Deletion in the N-terminal half of olfactomedin 1 modifies its interaction with synaptic proteins and causes brain dystrophy and abnormal behavior in mice

Experimental Neurology

Volumn 250, Issue , 2013, Pages 205-218

  Nakaya, Naoki ^a   Sultana, Afia ^a   Munasinghe, Jeeva ^b   Cheng, Aiwu ^c   Mattson, Mark P ^c   Tomarev, Stanislav I ^a  

^a NATIONAL EYE INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

AMPA receptor; Anxiety behavior; Cell signaling; Mouse; Neurobiology; Olfactomedin 1; Olfactory defects; Proteomics

Indexed keywords

AMINO ACID; CALCIUM CHANNEL; CALCIUM CHANNEL CAV2.1; CALCIUM ION; GLUTAMATE RECEPTOR 2; GLYCOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MUTANT PROTEIN; OLFACTOMEDIN 1; PROTEIN; PROTEIN KIDINS220; SYNAPTIC PROTEIN; TENEURIN 4; UNCLASSIFIED DRUG;

ADULT ANIMAL; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTERIOR COMMISSURE; ARTICLE; BEHAVIOR DISORDER; BRAIN DISEASE; BRAIN SIZE; CALCIUM CELL LEVEL; CONTROLLED STUDY; CORPUS CALLOSUM; DISEASE COURSE; DYSTROPHY; ENZYME ACTIVATION; EXON; FEMALE; GENE; GENE DELETION; HOMOZYGOTE; LATENT PERIOD; MALE; MAZE TEST; MOUSE; MUTANT; NESTING; NEWBORN DEATH; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OLFACTORY SYSTEM; OLFM1 GENE; OPTIC NERVE; PATHOGENESIS; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; PROTEOMICS; SENSORY DYSFUNCTION; WEIGHT REDUCTION;

AMPA RECEPTOR; ANXIETY BEHAVIOR; CELL SIGNALING; MAGNETIC RESONANCE IMAGING; MOUSE; MRI; NEUROBIOLOGY; OLFACTOMEDIN 1; OLFACTORY DEFECTS; OLFM1; OLFM1 KNOCKOUT; OLFM1-KO; PROTEOMICS; Q-PCR; QUANTITATIVE RT-PCR;

AMINO ACID SEQUENCE; ANIMALS; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; BRAIN; EXONS; EXTRACELLULAR MATRIX PROTEINS; FEMALE; GLYCOPROTEINS; IMMUNOPRECIPITATION; MAGNETIC RESONANCE IMAGING; MALE; MICE; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; PROTEOMICS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE DELETION;

EID: 84886916932     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2013.09.019     Document Type: Article

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