Fluoxetine inhibits dendrite atrophy of hippocampal neurons by decreasing nitric oxide synthase expression in rat depression model

Acta Pharmacologica Sinica

Volumn 22, Issue 10, 2001, Pages 865-870

  Luo, L ^a   Tan, R X ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Antidepressive agents; Fluoxetine; Hippocampus; Neurons; Nitric oxide synthase

Indexed keywords

ANTIDEPRESSANT AGENT; FLUOXETINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; ANTIDEPRESSIVE AGENTS, SECOND GENERATION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATROPHY; CELL STRUCTURE; DENDRITE; DEPRESSION; DRUG EFFECT; DRUG MECHANISM; HIPPOCAMPUS; HISTOCHEMISTRY; MALE; MENTAL STRESS; NISSL STAINING; NONHUMAN; PROTEIN EXPRESSION; RAT; TREATMENT OUTCOME; ANIMAL; BIOSYNTHESIS; ENZYMOLOGY; NERVE CELL; PATHOLOGY; RAT STRAIN;

ANIMAL; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; ATROPHY; DENDRITES; DEPRESSION; FLUOXETINE; HIPPOCAMPUS; MALE; NEURONS; NITRIC-OXIDE SYNTHASE; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, NON-U.S. GOV'T;

EID: 0034815514     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. The neurobiology of depression
2. Antidepressants for the new millennium
3. New developments in the treatment of depression
4. Basic psychopharmacology of antidepressants, part 1: Antidepressants have seven distinct mechanisms of action
5. Antidepressants and the brain
6. Fluoxetine-resistant mutants in C elegans define a novel family of transmembrane proteins
7. Aleration in neuropeptide Y and Y1 receptor mRNA expression in brain from an animal model of depression: Region specific adaptation after fluoxetine treatment
8. Regulation of seotonin1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: Implications for the neurobiology of depression
9. Effect of chronic restraint stress and tianeptine on growth factors, growth-associated protein-43 and microtubule-associated protein 2 mRNA expression in the rat hippocampus
10. Novel therapeutic approaches beyond the serotonin receptor
11. Chronic mild stress-induced anhedonia: A realistic animal model of depression
12. Induction of NADPH-diaphorase activity in the hippocampus in a rat model of cerebral ischemic tolerance
13. Distribution of NADPH-diaphorase cells in visual and somatosensory cortex in four mammalian species
14. The chronic mild stress procedure as an animal model of depression: Valid, reasonably reliable, and useful
15. Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant
16. Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews
17. Evidence against changes in corticotroph CRF receptors in depressed patients
18. Stress and antidepressant effects on hippocampal and cortical 5-HT1A and 5-HT2 receptors and transport sites for serotonin
19. Raising questions about antidepressants
20. Neurotrophins and depression
21. Models of antidepressant action
22. Involvement of oxidative and L-arginine-NO pathway in the neurotoxicity of drugs of abuse in vitro
23. Cloning and characterization of inducible nitric oxide synthase from mouse macrophage
24. Localization of nitric oxide synthase indicating a neural role for nitric oxide
25. NMDA receptor activation produces concurrent generation of nitric oxide and reactive oxygen species: Implication for cell death
26. Nitric oxide synthase inhibitors have antidepressant-like properties in mice. 1. Acute treatments are active in the forced swim test
27. Central NO is involved in the antinociceptive action of intracistemal antidepressants in freely moving rats
28. Nitric oxide synthase inhibitors have antidepressant-like properties in mice. 2. Chronic treatment results in downregulation of cortical beta-adrenoceptors