèche, J. M.; Pourroy, G.; Buathong, S.; Derory, A.; Ulhaq-Bouillet, C.; Donnio, B.; Guillon, D.; Begin-Colin, S. Coupling Agent Effect on Magnetic Properties of Functionalized Magnetite-Based Nanoparticles Chem. Mater. 2008, 20, 5869-5875
67. Hu, F.; Joshi, H. M.; Dravid, V. P.; Meade, T. J.; High-Performance Nanostructured, M. R. Contrast Probes Nanoscale 2010, 2, 1884
68. 2 Relaxivity J. Magn. Reson. Imaging 2007, 26, 1634-1641
69. Marie, E.; Rotureau, E.; Dellacherie, E.; Durand, A. From Polymeric Surfactants to Colloidal Systems Colloids Surf., A 2007, 308, 25-32
70. Ladaviere, C.; Averlant-Petit, M. C.; Fabre, O.; Durand, A.; Dellacherie, E.; Marie, E. Preparation of Polysaccharide-Coated Nanoparticles by Emulsion Polymerization of Styrene Colloid Polym. Sci. 2007, 285, 621-630