P38-MAPK signaling pathway is not involved in osteogenic differentiation during early response of mesenchymal stem cells to continuous mechanical strain

Molecular and Cellular Biochemistry

Volumn 378, Issue 1-2, 2013, Pages 19-28

  Zhang, Peng ^a   Wu, Yuqiong ^a   Dai, Qinggang ^a   Fang, Bing ^a   Jiang, Lingyong ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Bone mesenchymal stem cell; Continuous mechanical strain; Osteogenesis; P38 Runx2

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALKALINE PHOSPHATASE; IMIDAZOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE P38; PYRIDINE DERIVATIVE; RUNX2 PROTEIN, RAT; TRANSCRIPTION FACTOR RUNX2;

ANIMAL; ARTICLE; BONE DEVELOPMENT; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SHAPE; CELL SURVIVAL; DRUG ANTAGONISM; MECHANOTRANSDUCTION; MESENCHYMAL STROMA CELL; METABOLISM; PHYSIOLOGICAL STRESS; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ALKALINE PHOSPHATASE; ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SHAPE; CELL SURVIVAL; CELLS, CULTURED; CORE BINDING FACTOR ALPHA 1 SUBUNIT; IMIDAZOLES; MAP KINASE SIGNALING SYSTEM; MECHANOTRANSDUCTION, CELLULAR; MESENCHYMAL STROMAL CELLS; OSTEOGENESIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; STRESS, PHYSIOLOGICAL;

EID: 84886791046     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1589-7     Document Type: Article

References (58)

1. Duncan RL, Turner C.H. (1995) Mechanotransduction and the functional response of bone to mechanical strain. Calcif Tissue Int 57:344-358
2. Umemura Y, Baylink DJ, Wergedal JE, Mohan S, Srivastava AK (2002) A time course of bone response to jump exercise in C57BL/6J mice. J Bone Miner Metab 20:209-215
3. Henneman S, Von den Hoff JW, Maltha JC (2008) Mechanobiology of tooth movement. Eur J Orthod 30:299-306
4. Beck BR, Kent K, Holloway L, Marcus R (2006) Novel, highfrequency, low-strain mechanical loading for premenopausal women with low bone mass: early findings. J Bone Miner Metab 24:505-507
5. Donahue SW, Jacobs CR, Donahue HJ (2001) Flow-induced calcium oscillations in rat osteoblasts are age, loading frequency, and shear stress dependent. Am J Physiol Cell Physiol 281: C1635-C1641
6. Rath B, Nam J, Knobloch TJ, Lannutti JJ, Agarwal S (2008) Compressive forces induce osteogenic gene expression in calvarial osteoblasts. J Biomech 41:1095-1103
7. Suzuki N, Yoshimura Y, Deyama Y, Suzuki K, Kitagawa Y (2008) Mechanical stress directly suppresses osteoclast differentiation in RAW264.7 cells. Int J Mol Med 21:291-296
8. Costessi A, Pines A, D'Andrea P et al (2005) Extracellular nucleotides activate Runx2 in the osteoblast-like HOBIT cell line: a possible molecular link between mechanical stress and osteoblasts' response. Bone 36:418-432
9. Huiskes R, Ruimerman R, van Lenthe GH, Janssen JD (2000) Effects of mechanical forces on maintenance and adaptation of form in trabecular bone. Nature 405:704-706
10. Chao EY, Inoue N (2003) Biophysical stimulation of bone fracture repair, regeneration and remodelling. Eur Cell Mater 6:72-84 discussion 84-75
11. Thorpe SD, Buckley CT, Vinardell T, O'Brien FJ, Campbell VA, Kelly DJ (2010) The response of bone marrow-derived mesenchymal stem cells to dynamic compression following TGF-beta3 induced chondrogenic differentiation. Ann Biomed Eng 38:2896-2909
12. Li H, Marijanovic I, Kronenberg MS et al (2008) Expression and function of Dlx genes in the osteoblast lineage. Dev Biol 316:458-470
13. Karsenty G, Ducy P, Starbuck M et al (1999) Cbfa1 as a regulator of osteoblast differentiation and function. Bone 25:107-108
14. Nakashima K, Zhou X, Kunkel G et al (2002) The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108:17-29
15. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G (1997) Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89:747-754
16. Mundlos S, Otto F, Mundlos C et al (1997) Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia. Cell 89:773-779
17. Ahdjoudj S, Lasmoles F, Holy X, Zerath E, Marie PJ (2002) Transforming growth factor beta2 inhibits adipocyte differentiation induced by skeletal unloading in rat bone marrow stroma. J Bone Miner Res 17:668-677
18. Arnsdorf EJ, Tummala P, Kwon RY, Jacobs CR (2009) Mechanically induced osteogenic differentiation - the role of RhoA, ROCKII and cytoskeletal dynamics. J Cell Sci 122:546-553
19. Hie M, Tsukamoto I (2010) Increased expression of the receptor for activation of NF-kappaB and decreased runt-related transcription factor 2 expression in bone of rats with streptozotocin-induced diabetes. Int J Mol Med 26:611-618
20. Ziros PG, Gil AP, Georgakopoulos T et al (2002) The bone-specific transcriptional regulator Cbfa1 is a target of mechanical signals in osteoblastic cells. J Biol Chem 277:23934-23941
21. Johnson GL, Lapadat R (2002) Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298:1911-1912
22. Matsuda N, Morita N, Matsuda K, Watanabe M (1998) Proliferation and differentiation of human osteoblastic cells associated with differential activation of M.A.P kinases in response to epidermal growth factor, hypoxia, and mechanical stress in vitro. Biochem Biophys Res Commun 249:350-354
23. Lai CF, Cheng SL (2002) Signal transductions induced by bone morphogenetic protein-2 and transforming growth factorbeta in normal human osteoblastic cells. J Biol Chem 277:15514-15522
24. Rubin J, Rubin C, Jacobs CR (2006) Molecular pathways mediating mechanical signaling in bone. Gene 367:1-16
25. Kawarizadeh A, Bourauel C, Gotz W, Jager A (2005) Early responses of periodontal ligament cells to mechanical stimulus in vivo. J Dent Res 84:902-906
26. Liedert A, Kaspar D, Blakytny R, Claes L, Ignatius A (2006) Signal transduction pathways involved in mechanotransduction in bone cells. Biochem Biophys Res Commun 349:1-5
27. Maniatopoulos C, Sodek J, Melcher AH (1988) Bone formation in vitro by stromal cells obtained from bone marrow of young adult rats. Cell Tissue Res 254:317-330
28. Umemura Y, Nagasawa S, Honda A, Singh R (2008) High-impact exercise frequency per week or day for osteogenic response in rats. J Bone Miner Metab 26:456-460
29. Franceschi RT, Xiao G, Jiang D, Gopalakrishnan R, Yang S, Reith E (2003) Multiple signaling pathways converge on the Cbfa1/Runx2 transcription factor to regulate osteoblast differentiation. Connect Tissue Res 44(Suppl 1):109-116
30. Melsen B (2001) Tissue reaction to orthodontic tooth movement - a new paradigm. Eur J Orthod 23:671-681
31. Kaspar D, Seidl W, Neidlinger-Wilke C, Beck A, Claes L, Ignatius A (2002) Proliferation of human-derived osteoblast-like cells depends on the cycle number and frequency of uniaxial strain. J Biomech 35:873-880
32. McGuinness NJ, Wilson AN, Jones ML, Middleton J (1991) A stress analysis of the periodontal ligament under various orthodontic loadings. Eur J Orthod 13:231-242
33. Jagodzinski M, Breitbart A, Wehmeier M et al (2008) Influence of perfusion and cyclic compression on proliferation and differentiation of bone marrow stromal cells in 3-dimensional culture. J Biomech 41:1885-1891
34. Riddle RC, Taylor AF, Genetos D.C., Donahue HJ (2006) M.A.P kinase and calcium signaling mediate fluid flow-induced human mesenchymal stem cell proliferation. Am J Physiol Cell Physiol 290:C776-C784
35. Song G, Ju Y, Shen X, Luo Q, Shi Y, Qin J (2007) Mechanical stretch promotes proliferation of rat bone marrow mesenchymal stem cells. Colloids Surf B Biointerfaces 58:271-277
36. Caetano-Lopes J, Canhao H, Fonseca JE (2007) Osteoblasts and bone formation. Acta Reumatol Port 32:103-110
37. Yoshikawa T, Peel SA, Gladstone J.R., Davies JE (1997) Biochemical analysis of the response in rat bone marrow cell cultures to mechanical stimulation. Biomed Mater Eng 7:369-377
38. Jagodzinski M, Drescher M, Zeichen J et al (2004) Effects of cyclic longitudinal mechanical strain and dexamethasone on osteogenic differentiation of human bone marrow stromal cells. Eur Cell Mater 7:35-41 discussion 41
39. Wozniak M, Fausto A, Carron CP, Meyer DM, Hruska KA (2000) Mechanically strained cells of the osteoblast lineage organize their extracellular matrix through unique sites of alphavbeta3-integrin expression. J Bone Miner Res 15:1731-1745
40. Eriksen EF (2010) Cellular mechanisms of bone remodeling. Rev Endocr Metabol Disord 11:219-227
41. Nakashima K, de Crombrugghe B (2003) Transcriptional mechanisms in osteoblast differentiation and bone formation. Trends Genet 19:458-466
42. Fan X, Rahnert JA, Murphy TC, Nanes MS, Greenfield EM, Rubin J (2006) Response to mechanical strain in an immortalized pre-osteoblast cell is dependent on ERK1/2. J Cell Physiol 207:454-460
43. Suzuki A, Guicheux J, Palmer G et al (2002) Evidence for a role of p38 M.A.P kinase in expression of alkaline phosphatase during osteoblastic cell differentiation. Bone 30:91-98
44. Xiao G, Jiang D, Thomas P et al (2000) M.A.PK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1. J Biol Chem 275:4453-4459
45. Cuadrado A, Nebreda AR (2010) Mechanisms and functions of p38 M.A.PK signalling. Biochem J 429:403-417
46. Rey A, Manen D, Rizzoli R, Ferrari SL, Caverzasio J (2007) Evidences for a role of p38 M.A.P kinase in the stimulation of alkaline phosphatase and matrix mineralization induced by parathyroid hormone in osteoblastic cells. Bone 41:59-67
47. Jessop HL, Rawlinson SC, Pitsillides AA, Lanyon LE (2002) Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways. Bone 31:186-194
48. Kusumi A, Sakaki H, Kusumi T et al (2005) Regulation of synthesis of osteoprotegerin and soluble receptor activator of nuclear factor-kappaB ligand in normal human osteoblasts via the p38 mitogen-activated protein kinase pathway by the application of cyclic tensile strain. J Bone Miner Metab 23:373-381
49. Hatton JP, Pooran M, Li CF, Luzzio C, Hughes-Fulford M (2003) A short pulse of mechanical force induces gene expression and growth in MC3T3-E1 osteoblasts via an ERK 1/2 pathway. J Bone Miner Res 18:58-66
50. Wu Y, Zhang X, Zhang P, Fang B, Jiang L (2012) Intermittent traction stretch promotes the osteoblastic differentiation of bone mesenchymal stem cells by the ERK1/2-activated Cbfa1 pathway. Connect Tissue Res 53(6):451-459
51. Zhang P, Wu Y, Jiang Z, Jiang L, Fang B (2012) Osteogenic response of mesenchymal stem cells to continuous mechanical strain is dependent on ERK1/2-Runx2 signaling. Int J Mol Med 29:1083-1089
52. Simmons C.A., Matlis S, Thornton AJ, Chen S, Wang CY, Mooney DJ (2003) Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular signal-regulated kinase (ERK1/2) signaling pathway. J Biomech 36:1087-1096
53. Hotokezaka H, Sakai E, Kanaoka K et al (2002) U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells. J Biol Chem 277:47366-47372
54. Zhang H, Shi X, Hampong M, Blanis L, Pelech S (2001) Stressinduced inhibition of ERK1 and ERK2 by direct interaction with p38 M.A.P kinase. J Biol Chem 276:6905-6908
55. Rubin J, Murphy TC, Zhu L, Roy E, Nanes MS, Fan X (2003) Mechanical strain differentially regulates endothelial nitric-oxide synthase and receptor activator of nuclear kappa B ligand expression via ERK1/2 M.A.PK. J Biol Chem 278:34018-34025
56. Tsuji K, Uno K, Zhang GX, TamuraM(2004) Periodontal ligament cells under intermittent tensile stress regulate mRNA expression of osteoprotegerin and tissue inhibitor of matrix metalloprotease-1 and -2. J Bone Miner Metab 22:94-103
57. Tazoe M, Mogi M, Goto S, Togari A (2003) Involvement of p38M.A.P kinase in bone morphogenetic protein-4-induced osteoprotegerin in mouse bone-marrow-derived stromal cells. Arch Oral Biol 48: 615-619
58. Ulsamer A, Ortuno MJ, Ruiz S et al (2008) BMP-2 induces Osterix expression through up-regulation of Dlx5 and its phosphorylation by p38. J Biol Chem 283:3816-3826