Discovery and optimisation of a selective non-steroidal glucocorticoid receptor antagonist

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 1, 2011, Pages 137-140

  Brown, Angus R ^a   Bosies, Michael ^a   Cameron, Helen ^a   Clark, John ^a   Cowley, Angela ^a   Craighead, Mark ^a   Elmore, Moira A ^a   Firth, Alistair ^a   Goodwin, Richard ^a   Goutcher, Susan ^a   Grant, Emma ^a   Grassie, Morag ^a   Grove, Simon J A ^a   Hamilton, Niall M ^a   Hampson, Hannah ^a   Hillier, Alison ^a   Ho, Koc Kan ^c   Kiczun, Michael ^a   Kingsbury, Celia ^c   Kultgen, Steven G ^c   Littlewood, Peter T A ^a   Lusher, Scott J ^b   MacDonald, Susan ^a   McIntosh, Lorraine ^a   McIntyre, Theresa ^a   Mistry, Ashvin ^a   Morphy, J Richard ^a   Nimz, Olaf ^a   Ohlmeyer, Michael ^c   Pick, Jack ^a   Rankovic, Zoran ^a   Sherborne, Brad ^a   Smith, Alasdair ^a   Speake, Michael ^a   Spinks, Gayle ^a   Thomson, Fiona ^a   Watson, Lynn ^a   Weston, Mark ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b Merck Research Laboratories (MSD)   (Netherlands)

^c PHARMACOPEIA INC   (United States)

Author keywords

Glucocorticoid receptor; GR antagonist; Nuclear receptor

Indexed keywords

GLUCOCORTICOID RECEPTOR ANTAGONIST; SULFONAMIDE;

ARTICLE; DRUG BIOAVAILABILITY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STABILITY; HIGH THROUGHPUT SCREENING; HUMAN; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; DRUG EVALUATION, PRECLINICAL; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; HYDROCORTISONE; MICROSOMES; RATS; RECEPTORS, GLUCOCORTICOID; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 78650515962     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.11.054     Document Type: Article

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