SSRI-induced sexual dysfunction: Fluoxetine, paroxetine, sertraline, and fluvoxamine in a prospective, multicenter, and descriptive clinical study of 344 patients

Journal of Sex and Marital Therapy

Volumn 23, Issue 3, 1997, Pages 176-194

  Montejo Gonzalez, Angel L ^a   Liorca, G ^a   Izquierdo, J A ^a   Ledesma, A ^a   Bousono, M ^a   Calcedo, A ^a   Carrasco, J L ^a   Ciudad, J ^a   Daniel, E ^a   de la Gandara, J ^a   Derecho, J ^a   Franco, M ^a   Gomez, M J ^a   Macias, J A ^a   Martin, T ^a   Perez, V ^a   Sanchez, J M ^a   Sanchez, S ^a   Vicens, E ^a  

^a HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOXETINE; FLUVOXAMINE; PAROXETINE; SERTRALINE;

ADULT; ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; FEMALE; HUMAN; IMPOTENCE; INCIDENCE; LIBIDO; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; ORGASM; SEXUAL DYSFUNCTION;

1-NAPHTHYLAMINE; ADULT; FEMALE; FLUOXETINE; FLUVOXAMINE; HUMANS; MALE; MIDDLE AGED; PAROXETINE; PROSPECTIVE STUDIES; QUESTIONNAIRES; SEROTONIN UPTAKE INHIBITORS; SERTRALINE; SEVERITY OF ILLNESS INDEX; SEXUAL DYSFUNCTIONS, PSYCHOLOGICAL;

EID: 0030734647     PISSN: 0092623X     EISSN: 15210715     Source Type: Journal    
DOI: 10.1080/00926239708403923     Document Type: Article

References (129)

1. Barnes T, Bamber RWK, Watson JP: Psychotropic drugs and sexual behavior. Br J Med, 6: 596-601, 1979.
2. Couper-Smartt JD, Rodham R: A technique for surveying side effects of tryciclic drugs with reference to reported sexual effects. J Int Med Res, 1: 473-476, 1973.
3. Beaumont, G: Sexual side-effects of clomipramine (Anafranil). J Int Med Res, 1, 469-472, 1973.
4. Nininger J: Inhibition of ejaculation by amitriptyline Am J Psychiatry, 135: 750-751, 1978.
5. Mitchel JE, Popkin MK: Antidepressant drug therapy and sexual dysfunction in men. A review. J Clin Psychopharmacol, 3: 76-80, 1983.
6. Merino MJ, Garcia M: Antidepresivos y disfunciones sexuales: Biologia, clasificacion y tratamiento [Antidepressants and sexual dysfunction: Biology, classification, and treatment]. Rev AsocEsp Neuropsiqu, XV, 54: 431-442, 1995.
7. Setde EC Jr: Antidepressant side effects: Issues and options [Monograph]. J Clin Psychiatry, 10(1): 48-61, 1992.
8. Pollack MH, Reiter S, Hammerness P: Genitourinary and sexual adverse effects of psychotropic medication. Int J Psychiatry Med, 22. 305-327, 1992.
9. Baldwin DS: Psychotropic drugs and sexual dysfunction Int Rev Psychiatry, 7, 261-273, 1995.
10. Buffom J: Pharmacology: The effects of drugs on sexual dysfunction: A review. J Psychoactive Drugs, 14(1-2): 4-45, 1982.
11. Davidson JR: Sexual dysfunction and antidepressants Depression, 2: 233-240, 1994/1995.
12. Harrison WM, Rabkin JG, Ehrhardt AA, et al.: Effects of antidepressant medication on sexual function. A controlled study. J Clin Psychopharmacol, 6: 144-149, 1986.
13. Segraves RT: Effects of psychotropic drugs on human erection and ejaculation. Arch Gen Psychiatry, 46: 275-284, 1989.
14. Nofzinger EA, Thase ME, Reynolds CF, et al.: Antidepressants and sexual function in depressed men. In New research program and abstracts of the 146th Annual Meeting of the American Psychiatric Association, May 26, 1993; San Francisco, California, Abstract NR7456, p. 174. Washington, DC: American Psychiatric Association, 1993.
15. Lesko LM, Stotland, Segraves T: Three cases of anorgasmia associated with MAOI. Am J Psychiatry, 139. 1383-1384, 1982.
16. Quirk KC, Einarson, TR: Sexual dysfunction and clomipramine. Can J Psychiatry, 27: 228-231, 1983.
17. Schubert, DSP: Reversal of doxepine-induced hypoactive sexual desire by substitution of nortriptyline.J Sex Educ Ther, 18: 42-44, 1992.
18. Cohn CK, Shrivastava R, Mendels, J: Doubled blind multicenter comparison of sertraline and amytriptiline in elderly depressed patients. J Clin Psychiatry, 51(12, Suppl B): 18-27, 1990.
19. Patterson, WM: Fluoxetine induced sexual dysfunction [letter]. J Clin Psychiatry, 54: 71, 1993.
20. Monteiro WO, Noshirvani HF, Marks IM, et al.: Anorgasmia from clomipramine in obsessive-compulsive disorder. A controlled trial. Br J Psychiatry, 151: 107-112, 1987.
21. Flores, MP, Montes MJ, Cambronero, V., et al.: Inhibition por paroxetina de la eyaculacon (a proposito de 2 casos) [Inhibition of ejaculation by paroxetine (a study of 2 patients)]. Anales de Psiquiatria, 10(Suppl. 1): 58-59, 1994.
22. Aizenberg D, Zemishlany Z, Hermesh H, et al.: Painful ejaculation associated with antidepressants in four patients J Clin Psychiatry, 52: 461-463, 1991.
23. Medell JG: Repeated observations of yawning, clitoral engorgement and orgasm associated with fluoxetine administration [letter]. J Clin Psychopharmacol, 9: 63-65, 1989.
24. Cohen, A: Fluoxetine-induced yawning and anorgasmia reversed by ciproheptadine treatment. J Clin Psychiatry, 53: 174, 1992.
25. McLean JD, Forsythe RG, Kapkin, IA: Unusual side effects of clomipramine associated with yawning. Can J Psychiatry, 28: 569-570, 1983.
26. King VL, Horowitz IR: Vaginal anesthesia associated with fluoxetine use [letter]. Am J Psychiatry, 150. 984-985, 1993.
27. Neill JR: Penile anesthesia associated with fluoxetine use [letter]. Am J Psychiatry, 148: 1603, 1991.
28. Gartrell N: Increased lTetrahedron Letto in women receiving trazodone. Am J Psychiatry, 143: 781-782, 1986.
29. Chiang PH, Tsai EM, Chiang CP: The role of trazodone in the treatment of erectile dysfunction. Kao-Hsiung I Hsueh Ko Hsueh Tsa Chih [Kaohsiung Journal of Medical Sciences], 70(6): 287-294, 1994.
30. Ahmad, S: Paroxetine induced priapism [letter]. Arch Intern Med, 155: 645, 1995.
31. Monteiro WO, Noshirvani HF, Marks IM, et al.: Anorgasmia from clomipramine in obsessive-compulsive disorder: A controlled trial. Br J Psychiatry, 151: 107-112, 1987.
32. Shen, WW, Sata LS: Inhibited female orgasm resulting from psychotropic drugs: A clinical review. J Reprod Med, 28: 497-499, 1983.
33. Leo D, Magni G: Sexual side effects of antidepressant drugs. Psychosomatics, 24(12): 1076-1082, 1983.
34. Segraves RT: Psychiatric drugs and orgasm in the human female. J Psychosom Obstet Gynecol, 4: 125-128, 1985.
35. Segraves RT: Sexual side-effects of psychiatric drugs Int J Psychiatry Med, 18(3): 243-252, 1988.
36. Kline MD: Fluoxetine and anorgasmia. Am J. Psychiatry, 146: 804-805, 1989. Herman JB, Brotman AW, Pollack MH, et al.: Fluoxetine-induced sexual dysfunction. J Clin Psychiatry, 51: 25-27, 1990.
37. Musher JS: Anorgasmia with the use of fluoxetine [letter]. Am J Psychiatry, 147: 948, 1990.
38. Drucker F, Hoel JB: Fluoxetine and sexual dysfunction JAMA, 272(3): 242, 1994.
39. Dorevitch A, Davis H: Fluvoxamine-associated sexual dysfunction. Ann Pharma-cother, 28(7-8): 872-874, 1994.
40. Segraves RT: Antidepressant-induced sexual disorder. J Sex Marital Ther, 27(3): 192-201, 1995.
41. Hsu JH, Shen WW: Male sexual side effects associated with antidepressants: A descriptive clinical study of 32 patients. Int J Psychiatry Med, 25(2): 191-201, 1995.
42. Shen WW, Hsu JH: Female sexual side effects associated with selective serotonin reuptake inhibitors: A descriptive clinical study of 33 patients. Int J Psychiatry Med, 25(3): 239-248, 1995.
43. Montejo AL, Llorca G., Izquierdo JA, et al.: Sexual dysfunction with SSRIs: A comparative analysis. In Abstracts of 149th Annual Meeting of the American Psychiatric Association, May 1996, New York: 266-267. Washington, DC: American Psychiatric Association, 1996.
44. McGilp R: Case report (2): Paroxetine and delayed ejaculation. A treatable side effect. J Drug Dev, 5(4): 265-266, 1993.
45. Kowalsky A, Stanley RO, Dennerstein G, et al.: The sexual side effects of antidepressant medication: A double blind comparison of two antidepressants in a nonpsychi-atric population. Br J Psychiatry, 147: 413-418, 1985.
46. Fuell D: Ejaculatory disturbances in volunteer and depressed patient studies with paroxetine (internal position paper, Smith Kline Beecham), 1992.
47. Remy L: The effect of selective 5HT re-uptake inhibitors on 5-methoxy-N, N, di-methyltriptamine induced ejaculation in the rat. Br J Pharmacol, 87: 639-648, 1986.
48. Baldesarani RJ, Mars E: Fluoxetine and side effects [letter]. Arch Gen Psychiatry, 47: 191-192, 1990.
49. Zemishlany Z: The effects of methylenedioxy-methanphetamine (“Ecstasy”) on human sexual function. In Abstracts of the 149th Annual Meeting of the American Psychiatric Association, May 1996, New York. 265. Washington, DC: American Psychiatric Association, 1996.
50. Sorscher SM, Dilsaver SC: Antidepressant-induced sexual dysfunction in men: Due to cholinergic blockade? J Clin Psychopharmacol, 6: 53-55, 1986.
51. Zajecka J; Fawcet J, et al.: The role of serotonin in sexual dysfunction: Fluoxetine associated orgasm dysfunction J Clin Psychiatry, 52. 66-67, 1991.
52. Kurt U, Ozkardes H, Altug U, et al.: The efficacy of antiserotoninergic agents in the treatment of erectile dysfunction. J Urol, 152(2): 407-409, 1994.
53. Rodriguez M, Castro R, Hernandez G, et al.: Different roles of catecholaminergic and serotonergic neurons in the medial forebrain bundle on male rat sexual behavior. Physiol Behav, 33: 5-11, 1984.
54. Mas M, et al.: Stimulation of spinal serotonergic receptor facilitates seminal emission and suppresses penile erectile reflexes. Brain Research, 342: 639-648, 1985.
55. Dunbar GC, Cohn JB, Fabre LF, et al.: A comparison of paroxetine, imipramine and placebo in depressed out-patients Br J Psychiatry, 159. 394-398, 1991.
56. Pollack MH, Rosenbaum JF: Management of antidepressant-induced side-effects: A practical guide for the clinician. J Clin Psychiatry, 48: 3-8, 1987.
57. Segraves RT: Treatment of drug-induced anorgasmia. Br J Psychiatry, 165:554, 1994.
58. Jacobsen FM: Managing sexual dysfunction and SSRIs Psychiatric Times, 12: 38-39, 1995.
59. Nurnberg HG, Levine PE: Spontaneous remission of MAO-I induced anorgasmia. Am J Psychiatry, 144: 805-807, 1987.
60. Sovner R: Treatment of tricyclic antidepressant-induced orgasmic inhibition with cyproheptadine [letter]. J Clin Psychopharmacol, 4: 169, 1984.
61. Castro RM de: Reversal of MAOI-induced anorgasmia with cyproheptadine [letter]. Am J Psychiatry, 142: 783, 1985.
62. Steele TE, Howell EF: Cyproheptadine for imipramine-induced anorgasmia [letter]. J Clin Psychopharmacol, 6: 326-327, 1986.
63. Arnott S; Nutt D: Successful treatment of fluvoxamine-induced anorgasmia by cyproheptadine. Br J Psychiatry, 164: 838-839, 1994.
64. McCormick S; Olin J; Wrotman AW: Reversal of fluoxetine induced anorgasmia by cyproheptadine in two patients. J Clin Psychiatry, 51: 383-384, 1990.
65. Cohen A: Fluoxetine-induced yawning and anorgasmia reversed by ciproheptadine treatment. J Clin Psychiatry, 53: 174, 1992.
66. Riley A, Riley EJ: Cyproheptadine and antidepressant-induced anorgasmia [letter]. Br J Psychiatry, 148: 217-218, 1986.
67. Price J, Grunhaus LJ: Treatment of clomipramine-induced anorgasmia with yohimbine: A case report. J Clin Psychiatry, 51: 32-33, 1990.
68. Hollander E; McCarley A: Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers. J Clin Psychiatry, 53: 207-209, 1992.
69. Jacobsen FM: Fluoxetine-induced sexual dysfunction and an open trial of yohimbine. J Clin Psychiatry, 53: 119-122, 1992.
70. Balon R: Fluoxetine-induced sexual dysfunction and yohimbine. J Clin Psychiatry, 54: 4, 161, 1993.
71. Singh A, Scurlock H, Catalan J: Paroxetine induced erectile dysfunction successfully treated with yohimbine in patients suffering from HIV infection. J Serotonin Res, 4: 283-285, 1995.
72. Jacobsen FM: A double-blind placebo-controlled trial of yohimbine for treatment of SRI-induced sexual dysfunction. In Abstracts of the 149th Annual Meeting of the American Psychiatric Association, May 1996, New York. 266. Washington, DC: American Psychiatric Association, 1996.
73. Nessel MA: Yohimbine and pentoxifiline in the treatment of erectile dysfunction [letter]. Am J Psychiatry, 151(3): 453, 1994.
74. Balogh S, Hendricks SE, Kang, J: Treatment of fluoxetine-induced anorgasmia with amantadine [letter]. J Clin Psychiatry, 53: 212-213, 1992.
75. Shrivastava RK, Shrivastava S, Overweg N: Amantadine in the treatment of sexual dysfunction associated with selective serotonin reuptake inhibitors [letter]. J Clin Psychopharmacol, 15(1): 83-84, 1995.
76. Gidin MJ: Treatment of sexual side effects with dopaminergic agents [letter]. J Clin Psychiatry, 56(3): 124, 1995.
77. Norden MJ: Buspirone treatment of sexual dysfunction associated with selective serotonin re-uptake inhibitors Depression, 2: 109-112, 1994.
78. Gross MD: Reversal by bethanechol of sexual dysfunction caused by anticholinergic antidepressants. Am J Psychiatry, 139: 1193-1194, 1982.
79. Yager J: Bethanechol chloride can reverse erectile and ejaculatory dysfunction by tricyclic antidepressants and mazindol: Case report. J Clin Psychiatry, 47: 210-211, 1986.
80. Segraves RT: Reversal by bethanechol of imipramine-induced ejaculatory dysfunction. Am J Psychiatry, 144: 1243-1244, 1987.
81. Cohen A: Treatment of antidepressant-induced sexual dysfunction with ginkgo biloba extract. In Abstracts of the 149th Annual Meeting of the American Psychiatric Association, May 1996. New York 266. Washington, DC: American Psychiatric Association, 1996.
82. Walker PW, Cole JO, Gardner EA, et al.: Improvement in fluoxetine-associated sexual dysfunction in patients switched to bupropion. J Clin Psychiatry, 54: 459-465, 1993.
83. Labbate LA, Pollack MH: Treatment of fluoxetine-induced sexual dysfunction with bupropion: A case report. Ann Clin Psychiatry, 6(1): 13-15, 1994.
84. Gardner EA, Johnston JA: Bupropion: An antidepressant without sexual pathophysiological action. J Clin Psychopharmacol, 5: 24-29, 1985.
85. Sovner R: Anorgasmia associated with imipramine but not desipramine: Case report. J Clin Psychiatry, 44: 345-346, 1983.
86. Philipp M, Kohnen R, Benkert O: A comparison study of moclobemide and doxe-pine in major depression with special reference to effects of sexual dysfunction. Int Clin Psychopharmacol, 7: 123-132, 1993.
87. Ferguson JM, Shrivastava RK, Stahl S, et al.: Effects of double-blind treatment with nefazodone or sertraline on re-emergence of sexual dysfunction in depressed patients. In Abstracts of 149th Annual Meeting of the American Psychiatric Association, May 1996, New York NR 358. Washington, DC: American Psychiatric Association, 1996.
88. Rothschild A: Selective serotonin reuptake inhibitor-induced sexual dysfunction: Efficacy of a drug holiday. Am J Psychiatry, 152: 1514-1516, 1995.
89. Feder R: Reversal of antidepressant activity of fluoxetine in three patients. J Clin Psychiatry; 52. 163-164, 1991.
90. Goldbloom DS, Kennedy SH: Adverse interaction of fluoxetine and cyproheptadine in two patients with bulimia nervosa. J Clin Psychiatry, 52. 261-262, 1991.
91. Baier D, Philipp M: Effects of antidepressants on sexual function. Fortschr Neurol Psychiatr, 62. 14-21, 1994.
92. Segraves RT: Overview of sexual dysfunction complicating the treatment of depression [Monograph].J Clin Psychiatry, 10(2): 4-8, 1992.
93. Balon R, Yeragany VK, Pohl R, Ramesh C: Sexual dysfunction during antidepressant treatment. J Clin Psychiatry, 54(6): 209-212, 1993.
94. Cohn CK, Shrivastava R, Mendels J: Doubled blind multicenter comparison of sertraline and amytriptiline in elderly depressed patients. J Clin Psychiatry, 52(12, Suppl B): 18-27, 1990.
95. Stratta P, Mancini F, Cupillary M, et al.: Fluoxetine in premature ejaculation. Human Psychopharmacol, 8: 61-64, 1993.
96. Power-Smith P: Beneficial sexual side-effects from fluoxetine. Br J Psychiatry, 164: 249-250, 1994.
97. MacHale S, Phanjoo AL: SSRIs to treat sexual dysfunction [letter]. Br J Psychiatry, 164: 854, 1994.
98. Forster P, King J: Fluoxetine for premature ejaculation [letter]. Am J Psychiatry, 151(10): 1523, 1994.
99. Wise TN: Sertraline as a treatment for premature ejaculation. J Clin Psychiatry, 55(9): 417, 1994.
100. Assalian P: Clomipramine in the treatment of premature ejaculation. J Sex Res, 24: 213-215, 1988.
101. Waldinger MD, Hengeveld MW, Zwinderman AH: Paroxetine treatment of premature ejaculation: A double blind, randomized, placebo-controlled study. Am J Psychiatry, 151: 1377-1379, 1994
102. Zohar J, Kaplan J, Benjamin J: Compulsive exhibitionism successfully treated with fluvoxamine. A controlled case study. J Clin Psychiatry, 55(3):86-88, 1994.
103. Hyttel J: Pharmacological profile of selective serotonin reuptake inhibitors (SSRI). Intern Clin Psychopharmacol, 9(Suppl 1): 19-26, 1994.
104. Aldrich A: Retrospective review of psychotropic-induced sexual dysfunction in women. In Abstracts of the 149th Annual Meeting of the American Psychiatric Association, May 1996, New York: 266. Washington, DC: American Psychiatric Association, 1996.
105. Segraves RT: Psychiatric drugs and orgasm in the human female. J Psychosom Obstet Gynecol, 4: 125-128, 1985.
106. Magnus RV, Dean BC: Clorazepate: Double-blind crossover comparison of a single nightly dose with diazepam twice daily in anxiety. Dis Nerv Syst, 38, 317-321, 1977.
107. Hughes JM: Failure to ejaculate with chlordiazepoxide. Am f Psychiatry, 121: 610-611, 1964.
108. Sangal R: Inhibited female orgasm as a side effect of alprazolam. Am J Psychiatry, 142: 1223-1224, 1985.
109. Lydiard RB, Howell EF, Laraia MT, et al.: Sexual side effects of alprazolam [letter]. Am J Psychiatry, 144: 254-255, 1987.
110. Munjack DJ, Crocker B: Alprazolam-induced ejaculatory inhibition. J Clin Psycho-pharmacol, 6: 57-58, 1986.
111. Uhde TW, Tancer ME, Shea CA: Sexual dysfunction related to alprazolam treatment of social phobia. Am J Psychiatry, 145: 531-532, 1988.
112. Yeragani VK, Pohl R, Balon R: Sexual dysfunction related to alprazolam treatment of social phobia [letter]. Am J Psychiatry, 145: 531-532, 1988.
113. Segraves RT: Treatment of premature ejaculation with lorazepam. Am f Psychiatry, 144: 1240, 1987.
114. Benazzi F, Mazzoli M: Fluoxetine-induced sexual dysfunction: A dose- dependent effect?. Pharmacopsychiatry, 27(6): 246, 1994.
115. Beasley CM, Bosomworth JC, et al.: Fluoxetine: Relationships among dose response, adverse events and plasma concentrations in the treatment of depression. Psycho-pharmacol Bull, 26. 18-24, 1990.
116. Fahrer R, Nazar J, Suarez M, et al.: Efficacy and tolerance of moclobemide in 120 patients with depressive syndrome. In Therapeutic advantages of moclobemide rima reversible inhibition of MAO-A: Proceedings of the Sixth European Congress of the Association of European Psychiatry, November, 1992, Barcelona, Spain.
117. Schweitzer I, Tiller J, Maguire K, Davies B: Treatment of atypical depression with moclobemide. A sequential double controlled study. Int J Clin Pharm Res, 9(2): 111-117, 1989.
118. Rudorfer MV, Manji HK, Potter WZ: Comparative tolerability profiles of the newer versus older antidepressants. Drug Safety, 10(1): 18-46, 1994.
119. Reynaert C, Parent M, Mirel J, et al.: Moclobemide versus fluoxetine for a major depressive episode. Psychopharmacology, 118: 183-187, 1995.
120. Philipp M, Kohnen R, Benkert O: A comparison study of moclobemide and doxe-pine in major depression with special reference to effects on sexual dysfunction. Int. Clin Psychopharmacol, 7: 149-153, 1993.
121. Kennedy SH, Ralevski E, Davis C, Neitzert C: The effects of moclobemide on sexual desire and function in heakhy volunteers. Eur Neuropsychopharmacol, 6: 177-181, 1996.
122. Davidson JR: Monoamine oxidase inhibitors. In: Paykel ES ed, Handbook of affective disorders. 2nd ed. New York: Guilford Press; 1992: 345-358.
123. Bressler R, Katz MD: Drug therapy for geriatric depression. Drugs & Aging, 3(3): 195-219, 1993.
124. Harrison WM, Stewart J, Ehrhardt AA, et al.: A controlled study of the effects of antidepressants on sexual function. Psychopharmacol Bull, 21(1): 85-88, 1985.
125. Warneke L: Phenelzine and sexuality [letter]. J Clin Psychiatry, 55(5): 216-217, 1994.
126. Versiani M, Nardi AE, Mundim FD, et al.: Pharmacotherapy of social phobia. A controlled study with moclobemide and phenelzine. Br J Psychiatry, 161: 353-360, 1992.
127. Mann JJ, Aarons SF, Wilner PJ, et al.: A controlled study of the antidepressant efficacy and side effects of deprenyl. Arch Gen Psychiatry, 46: 45-50, 1989.
128. Schiavi RC: Interview, psychometric and psychophysiologic strategies to assess sexual disorder etiology [Monograph]. J Clin Psychiatry, 10(2): 19-26, 1992.
129. Wise TN: A model for the assessment of sexual dysfunction etiology [Monograph]. J Clin Psychiatry, 10(2): 11-18, 1992.