Anxiolytic-like effects of acute and chronic GABA transporter inhibition in rats

Journal of Neural Transmission

Volumn 109, Issue 5-6, 2002, Pages 871-880

  Schmitt, U ^a   Luddens H ^a   Hiemke, C ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Benzodiazepines; Chronic treatment; Elevated plus maze; GABA transporter (GAT); Tiagabine

Indexed keywords

4 AMINOBUTYRIC ACID; DIAZEPAM; TIAGABINE; ZOLPIDEM;

4 AMINOBUTYRIC ACID UPTAKE; ANIMAL BEHAVIOR; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; EXPLORATORY BEHAVIOR; MALE; MAZE TEST; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-ANXIETY AGENTS; BEHAVIOR, ANIMAL; CARRIER PROTEINS; DIAZEPAM; DRUG ADMINISTRATION SCHEDULE; DRUG SYNERGISM; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; MALE; MAZE LEARNING; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; NIPECOTIC ACIDS; ORGANIC ANION TRANSPORTERS; PYRIDINES; RATS; RATS, INBRED STRAINS; TIME FACTORS;

EID: 0036322305     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007020200071     Document Type: Article

References (34)

1. GABAergic drugs and conflict behavior in the rat: Lack of similarities with the actions of benzodiazepines
2. Diazepam changing risk assessment in an anxiety/defense test battery
3. GABA transporter heterogeneity: Pharmacology and cellular localization
4. Effects of the GABA-uptake inhibitor tiagabine on electroencephalogram, spike-wave discharges and behavior of rats
5. Ethological comparison of the effects of diazepam and acute/chronic imipramine and the behavior of mice in the elevated plus-maze
6. GABAergic influences on plus-maze behaviour in mice
7. The gamma-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats
8. Neuropharmacological evidence for an interaction between the GABA uptake inhibitor CI-966 and anxiolytic benzodiazepines
9. 1) selective benzodiazepine receptor ligands
10. Cloning and expression of rat brain GABA transporter
11. A review of the validity and variability of the elevated plus-maze as an animal model of anxiety
12. A receptor mRNA levels in the rat cortex
13. Uptake and metabolism of γ-amino-butyric acid by neurones and glial cells
14. The effects of repeated administration of diazepam, MK-801 and CGP 37849 on rat behavior in two animal models of anxiety
15. A receptor pharmacology
16. Anxiolytic drugs: Dependence, addiction and abuse
17. A/benzodiazepine receptor heterogeneity
18. Neuronal and glial gamma-aminobutyric acid transporters are distinct proteins
19. The relationship between fear induced by novel stimulation and exploratory behavior
20. A-receptor subunits in mice to identify specific anxiolytic requirements
21. Anxiolytic effect of NO-328, a GABA uptake inhibitor
22. Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: A novel test of anxiety in the rat
23. Validation of open: Close arm entries in the elevated plus-maze a measure of anxiety in the rat
24. Benzodiazepine actions mediated by specific gamma-aminobutyric acid (A) receptor subtypes
25. A receptor subtypes: Dissecting their pharmacological functions
26. Strain Differences in open-field and elevated plus-maze behavior of rats without and with pre-test handling
27. Combination of open field and elevated plus-maze: A suitable test battery to assess strain as well as treatment differences in rat behavior
28. Effects of GABA-transporter (GAT) inhibitors on rat behaviour in open-field and elevated plus-maze
29. Chronic oral haloperidol and clozapine in rats: A behavioral evaluation
30. A receptor stimulation and GABA-transporter inhibition
31. A-receptors
32. Lack of tolerance to the anticonvulsant effects of tiagabine following chronic (21 day) treatment
33. NNC-711, a novel potent and selective γ-aminobutyric acid uptake inhibitor: Pharmacological characterization
34. 3H]tiagabine binding to sections from mice brain