Allosteric peptide regulators of chemokine receptors CXCR4 and CXCR7

Biochemical Pharmacology

Volumn 86, Issue 9, 2013, Pages 1263-1271

  Ehrlich, Anna ^a   Ray, Paramita ^a   Luker, Kathryn E ^a   Lolis, Elias J ^b,c   Luker, Gary D ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c YALE CANCER CENTER   (United States)

Author keywords

Bioluminescence; Chemokine; Chemokine receptor; Luciferase; Peptide

Indexed keywords

AMINO ACID; BETA ARRESTIN 2; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR7; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PEPTIDE; SCAVENGER; STROMAL CELL DERIVED FACTOR 1;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CHEMOTAXIS; CONTROLLED STUDY; LONG TERM CARE; PRIORITY JOURNAL;

BIOLUMINESCENCE; CHEMOKINE; CHEMOKINE RECEPTOR; LUCIFERASE; PEPTIDE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ARRESTINS; BINDING, COMPETITIVE; CELL LINE, TUMOR; CHEMOKINE CXCL12; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIGANDS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MOLECULAR SEQUENCE DATA; MOLECULAR TARGETED THERAPY; PEPTIDES; RECEPTORS, CXCR; RECEPTORS, CXCR4; SIGNAL TRANSDUCTION;

EID: 84886726005     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.08.019     Document Type: Article

References (47)

1. X. Yan, S. Cai, X. Xiong, W. Sun, X. Dai, and S. Chen Chemokine receptor CXCR7 mediates human endothelial progenitor cells survival, angiogenesis, but not proliferation J Cell Biochem 113 2012 1437 1446
2. F. Sierro, C. Biben, L. Martinez-Munoz, M. Mellado, R. Rashohoff, and M. Li Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7 Proc Natl Acad Sci USA 104 2007 14759 14764
3. J. Sanchez-Alcaniz, S. Haege, W. Mueller, R. Pla, F. Mackay, and S. Schulz Cxcr7 controls neuronal migration by regulating chemokine responsiveness Neuron 69 2011 77 90
4. Y. Wang, G. Li, A. Stanco, J. Long, D. Crawford, and G. Potter CXCR4 and CXCR7 have distinct functions in regulating interneuron migration Neuron 69 2011 61 76
5. K. Tachibana, S. Hirota, H. Iizasa, H. Yoshida, K. Kawabata, and Y. Kataoka The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract Nature 393 1998 591 594
6. M. Li, C. Chang, J. Lathia, L. Wang, H. Pacenta, and A. Cotleur Chemokine receptor CXCR4 signaling modulates the growth factor-induced cell cycle of self-renewing and multipotent neural progenitor cells Glia 59 2011 108 118
7. N. Moll, and R. Ransohoff CXCL12 and CXCR4 in bone marrow physiology Expert Rev Hematol 3 2010 315 322
8. F. Decaillot, M. Kazmi, Y. Lin, S. Ray-Saha, T. Sakmar, and P. Sachdev CXCR7/CXCR4 heterodimer constitutively recruits {beta}-arrestin to enhance cell migration J Biol Chem 286 2011 32188 32197
9. N. Shimizu, Y. Soda, K. Kanbe, H. Liu, R. Mukai, and T. Kitamura A putative G protein-coupled receptor, RDC1, is a novel coreceptor for human and simian immunodeficiency viruses J Virol 74 2000 619 626
10. D. Duda, S. Kozin, N. Kirkpatrick, L. Xu, D. Fukumura, and R. Jain CXCL12 (SDF1alpha) - CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anti-cancer therapies? Clin Cancer Res 17 2011 2074 2080
11. B. Bakondi, I. Shimada, B. Peterson, and J. Spees SDF-1α secreted by human CD133-derived multipotent stromal cells promotes neural progenitor cell survival through CXCR7 Stem Cells Dev 20 2011 1021 1029
12. Y. Wang, J. Huang, Y. Li, and G. Yang Roles of chemokine CXCL12 and its receptors in ischemic stroke Curr Drug Targets 13 2012 166 172
13. N. Karin The multiple faces of CXCL12 (SDF-1α) in the regulation of immunity during health and disease J Leukoc Biol 88 2010 463 474
14. Y. Tang, W. Zhu, M. Cheng, L. Chen, J. Zhang, and T. Sun Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression Circ Res 104 2009 1209 1216
15. B. Teicher, and S. Fricker CXCL12 (SDF-1)/CXCR4 pathway in cancer Clin Cancer Res 16 2010 2927 2931
16. K. Balabanian, B. Lagane, S. Infantino, K. Chow, J. Harriague, and B. Moepps The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes J Biol Chem 280 2005 35760 35766
17. J. Burns, B. Summers, Y. Wang, A. Melikian, R. Berahovich, and Z. Miao A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development J Exp Med 203 2006 2201 2213
18. B. Boldajipour, S. Mahabaleshwar, E. Kardash, M. Reichman-Fried, H. Blaser, and S. Minina Control of chemokine-guided cell migration by ligand sequestration Cell 132 2008 463 473
19. K. Luker, J. Steele, L. Mihalko, and G. Luker Constitutive and chemokine-dependent internalization and recycling of CXCR7 in breast cancer cells to degrade chemokine ligands Oncogene 29 2010 4599 4610
20. S. Rajagopal, J. Kim, S. Ahn, S. Craig, C. Lam, and N. Gerard Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7 Proc Natl Acad Sci USA 107 2010 628 632
21. P. Ray, L. Mihalko, N. Coggins, P. Moudgil, A. Ehrlich, and K. Luker Carboxy-terminus of CXCR7 regulates receptor localization and function Int J Biochem Cell Biol 44 2012 669 678
22. K. Luker, M. Gupta, J. Steele, B. Foerster, and G. Luker Imaging ligand-dependent activation of CXCR7 Neoplasia 11 2009 1022 1035
23. M. Witmans, D. Maussang, F. Sirci, D. Scholten, M. Canals, and A. Mujic-Delic Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists Eur J Med Chem 51 2012 184 192
24. B. Zabel, Y. Wang, S. Lewen, R. Berahovich, M. Penfold, and P. Zhang Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands J Immunol 183 2009 3204 3211
25. + cell migratioin in myeloproliferative neoplasms Cancer Res 70 2010 3402 3410
26. N. Heveker, M. Montes, L. Germeroth, A. Amara, A. Trautmann, and M. Alizon Dissociation of the signalling and antiviral properties of SDF-1-derived small peptides Curr Biol 8 1998 369 376
27. P. Loetscher, J. Gong, B. Dewald, M. Baggiolini, and I. Clark-Lewis N-terminal peptides of stromal cell-derived factor-1 with CXC chemokine receptor 4 agonist and antagonist activities J Biol Chem 278 1998 22279 22283
28. S. Struyf, S. Noppen, T. Loos, A. Mortier, M. Gouwy, and H. Verbeke Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV activity via CXCR4 J Immunol 182 2009 666 674
29. A. Sachpatzidis, B. Benton, J. Manfredi, H. Wang, A. Hamilton, and D. Hg Identification of allosteric peptide agonists of CXCR4 J Biol Chem 278 2003 896 907
30. N. Coggins, D. Trakimas, S. Chang, A. Ehrlich, P. Ray, and K. Luker Systems level analysis of integrated CXCR4 and CXCR7 signaling outputs to β-arrestin2 BMC Comput Biol 2013 (submitted for publication)
31. K. Luker, M. Gupta, and G. Luker Imaging CXCR4 signaling with firefly luciferase complementation Anal Chem 80 2008 5565 5573
32. K. Luker, M. Gupta, and G. Luker Bioluminescent CXCL12 fusion protein for cellular studies of CXCR4 and CXCR7 Biotechniques 47 2009 625 632
33. K. Luker, L. Mihalko, B. Schmidt, S. Lewin, P. Ray, and D. Shcherbo In vivo imaging of ligand receptor binding with Gaussia luciferase complementation Nat Med 18 2012 172 177
34. E. Salomonnson, A. Stacer, A. Ehrlich, K. Luker, and G. Luker Imaging CXCL12-CXCR4 signaling in ovarian cancer PLoS ONE 8 2013 e51500
35. H. Cho, K. Kyoung, M. Seo, Y. Kim, Y. Bae, and J. Jung Overexpression of CXCR4 increases migration and proliferation of human adipose tissue stromal cells Stem Cells Dev 15 2006 853 864
36. J. Song, S. Cavnar, A. Walker, K. Luker, M. Gupta, and Y. Tung Microfluidic endothelium for studying the intravascular adhesion of metastatic breast cancer cells PLoS ONE 4 2009 e5756
37. V. Friand, O. Haddad, D. Papy-Garcia, H. Hlawaty, R. Vassy, and Y. Hamma-Kourbali Glycosaminoglycan mimetics inhibit SDF-1/CXCL12-mediated migration and invasion of human hepatoma cells Glycobiology 19 2009 1511 1524
38. U. Naumann, E. Cameroni, M. Pruenster, S. Mahabaleshwar, E. Raz, and H. Zerwes CXCR7 functions as a scavenger for CXCL12 and CXCL11 PLoS ONE 5 2010 e9175
39. W. Ma, Y. Liu, N. Ellison, and J. Shen Induction of C-X-C chemokine receptor type 7 (CXCR7) switches stromal cell-derived factor-1 (SDF-1) signaling and phagocytic activity in macrophages linked to atherosclerosis J Biol Chem 288 2013 15481 15494
40. K. Hattermann, J. Held-Feindt, R. Lucius, S. Muerkoster, M. Penfold, and T. Schall The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects Cancer Res 70 2010 3299 3308
41. P. Conn, A. Christopoulos, and C. Lindsley Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders Nat Rev Drug Discov 8 2009 41 54
42. L. Wang, B. Martin, R. Brenneman, L. Luttrell, and S. Maudsley Allosteric modulators of g protein-coupled receptors: future therapeutics for complex physiological disorders J Pharmacol Exp Ther 331 2009 340 348
43. J. Janz, Y. Ren, R. Looby, M. Kazmi, P. Sachdev, and A. Grunbeck Direct interaction between an allosteric agonist pepducin and the chemokine receptor CXCR4 J Am Chem Soc 133 2011 15878 15881
44. R. Mosi, V. Anastassova, J. Cox, M. Darkes, S. Idzan, and J. Labrecque The molecular pharmacology of AMD11070: an orally bioavailable CXCR4 HIV entry inhibitor Biochem Pharmacol 83 2012 472 479
45. I. Kalatskaya, Y. Berchiche, S. Gravel, B. Limberg, J. Rosenbaum, and N. Heveker AMD3100 is a CXCR7 ligand with allosteric agonist properties Mol Pharmacol 75 2009 1240 1247
46. S. Gravel, C. Malouf, P. Boulais, Y. Berchiche, S. Oishi, and N. Fujii The peptidomimetic CXCR4 antagonist TC14012 recruits beta-arrestin 2 to CXCR7: roles of receptor domains J Biol Chem 285 2010 37939 37943
47. K. Luker, M. Gupta, and G. Luker Imaging chemokine receptor dimerization with firefly luciferase complementation FASEB J 23 2009 823 834