Infrequent overexpression of p53 protein in Epstein-Barr virus-associated gastric carcinomas

Japanese Journal of Cancer Research

Volumn 88, Issue 3, 1997, Pages 262-266

  Ojima, Hitoshi ^a   Fukuda, Toshio ^a   Nakajima, Takashi ^a   Nagamachi, Yukio ^a  

^a GUNMA UNIVERSITY   (Japan)

Author keywords

Epstein Barr virus; Gastric carcinoma with lymphoid stroma; In situ hybridization; p53 protein

Indexed keywords

PROTEIN P53; VIRUS RNA;

ADULT; AGED; ARTICLE; CELL NUCLEUS; EPSTEIN BARR VIRUS; FEMALE; GENE MUTATION; GENE OVEREXPRESSION; HERPES VIRUS INFECTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH ADENOCARCINOMA; STOMACH CARCINOMA; STROMA; TUMOR CELL;

EID: 0030942918     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.1997.tb00376.x     Document Type: Article

References (45)

1. Young, L. S. and Rowe, M. Epstein-Barr virus, lymphomas and Hodgkin's disease. Semin. Cancer Biol., 3, 273-284 (1992).
2. Ambinder, R. F. and Mann, R. B. Detection and characterization of Epstein-Barr virus in clinical specimens. Am. J. Pathol., 145, 239-252 (1994).
3. Carbone, A., Dolcetti, R., Gloghini, A., Maestro, R., Vaccher, E., Di Luca, D., Tirelli, U. and Biocchi, M. Immunophenotypic and molecular analysis of acquired immune deficiency syndrome-related and Epstein-Barr virus-associated lymphomas: a comparative study, Hum. Pathol. 27, 133-146 (1996).
4. Fukayama, M., Ibuka, T., Hayashi, Y., Ooba, T., Koike, M. and Mizutani, S. Epstein-Barr virus in pyothoraxassociated pleural lymphoma. Am. J. Pathol., 143, 1044-1049 (1993).
5. Sasajima, Y., Yamabe, H., Kobashi, Y., Hirai, K. and Mori, S. High expression of the Epstein-Barr virus latent protein EB nuclear antigen-2 on pyothorax-associated lymphomas. Am. J. Pathol., 143, 1280-1285 (1993).
6. Lezzoni, J. C., Gaffey, M. J. and Weiss, L. M. The role of Epstein-Barr virus in lymphoepithelioma-like carcinomas. Am. J. Clin. Pathol., 103, 308-315 (1995).
7. Shibata, D. and Weiss, L. M. Epstein-Barr virus-associated gastric adenocarcinoma. Am. J. Pathol., 140, 769-774 (1992).
8. Shibata, D., Hawes, D., Stemmermann, G. N. and Weiss, L. M. Epstein-Barr virus-associated gastric adenocarcinoma among Japanese Americans in Hawaii. Cancer Epidemiol. Biomarkers Prev., 2, 213-217 (1993).
9. Tokunaga, M., Land, C. E., Uemura, Y., Tokudome, T., Tanaka, S. and Sato, E. Epstein-Barr virus in gastric carcinoma. Am. J. Pathol., 143, 1250-1254 (1993).
10. Tokunaga, M., Uemura, Y., Tokudome, T., Ishidate, T., Masuda, H., Okazaki, E., Kaneko, K., Naoe, S., Ito, M., Okamura, A., Shimada, A., Sato, E. and Land, C. E. Epstein-Barr virus related gastric cancer in Japan: a molec- ular patho-epidemiological study. Acta Pathol. Jpn., 43, 574-581 (1993).
11. Oda, K., Tamaru, J., Takenouchi, T., Mikata, A., Nunomura, M., Saitoh, N., Sarashina, H. and Nakajima, N. Association of Epstein-Barr virus with gastric carcinoma with lymphoid stroma. Am. J. Pathol., 143, 1063-1071 (1993).
12. Leoncini, L., Vindigni, C., Megha, T., Funto, I., Pacenti, L., Musaro, M., Renier, A., Seri, M., Anagnostopoulos, A. and Tosi, P. Epstein-Barr virus and gastric cancer: data and unanswered questions. Int. J. Cancer, 53, 898-901 (1993).
13. Imai, S., Koizumi, S., Sugiura, M., Tokunaga, M., Uemura, Y., Yamamoto, N., Tanaka, S., Sato, E. and Osato, T. Gastric carcinoma: monoclonal epithelial malignant cells expressing Epstein-Barr virus latent infection protein. Proc. Natl. Acad. Sci. USA, 91, 9131-9135 (1994).
14. Nakamura, S., Ueki, T., Yao, T., Ueyama, T. and Tsuneyoshi, M. Epstein-Barr virus in gastric carcinoma with lymphoid stroma. Cancer, 73, 2239-2249 (1994).
15. Takano, Y., Kato, Y. and Sugano, H. Epstein-Barr-virusassociated medullary carcinomas with lymphoid infiltration of the stomach. J. Cancer Res. Clin. Oncol., 120, 303-308 (1994).
16. Yamamoto, N., Tokunaga, M., Uemura, Y., Tanaka, S., Shirahama, H., Nakamura, T., Land, C. E. and Sato, E. Epstein-Barr virus and gastric remnant cancer. Cancer, 74, 805-809 (1994).
17. Fukayama, M., Hayashi, Y., Iwasaki, Y., Chong, J., Ooba, T., Takizawa, T., Koike, M., Mizutani, S., Miyaki, M. and Hirai, K. Epstein-Barr virus-associated gastric carcinoma and Epstein-Barr virus infection of the stomach. Lab. Invest., 71, 73-81 (1994).
18. Yuen, S. T., Chung, L. P., Leung, S. Y., Luk, I. S. C., Chan, S. Y. and Ho, J. In situ detection of Epstein-Barr virus in gastric and colorectal adenocarcinomas. Am. J. Surg. Pathol., 18, 1158-1163 (1994).
19. Horiuchi, K., Mishima, K., Ohsawa, M. and Aozasa, K. Carcinoma of stomach and breast with lymphoid stroma: localisation of Epstein-Barr virus. J. Clin. Pathol., 47, 538-540 (1994).
20. Ott, G., Kirchner, T. and Muller-Hermelink, H. K. Monoclonal Epstein-Barr virus genomes but lack of EBVrelated protein expression in different types of gastric carcinomas. Histopathology, 25, 323-329 (1994).
21. Shousha, S. and Lugmani, Y. A. Epstein-Barr virus in gastric carcinoma and adjacent normal gastric and duodenal mucosa. J. Clin. Pathol., 47, 695-698 (1994).
22. Harn, H.-J., Chang, J.-Y., Wang, M.-W., Ho, L.-I, Lee, H.-S., Chiang, J.-H. and Lee, W.-H. Epstein-Barr virus-associated gastric adenocarcinoma in Taiwan. Hum. Pathol., 26, 267-271 (1995).
23. Takano, Y. and Kalo, Y. Epstein-Barr virus association with early cancers found together with gastric medullary carcinomas demonstrating lymphoid infiltration. J. Pathol., 175, 39-44 (1995).
24. Matsunou, H., Konishi, F., Hori, H., Ikeda, T., Sasaki, K., Hirose, Y. and Yamamichi, N. Characteristics of Epstein-Barr virus-associated gastric carcinoma with lymphoid stroma in Japan. Cancer, 77, 1998-2004 (1996).
25. Ojima, H., Fukuda, T., Nakajima, T., Takenoshita, S. and Nagamachi, Y. Discrepancy between clinical and pathological lymph node evaluation in Epstein-Barr virus-associated gastric cancers. Anticancer Res., 16, 3081-3084 (1996).
26. Tahara, E. Molecular mechanism of stomach carcinogenesis. J. Cancer Res. Clin. Oncol., 119, 265-272 (1993).
27. Craanen, M. E., Blok, P., Offerhaus, G. J. A. and Tytgat, G. N. J. Chronology of p53 protein accumulation in gastric carcinogenesis. Gut, 36, 8848-8852 (1995).
28. Poremba, C., Yandel, D. W., Huang, Q., Little, J. B., Meilin, W., Schmid, K. W., Bocker, W., DockhornDworniczak, B. Frequency and spectrum of p53 mutation in gastric cancer - a molecular genetic and immunohistochemical study. Virchows Arch., 426, 447-455 (1995).
29. Japanese Research Society for Gastric Cancer. "The General Rules for the Gastric Cancer Study in Surgery and Pathology," 12th Ed. (1993).
30. Shi, S. R., Key, M. E. and Kalra, K. L. Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J. Histochem. Cytochem., 39, 741-748 (1991).
31. Sakurai, S., Sano, T., Maeshima, A., Kashiwabara, K., Oyama, T., Fukuda, T. and Nakajima, T. Clinicopathological and molecular biological studies of gastric adenomas with special reference to p53 abnormality. Virchom Arch., 427, 119-124 (1995).
32. Lauren, P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal type carcinoma: an attempt at a histological classification. Acta Pathol. Microbiol. Scand., 64, 31-49 (1965).
33. Yamada, Y. and Kato, Y. Greater tendency for submucosal invasion in fundic area gastric carcinomas than those arising in the pyloric area. Cancer, 63, 1757-1760 (1989).
34. Davessar, K., Pezzulo, J. C., Kessimian, N., Hale, J. H., Jauregui, H. O. Gastric adenocarcinoma: prognostic significance of several pathologic parameters and histologic classification. Hum. Pathol., 21, 325-332 (1990).
35. Correa, P. Precursors of gastric and esophageal cancer. Cancer, 50, 2554-2565 (1982).
36. Hurlimann, J. and Saraga, E. P. Expression of p53 protein in gastric carcinomas. Am. J. Surg, Patho., 18, 1247-1253 (1994).
37. Kitayama, Y., Sugimura, H., Tanaka, M., Nakamura, S. and Kino, I. Expression of p53 and flow cytometric DNA analysis of isolated neoplastic glands of the stomach: an application of the gland isolation method. Virchows Arch., 426, 557-562 (1995).
38. Gulley, M. L., Pulitzer, D. R., Eagan, P. A. and Schneider, B. G. Epstein-Barr virus infection is an early event in gastric carcinogenesis and is independent of bel-2 expression and p53 accumulation. Hum. Pathol., 27, 20-27 (1996).
39. Watanabe, H., Enjoji, M. and Imai, T. Gastric carcinoma with lymphoid stroma: its morphologic characteristics and prognostic correlations. Cancer, 38, 232-243 (1976).
40. Montenarh, M. Biochemical properties of the growth suppressor/oncoprotein p53. Oncogene, 7, 1673-1680 (1992).
41. Crook, T., Wrede, D., Tidy, J. A., Mason, W. P., Evans, D. J. and Vousden, K. H. Clonal p53 mutations in primary cervical cancer: association with human-papillomavirus-negative tumours. Lancet, 339, 1070-1073 (1992).
42. Parrel, P. J. Epstein-Barr virus immortalising genes. Trends Microbiol., 3, 105-109 (1995).
43. Szekely, L., Selivanova, G., Magnusson, K. P., Klein, G. and Wiman, K. G. EBNA-5, an Epstein-Barr virusencoded nuclear antigen, binds to the retinoblastoma and p53 proteins. Proc. Natl. Acad. Sci. USA, 90, 5455-5459 (1993).
44. Line, D., Shields, M. T., Ullrich, S. J., Appella, E. and Mercer, W. E. Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase. Proc. Natl. Acad. Sci. USA, 89, 9210-9214 (1992).
45. Shaw, P., Bovey, R., Tardy, S., Sahli, R., Sordat, B. and Costa, J. Induction of apotosis by wild-type p53 in a human colon tumor-derived cell line. Proc. Natl. Acad. Sci. USA, 89, 4495-4499 (1992).