NF-κB activation was involved in reactive oxygen species-mediated apoptosis and autophagy in 1-oxoeudesm-11(13)-eno-12,8α-lactone-treated human lung cancer cells

Archives of Pharmacal Research

Volumn 37, Issue 8, 2014, Pages 1039-1052

  Liu, Shanshan ^a,b   Wu, Di ^c   Li, Lin ^a   Sun, Xiao ^a   Xie, Weidong ^a   Li, Xia ^a  

^a SHANDONG UNIVERSITY   (China)

^b PEKING UNION MEDICAL COLLEGE   (China)

^c CHANGCHUN UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Apoptosis; Aster himalaicus; Autophagy; Human lung cancer; Keywords:: 1 oxoeudesm 11(13) eno 12,8 lactone; NF B; ROS

Indexed keywords

1-OXOEUDESM-11(13)-ENO-12,8-LACTONE; ANTINEOPLASTIC AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; REACTIVE OXYGEN METABOLITE; SESQUITERPENE;

APOPTOSIS; ASTERACEAE; AUTOPHAGY; CELL SURVIVAL; CHEMISTRY; CULTURE TECHNIQUE; DRUG EFFECTS; HUMAN; ISOLATION AND PURIFICATION; LUNG TUMOR; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; ASTER PLANT; AUTOPHAGY; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; LUNG NEOPLASMS; NF-KAPPA B; REACTIVE OXYGEN SPECIES; SESQUITERPENES, EUDESMANE;

EID: 84886733879     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-013-0270-8     Document Type: Article

References (42)

1. Alvero, A.B.; M.K. Montagna, R. Chen, K.H. Kim, K. Kyungjin, I. Visintin, H.H. Fu, D. Brown, and G. Mor. 2009. NV-128, a novel isoflavone derivative, induces caspase-independent cell death through the Akt/mammalian target of rapamycin pathway. Cancer 115: 3204-3216.
2. Amaravadi, R.K.; D. Yu, J.J. Lum, T. Bui, M.A. Christophorou, G.I. Evan, A. Thomas-Tikhonenko, and C.B. Thompson. 2007. Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. Journal of Clinical Investigation 117: 326-336.
3. Bolt, A.M.; R.M. Byrd, and W.T. Klimecki. 2010. Autophagy is the predominant process induced by arsenite in human lymphoblastoid cell lines. Toxicology and Applied Pharmacology 244: 366-373.
4. Carson, D.A.; and J.M. Ribeiro. 1993. Apoptosis and disease. Lancet 341: 1251-1254.
5. Chen, Y.; E. Mcmillan-Ward, J. Kong, S.J. Israels, and S.B. Gibson. 2008. Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells. Cell Death and Differentiation 15: 171-182.
6. Cheng, Y.; F. Qiu, and T. Ikejima. 2009. Molecular mechanisms of oridonin-induced apoptosis and autophagy in murine fibrosarcoma L929 cells. Autophagy 5: 430-431.
7. Chiu, H.W.; J.H. Lin, Y.A. Chen, S.Y. Ho, and Y.J. Wang. 2010. Combination treatment with arsenic trioxide and irradiation enhances cell-killing effects in human fibrosarcoma cells in vitro and in vivo through induction of both autophagy and apoptosis. Autophagy 6: 353-365.
8. Cui, M.; Y. Zhang, S. Liu, W. Xie, M. Ji, H. Lou, and X. Li. 2011. 1-oxoeudesm-11(13)-ene-12,8alpha-lactone-induced apoptosis via ROS generation and mitochondria activation in MCF-7 cells. Archives of Pharmacal Research 34: 1323-1329.
9. Cui, Q.; S. Tashiro, S. Onodera, M. Minami, and T. Ikejima. 2007. Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cells. Biological and Pharmaceutical Bulletin 30: 859-864.
10. Djavaheri-Mergny, M.; M. Amelotti, J. Mathieu, F. Besancon, C. Bauvy, S. Souquere, G. Pierron, and P. Codogno. 2006. NF-kappaB activation represses tumor necrosis factor-alpha-induced autophagy. Journal of Biological Chemistry 281: 30373-30382.
11. Fujioka, S.; C. Schmidt, G.M. Sclabas, Z. Li, H. Pelicano, B. Peng, A. Yao, J. Niu, W. Zhang, D.B. Evans, J.L. Abbruzzese, P. Huang, and P.J. Chiao. 2004. Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB. Journal of Biological Chemistry 279: 27549-27559.
12. Galluzzi, L.; M.C. Maiuri, I. Vitale, H. Zischka, M. Castedo, L. Zitvogel, and G. Kroemer. 2007. Cell death modalities: classification and pathophysiological implications. Cell Death and Differentiation 14: 1237-1243.
13. Hwang, M.S.; and W.K. Baek. 2010. Glucosamine induces autophagic cell death through the stimulation of ER stress in human glioma cancer cells. Biochemical and Biophysical Research Communications 399: 111-116.
14. Jin, S. 2006. Autophagy, mitochondrial quality control, and oncogenesis. Autophagy 2: 80-84.
15. Kabeya, Y.; N. Mizushima, T. Ueno, A. Yamamoto, T. Kirisako, T. Noda, E. Kominami, Y. Ohsumi, and T. Yoshimori. 2000. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO Journal 19: 5720-5728.
16. Kim, B.C.; H.G. Kim, S.A. Lee, S. Lim, E.H. Park, S.J. Kim, and C.J. Lim. 2005. Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathway. Biochemical Pharmacology 70: 1398-1407.
17. Kim, S.; and A. Moon. 2004. Capsaicin-induced apoptosis of H-ras-transformed human breast epithelial cells is Rac-dependent via ROS generation. Archives of Pharmacal Research 27: 845-849.
18. Kucharczak, J.; M.J. Simmons, Y. Fan, and C. Gelinas. 2003. To be, or not to be: NF-kappaB is the answer-role of Rel/NF-kappaB in the regulation of apoptosis. Oncogene 22: 8961-8982.
19. Le, X.F.; W. Mao, Z. Lu, B.Z. Carter, and R.C. Bast Jr. 2010. Dasatinib induces autophagic cell death in human ovarian cancer. Cancer 116: 4980-4990.
20. Li, X.; and Z. Fan. 2010. The epidermal growth factor receptor antibody cetuximab induces autophagy in cancer cells by downregulating HIF-1alpha and Bcl-2 and activating the beclin 1/hVps34 complex. Cancer Research 70: 5942-5952.
21. Liang, X.H.; S. Jackson, M. Seaman, K. Brown, B. Kempkes, H. Hibshoosh, and B. Levine. 1999. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402: 672-676.
22. Liang, Y.; Y. Zhou, and P. Shen. 2004. NF-kappaB and its regulation on the immune system. Cellular and Molecular Immunology 1: 343-350.
23. Luo, J.L.; H. Kamata, and M. Karin. 2005. IKK/NF-kappaB signaling: balancing life and death-a new approach to cancer therapy. Journal of Clinical Investigation 115: 2625-2632.
24. Maiuri, M.C.; E. Zalckvar, A. Kimchi, and G. Kroemer. 2007. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nature Reviews Molecular Cell Biology 8: 741-752.
25. Mathew, R.; V. Karantza-Wadsworth, and E. White. 2007. Role of autophagy in cancer. Nature Reviews Cancer 7: 961-967.
26. Mayo, M.W.; and A.S. Baldwin. 2000. The transcription factor NF-kappaB: control of oncogenesis and cancer therapy resistance. Biochimica et Biophysica Acta 1470: M55-M62.
27. Mizushima, N.; A. Yamamoto, M. Hatano, Y. Kobayashi, Y. Kabeya, K. Suzuki, T. Tokuhisa, Y. Ohsumi, and T. Yoshimori. 2001. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. Journal of Cell Biology 152: 657-668.
28. Moretti, L.; Y.I. Cha, K.J. Niermann, and B. Lu. 2007. Switch between apoptosis and autophagy: radiation-induced endoplasmic reticulum stress? Cell Cycle 6: 793-798.
29. Munafo, D.B.; and M.I. Colombo. 2001. A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation. Journal of Cell Science 114: 3619-3629.
30. Perkins, N.D. 2007. Integrating cell-signalling pathways with NF-kappaB and IKK function. Nature Reviews Molecular Cell Biology 8: 49-62.
31. Sakon, S.; X. Xue, M. Takekawa, T. Sasazuki, T. Okazaki, Y. Kojima, J.H. Piao, H. Yagita, K. Okumura, T. Doi, and H. Nakano. 2003. NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. EMBO Journal 22: 3898-3909.
32. Sarraf, C.E.; and I.D. Bowen. 1988. Proportions of mitotic and apoptotic cells in a range of untreated experimental tumours. Cell and tissue kinetics 21: 45-49.
33. Sasaki, K.; N.H. Tsuno, E. Sunami, G. Tsurita, K. Kawai, Y. Okaji, T. Nishikawa, Y. Shuno, K. Hongo, M. Hiyoshi, M. Kaneko, J. Kitayama, K. Takahashi, and H. Nagawa. 2010. Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells. BMC Cancer 10: 370.
34. Scheidereit, C. 2006. IkappaB kinase complexes: gateways to NF-kappaB activation and transcription. Oncogene 25: 6685-6705.
35. Scherz-Shouval, R.; E. Shvets, E. Fass, H. Shorer, L. Gil, and Z. Elazar. 2007. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO Journal 26: 1749-1760.
36. Schlottmann, S.; F. Buback, B. Stahl, R. Meierhenrich, P. Walter, M. Georgieff, and U. Senftleben. 2008. Prolonged classical NF-kappaB activation prevents autophagy upon E. coli stimulation in vitro: a potential resolving mechanism of inflammation. Mediators of Inflammation 2008: 725854.
37. Sinha, S.; and B. Levine. 2008. The autophagy effector Beclin 1: a novel BH3-only protein. Oncogene 27(Suppl 1): S137-S148.
38. Sy, L.K.; S.C. Yan, C.N. Lok, R.Y. Man, and C.M. Che. 2008. Timosaponin A-III induces autophagy preceding mitochondria-mediated apoptosis in HeLa cancer cells. Cancer Research 68: 10229-10237.
39. Tanida, I.; T. Ueno, and E. Kominami. 2004. LC3 conjugation system in mammalian autophagy. International Journal of Biochemistry and Cell Biology 36: 2503-2518.
40. Vaux, D.L.; and S.J. Korsmeyer. 1999. Cell death in development. Cell 96: 245-254.
41. Xie, W.D.; C.W. Weng, Y.F. Niu, P.X. Lai, and K.H. Row. 2010. Eudesmane sesquiterpenes and other constituents from Aster himalaicus. Chemistry and Biodiversity 7: 221-224.
42. Zu, K.; L. Hawthorn, and C. Ip. 2005. Up-regulation of c-Jun-NH2-kinase pathway contributes to the induction of mitochondria-mediated apoptosis by alpha-tocopheryl succinate in human prostate cancer cells. Molecular Cancer Therapeutics 4: 43-50.