Lymphoepithelioma-like carcinoma of the stomach: A case report and review of the literature

Diagnostic Pathology

Volumn 8, Issue 1, 2013, Pages

  Bittar, Zeid ^a   Fend, Falko ^a   Quintanilla Martinez, Leticia ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

EBV; Lymphoepithelioma like carcinoma; Microsatellite instability; Prognosis

Indexed keywords

MICROSATELLITE DNA;

AGED; BIOPSY; CARCINOMA; CASE REPORT; EPSTEIN BARR VIRUS; EPSTEIN BARR VIRUS INFECTION; HUMAN; ISOLATION AND PURIFICATION; MALE; PATHOLOGY; PROGNOSIS; REVIEW; STOMACH; STOMACH TUMOR; VIROLOGY;

AGED; BIOPSY; CARCINOMA; EPSTEIN-BARR VIRUS INFECTIONS; HERPESVIRUS 4, HUMAN; HUMANS; MALE; MICROSATELLITE REPEATS; PROGNOSIS; STOMACH; STOMACH NEOPLASMS;

EID: 84886744709     PISSN: None     EISSN: 17461596     Source Type: Journal    
DOI: 10.1186/1746-1596-8-184     Document Type: Article

References (30)

1. Watanabe H, Enjoji M, Imai T. Gastric carcinoma with lymphoid stroma: its morphologic characteristic and prognostic correlations. Cancer 1976, 38:232-243. 10.1002/1097-0142(197607)38:1<232::AID-CNCR2820380135>3.0.CO;2-4, 947518.
2. Torlakovic G, Snover DC, Torlakovic E. Simultaneous EBV-positive lymphoepithelioma-like carcinoma and EBV-negative intestinal type adenocarcinoma in a patient with Helicobacter pylori-associated chronic gastritis. Am J Clin Pathol 2004, 121:237-243. 10.1309/MD3BD8Y1Q5X983LG, 14983938.
3. Horiuchi K, Mishima K, Ohsawa M, et al. Carcinoma of stomach and breast with lymphoid stroma: localization of Epstein Barr virus. J Clin Pathol 1994, 47:538-540. 10.1136/jcp.47.6.538, 494746, 8063937.
4. Corvalan A, Koriyama C, Akiba S, et al. Epstein-Barr virus in gastric carcinoma is associated with localization in the cardia and with a diffuse histology: a study in one area of Chile. Int J Canc 2001, 94:527-530.
5. Grogg KL, Lohse CM, Pankratz VS, et al. Lymphocyte-rich gastric cancer: association with Epstein-Barr virus, microsatellite instability, histology and survival. Mod Pathol 2003, 16:641-651. 10.1097/01.MP.0000076980.73826.C0, 12861059.
6. Fukayama M, Ushiku T. Epstein-Barr virus-associated gastric carcinoma. Pathol Res Pract 2011, 207:529-537. 10.1016/j.prp.2011.07.004, 21944426.
7. Takada K. Epstein-Barr virus and gastric carcinoma. Mol Pathol 2000, 53:255-261. 10.1136/mp.53.5.255, 1186978, 11091849.
8. Hiroshi S, Akinori N, Masayuki K, et al. Oesophageal and gastric cancer. J Gastroenterol Hepatol 1999, 14:534-539.
9. Iwashita A, Ueyama T, Yamada Y, et al. Clinicopathological study on medullary carcinoma with lymphoid stroma of the stomach. I to Cho (Stomach and Intestine) 1991, 10:1159-1166. [Japanese with English abstract].
10. Minamoto T, Mai M, Watanabe K, et al. Medullary carcinoma with lymphocytic infiltration of the stomach. Clinicopathologic study of the subpopulations of infiltrating lymphocytes in the tumor. Cancer 1990, 66:945-952. 10.1002/1097-0142(19900901)66:5<945::AID-CNCR2820660523>3.0.CO;2-X, 2386921.
11. Shibata D, Tokunaga M, Uemura Y, et al. Association of Epstein-Barr virus with undifferentiated gastric carcinomas with intense lymphoid infiltration, lymphoepithelioma-like carcinoma. Am J Pathol 1991, 139:469-474. 1886210, 1653517.
12. Beek JV, Hausen AZ, Kranenbarg EK, et al. EBV-positive gastric adenocarcinomas: a distinct clinicopathologic entity with a low frequency of lymph node involvement. J Clin Oncol 2004, 22:664-670. 10.1200/JCO.2004.08.061, 14966089.
13. Chang MS, Kim WH, Kim CW, et al. Epstein-Barr virus in gastric carcinomas with lymphoid stroma. Histopathology 2000, 37:309-315. 10.1046/j.1365-2559.2000.01014.x, 11012737.
14. Kang GH, Lee S, Kim WH, et al. Epstein-Barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma. Am J Pathol 2002, 160:787-794. 10.1016/S0002-9440(10)64901-2, 1867170, 11891177.
15. Shibata D, Weiss LM. Epstein-Barr virus-associated gastric adenocarcinoma. Am J Pathol 1992, 140:769-774. 1886378, 1314023.
16. Uemura Y, Tokunaga M, Arikawa J, et al. A unique morphology of Epstein-Barr virus related early gastric carcinoma. Canc Epidemiol Biomarkers Prev 1994, 3:607-611.
17. Vo QN, Geradts J, Gulley ML, et al. Epstein-Barr virus in gastric adenocarcinomas: association with ethnicity and CDKN2A promoter methylation. J Clin Pathol 2002, 55:669-675. 10.1136/jcp.55.9.669, 1769746, 12194996.
18. Osato T, Imai S. Epstein-Barr virus and gastric carcinoma. Semin Canc Biol 1996, 7:175-182.
19. Kaneda A, Kaminishi M, Yanagihara K, et al. Identification of silencing of nine genes in human gastric cancers. Canc Res 2002, 62:6645-6650.
20. Hino R, Uozaki H, Murakami N, et al. Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma. Canc Res 2009, 69:2766-2774.
21. Chang MS, Uozaki H, Chong JM, et al. CpG island methylation status in gastric carcinoma with and without infection of Epstein-Barr virus. Clin Canc Res 2006, 12:2995-3002.
22. Lee JH, Park SJ, Abraham SC, et al. Frequent CpG island methylation in precursor lesion and early lesions and early gastric adenocarcinomas. Oncogene 2004, 23:4646-4654. 10.1038/sj.onc.1207588, 15064707.
23. Chang MS, Lee HS, Kin CW, et al. Clinocopathologic characteristics of Epstein-Barr virus-incorporated gastric cancers in Korea. Pathol Res Pract 2001, 197:395-400. 10.1078/0344-0338-00052, 11432666.
24. Chong JM, Fukayama M, Hayashi Y, et al. Microsatellite instability in the progression of gastric carcinoma. Canc Res 1994, 54:4595-4597.
25. Leung SY, Yuen ST, Chung LP, et al. Microsatellite instability, Epstein Barr virus, mutation of type II transforming growth factor receptor and BAX in gastric carcinomas in Hong Kong Chinese. Br J Canc 1999, 79:582-588.
26. Ojima H, Fukuda T, Nakajima T, et al. Infrequent overexpression of p53 protein in Epstein-Barr virus-associated gastric carcinomas. Jpn J Canc Res 1997, 88:262-266.
27. Leung SY, Chau KY, Yuen ST, et al. p53 overexpression is different in Epstein-Barr virus-associated and Epstein-Barr virus-negative carcinoma. Histopathology 1998, 33:311-317.
28. Fukayama M, Chong JM, Kaizaki Y. Epstein-Barr virus and gastric carcinoma. Gastric Canc 1998, 1:104-114.
29. Kijima Y, Ishigami S, Hokita S, et al. The comparison of the prognosis between Epstein-Barr virus (EBV)-positive gastric carcinoma and EBV-negative ones. Canc Lett 2003, 200:33-40.
30. Beghelli S, de Manzoni G, Barbi S, et al. Microsatellite instability in gastric cancer is associated with better prognosis in only stage II cancers. Surgery 2006, 139:347-356. 10.1016/j.surg.2005.08.021, 16546499.