Eicosanoid Signaling and Vascular Dysfunction: Methylmercury-Induced Phospholipase D Activation in Vascular Endothelial Cells

Cell Biochemistry and Biophysics

Volumn 67, Issue 2, 2013, Pages 317-329

  Sherwani, Shariq I ^a   Pabon, Sheila ^a   Patel, Rishi B ^a   Sayyid, Muzzammil M ^a   Hagele, Thomas ^a   Kotha, Sainath R ^a   Magalang, Ulysses J ^a   Maddipati, Krishna R ^b   Parinandi, Narasimham L ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cyclooxygenase; Eicosanoid signaling; Lipoxygenase; Phospholipase D; PLD; Vascular endothelial cells

Indexed keywords

BOVINAE;

ENZYME INHIBITOR; ICOSANOID; LACTATE DEHYDROGENASE; LIPOXYGENASE; METHYLMERCURY DERIVATIVE; PHOSPHOLIPASE A2; PHOSPHOLIPASE D; PROSTAGLANDIN SYNTHASE; SERINE;

ANIMAL; ARTICLE; BIOCATALYSIS; BIOSYNTHESIS; BLOOD VESSEL; CATTLE; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME ACTIVATION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; PULMONARY ARTERY; SECRETION (PROCESS); SIGNAL TRANSDUCTION; TIME;

ANIMALS; BIOCATALYSIS; BLOOD VESSELS; CATTLE; DOSE-RESPONSE RELATIONSHIP, DRUG; EICOSANOIDS; ENDOTHELIAL CELLS; ENZYME ACTIVATION; ENZYME INHIBITORS; L-LACTATE DEHYDROGENASE; LIPOXYGENASE; METHYLMERCURY COMPOUNDS; PHOSPHOLIPASE D; PHOSPHOLIPASES A2; PHOSPHORYLATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PULMONARY ARTERY; SERINE; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84886586710     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12013-011-9304-3     Document Type: Article

References (49)

1. Clarkson, T. W., Magos, L., & Myers, G. J. (2003). The toxicology of mercury-current exposures and clinical manifestations. New England Journal of Medicine, 349(18), 1731-1737.
2. Bolger, P. M., & Schwetz, B. A. (2002). Mercury and health. New England Journal of Medicine, 347(22), 1735-1736.
3. Mutter, J., Naumann, J., Schneider, R., Walach, H., & Haley, B. (2005). Mercury and autism: Accelerating evidence? Neuroendocrinology Letters, 26(5), 439-446.
4. Mutter, J., Naumann, J., Sadaghiani, C., Walach, H., & Drasch, G. (2004). Amalgam studies: Disregarding basic principles of mercury toxicity. International Journal of Hygiene and Environmental Health, 207(4), 391-397.
5. Ustinaviciene, R., Obelenis, V., & Ereminas, D. (2004). Occupational health problems in modern work environment. Medicina (Kaunas), 40(9), 897-904.
6. Renneberg, A. J., & Dudas, M. J. (2001). Transformations of elemental mercury to inorganic and organic forms in mercury and hydrocarbon co-contaminated soils. Chemosphere, 45(6-7), 1103-1109.
7. Clarkson, T. W. (2002). The three modern faces of mercury. Environmental Health Perspectives, 110(Suppl 1), 11-23.
8. Landmark, K., & Aursnes, I. (2004). Mercury, fish, fish oil and the risk of cardiovascular disease. Tidsskrift for den Norske Laegeforening, 124(2), 198-200.
9. Nash, R. A. (2005). Metals in medicine. Alternative Therapies in Health and Medicine, 11(4), 18-25.
10. Kostka, B. (1991). Toxicity of mercury compounds as a possible risk factor for cardiovascular diseases. British Journal of Industrial Medicine, 48(12), 845.
11. Yoshizawa, K., Rimm, E. B., Morris, J. S., Spate, V. L., Hsieh, C. C., Speigelman, D., et al. (2002). Mercury and the risk of coronary heart disease in men. New England Journal of Medicine, 347(22), 1755-1760.
12. Kim, D. S., Lee, E. H., Yu, S. D., Cha, J. H., & Ahn, S. C. (2005). Heavy metal as risk factor of cardiovascular disease-an analysis of blood lead and urinary mercury. Journal of Preventive Medicine and Public Health, 38(4), 401-407.
13. Guallar, E., Sanz-Gallardo, M. I., van't Veer, P., Bode, P., Aro, A., Gomez-Aracena, J., et al. (2002). Mercury, fish oils, and the risk of myocardial infarction. New England Journal of Medicine, 347(22), 1747-1754.
14. Wolf, M. B., & Baynes, J. W. (2007). Cadmium and mercury cause an oxidative stress-induced endothelial dysfunction. BioMetals, 20(1), 73-81.
15. Hagele, T. J., Mazerik, J. N., Gregory, A., Kaufman, B., Magalang, U., Kuppusamy, M. L., et al. (2007). Mercury activates vascular endothelial cell phospholipase D through thiols and oxidative stress. The International Journal of Toxicology, 26(1), 57-69.
16. Varadharaj, S., Steinhour, E., Hunter, M. G., Watkins, T., Baran, C. P., Magalang, U., et al. (2006). Vitamin C-induced activation of phospholipase D in lung microvascular endothelial cells: Regulation by MAP kinases. Cellular Signalling, 18(9), 1396-1407.
17. Sliman, S. M., Eubank, T. D., Kotha, S. R., Kuppusamy, M. L., Sherwani, S. I., Butler, E. S., et al. (2009). Hyperglycemic oxoaldehyde, glyoxal, causes barrier dysfunction, cytoskeletal alterations, and inhibition of angiogenesis in vascular endothelial cells: Aminoguanidine protection. Molecular and Cellular Biochemistry, 333(1-2), 9-26.
18. Brindley, D. N., & Waggoner, D. W. (1996). Phosphatidate phosphohydrolase and signal transduction. Chemistry and Physics of Lipids, 80(1-2), 45-57.
19. Steinhour, E., Sherwani, S. I., Mazerik, J. N., Ciapala, V., O'Connor Butler, E., Cruff, J. P., et al. (2008). Redox-active antioxidant modulation of lipid signaling in vascular endothelial cells: Vitamin C induces activation of phospholipase D through phospholipase A2, lipoxygenase, and cyclooxygenase. Molecular and Cellular Biochemistry, 315(1-2), 97-112.
20. Chakraborti, S. (2003). Phospholipase A(2) isoforms: A perspective. Cellular Signalling, 15(7), 637-665.
21. Balsinde, J., Winstead, M. V., & Dennis, E. A. (2000). Phospholipase A2 regulation of acachidonic acid mobilization. FEBS Letters, 531, 2-6.
22. Dennis, E. A., Rhee, S. G., Billah, M. M., & Hannun, Y. A. (1991). Role of phospholipase in generating lipid second messengers in signal transduction. FASEB Journal, 5(7), 2068-2077.
23. Exton, J. H. (1997). New developments in phospholipase D. Journal of Biological Chemistry, 272(25), 15579-15582.
24. Natarajan, V. (1995). Oxidants and signal transduction in vascular endothelium. Journal of Laboratory and Clinical Medicine, 125(1), 26-37.
25. Singer, W. D., Brown, H. A., Jiang, X., & Sternweis, P. C. (1996). Regulation of phospholipase D by protein kinase C is synergistic with ADP-ribosylation factor and independent of protein kinase activity. Journal of Biological Chemistry, 271(8), 4504-4510.
26. Mazerik, J. N., Hagele, T., Sherwani, S., Ciapala, V., Butler, S., Kuppusamy, M. L., et al. (2007). Phospholipase A2 activation regulates cytotoxicity of methylmercury in vascular endothelial cells. The International Journal of Toxicology, 26(6), 553-569.
27. Mazerik, J. N., Mikkilineni, H., Kuppusamy, V. A., Steinhour, E., Peltz, A., Marsh, C. B., et al. (2007). Mercury activates phospholipase a(2) and induces formation of arachidonic acid metabolites in vascular endothelial cells. Toxicology Mechanisms and Methods, 17(9), 541-557.
28. Peltz, A., Sherwani, S. I., Kotha, S. R., Mazerik, J. N., O'Connor Butler, E. S., Kuppusamy, M. L., et al. (2009). Calcium and calmodulin regulate mercury-induced phospholipase D activation in vascular endothelial cells. The International Journal of Toxicology, 28(3), 190-206.
29. Murphy, R. C., Barkley, R. M., Zemski Berry, K., Hankin, J., Harrison, K., Johnson, C., et al. (2005). Electrospray ionization and tandem mass spectrometry of eicosanoids. Analytical Biochemistry, 346(1), 1-42.
30. Lambert, I. H., Pedersen, S. F., & Poulsen, K. A. (2006). Activation of PLA2 isoforms by cell swelling and ischaemia/hypoxia. Acta physiologica (Oxford), 187(1-2), 75-85.
31. Nigam, S., & Schewe, T. (2000). Phospholipase A(2)s and lipid peroxidation. Biochimica et Biophysica Acta, 1488(1-2), 167-181.
32. 2+-independent phospholipase A2 on arachidonic acid release induced by reactive oxygen species. Archives of Biochemistry and Biophysics, 392(2), 257-262.
33. Xu, J., Yu, S., Sun, A. Y., & Sun, G. Y. (2003). Oxidant-mediated AA release from astrocytes involves cPLA(2) and iPLA(2). Free Radical Biology and Medicine, 34(12), 1531-1543.
34. Shanker, G., & Aschner, M. (2001). Identification and characterization of uptake systems for cystine and cysteine in cultured astrocytes and neurons: Evidence for methylmercury-targeted disruption of astrocyte transport. Journal of Neuroscience Research, 66(5), 998-1002.
35. Shanker, G., Syversen, T., Aschner, J. L., & Aschner, M. (2005). Modulatory effect of glutathione status and antioxidants on methylmercury-induced free radical formation in primary cultures of cerebral astrocytes. Brain research. Molecular brain research, 137(1-2), 11-22.
36. Verity, M. A., Sarafian, T., Pacifici, E. H., & Sevanian, A. (1994). Phospholipase A2 stimulation by methyl mercury in neuron culture. Journal of Neurochemistry, 62(2), 414-705.
37. Reiss, A. B., & Edelman, S. D. (2006). Recent insights into the role of prostanoids in atherosclerotic vascular disease. Current Vascular Pharmacology, 4(4), 395-408.
38. Bogatcheva, N. V., Sergeeva, M. G., Dudek, S. M., & Verin, A. D. (2005). Arachidonic acid cascade in endothelial pathobiology. Microvascular Research, 69(3), 107-127.
39. Sugiyama, T., Sakai, T., Nozawa, Y., & Oka, N. (1994). Prostaglandin F2 alpha-stimulated phospholipase D activation in osteoblast-like MC3T3-E1 cells: Involvement in sustained 1, 2-diacylglycerol production. Biochemical Journal, 298(Pt 2), 479-484.
40. Kozawa, O., Suzuki, A., Kotoyori, J., Tokuda, H., Watanabe, Y., Ito, Y., et al. (1994). Prostaglandin F2 alpha activates phospholipase D independently from activation of protein kinase C in osteoblast-like cells. Journal of Cellular Biochemistry, 55(3), 373-379.
41. 2+/calmodulin. Cellular Signalling, 7(1), 45-51.
42. Natarajan, V., Taher, M. M., Roehm, B., Parinandi, N. L., Schmid, H. H., Kiss, Z., et al. (1993). Activation of endothelial cell phospholipase D by hydrogen peroxide and fatty acid hydroperoxide. The Journal of Biological Chemistry, 268(2), 930-937.
43. Yamamoto, H., Endo, T., Kiya, T., Goto, T., Sagae, S., Ito, E., et al. (1995). Activation of phospholipase D by prostaglandin F2 alpha in rat luteal cells and effects of inhibitors of arachidonic acid metabolism. Prostaglandins, 50(4), 201-211.
44. Hurt-Camejo, E., Camejo, G., Peilot, H., Oorni, K., & Kovanen, P. (2001). Phospholipase A(2) in vascular disease. Circulation Research, 89(4), 298-304.
45. Phillis, J. W., & O'Regan, M. H. (2003). The role of phospholipases, cyclooxygenases, and lipoxygenases in cerebral ischemic/traumatic injuries. Critical Reviews in Neurobiology, 15(1), 61-90.
46. Avis, I. M., Jett, M., Boyle, T., Vos, M. D., Moody, T., Treston, A. M., et al. (1996). Growth control of lung cancer by interruption of 5-lipoxygenase-mediated growth factor signaling. Journal of Clinical Investigation, 97(3), 806-813.
47. Steele, V. E., Holmes, C. A., Hawk, E. T., Kopelovich, L., Lubet, R. A., Crowell, J. A., et al. (1999). Lipoxygenase inhibitors as potential cancer chemopreventives. Cancer Epidemiology, Biomarkers and Prevention, 8(5), 467-483.
48. Tang, D. G., Chen, Y. Q., & Honn, K. V. (1996). Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. Proceedings of the National Academy of Sciences, United States of America, 93(11), 5241-5246.
49. Whitman, S., Gezginci, M., Timmermann, B. N., & Holman, T. R. (2002). Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase. Journal of Medicinal Chemistry, 45(12), 2659-2661.