Smoothing T cell roads to the tumor: Chemokine post-translational regulation

OncoImmunology

Volumn 1, Issue 3, 2012, Pages 390-392

  Molon, Barbara ^a   Viola, Antonella ^b   Bronte, Vincenzo ^c  

^a VENETO INSTITUTE OF ONCOLOGY IOV IRCCS   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY HOSPITAL OF VERONA   (Italy)

Author keywords

Cancer; Chemokines; CTLs; Immunotherapy; MDSCs; Reactive nitrogen species

Indexed keywords

3 NITROTYROSINE; ANTIOXIDANT; ARGINASE; AT 38; CHEMOKINE; CHEMOKINE RECEPTOR CCR2; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE SYNTHASE; REACTIVE NITROGEN SPECIES; UNCLASSIFIED DRUG;

ADOPTIVE IMMUNOTHERAPY; ARTICLE; CANCER IMMUNOTHERAPY; COLON CARCINOMA; CYTOTOXIC T LYMPHOCYTE; DRUG EFFICACY; FIBROSARCOMA; HUMAN; NITRATIVE STRESS; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; PROSTATE CARCINOMA; PROTEIN EXPRESSION; PROTEIN PROCESSING; SUPPRESSOR CELL; T LYMPHOCYTE; THYMOMA; TUMOR ASSOCIATED LEUKOCYTE; TUMOR IMMUNITY;

EID: 84886744655     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.4161/onci.19069     Document Type: Article

References (10)

1. Facciabene A, Peng X, Hagemann IS, Balint K, Barchetti A, Wang LP, et al. Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature 2011, 475:226-30. http://dx.doi.org/10.1038/nature10169
2. Lu T, Ramakrishnan R, Altiok S, Youn JI, Cheng P, Celis E, et al. Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice. J Clin Invest 2011, 121:4015-29. http://dx.doi.org/10.1172/JCI45862
3. Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, Lagorce-Pages C, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 2006, 313: 1960-4.
4. Bronte V, Zanovello P. Regulation of immune responses by L-arginine metabolism. Nature 2005, 5:641-54.
5. Kasic T, Colombo P, Soldani C, Wang CM, Miranda E, Roncalli M, et al. Modulation of human T-cell functions by reactive nitrogen species. Eur J Immunol 2011, 41:1843-9. http://dx.doi.org/10.1002/eji.201040868
6. Nagaraj S, Gupta K, Pisarev V, Kinarsky L, Sherman S, Kang L, et al. Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer. Nat Med 2007, 13:828-35. http://dx.doi.org/10.1038/nm1609
7. Mrass P, Takano H, Ng LG, Daxini S, Lasaro MO, Iparraguirre A, et al. Random migration precedes stable target cell interactions of tumor-infiltrating T cells. J Exp Med 2006, 203:2749-61. http://dx.doi.org/10.1084/jem.20060710
8. Schaer DA, Li Y, Merghoub T, Rizzuto GA, Shemesh A, Cohen AD, et al. Detection of intra-tumor self antigen recognition during melanoma tumor progression in mice using advanced multimode confocal/two photon microscope. PLoS ONE 2011, 6:e21214. http://dx.doi.org/10.1371/journal. pone.0021214
9. Bronte V, Kasic T, Gri G, Gallana K, Borsellino G, Marigo I, et al. Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers. J Exp Med 2005, 201:1257-68. http://dx. doi.org/10.1084/jem.20042028
10. De Santo C, Serafini P, Marigo I, Dolcetti L, Bolla M, Del Soldato P, et al. Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination. Proc Natl Acad Sci USA 2005, 102:4185-90. http://dx.doi.org/10.1073/pnas.0409783102