Microsatellite instability, Epstein-Barr virus, mutation of type II transforming growth factor β receptor and BAX in gastric carcinomas in Hong Kong Chinese

British Journal of Cancer

Volumn 79, Issue 3-4, 1999, Pages 582-588

  Leung, S Y ^a,b   Yuen, S T ^a   Chung, L P ^a   Chu, K M ^a   Wong, M P ^a   Branicki, F J ^a   Ho, J C I ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b QUEEN MARY HOSPITAL   (Hong Kong)

Author keywords

BAX; Epstein Barr virus; Gastric carcinoma; Hong Kong Chinese; Microsatellite instability; T RII

Indexed keywords

PROTEIN BAX; SOMATOMEDIN B; SOMATOMEDIN B RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA2;

ARTICLE; CHINESE; EPSTEIN BARR VIRUS; GENE INACTIVATION; GENE LOCUS; GENE MUTATION; HUMAN; HUMAN TISSUE; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; STOMACH CARCINOMA; TISSUE DISTRIBUTION;

ADULT; AGED; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA; CELL TRANSFORMATION, NEOPLASTIC; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; FEMALE; GENES, TUMOR SUPPRESSOR; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 4, HUMAN; HONG KONG; HUMANS; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; STOMACH NEOPLASMS; TUMOR VIRUS INFECTIONS;

EID: 0032938931     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690092     Document Type: Article

References (52)

1. Aaltonen LA, Peltomaki P, Loach FS, Sistonen P, Pylkkanen L, Mecklin JP, Jarvinen H, Powell SM, Jen J, Hamilton SR, Petersen GM, Kinzler KW, Vogelstein B and De La Chapelle A (1993) Clues to the pathogenesis of familial colorectal cancer. Science 260: 812-816
2. Akiyama Y, Nakasaki H, Nihei Z, Iwama T, Nomizu T, Utsunomiya J and Yuasa Y (1996) Frequent microsatellite instabilities and analyses of the related genes in familial gastric cancers. Jpn J Cancer Res 87: 595-601
3. Anagnostopoulos I and Hummel M (1996) Epstein-Barr virus in tumours. Histopathology 29: 297-315
4. Bedi GC, Westra WH, Farzadegan H, Pitha PM and Sidransky D (1995) Microsatellite instability in primary neoplasms from HIV + patients. Nature Med 1: 65-68
5. Bocker T, Diermann J, Friedl W, Gebert J, Holinski Feder E, Karner H, Von Knebel Doeberitz M, Koelble K, Moeslein G, Schackert HK, Wirtz HC, Fishel R and Ruschoff J (1997) Microsatellite instability analysis: a multicenter study for reliability and quality control. Cancer Res 57: 4739-1743
6. Bronner CE, Baker SM, Morrison PT, Warren G, Smith LG, Lescoe MK, Kano M, Earabino C, Lipford J, Lindblom A, Tannergard P, Bollag RJ, Godwin AR, Ward DC, Nordenskjold M, Fishel R, Kolodner R and Liskay RM (1994) Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 368: 258-261
7. Chan TL, Yuen ST, Chung LP, Ho J, Leung SY, Chan AS and Chan LC (1997) Replication errors (RER) and mismatch repair (MMR) gene mutations in young colorectal carcinoma patients in Hong Kong Chinese. In Proceedings of Keystone Symposium on Molecular and Cellular Biology - Genetics of Human Cancer: Pathogenesis and Diagnosis, Colorado, p. 9
8. Chong JM, Fukayama M, Hayashi Y, Takizawa T, Koike M, Konishi M, Kikuchi Yanoshita R and Miyaki M (1994) Microsatellite instability in the progression of gastric carcinoma. Cancer Res 54: 4595-4597
9. Chung YJ, Song JM, Lee JY, Jung YT, Seo EJ, Choi SW and Rhyu MG (1996) Microsatellite instability-associated mutations associate preferentially with the intestinal type of primary gastric carcinomas in a high-risk population. Cancer Res 56: 4662-4665
10. Chung YJ, Park SW, Song JM, Lee KY, Seo EJ, Choi SW and Rhyu MG (1997) Evidence of genetic progression in human gastric carcinomas with microsatellite instability. Oncogene 15: 1719-1726
11. Dietmaier W, Wallinger S, Boeker T, Kullmann F, Fishel R and Ruschoff J (1997) Diagnostic microsatellite instability: definition and correlation with mismatch repair protein expression. Cancer Res 57: 4749-1756
12. Dos Santos NR, Seruca R, Constancia M, Seixas M and Sobrinho Simoes M (1996) Microsatellite instability at multiple loci in gastric carcinoma: clinicopathologic implications and prognosis. Gastroenterology 110: 38-14
13. Eshleman JR and Markowitz SD (1995) Microsatellite instability in inherited and sporadic neoplasms. Curr Opinion Oncol 7: 83-89
14. Fishel R, Lescoe MK, Rao MR, Copeland NG, Jenkins NA, Garber J, Kane M and Kolodner R (1993) The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 75: 1027-1038
15. Hamilton Dutoit SJ and Pallesen G (1994) Detection of Epstein-Barr virus small RNAs in routine paraffin sections using non-isotopic RNA/RNA in situ hybridization. Histopathology 25: 101-111
16. Han HJ, Yanagisawa A, Kato Y, Park JG and Nakamura Y (1993) Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer. Cancer Res 53: 5087-5089
17. Hong Kong Cancer Registry (1996) Cancer Incidence and Mortality in Hong Kong 1992, p. 4. Hospital Authority: Hong Kong
18. Kehrl JH (1991) Transforming growth factor-beta: an important mediator of immunoregulation. Int J Cell Cloning 9: 438-450
19. Keller G, Grimm V, Vogelsang H, Bischoff P, Mueller J, Siewert JR and Hofler H (1996) Analysis for microsatellite instability and mutations of the DNA mismatch repair gene hMLH1 in familial gastric cancer. Int J Cancer 68: 571-576
20. Kim H, Jen J, Vogelstein B and Hamilton SR (1994) Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. Am J Pathol 145: 148-156
21. Lin JT, Wu MS, Shun CT, Lee WJ, Wang JT, Wang TH and Sheu JC (1995) Microsatellite instability in gastric carcinoma with special references to histopathology and cancer stages. Eur J Cancer 31A: 1879-1882
22. Liu B, Parsons RE, Hamilton SR, Petersen GM, Lynch HT, Watson P, Markowitz S, Willson JK, Green J, De La Chapelle A, Kinzler KW and Vogelstein B (1994) hMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds. Cancer Res 54: 4590-1594
23. Liu B, Farrington SM, Petersen GM, Hamilton SR, Parsons R, Papadopoulos N, Fujiwara T, Jen J, Kinzler KW, Wyllie AH, Vogelstein B and Dunlop MG (1995) Genetic instability occurs in the majority of young patients with colorectal cancer. Nature Med 1: 348-352
24. Liu B, Parsons R, Papadopoulos N, Nicolaides NC, Lynch HT, Watson P, Jass JR, Dunlop M, Wyllie A, Peltomaki P, De La Chapelle A, Hamilton SR, Vogelstein B and Kinzler KW (1996) Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. Nature Med 2: 169-174
25. Lynch HT, Smyrk T and Lynch JF (1996) Overview of natural history, pathology, molecular genetics and management of HNPCC (Lynch syndrome). Int J Cancer 69: 38-43
26. Markowitz S, Wang J, Myeroff L, Parsons R, Sun L, Lutterhaugh J, Fan RS, Zhorowska E, Kinzler KW, Vogelstein B, Braltain M and Willson JK (1995) Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science 268: 1336-1338
27. Marra G and Boland CR (1995) Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives. J Natl Cancer Inst 87: 1114-1125
28. Myeroff LL, Parsons R, Kim SJ, Hedrick L, Cho KR, Orth K, Mathis M, Kinzler KW, Lutterhaugh J, Park K, Bang YJ, Lee HY, Park JG, Lynch HT, Roberts AB, Vogelstein B and Markowitz SD (1995) A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability. Cancer Res 55: 5545-5547
29. Nakamura S, Ueki T, Yao T, Ucyama T and Tsuneyoshi M (1994) Epstein-Barr virus in gastric carcinoma with lymphoid stroma. Special reference to its detection by the polymerase chain reaction and in situ hybridization in 99 tumors, including a morphologic analysis. Cancer 73: 2239-2249
30. Nicolaides NC, Papadopoulos N, Liu B, Wei YF, Carter KC, Ruben SM, Rosen CA, Haseltine WA, Fleischmann RD, Fraser CM, Adams MD, Venter JC, Dunlop MG, Hamilton SR, Petersen GM, De La Chapelle A, Vogelstein B and Kinzler KW (1994) Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature 371: 75-80
31. Ohue M, Tomita N, Monden T, Miyoshi Y, Ohnishi T, Izawa H, Kawahata Y, Sasaki M, Sekimoto M, Nishisho I, Shiozaki H and Monden M (1996) Mutations of the transforming growth factor beta type II receptor gene and microsatellite instability in gastric cancer. Int J Cancer 68: 203-206
32. Otl G, Kirchner T and Muller Hermelink HK (1994) Monoclonal Epstein-Barr virus genomes bill lack of EBV-related protein expression in different types of gastric carcinoma. Histopathology 25: 323-329
33. Ottini L, Palli D, Falchetli M, D'Amico C, Amorosi A, Saieva C, Calzolari A, Cimoli F, Tatarelli C, Marchis LD, Masala G, Mariani-Costantini R and Cama A (1997) Microsatellite instability in gastric cancer is associated with tumor location and family history in a high-risk population from Tuscany. Cancer Res 57: 4523-1529
34. Ouyang H, Shiwaku HO, Hagiwara H, Miura K, Abe T, Kato Y, Ohtani H, Shiba K, Souza RF, Meltzer SJ and Horii A (1997) The insulin-like growth factor II receptor gene is mutated in genetically unstable cancers of the endometrium, stomach, and colorectum. Cancer Res 57: 1851-1854
35. Papadopoulos N, Nicolaides NC, Wei YF, Ruhen SM, Carter KC, Rosen C, Haseltine WA, Fleischmann RD, Fraser CM, Adams MD, Venter JC, Hamilton SR, Petersen GM, Watson P, Lynch HT, Peltomaki P, Mecklin JP, De La Chapelle A, Kinzler KW and Vogelstein B (1994) Mutation of a mutL homolog in hereditary colon cancer. Science 263: 1625-1629
36. Parkin DM, Pisani P and Ferlay J (1993) Estimates of the worldwide incidence of eighteen major cancers in 1985. Int J Cancer 54: 594-606
37. Parsons R, Myeroff LL, Liu B, Willson JK, Markowitz SD, Kinzler KW and Vogelstein B (1995) Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer. Cancer Res 55: 5548-5550
38. Pisani P, Parkin DM and Ferlay J (1993) Estimates of the worldwide mortality from eighteen major cancers in 1985. Implications for prevention and projections of future burden. Int J Cancer 55: 891-903
39. Rampino N, Yamamoto H, Ionov Y, Li Y, Sawai H, Reed JC and Perucho M (1997) Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 275: 967-969
40. Renault B, Calistri D, Buonsanti G, Nanni O, Amadori D and Ranzani GN (1996) Microsatellite instability and mutations of p53 and TGF-beta RII genes in gastric cancer Hum Genet 98: 601-607
41. Rhyu MG, Park WS and Meltzer SJ (1994) Microsatellite instability occurs frequently in human gastric carcinoma. Oncogene 9: 29-32
42. Rusehoff J, Dietmaier W, Luttges J, Seitz G, Bocker T, Zirngibl H, Schlegel J, Schackert HK, Jauch KW and Hofstaedter F (1997) Poorly differentiated colonic adenocarcinoma, medullary type: clinical, phenotypic, and molecular characteristics. Am J Pathol 150: 1815-1825
43. Schalling M, Ekmah M, Kaaya EE, Linde A and Biberfeld P (1995) A role for a new herpes virus (KSHV) in different forms of Kaposi's sarcoma. Nature Med 1: 707-708
44. Shibata D and Weiss LM (1992) Epstein-Barr virus-associated gastric adenocarcinoma. Am J Pathol 1-40: 769-774
45. Shibata D, Weiss LM, Hernandez AM, Nathwani BN, Bernstein L and Levine AM (1993) Epstein-Barr virus-associated non-Hodgkin's lymphoma in patients infected with the human immunodeficiency virus. Blood 81: 2102-2109
46. Souza RF. Appel R, Yin J, Wang S, Smolinski KN, Abraham JM, Zou TT, Shi YQ, Lei J, Cottrell J, Cymes K, Biden K, Simms L, Leggett B, Lynch PM, Frazier M, Powell SM, Harpaz N, Sugimura H, Young J and Meltzer SJ (1996) Microsatellite instability in the insulin-like growth factor II receptor gene in gastrointestinal tumours. Nature Genet 14: 255-257
47. Striekler JG, Zheng J, Shu Q, Burgart LJ, Alberts SR and Shibata D (1994) p53 mutations and microsatellite instability in sporadic gastric cancer: when guardians fail. Cancer Res 54: 4750-4755
48. Tokunaga M, Uemura Y, Tokudome T, Ishidate T, Masuda H, Okazaki E, Kaneko K, Naoe S, Ito M, Okamura A, Shimada A, Sato E and Land CE (1993) Epstein-Barr virus related gastric cancer in Japan: a molecular pathoepidemiological study. Acta Pathol Jpn 43: 574-581
49. Watanabe H, Enjoji M and Imai T (1976) Gastric carcinoma with lymphoid stroma. Its morphologic characteristics and prognostic correlations. Cancel 38: 232-243
50. Wojtowicz Praga S (1997) Reversal of tumor-induced immunosuppression: a new approach In cancer therapy. J Immunother 20: 165-177
51. Yamamoto H, Sawai H and Perucho M (1997) Frameshift somatic mutations in gastrointestinal cancer of the microsatellite mutator phenotype. Cancer Res 57: 4420-4426
52. Yuen ST, Chung LP, Leung SY, Luk IS, Chan SY and Ho J (1994) In situ detection of Epstein Barr virus in gastric and colorectal adenocarcinomas. Am J Surg Pathol 18: 1158-1163