Adeno-associated viruses serotype 2-mediated RNA interference efficiently inhibits rabies virus replication in vitro and in vivo

Journal of Veterinary Medical Science

Volumn 75, Issue 10, 2013, Pages 1355-1361

  Wu, Hong Xia ^a,b   Wang, Hua Lei ^b   Guo, Xiao Feng ^a   Yang, Yu Jiao ^b   Ma, Jin Zhu ^b   Wang, Tie Cheng ^b   Gao, Yu Wei ^b   Zhao, Yong Kun ^b   Yang, Song Tao ^b   Xia, Xian Zhu ^b  

^a SOUTH CHINA AGRICULTURAL UNIVERSITY   (China)

^b BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

Author keywords

AAV2 vectors; Inhibit; N gene; RABV; SiRNA

Indexed keywords

NUCLEOPROTEIN; SMALL INTERFERING RNA; VIRUS RNA;

ADENO ASSOCIATED VIRUS; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CELL LINE; CHEMISTRY; DRUG ANTAGONISM; FEMALE; GENE VECTOR; GENETICS; IMMUNOLOGY; MOUSE; NONPARAMETRIC TEST; PLASMID; RABIES; RABIES VIRUS; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; VIROLOGY; VIRUS REPLICATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL LINE; DEPENDOVIRUS; FEMALE; GENETIC VECTORS; MICE; MICE, INBRED BALB C; NUCLEOPROTEINS; PLASMIDS; RABIES; RABIES VIRUS; REAL-TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, SMALL INTERFERING; RNA, VIRAL; STATISTICS, NONPARAMETRIC; VIRUS REPLICATION;

EID: 84886807057     PISSN: 09167250     EISSN: 13477439     Source Type: Journal    
DOI: 10.1292/jvms.13-0127     Document Type: Article

References (22)

1. Afione, S. A., Conrad, C. K., Kearns, W. G., Chunduru, S., Adams, R., Reynolds, T. C., Guggino, W. B., Cutting, G. R., Carter, B. J. and Flotte, T. R. 1996. In vivo model of adeno-associated virus vector persistence and rescue. J. Virol. 70: 3235-3241. [Medline]
2. Brandao, P. E., Castilho, J. G., Fahl, W., Carnieli, P. J., Oliveira, R. N., Macedo, C. I., Carrieri, M. L. and Kotait, I. 2007. Shortinterfering RNAs as antivirals against rabies. Braz. J. Infect. Dis. 11: 224-225. [Medline] [CrossRef]
3. Burger, C., Gorbatyuk, O. S., Velardo, M. J., Peden, C. S., Williams, P., Zolotukhin, S., Reier, P. J., Mandel, R. J. and Muzyczka, N. 2004. Recombinant AAV viral vectors pseudotyped with viral capsids from 4. serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system. Mol. Ther. 10: 302-317. [Medline] [CrossRef]
4. Daya, S. and Berns, K. I. 2008. Gene therapy using adenoassociated virus vectors. Clin. Microbiol. Rev. 21: 583-593. [Medline] [CrossRef]
5. Fischer, A., Hacein-Bey-Abina, S., Lagresle, C., Garrigue, A. and Cavazana-Calvo, M. 2005. [Gene therapy of severe combined immunodeficiency disease: proof of principle of efficiency and safety issues. Gene therapy, primary immunodeficiencies, retrovirus, lentivirus, genome]. Bull. Acad. Natl. Med. 189: 779-785 (in French). [Medline]
6. Fisher, K. J., Jooss, K., Alston, J., Yang, Y., Haecker, S. E., High, K., Pathak, R., Raper, S. E. and Wilson, J. M. 1997. Recombinant adeno-associated virus for muscle directed gene therapy. Nat. Med. 3: 306-312. [Medline] [CrossRef]
7. Gupta, P. K., Sonwane, A. A., Singh, N. K., Meshram, C. D., Dahiya, S. S., Pawar, S. S., Gupta, S. P., Chaturvedi, V. K. and Saini, M. 2012. Intracerebral delivery of small interfering RNAs (siRNAs) using adenoviral vector protects mice against lethal peripheral rabies challenge. Virus Res. 163: 11-18. [Medline] [CrossRef]
8. Israsena, N., Supavonwong, P., Ratanasetyuth, N., Khawplod, P. and Hemachudha, T. 2009. Inhibition of rabies virus replication by multiple artificial microRNAs. Antiviral Res. 84: 76-83. [Medline] [CrossRef]
9. Jackson, A. C. 2006. Rabies: new insights into pathogenesis and treatment. Curr. Opin. Neurol. 19: 267-270. [Medline] [Cross-Ref]
10. Kumar, P., Ban, H. S., Kim, S. S., Wu, H., Pearson, T., Greiner, D. L., Laouar, A., Yao, J., Haridas, V., Habiro, K., Yang, Y. G., Jeong, J. H., Lee, K. Y., Kim, Y. H., Kim, S. W., Peipp, M., Fey, G. H., Manjunath, N., Shultz, L. D., Lee, S. K. and Shankar, P. 2008. T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell 134: 577-586. [Medline] [CrossRef]
11. Li, B. J., Tang, Q., Cheng, D., Qin, C., Xie, F. Y., Wei, Q., Xu, J., Liu, Y., Zheng, B. J., Woodle, M. C., Zhong, N. and Lu, P. Y. 2005. Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque. Nat. Med. 11: 944-951. [Medline]
12. Mease, P. J., Hobbs, K., Chalmers, A., El-Gabalawy, H., Bookman, A., Keystone, E., Furst, D. E., Anklesaria, P. and Heald, A. E. 2009. Local delivery of a recombinant adenoassociated vector containing a tumour necrosis factor alpha antagonist gene in inflammatory arthritis: a phase 1 dose-escalation safety and tolerability study. Ann. Rheum. Dis. 68: 1247-1254. [Medline] [CrossRef]
13. Morrissey, D. V., Lockridge, J. A., Shaw, L., Blanchard, K., Jensen, K., Breen, W., Hartsough, K., Machemer, L., Radka, S., Jadhav, V., Vaish, N., Zinnen, S., Vargeese, C., Bowman, K., Shaffer, C. S., Jeffs, L. B., Judge, A., MacLachlan, I. and Polisky, B. 2005. Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. Nat. Biotechnol. 23: 1002-1007. [Medline] [CrossRef]
14. Padwad, Y. S., Mishra, K. P., Jain, M., Chanda, S., Karan, D. and Ganju, L. 2009. RNA interference mediated silencing of Hsp60 gene in human monocytic myeloma cell line U937 revealed decreased dengue virus multiplication. Immunobiology 214: 422-429. [Medline] [CrossRef]
15. Pandiri, A. R., Reed, W. M., Mays, J. K. and Fadly, A. M. 2007. Influence of strain, dose of virus, and age at inoculation on subgroup J avian leukosis virus persistence, antibody response, and oncogenicity in commercial meat-type chickens. Avian Dis. 51: 725-732. [Medline] [CrossRef]
16. Song, E., Lee, S. K., Wang, J., Ince, N., Ouyang, N., Min, J., Chen, J., Shankar, P. and Lieberman, J. 2003. RNA interference targeting Fas protects mice from fulminant hepatitis. Nat. Med. 9: 347-351. [Medline] [CrossRef]
17. Sonwane, A. A., Dahiya, S. S., Saini, M., Chaturvedi, V. K., Singh, R. P. and Gupta, P. K. 2012. Inhibition of rabies virus multiplication by siRNA delivered through adenoviral vector in vitro in BHK-21 cells and in vivo in mice. Res. Vet. Sci. 93: 498-503. [Medline] [CrossRef]
18. Urabe, M., Ding, C. and Kotin, R. M. 2002. Insect cells as a factory to produce adeno-associated virus type 2 vectors. Hum. Gene Ther. 13: 1935-1943. [Medline] [CrossRef]
19. Willoughby, R. E. Jr., Tieves, K. S., Hoffman, G. M., Ghanayem, N. S., Amlie-Lefond, C. M., Schwabe, M. J., Chusid, M. J. and Rupprecht, C. E. 2005. Survival after treatment of rabies with induction of coma. N. Engl. J. Med. 352: 2508-2514. [Medline] [CrossRef]
20. Yang, Y. J., Zhao, P. S., Zhang, T., Wang, H. L., Liang, H. R., Zhao, L. L., Wu, H. X., Wang, T. C., Yang, S. T. and Xia, X. Z. 2012. Small interfering RNAs targeting the rabies virus nucleoprotein gene. Virus Res. 169: 169-174. [Medline] [CrossRef]
21. Zhang, W., Wang, C. Y., Yang, S. T., Qin, C., Hu, J. L. and Xia, X. Z. 2009. Inhibition of highly pathogenic avian influenza virus H5N1 replication by the small interfering RNA targeting polymerase A gene. Biochem. Biophys. Res. Commun. 390: 421-426. [Medline] [CrossRef]
22. Zhang, Y., Chirmule, N., Gao, G. and Wilson, J. 2000. CD40 ligand-dependent activation of cytotoxic T lymphocytes by adeno-associated virus vectors in vivo: role of immature dendritic cells. J. Virol. 74: 8003-8010. [Medline] [CrossRef]