Neuroactive steroids and the nervous system: Further observations on an incomplete tricky puzzle

Journal of Neuroendocrinology

Volumn 25, Issue 11, 2013, Pages 957-963

  Melcangi, R C ^a   Panzica, G C ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; STEROID; STEROID HORMONE; STEROID RECEPTOR; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; HORMONE;

AGE DISTRIBUTION; CELL DIFFERENTIATION; CENTRAL NERVOUS SYSTEM; EDITORIAL; EPIGENETICS; MENTAL DISEASE; NERVOUS SYSTEM; NERVOUS TISSUE; NEUROENDOCRINE SYSTEM; NEUROENDOCRINOLOGY; NEUROPROTECTION; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; STEROIDOGENESIS; SYNAPSE; ANIMAL; GENETICS; HUMAN; METABOLISM; NERVOUS SYSTEM FUNCTION; PHYSIOLOGY;

ANIMALS; HORMONES; HUMANS; NERVOUS SYSTEM; NERVOUS SYSTEM PHYSIOLOGICAL PHENOMENA; NEUROTRANSMITTER AGENTS;

EID: 84886706967     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/jne.12110     Document Type: Editorial

References (75)

1. Medvei VC. A History of Endocrinology. Lancaster: MTP Press Limited, 1982.
2. Kim YS, Stumpf WE, Sar M, Martinez-Vargas MC. Estrogen and androgen target cells in the brain of fishes, reptiles and birds: phylogeny and onthogeny. Am Zool 1978; 18: 425-433.
3. Stumpf WE, Sar M, Keefer DA. Atlas of estrogen target cells in rat brain. In: Stumpf WE, Grant LD, eds. Anatomical Neuroendocrinology. Basel: Karger, 1975; 104-119.
4. Tsai MJ, O'Malley BW. Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu Rev Biochem 1994; 63: 451-486.
5. Villee CA, Hagerman DD. Effects of estradiol on the metabolism of human placenta in vitro. J Biol Chem 1953; 205: 873-882.
6. Towle AC, Sze PY. Steroid binding to synaptic plasma membrane: differential binding of glucocorticoids and gonadal steroids. J Steroid Biochem 1983; 18: 135-143.
7. Majewska MD, Mienville JM, Vicini S. Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons. Neurosci Lett 1988; 90: 279-284.
8. Majewska MD, Harrison NL, Schwartz RD, Barker JL, Paul SM. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 1986; 232: 1004-1007.
9. Naftolin F, Mac Lusky N. Aromatization hypothesis revisited. In: Serio M, ed. Sexual Differentiation: Basic and Clinical Aspects. New York, NY: Raven Press 1984: 79-91.
10. Corpechot C, Robel P, Axelson M, Sjovall J, Baulieu EE. Characterization and measurement of dehydroepiandrosterone sulfate in rat brain. Proc Natl Acad Sci USA 1981; 78: 4704-4707.
11. Baulieu EE. Neurosteroids: a new function in the brain. Biol Cell 1991; 71: 3-10.
12. Mani SK, Portillo W, Reyna A. Steroid hormone action in the brain: cross-talk between signalling pathways. J Neuroendocrinol 2009; 21: 243-247.
13. Rupprecht R, Holsboer F. Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives. Trends Neurosci 1999; 22: 410-416.
14. Panzica GC, Balthazart J, Frye CA, Garcia-Segura LM, Herbison AE, Mensah-Nyagan AG, McCarthy MM, Melcangi RC. Milestones on steroids and the nervous system: 10 years of basic and translational research. J Neuroendocrinol 2012; 24: 1-15.
15. Melcangi RC, Garcia-Segura LM. Sex-specific therapeutic strategies based on neuroactive steroids: in search for innovative tools for neuroprotection. Horm Behav 2010; 57: 2-11.
16. Melcangi RC, Panzica G, Garcia-Segura LM. Neuroactive steroids: focus on human brain. Neuroscience 2011; 191: 1-5.
17. Melcangi RC, Panzica GC. Allopregnanolone: state of the art. Progr Neurobiol 2013; http://dx.doi.org/10.1016/j.pneurobio.2013.09.005, in press.
18. O'Malley BW, Means AR. Female steroid hormones and target cell nuclei. Science 1974; 183: 610-620.
19. Shibata H, Spencer TE, Onate SA, Jenster G, Tsai SY, Tsai MJ, O'Malley BW. Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action. Recent Prog Horm Res 1997; 52: 41-65.
20. Lonard DM, O'Malley BW. Nuclear receptor coregulators: modulators of pathology and therapeutic targets. Nat Rev Endocrinol 2012; 8: 598-604.
21. Tetel M, Acharya K. Nuclear receptor coactivators: Regulators of steroid action in brain and behavior. J Neuroendocrinol 2013; 25: 1209-1218.
22. Champagne FA, Rissman EF. Behavioral epigenetics: a new frontier in the study of hormones and behavior. Horm Behav 2011; 59: 277-278.
23. McCarthy MM, Auger AP, Bale TL, De Vries GJ, Dunn GA, Forger NG, Murray EK, Nugent BM, Schwarz JM, Wilson ME. The epigenetics of sex differences in the brain. J Neurosci 2009; 29: 12815-12823.
24. McCarthy M, Nugent B. Epigenetic contributions to hormonally mediated sexual differentiation of the brain. J Neuroendocrinol 2013; 25: 1133-1140.
25. Kigar S, Auger A. Epigenetic mechanisms may underlie the etiology of sex differences in mental health risk and resilience. J Neuroendocrinol 2013; 25: 1141-1150.
26. Frick KM. Epigenetics, estradiol, and hippocampal memory consolidation. J Neuroendocrinol 2013; 25: 1151-1162.
27. Galea L, Wainwright S, Roes M, Duarte-Guterman P, Chow C, Hamson D. Sex, hormones, and neurogenesis in the hippocampus: Hormonal modulation of neurogenesis and potential functional implications. J Neuroendocrinol 2013; 25: 1039-1061.
28. Petersen S, Intlekofer K, Moura-Conlon P, Brewer D, Del Pino Sans J, Lopez J. Non-Classical Progesterone Signalling Molecules in the Nervous System. J Neuroendocrinol 2013; 25: 991-1001.
29. Marin R, Casañas V, Pérez J, Fabelo N, Fernandez C, Diaz M. Oestrogens as Modulators of Neuronal Signalosomes and Brain Lipid Homeostasis Related to Protection Against Neurodegeneration. J Neuroendocrinol 2013; 25: 1104-1115.
30. Hazell GG, Yao ST, Roper JA, Prossnitz ER, O'Carroll AM, Lolait SJ. Localisation of GPR30, a novel G protein-coupled oestrogen receptor, suggests multiple functions in rodent brain and peripheral tissues. J Endocrinol 2009; 202: 223-236.
31. Srivastava D, Evans P. GPER 1: trials and tribulations of a Membrane Oestrogen Receptor. J Neuroendocrinol 2013; 25: 1219-1230.
32. Bourguignon JP, Franssen D, Gerard A, Janssen S, Pinson A, Naveau E, Parent AS. Early neuroendocrine disruption in hypothalamus and hippocampus: developmental effects including female sexual maturation and implications for endocrine disrupting chemical screening. J Neuroendocrinol 2013; 25: 1079-1087.
33. Panzica GC, Bo E, Martini MA, Miceli D, Mura E, Viglietti-Panzica C, Gotti S. Neuropeptides and enzymes are targets for the action of endocrine disrupting chemicals in the vertebrate brain. J Toxicol Environ Health B Crit Rev 2011; 14: 449-472.
34. Balthazart J, Ball GF. Is brain estradiol a hormone or a neurotransmitter? Trends Neurosci 2006; 29: 241-249.
35. Babayan AH, Kramár EA. Rapid effects of oestrogen on synaptic plasticity: interactions with actin and its signaling proteins. J Neuroendocrinol 2013; 25: 1163-1172.
36. Micevych P, Sinchak K. Temporal and concentration dependent estradiol effects on neural pathways mediating sexual receptivity. J Neuroendocrinol 2013; 25: 1012-1023.
37. Kwakowsky A, Potapov D, Abrahám I. Tracking of single receptor molecule mobility in neuronal membranes: quick theoretical and practical guide. J Neuroendocrinol 2013; 25: 1231-1238.
38. Reddy DS. Neurosteroids: endogenous role in the human brain and therapeutic potentials. Prog Brain Res 2010; 186: 113-137.
39. Rupprecht R, di Michele F, Hermann B, Strohle A, Lancel M, Romeo E, Holsboer F. Neuroactive steroids: molecular mechanisms of action and implications for neuropsychopharmacology. Brain Res Rev 2001; 37: 59-67.
40. Biagini G, Rustichelli C, Curia G, Vinet J, Lucchi C, Pugnaghi M, Meletti S. Neurosteroids And Epileptogenesis. J Neuroendocrinol 2013; 25: 980-990.
41. Bortolato M, Muroni A, Marrosu F. Treatment of Tourette's syndrome with finasteride. The Am J Psych 2007; 164: 1914-1915.
42. Muroni A, Paba S, Puligheddu M, Marrosu F, Bortolato M. A preliminary study of finasteride in Tourette syndrome. Mov Disord 2011; 26: 2146-2147.
43. Bortolato M, Frau R, Godar S, Mosher L, Paba S, Marrosu F, Devoto P. The implication of neuroactive steroids in Tourette syndrome pathogenesis: a role for 5α-reductase? J Neuroendocrinol 2013; 25: 1196-1208.
44. Baram TZ, Mitchell WG, Snead OC III, Horton EJ, Saito M. Brain-adrenal axis hormones are altered in the CSF of infants with massive infantile spasms. Neurology 1992; 42: 1171-1175.
45. Welberg LAM, Seckl JR. Prenatal stress, glucocorticoids and the programming of the brain. J Neuroendocrinol 2001; 13: 113-128.
46. Iacobas D, Iacobas S, Chachua T, Goletiani C, Sidyelyeva G, Velíšková J, Velíšek L. Prenatal corticosteroids modify glutamatergic and GABAergic synapse genomic fabric: insights from a novel animal model of infantile spasms. J Neuroendocrinol 2013; 25: 964-979.
47. Deutsch ER, Espinoza TR, Atif F, Woodall E, Kaylor J, Wright DW. Progesterone's role in neuroprotection, a review of the evidence. Brain Res 2013; 1530: 82-105.
48. Baudry M, Bi X, Aguirre C. Progesterone-estrogen interactions in synaptic plasticity and neuroprotection. Neuroscience 2013; 239: 280-294.
49. Giatti S, Boraso M, Melcangi RC, Viviani B. Neuroactive steroids, their metabolites, and neuroinflammation. J Mol Endocrinol 2012; 49: R125-R134.
50. De Nicola A, Gonzalez-Deniselle M, Garay L, Meyer M, Gargiulo-Monachelli G, Guennoun R, Schumacher M, Carreras M, Poderoso J. Progesterone protective effects in neurodegeneration and neuroinflammation. J Neuroendocrinol 2013; 25: 1095-1103.
51. Moser JM, Bigini P, Schmitt-John T. The wobbler mouse, an ALS animal model. Mol Gen Genom 2013; 288: 207-229.
52. Giatti S, Caruso D, Boraso M, Abbiati F, Ballarini E, Calabrese D, Pesaresi M, Rigolio R, Santos-Galindo M, Viviani B, Cavaletti G, Garcia-Segura LM, Melcangi RC. Neuroprotective effects of progesterone in chronic experimental autoimmune encephalomyelitis. J Neuroendocrinol 2012; 24: 851-861.
53. Stein DG. Progesterone exerts neuroprotective effects after brain injury. Brain Res Rev 2008; 57: 386-397.
54. Stein DG. Progesterone in the treatment of acute traumatic brain injury: a clinical perspective and update. Neuroscience 2011; 191: 101-106.
55. Wong R, Bath P, Kendall D, Gibson C. Progesterone and cerebral ischaemia: the relevance of ageing. J Neuroendocrinol 2013; 25: 1088-1094.
56. Stein DG. Brain damage, sex hormones and recovery: a new role for progesterone and estrogen? Trends Neurosci 2001; 24: 386-391.
57. Sohrabji F, Williams M. Stroke neuroprotection: Estrogen and IGF-1 interactions and the role of microglia. J Neuroendocrinol 2013; 25: 1173-1181.
58. Aste N, Panzica GC, Viglietti-Panzica C, Harada N, Balthazart J. Distribution and effects of testosterone on aromatase mRNA in the quail forebrain: a non-radioactive in situ hybridization study. J Chem Neuroanat 1998; 14: 103-115.
59. Panzica GC, Viglietti-Panzica C, Balthazart J. The sexually dimorphic medial preoptic nucleus of quail: a key brain area mediating steroid action on male sexual behavior. Front Neuroendocrinol 1996; 17: 51-125.
60. Balthazart J, Taziaux M, Holloway K, Ball GF, Cornil CA. Behavioral effects of brain-derived estrogens in birds. Ann NY Acad Sci 2009; 1163: 31-48.
61. Ball GF, Balthazart J. Seasonal and hormonal modulation of neurotransmitter systems in the song control circuit. J Chem Neuroanat 2010; 39: 82-95.
62. Schlinger BA, Remage-Healey L. Neurosteroidogenesis: insights from studies of songbirds. J Neuroendocrinol 2012; 24: 16-21.
63. Saldanha CJ, Duncan KA, Walters BJ. Neuroprotective actions of brain aromatase. Front Neuroendocrinol 2009; 30: 106-118.
64. Saldanha C, Burstein S, Duncan K. Induced synthesis of estrogens by glia in the songbird brain. J Neuroendocrinol 2013; 25: 1032-1039.
65. Cornil C, Ball GF, Balthazart J. Functional significance of the rapid regulation of brain estrogen action: Where do the estrogens come from? Brain Res 2006; 1126: 2-26.
66. Cornil C, Seredynski A, de Bournonville C, Dickens M, Charlier T, Ball G, Balthazart J. Rapid control of reproductive behaviour by locally synthesised oestrogens: focus on aromatase. J Neuroendocrinol 2013; 25: 1070-1078.
67. Remage-Healey L, Jeon S, Joshi N. Recent evidence for rapid synthesis and action of estrogens during auditory processing in a songbird. J Neuroendocrinol 2013; 25: 1024-1032.
68. Ervin K, Phan A, Gabor C, Choleris E. Rapid Oestrogenic regulation of social and non-social learning. J Neuroendocrinol 2013; 25: 1116-1132.
69. Frye CA, Koonce CJ, Walf AA. Pregnane xenobiotic receptors and membrane progestin receptors: role in neurosteroid-mediated motivated behaviors. J Neuroendocrinol 2013; 25: 1002-1011.
70. Araujo AB, Wittert GA. Endocrinology of the aging male. Best Pract Res Clin Endocrinol Metab 2011; 25: 303-319.
71. Boulware MI, Kent BA, Frick KM. The impact of age-related ovarian hormone loss on cognitive and neural function. Curr Topics Behav Neurosci 2012; 10: 165-184.
72. Sorwell K, Urbanski H. Causes and consequences of age-related steroid hormone changes: insights gained from nonhuman primates. J Neuroendocrinol 2013; 25: 1062-1069.
73. Chakraborty TR, Gore AC. Aging-related changes in ovarian hormones, their receptors, and neuroendocrine function. Exp Biol Med 2004; 229: 977-987.
74. Smith RG, Betancourt L, Sun Y. Molecular endocrinology and physiology of the aging central nervous system. Endocr Rev 2005; 26: 203-250.
75. Hogervorst E. Effects of gonadal hormones on cognitive behavior in elderly men and women. J Neuroendocrinol 2013; 25: 1182-1195.