Non-apoptotic routes to defeat cancer

OncoImmunology

Volumn 1, Issue 1, 2012, Pages 94-96

  Guerriero, Jennifer L ^a,c   Ditsworth, Dara ^b   Zong, Wei Xing ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Chemotherapy; HMGB1; Innate immunity; Necrosis; Tumor associated macrophage

Indexed keywords

CYCLOPHOSPHAMIDE; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 4; PROTEIN BAK; PROTEIN BAX; PROTEIN P53; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; CANCER CELL CULTURE; CANCER REGRESSION; CANCER RESISTANCE; CELL DEATH; CELL INFILTRATION; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; DRUG RESPONSE; FIBROSARCOMA; HUMAN; INNATE IMMUNITY; MACROPHAGE ACTIVATION; MALIGNANT NEOPLASTIC DISEASE; NATURAL KILLER CELL; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; UPREGULATION;

EID: 84886615113     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.4161/onci.1.1.17885     Document Type: Note

References (10)

1. Guerriero JL, Ditsworth D, Fan Y, Zhao F, Crawford HC, Zong WX. Chemotherapy induces tumor clearance independent of apoptosis. Cancer Res 2008; 68:9595-600; PMID:19047135; DOI:10.1158/0008-5472.CAN-08-2452.
2. Brown JM, Attardi LD. The role of apoptosis in cancer development and treatment response. Nat Rev Cancer 2005; 5:231-7; PMID:15738985; DOI:10.1038/nrc1560.
3. Lowe SW, Lin AW. Apoptosis in cancer. Carcinogenesis 2000; 21:485-95; PMID:10688869; DOI:10.1093/carcin/21.3.485.
4. Amaravadi RK, Thompson CB. The roles of therapy-induced autophagy and necrosis in cancer treatment. Clin Cancer Res 2007; 13:7271-9; PMID:18094407; DOI:10.1158/1078-0432.CCR-07-1595.
5. Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002; 418:191-5; PMID:12110890; DOI:10.1038/nature00858.
6. Thorburn J, Horita H, Redzic J, Hansen K, Frankel AE, Thorburn A. Autophagy regulates selective HMGB1 release in tumor cells that are destined to die. Cell Death Differ 2009; 16:175-83; PMID:18846108; DOI:10.1038/cdd.2008.143.
7. Guerriero JL, Ditsworth D, Catanzaro JM, Sabino G, Furie MB, Kew RR, et al. DNA Alkylating Therapy Induces Tumor Regression through an HMGB1-Mediated Activation of Innate Immunity. J Immunol 2011; 186:3517-26; PMID:21300822; DOI:10.4049/jimmunol.1003267.
8. Chowdhury D, Lieberman J. Death by a thousand cuts: granzyme pathways of programmed cell death. Annu Rev Immunol 2008; 26:389-420; PMID:18304003; DOI:10.1146/annurev.immunol.26.021607.090404.
9. Solinas G, Germano G, Mantovani A, Allavena P. Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J Leukoc Biol 2009; 86:1065-73; PMID:19741157; DOI:10.1189/jlb.0609385.
10. DeNardo DG, Brennan DJ, Rexhepaj E, Ruffell B, Shiao SL, Madden SF, et al. Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. Cancer Discovery 2011; 1:54-67; DOI:10.1158/2159-8274.CD-10-0028.