Ruthenium dihydroxybipyridine complexes are tumor activated prodrugs due to low pH and blue light induced ligand release

Journal of Inorganic Biochemistry

Volumn 130, Issue 1, 2014, Pages 103-111

  Hufziger, Kyle T ^a   Thowfeik, Fathima Shazna ^b   Charboneau, David J ^a   Nieto, Ismael ^c   Dougherty, William G ^a   Kassel, W Scott ^a   Dudley, Timothy J ^d   Merino, Edward J ^b   Papish, Elizabeth T ^c,e   Paul, Jared J ^a  

^a VILLANOVA UNIVERSITY   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

^c DREXEL UNIVERSITY   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e UNIVERSITY OF ALABAMA   (United States)

Author keywords

Anti cancer; Light activated; pH selective; Polypyridyl; Prodrug; Ruthenium

Indexed keywords

BIPYRIDINE DERIVATIVE; LIGAND; PRODRUG; RUTHENIUM COMPLEX;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BLUE LIGHT; CONTROLLED STUDY; DISSOCIATION; DRUG DESIGN; ELECTROCHEMISTRY; HUMAN; HUMAN CELL; IRRADIATION; PH; PROTON TRANSPORT; ULTRAVIOLET SPECTROSCOPY; X RAY CRYSTALLOGRAPHY;

ANTI-CANCER; LIGHT-ACTIVATED; PH-SELECTIVE; POLYPYRIDYL; PRODRUG; RUTHENIUM;

ANTINEOPLASTIC AGENTS; CRYSTALLOGRAPHY, X-RAY; ELECTROCHEMISTRY; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; LIGANDS; LIGHT; MOLECULAR STRUCTURE; ORGANOMERCURY COMPOUNDS; PRODRUGS; RUTHENIUM;

EID: 84886743027     PISSN: 01620134     EISSN: 18733344     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2013.10.008     Document Type: Article

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