RhoA/ROCK-dependent pathway is required for TLR2-mediated IL-23 production in human synovial macrophages: Suppression by cilostazol

Biochemical Pharmacology

Volumn 86, Issue 9, 2013, Pages 1320-1327

  Park, So Youn ^a   Lee, Sung Won ^c   Lee, Won Suk ^a,b   Rhim, Byung Yong ^b   Lee, Seung Jin ^a   Kwon, Sang Mo ^b   Hong, Ki Whan ^a   Kim, Chi Dae ^a,b  

^a Pusan National University   (South Korea)

^b Pusan National University School of Medicine   (South Korea)

^c Dong A University   (South Korea)

Author keywords

Cilostazol; IL 23; RA synovial macrophages; RhoA; TLR2

Indexed keywords

CILOSTAZOL; EXOENZYME C3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 23; LIPOTEICHOIC ACID; RHO KINASE; TOLL LIKE RECEPTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; DNA BINDING; HUMAN; HUMAN CELL; KNEE; MACROPHAGE; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID;

CIA; CILOSTAZOL; COLLAGEN INDUCED ARTHRITIS; IL-23; INTERLEUKIN-23; LIPOTEICHOIC ACID; LTA; RA; RA SYNOVIAL MACROPHAGES; RHEUMATOID ARTHRITIS; RHOA; TLR2; TOLL LIKE RECEPTOR 2;

ADP RIBOSE TRANSFERASES; AMIDES; ANIMALS; ARTHRITIS, RHEUMATOID; BOTULINUM TOXINS; CASE-CONTROL STUDIES; CYCLIC AMP; HUMANS; INTERLEUKIN-23; KNEE JOINT; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED DBA; NF-KAPPA B; NITRILES; PYRIDINES; REFERENCE VALUES; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; SULFONES; SYNOVIAL FLUID; TEICHOIC ACIDS; TETRAZOLES; THIONUCLEOTIDES; TOLL-LIKE RECEPTOR 2;

EID: 84886725095     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.08.017     Document Type: Article

References (29)

1. Y. Ma, and R.M. Pope The role of macrophages in rheumatoid arthritis Curr Pharm Des 11 2005 569 580
2. M. Feldmann, F.M. Brennan, and R.N. Maini Role of cytokines in rheumatoid arthritis Annu Rev Immunol 14 1996 397 440
3. C.L. Langrish, Y. Chen, W.M. Blumenschein, J. Mattson, B. Basham, and J.D. Sedgwick IL-23 drives a pathogenic T cell population that induces autoimmune inflammation J Exp Med 201 2005 233 240
4. S. Akira, K. Takeda, and T. Kaisho Toll-like receptors: critical proteins linking innate and acquired immunity Nat Immunol 2 2001 675 680
5. A. Aderem, and R.J. Ulevitch Toll-like receptors in the induction of the innate immune response Nature 406 2000 782 787
6. R. Schwandner, R. Dziarski, H. Wesche, M. Rothe, and C.J. Kirschning Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2 J Biol Chem 274 1999 17406 17409
7. F. Re, and J.L. Strominger Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells J Biol Chem 276 2004 37692 37699
8. C.A. Murphy, C.L. Langrish, Y. Chen, W. Blumenschein, T. McClanahan, and R.A. Kastelein Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation J Exp Med 198 2003 1951 1957
9. Y. Takai, T. Sasaki, and T. Matozaki Small GTP-binding proteins Physiol Rev 81 2001 153 208
10. E. Sahai, and C.J. Marshall RHO-GTPases and cancer Nat Rev Cancer 2 2002 133 142
11. K. Burridge, and Wennerberg K. Rho Rac take center stage Cell 116 2004 167 179
12. S. Nakayamada, H. Kurose, K. Saito, A. Mogami, and Y. Tanaka Small GTP-binding protein Rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblasts Arthritis Res Ther 7 2005 R476 R484
13. Y. He, H. Xu, L. Liang, Z. Zhan, X. Yang, and X. Yu Antiinflammatory effect of Rho kinase blockade via inhibition of NF-kappaB activation in rheumatoid arthritis Arthritis Rheum 58 2008 3366 3376
14. A. Paradowska-Gorycka, A. Grzybowska-Kowalczyk, E. Wojtecka-Lukasik, and S. Maslinski IL-23 in the pathogenesis of rheumatoid arthritis Scand J Immunol 71 2010 134 145
15. S.Y. Park, J.H. Lee, C.D. Kim, W.S. Lee, W.S. Park, and J. Han Cilostazol suppresses superoxide production and expression of adhesion molecules in human endothelial cells via mediation of cAMP-dependent protein kinase-mediated maxi-K channel activation J Pharmacol Exp Ther 317 2006 1238 1245
16. F.L. Liu, C.H. Chen, S.J. Chu, J.H. Chen, J.H. Lai, and H.K. Sytwu Interleukin (IL)-23 p19 expression induced by IL-1beta in human fibroblast-like synoviocytes with rheumatoid arthritis via active nuclear factor-kappaB and AP-1 dependent pathway Rheumatology 6 2007 1266 1273
17. R.O. Williams, M. Feldmann, and R.N. Maini Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis Proc Natl Acad Sci USA 89 1992 9784 9788
18. D.S. O'Mahony, U. Pham, R. Iyer, T.R. Hawn, and W.C. Liles Differential constitutive and cytokine-modulated expression of human toll-like receptors in primary neutrophils, monocytes, and macrophages Int J Med Sci 5 2008 1 8
19. J. Li, B. Gran, G.X. Zhang, E.S. Ventura, I. Siglienti, and A. Rostami Differential expression and regulation of IL-23 and IL-12 subunits and receptors in adult mouse microglia J Neurol Sci 215 2003 95 103
20. S.Y. Park, S.W. Lee, S.H. Baek, C.W. Lee, W.S. Lee, and B.Y. Rhim Suppression of PU.1-linked TLR4 expression by cilostazol with decrease of cytokine production in macrophages from patients with rheumatoid arthritis Br J Pharmacol 168 2013 1401 1411
21. R. Seibl, T. Birchler, S. Loeliger, J.P. Hossle, R.E. Gay, and T. Saurenmann Expression and regulation of toll-like receptor 2 in rheumatoid arthritis synovium Am J Pathol 162 2003 1221 1227
22. M. Pierer, J. Rethage, R. Seibl, R. Lauener, F. Brentano, and U. Wagner Gay Kyburz SD. Chemokine secretion of rheumatoid arthritis synovial fibroblasts stimulated by toll-like receptor 2 ligands J Immunol 72 2004 1256 1265
23. L.A. Joosten, M.I. Koenders, R.L. Smeets, M. Heuvelmans-Jacobs, M.M. Helsen, and K. Takeda Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88 J Immunol 171 2003 6145 6153
24. D.J. Cua, J. Sherlock, Y. Chen, C.A. Murphy, B. Joyce, and B. Seymour Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain Nature 421 2003 744 748
25. S. Etienne-Manneville, and A. Hall Rho GTPases in cell biology Nature 420 2002 629 635
26. S.Y. Park, J.H. Lee, Y.K. Kim, C.D. Kim, B.Y. Rhim, and W.S. Lee Cilostazol prevents remnant lipoprotein particle-induced monocyte adhesion to endothelial cells by suppression of adhesion molecules and monocyte chemoattractant protein-1 expression via lectin-like receptor for oxidized low-density lipoprotein receptor activation J Pharmacol Exp Ther 312 2005 1241 1248
27. S. Akira, and K. Takeda Toll-like receptor signaling Nat Rev Immunol 4 2004 499 511
28. K. Redlich, S. Hayer, R. Ricci, J-P. David, M. Tohidast-Akrad, and G. Kollias Osteoclasts are essential for TNF-alpha-mediated joint destruction J Clin Invest 110 2002 1419 1427
29. G. Schett, C. Stach, J. Zwerina, R. Voll, and B. Manger How antirheumatic drugs protect joints from damage in rheumatoid arthritis Arthritis Rheum 58 2008 2936 2948