Sunitinib, a tyrosine kinase inhibitor, induces cytochrome P450 1A1 gene in human breast cancer MCF7 cells through ligand-independent aryl hydrocarbon receptor activation

Archives of Toxicology

Volumn 87, Issue 5, 2013, Pages 847-856

  Maayah, Zaid H ^a   El Gendy, Mohamed A M ^b   El Kadi, Ayman O ^b   Korashy, Hesham M ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

AhR; CYP1A1; MCF7; Sunitinib; XRE

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; DACTINOMYCIN; MESSENGER RNA; RESVERATROL; SUNITINIB; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; INDOLE DERIVATIVE; LIGAND; PROTEIN TYROSINE KINASE; PYRROLE DERIVATIVE; STILBENE DERIVATIVE;

ARTICLE; BREAST CANCER; CANCER CELL; CONTROLLED STUDY; CYTOSOL; DNA BINDING; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; REPORTER GENE; RNA SYNTHESIS; BIOSYNTHESIS; BREAST TUMOR; CELL STRAIN MCF 7; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYME INDUCTION; ENZYMOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; TRANSCRIPTION INITIATION;

MAMMALIA;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CYTOCHROME P-450 CYP1A1; DACTINOMYCIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INDOLES; LIGANDS; MCF-7 CELLS; PROTEIN-TYROSINE KINASES; PYRROLES; RECEPTORS, ARYL HYDROCARBON; RNA, MESSENGER; STILBENES; TRANSCRIPTIONAL ACTIVATION;

EID: 84886890570     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-012-0996-y     Document Type: Article

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