Chronic escitalopram treatment induces erectile dysfunction by decreasing nitric oxide bioavailability mediated by increased nicotinamide adenine dinucleotide phosphate oxidase activity and reactive oxygen species production

Urology

Volumn 82, Issue 5, 2013, Pages 1188.e1-1188.e7

  Kassan, Modar ^a   Lasker, George F ^a   Sikka, Suresh C ^a   Mandava, Sree Harsha ^a   Gokce, Ahmet ^a   Matrougui, Khalid ^a   Hellstrom, Wayne J G ^a   Kadowitz, Philip J ^a   Serefoglu, Ege Can ^a,b  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BAGCILAR TRAINING AND RESEARCH HOSPITAL   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; APOCYNIN; ESCITALOPRAM; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DRUG EFFECT; ENZYMATIC ASSAY; ENZYME ACTIVITY; ERECTILE DYSFUNCTION; LONG TERM CARE; MALE; MEAN ARTERIAL PRESSURE; NERVE STIMULATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; WESTERN BLOTTING;

ACETOPHENONES; ACETYLCHOLINE; ANIMALS; CITALOPRAM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ERECTILE DYSFUNCTION; MALE; NADPH OXIDASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PENILE ERECTION; PENIS; PHOSPHORYLATION; RATS; RATS, INBRED WKY; REACTIVE OXYGEN SPECIES; TREATMENT OUTCOME;

EID: 84886858552     PISSN: 00904295     EISSN: 15279995     Source Type: Journal    
DOI: 10.1016/j.urology.2013.07.037     Document Type: Article

References (30)

1. R.C. Kessler, O. Demler, and R.G. Frank Prevalence and treatment of mental disorders, 1990 to 2003 N Engl J Med 352 2005 2515 2523
2. S.H. Zuvekas Prescription drugs and the changing patterns of treatment for mental disorders, 1996-2001 Health Aff (Millwood) 24 2005 195 205
3. M. Olfson, and S.C. Marcus National patterns in antidepressant medication treatment Arch Gen Psychiatry 66 2009 848 856
4. D.K. Cherry, D.A. Woodwell, and E.A. Rechtsteiner National Ambulatory Medical Care Survey: 2005 summary Adv Data 2007 1 39
5. IMS Health. IMS National Prescription Audit PLUS. Available at: http://www.imshealth.com/deployedfiles/imshealth/Global/Content/StaticFile/ Top-Line-Data/2010-Top-Therapeutic-Classes-by-RX.pdf. Accessed May 15, 2013.
6. The IMS Institute for Healthcare Informatics. The Use of Medicines in the United States: Review of 2011. Available at: http://www.imshealth.com/ims/ Global/Content/Insights/IMS%20Institute%20for%20Healthcare%20Informatics/ IHII-Medicines-in-U.S-Report-2011.pdf. Accessed May 15, 2013.
7. J.C. Fournier, R.J. DeRubeis, and S.D. Hollon Antidepressant drug effects and depression severity: a patient-level meta-analysis JAMA 303 2010 47 53
8. C. Tanrikut, and P.N. Schlegel Antidepressant-associated changes in semen parameters Urology 69 2007 185 e5-185 e7
9. C. Tanrikut, A.S. Feldman, and M. Altemus Adverse effect of paroxetine on sperm Fertil Steril 94 2010 1021 1026
10. H. Koyuncu, E.C. Serefoglu, and E. Yencilek Escitalopram treatment for premature ejaculation has a negative effect on semen parameters Int J Impot Res 23 2011 257 261
11. M.R. Safarinejad Sperm DNA damage and semen quality impairment after treatment with selective serotonin reuptake inhibitors detected using semen analysis and sperm chromatin structure assay J Urol 180 2008 2124 2128
12. J. Angulo, C. Peiro, and C.F. Sanchez-Ferrer Differential effects of serotonin reuptake inhibitors on erectile responses, NO-production, and neuronal NO synthase expression in rat corpus cavernosum tissue Br J Pharmacol 134 2001 1190 1194
13. S.S. Gocmez, T. Utkan, N. Gacar, and Y. Sarioglu Chronic administration of fluoxetine impairs neurogenic and endothelium-dependent relaxation of the rabbit corpus cavernosum smooth muscle Eur J Pharmacol 670 2011 224 228
14. M. Kadioglu, E. Muci, and R. Ozyavuz Paroxetine inhibited the relaxations induced by EFS in mice corpus cavernosum: is it a NOS inhibition? Fundam Clin Pharmacol 24 2010 55 61
15. L. Luo, and R.X. Tan Fluoxetine inhibits dendrite atrophy of hippocampal neurons by decreasing nitric oxide synthase expression in rat depression model Acta Pharmacol Sin 22 2001 865 870
16. E.C. Serefoglu, and T.R. Saitz New insights on premature ejaculation: a review of definition, classification, prevalence and treatment Asian J Androl 14 2012 822 829
17. E. Kirino Escitalopram for the management of major depressive disorder: a review of its efficacy, safety, and patient acceptability Patient Prefer Adherence 6 2012 853 861
18. G.F. Lasker, E.A. Pankey, and A.V. Allain The selective rho-kinase inhibitor azaindole-1 has long-lasting erectile activity in the rat Urology 81 2013 465 e7-65 e14
19. M. Kassan, M. Galan, and M. Partyka Endoplasmic reticulum stress is involved in cardiac damage and vascular endothelial dysfunction in hypertensive mice Arterioscler Thromb Vasc Biol 32 2012 1652 1661
20. M. Galan, M. Kassan, and S.K. Choi A novel role for epidermal growth factor receptor tyrosine kinase and its downstream endoplasmic reticulum stress in cardiac damage and microvascular dysfunction in type 1 diabetes mellitus Hypertension 60 2012 71 80
21. R.C. Rosen, R.M. Lane, and M. Menza Effects of SSRIs on sexual function: a critical review J Clin Psychopharmacol 19 1999 67 85
22. G.J. Ahn, K.K. Kang, and D.S. Kim DA-8159 reverses selective serotonin reuptake inhibitor-induced erectile dysfunction in rats Urology 65 2005 202 207
23. A.L. Montejo-Gonzalez, G. Llorca, and J.A. Izquierdo SSRI-induced sexual dysfunction: fluoxetine, paroxetine, sertraline, and fluvoxamine in a prospective, multicenter, and descriptive clinical study of 344 patients J Sex Marital Ther 23 1997 176 194
24. S.H. Kennedy, B.S. Eisfeld, and S.E. Dickens Antidepressant-induced sexual dysfunction during treatment with moclobemide, paroxetine, sertraline, and venlafaxine J Clin Psychiatry 61 2000 276 281
25. I. Schweitzer, K. Maguire, and C. Ng Sexual side-effects of contemporary antidepressants: review Aust N Z J Psychiatry 43 2009 795 808
26. U. Werneke, S. Northey, and D. Bhugra Antidepressants and sexual dysfunction Acta Psychiatr Scand 114 2006 384 397
27. J. Angst Sexual problems in healthy and depressed persons Int Clin Psychopharmacol 13 suppl 6 1998 S1 S4
28. M.R. Safarinejad Safety and efficacy of escitalopram in the treatment of premature ejaculation: a double-blind, placebo-controlled, fixed-dose, randomized study J Clin Psychopharmacol 27 2007 444 450
29. W.J. Hellstrom Update on treatments for premature ejaculation Int J Clin Pract 65 2011 16 26
30. M.J. Taylor, L. Rudkin, and P. Bullemor-Day Strategies for managing sexual dysfunction induced by antidepressant medication Cochrane Database Syst Rev 5 2013 CD003382