Receptor for advanced glycation end-products promotes premature senescence of proximal tubular epithelial cells via activation of endoplasmic reticulum stress-dependent p21 signaling

Cellular Signalling

Volumn 26, Issue 1, 2014, Pages 110-121

  Liu, Jun ^a,b,c   Huang, Kun ^a   Cai, Guang Yan ^b   Chen, Xiang Mei ^b   Yang, Ju Rong ^a   Lin, Li Rong ^a   Yang, Jie ^a   Huo, Ben Gang ^a   Zhan, Jun ^a   He, Ya Ni ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

^c Dazhou Military Hospital of Chinese PLA   (China)

Author keywords

Diabetic nephropathy; ER stress; P21; Premature senescence; RAGE

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; BETA GALACTOSIDASE; CELL MARKER; CYCLIN DEPENDENT KINASE INHIBITOR 1; GLUCOSE REGULATED PROTEIN 78; SENESCENCE ASSOCIATED BETA GALACTOSIDASE; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL CYCLE REGULATION; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; G1 PHASE CELL CYCLE CHECKPOINT; GENE SILENCING; HUMAN; HUMAN TISSUE; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE EPITHELIUM; MALE; MOUSE; NONHUMAN; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE; SIGNAL TRANSDUCTION; UPREGULATION;

4-PBA; 4-PHENYLBUTYRATE; 4′,6-DIAMIDINO-2-PHENYLINDOLE; ADVANCED GLYCATION END-PRODUCTS; AGES; BOVINE SERUM ALBUMIN; BSA; DAPI; DIABETIC NEPHROPATHY; DN; ENDOPLASMIC RETICULUM; ER; ER STRESS; GFP; GLUCOSE-REGULATED PROTEIN 78; GREEN FLUORESCENT PROTEIN; GRP78; MOI; MULTIPLICITY OF INFECTION; P21; PREMATURE SENESCENCE; PROXIMAL TUBULAR EPITHELIAL CELLS; PTECS; RAGE; RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS; SA-Β-GAL; SAHF; SENESCENCE-ASSOCIATED HETEROCHROMATIC FOCI; SENESCENCE-ASSOCIATED-Β-GALACTOSIDASE; TG; THAPSIGARGIN; TM; TUNICAMYCIN;

AGED; ANIMALS; CELL AGING; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DIABETIC NEPHROPATHIES; ENDOPLASMIC RETICULUM STRESS; EPITHELIAL CELLS; FEEDBACK, PHYSIOLOGICAL; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; KIDNEY TUBULES, PROXIMAL; MICE; MIDDLE AGED; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION;

EID: 84886994467     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2013.10.002     Document Type: Article

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