Enzyme-activatable imaging probe reveals enhanced neutrophil elastase activity in tumors following photodynamic therapy

Journal of Biomedical Optics

Volumn 18, Issue 10, 2013, Pages

  Mitra, Soumya ^a   Modi, Kshitij D ^b   Foster, Thomas H ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b PERKINELMER INC   (United States)

Author keywords

photodynamic therapy neutrophil elastase neutrophil elastase 680 FAST molecular imaging in vivo imaging immune cell imaging photoactivatable probe confocal microscopy protease activity Photofrin 2 (1 hexyloxyethyl) 2 devinyl pyropheophorbide a

Indexed keywords

ELASTASE; FLUORESCENCE IMAGING; FLUORESCENT REPORTER; FLUOROGENIC PROBES; INFLAMMATORY RESPONSE; PHOTODYNAMIC THERAPY (PDT); POPULATION DENSITIES; PROTEASE ACTIVITIES;

CELL CULTURE; CELL PROLIFERATION; CELLS; ENZYMES; FLUORESCENCE; MAMMALS; MOLECULAR IMAGING; PHOTODYNAMIC THERAPY; PHOTOSENSITIZERS; POPULATION STATISTICS; PROBES;

TUMORS;

FLUORESCENT DYE; LEUKOCYTE ELASTASE; PHOTOFRIN II; PHOTOSENSITIZING AGENT;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; C3H MOUSE; CHEMISTRY; ENZYMOLOGY; EXPERIMENTAL MAMMARY NEOPLASM; FEMALE; FLUORESCENCE IMAGING; METABOLISM; METHODOLOGY; MOLECULAR IMAGING; MOUSE; PHOTOCHEMOTHERAPY; MAMMARY NEOPLASMS, EXPERIMENTAL; PROCEDURES;

ANIMALS; DIHEMATOPORPHYRIN ETHER; FEMALE; FLUORESCENT DYES; LEUKOCYTE ELASTASE; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MOLECULAR IMAGING; OPTICAL IMAGING; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS;

EID: 84886770495     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.JBO.18.10.101314     Document Type: Article

References (28)

1. P. Agostinis et al., "Photodynamic therapy of cancer: an update, " CA Cancer J. Clin. 61(4), 250-281 (2011).
2. M. Korbelik, "PDT-associated host response and its role in the therapy outcome, " Lasers Surg. Med. 38(5), 500-508 (2006).
3. W.J. de Vreeetal., "Evidence for an important role of neutrophils in the efficacy of photodynamic therapy in vivo, " Cancer Res. 56(13), 2908-2911 (1996).
4. P. C. Kousis et al., "Photodynamic therapy enhancement of antitumor immunity is regulated by neutrophils, " Cancer Res. 67(21), 10501-10510 (2007). (Pubitemid 350070826)
5. J. Sun et al., "Neutrophils as inflammatory and immune effectors in photodynamic therapy-treated mouse SCC VII tumours, " Photochem. Photobiol. Sci. 1(9), 690-695 (2002). (Pubitemid 37069785)
6. T. H. Foster et al., "Intratumor administration of the photosensitizer Pc 4 affords photodynamic therapy efficacy and selectivity at short drug-light intervals, " Transl. Oncol. 3(2), 135-141 (2010).
7. S. Mitra, O. Mironov, and T. H. Foster, "Confocal fluorescence imaging enables noninvasive quantitative assessment of host cell populations in vivo following photodynamic therapy, " Theranostics 2(9), 840-849 (2012).
8. M. Korbelik and I. Cecic, "Contribution of myeloid and lymphoid host cells to the curative outcome of mouse sarcoma treatment by photodynamic therapy, " Cancer Lett. 137(1), 91-98 (1999). (Pubitemid 29179500)
9. S. O. Gollnick and C. M. Brackett, "Enhancement of anti-tumor immunity by photodynamic therapy, " Immunol. Res. 46(1-3), 216-226 (2010).
10. A. Mantovani et al., "Neutrophils in the activation and regulation of innate and adaptive immunity, " Nat. Rev. Immunol. 11(8), 519-531 (2011).
11. U. Meyer-Hoffert and O. Wiedow, "Neutrophil serine proteases: mediators of innate immune responses, " Curr. Opin. Hematol. 18, 19-24 (2011).
12. C. T. Pham, "Neutrophil serine proteases: specific regulators of inflammation, " Nat. Rev. Immunol. 6(7), 541-550 (2006). (Pubitemid 43980526)
13. R. Benabid et al., "Neutrophil elastase modulates cytokine expression: contribution to host defense against pseudomonas aeruginosa-induced pneumonia, " J. Biol. Chem. 287(42), 34883-34894 (2012).
14. J. O. McIntyre and L. M. Matrisian, "Molecular imaging of proteolytic activity in cancer, " J. Cell Biochem. 90(6) 1087-1097 (2003). (Pubitemid 37485047)
15. R. Weissleder et al., "In vivo imaging of tumors with protease-activated near-infrared fluorescent probes, " Nat. Biotechnol. 17(4), 375-378 (1999). (Pubitemid 29166041)
16. M. Solomon et al., "Detection of enzyme activity in orthotopic murine breast cancer by fluorescence lifetime imaging using a fluorescence resonance energy transfer-based molecular probe, " J. Biomed. Opt. 16(6), 066019 (2011).
17. J. Baeten et al., "In vivo investigation of breast cancer progression by use of an internal control, " Neoplasia 11(3), 220-227 (2009).
18. P. A. Barber et al., "Infrared optical imaging of matrix metalloprotei-nases (MMPs) up regulation following ischemia reperfusion is ameliorated by hypothermia, " BMC Neurosci. 13(76), 76 (2012).
19. E. F Jones et al., "Characterization of human osteoarthritic cartilage using optical and magnetic resonance imaging, " Mol. Imag. Biol. 14(1), 32-39 (2012).
20. A. P. Castano, P. Mroz, and M. R. Hamblin, "Photodynamic therapy and anti-tumour immunity, " Nat. Rev. Cancer, 6(7), 535-545 (2006). (Pubitemid 43980542)
21. G. Krosl, M. Korbelik, and G. J. Dougherty, "Induction of immune cell infiltration into murine sccvii tumour by photofrin-based photodynamic therapy, " Br. J. Cancer 71(3), 549-555 (1995).
22. S. Kossodoetal., "Noninvasive in vivo quantification of neutrophil elastase activity in acute experimental mouse lung injury, " Int. J. Mol. Imag. 2011, 581406 (2011).
23. S. Miyoshi et al., "Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis, " Drug Des. Devel. Ther. 7, 305-316 (2013).
24. S. A. Gerber et al., "Preferential attachment of peritoneal tumor metastases to omental immune aggregates and possible role of a unique vascular microenvironment in metastatic survival and growth, " Am. J. Pathol. 169(5), 1739-1752 (2006). (Pubitemid 351182005)
25. N. Aikawa et al., "Reevaluation of the efficacy and safety of the neutrophil elastase inhibitor, sivelestat, for the treatment of acute lung injury associated with systemic inflammatory response syndrome; a phase IV study, " Pulm. Pharmacol. Ther. 24(5), 549-554 (2011).
26. S. O. Gollnick et al., "Altered expression of interleukin 6 and interleukin 10 as a result of photodynamic therapy in vivo, " Cancer Res. 57(18), 3904-3909 (1997). (Pubitemid 27427673)
27. D. A. Bellnier et al., "Murine pharmacokinetics and antitumor efficacy of the photodynamic sensitizer 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a, " J. Photochem. Photobiol. B 20(1), 55-61 (1993). (Pubitemid 23257594)
28. E. A. Mittendorf et al., "Breast cancer cell uptake of the inflammatory mediator neutrophil elastase triggers an anticancer adaptive immune response, " Cancer Res. 72(13), 3153-3162 (2012).