Breed-linked polymorphisms of porcine toll-like receptor 2 (TLR2) and TLR4 and the primary investigation on their relationship with prevention against Mycoplasma pneumoniae and bacterial LPS challenge

Immunogenetics

Volumn 65, Issue 11, 2013, Pages 829-834

  Fang, Xiaomin ^a   Liu, Xiao ^a   Meng, Cui ^a   Fu, Yanfeng ^a   Wang, Xuemin ^a   Li, Bixia ^a   Tu, Feng ^a   Zhao, Fang ^a   Ren, Shouwen ^a  

^a INSTITUTE OF PLANT PROTECTION   (China)

Author keywords

LPS; Mycoplasma pneumoniae; Pig; SNPs; Toll like receptor (TLR)

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; INTERLEUKIN 1BETA; MESSENGER RNA; PATTERN RECOGNITION RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; GRAM NEGATIVE INFECTION; IMMUNE RESPONSE; INFECTION SENSITIVITY; INNATE IMMUNITY; LUNG ALVEOLUS MACROPHAGE; MYCOPLASMA PNEUMONIAE; NONHUMAN; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SWINE;

ANIMALS; BREEDING; CELLS, CULTURED; FEMALE; IMMUNITY, INNATE; LIPOPOLYSACCHARIDES; MACROPHAGES, ALVEOLAR; MYCOPLASMA PNEUMONIAE; PNEUMONIA, MYCOPLASMA; POLYMORPHISM, SINGLE NUCLEOTIDE; SWINE; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

BACTERIA (MICROORGANISMS); MYCOPLASMA HYOPNEUMONIAE; MYCOPLASMA PNEUMONIAE; NEGIBACTERIA; SUIDAE; SUS;

EID: 84886787265     PISSN: 00937711     EISSN: 14321211     Source Type: Journal    
DOI: 10.1007/s00251-013-0727-4     Document Type: Article

References (26)

1. Akira S, Takeda K (2004) Toll-like receptor signalling. Nat Rev Immunol 4:499-511
2. Amass SF, Clark LK, van Alstine WG, Bowersock TL, Murphy DA, Knox KE, Albregts SR (1994) Interaction of Mycoplasma hyopneumoniae and Pasteurella multocida infections in swine. J Am Vet Med Assoc 204:102-107
3. Basta S, Carrasco CP, Knoetig SM, Rigden RC, Gerber H, Summerfield A, McCullough KC (2000) Porcine alveolar macrophages: poor accessory or effective suppressor cells for T-lymphocytes. Veterinary immunology and immunopathology 77:177-190
4. Bell JK, Mullen GE, Leifer CA, Mazzoni A, Davies DR, Segal DM (2003) Leucine-rich repeats and pathogen recognition in Toll-like receptors. Trends in immunology 24:528-533
5. Ben-Ali M, Barbouche M-R, Bousnina S, Chabbou A, Dellagi K (2004) Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients. Clinical and diagnostic laboratory immunology 11:625-626
6. Da Costa CU, Wantia N, Kirschning CJ, Busch DH, Rodriguez N, Wagner H, Miethke T (2004) Heat shock protein 60 from Chlamydia pneumoniae elicits an unusual set of inflammatory responses via Toll-like receptor 2 and 4 in vivo. Eur J Immunol 34:2874-2884
7. Deutscher AT, Jenkins C, Minion FC, Seymour LM, Padula MP, Dixon NE, Walker MJ, Djordjevic SP (2010) Repeat regions R1 and R2 in the P97 paralogue Mhp271 of Mycoplasma hyopneumoniae bind heparin, fibronectin and porcine cilia. Mol Microbiol 78:444-458
8. Eder W, Klimecki W, Yu L, von Mutius E, Riedler J, Braun-Fahrländer C, Nowak D, Martinez FD (2004) Toll-like receptor 2 as a major gene for asthma in children of European farmers. Journal of allergy and clinical immunology 113:482-488
9. Fang X, Xu N, Ren S (2008) Cloning, sequencing and identification of single nucleotide polymorphisms of partial sequence on the porcine CACNA1S gene. Science in China Series C: Life Sciences 51:317-325
10. Hawn TR, Verbon A, Janer M, Zhao LP, Beutler B, Aderem A (2005) Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease. Proc Natl Acad Sci U S A 102:2487-2489
11. Heine H, Ulmer AJ (2005) Recognition of bacterial products by toll-like receptors. Chem Immunol Allergy 86:99-119
12. Hussein YM, Awad HA, Shalaby SM, Ali A-SA, Alzahrani SS (2012) Toll-like receptor 2 and toll-like receptor 4 polymorphisms and susceptibility to asthma and allergic rhinitis: a case-control analysis. Cell Immunol 274:34-38
13. Into T, Nodasaka Y, Hasebe A, Okuzawa T, Nakamura J-i, Ohata N, Shibata K-i (2002) Mycoplasmal lipoproteins induce toll-like receptor 2-and caspases-mediated cell death in lymphocytes and monocytes. Microbiology and immunology 46:265-276
14. Liu L, Ma S (2007) Epidemiological characteristics and its prevention of swine enzootic pneumonia. Chinese Journal of Animal Husbandry and Veterinary Medicine 9:64-65
15. Liu S, Lin W, Shi X, Zhang J, Yao Y, Ming F (2007) Bi-PASA genetic marker and polymorphism of the porcine TLR2 gene. Heilongjiang Animal Science and Veterinary Medicine 1:7-9
16. - ΔΔCT method. Methods 25:402-408
17. Lorenz E, Mira JP, Cornish KL, Arbour NC, Schwartz DA (2000) A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection. Infection and immunity 68:6398-6401
18. Muneta Y, Uenishi H, Kikuma R, Yoshihara K, Shimoji Y, Yamamoto R, Hamashima N, Yokomizo Y, Mori Y (2003) Porcine TLR2 and TLR6: identification and their involvement in Mycoplasma hyopneumoniae infection. Journal of interferon & cytokine research 23:583-590
19. Nicolò C, Di Sante G, Procoli A, Migliara G, Piermattei A, Valentini M, Delogu G, Cittadini A, Constantin G, Ria F (2013) M. tuberculosis in the adjuvant modulates time of appearance of CNS-specific effector T cells in the spleen through a polymorphic site of TLR2. PloS one 8:e55819
20. Shao GQ, Liu MJ, Sun PY, Wang JC, Du G, Zhou Y, Liu D (2007) The establishment of an experimental swine model of swine mycoplasma pneumonia. Journal of Microbes and Infection 2:215-218
21. Shimizu T KY, Kuwano K (2005) A dipalmitoylated lipoprotein from Mycoplasma pneumoniae activates NF-kappa B through TLR1, TLR2, and TLR6. J Immunol 175:4641-4646
22. Shinkai H, Tanaka M, Morozumi T, Eguchi-Ogawa T, Okumura N, Muneta Y, Awata T, Uenishi H (2006) Biased distribution of single nucleotide polymorphisms (SNPs) in porcine Toll-like receptor 1 (TLR1), TLR2, TLR4, TLR5, and TLR6 genes. Immunogenetics 58:324-330
23. Xin JC, Wang L, Li Y (2006) Research progress on swine Mycoplasma hyopneumoniae. Swine Industry Science 23:18-22
24. Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, Hoshino K, Takeuchi O, Kobayashi M, Fujita T (2002) Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature 420:324-329
25. Yang I, Barton S, Rorke S, Cakebread J, Keith T, Clough J, Holgate S, Holloway J (2004) Toll-like receptor 4 polymorphism and severity of atopy in asthmatics. Genes and immunity 5:41-45
26. Zhang F, Gao XD, Wu WW, Gao Y, Zhang YW, Wang SP (2013) Polymorphisms in toll-like receptors 2, 4 and 5 are associated with Legionella pneumophila infection. Infection 23: (in press)