Redox-active antioxidant modulation of lipid signaling in vascular endothelial cells: Vitamin C induces activation of phospholipase D through phospholipase A2, lipoxygenase, and cyclooxygenase

Molecular and Cellular Biochemistry

Volumn 315, Issue 1-2, 2008, Pages 97-112

  Steinhour, Emily ^a   Sherwani, Shariq I ^a   Mazerik, Jessica N ^a   Ciapala, Valorie ^a   O'Connor Butler, Elizabeth ^a   Cruff, Jason P ^a   Magalang, Ulysses ^a   Parthasarathy, Sampath ^a   Sen, Chandan K ^a   Marsh, Clay B ^a   Kuppusamy, Periannan ^a   Parinandi, Narasimham L ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Arachidonate metabolite; Endothelial cell; Lipid signaling; Phospholipase A2; Phospholipase D; Redox active antioxidant; Vitamin C

Indexed keywords

ANTIOXIDANT; ARACHIDONIC ACID; ASCORBIC ACID; CALCIUM CHELATING AGENT; IRON CHELATING AGENT; LIPOXYGENASE; LIPOXYGENASE INHIBITOR; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; PHOSPHOLIPASE D; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; COW; DRUG EXPOSURE; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME REGULATION; ENZYME RELEASE; ENZYME SYNTHESIS; LIPID METABOLISM; LUNG BLOOD VESSEL; LUNG ENDOTHELIUM; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

ANIMALS; ANTIOXIDANTS; ARACHIDONIC ACID; ASCORBIC ACID; CALCIUM; CATALYSIS; CATTLE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; ENZYME ACTIVATION; ENZYME INHIBITORS; IRON CHELATING AGENTS; LIPID METABOLISM; LIPOXYGENASE; OXIDATION-REDUCTION; PHOSPHOLIPASE D; PHOSPHOLIPASES A2; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SIGNAL TRANSDUCTION; TIME FACTORS;

BOVINAE;

EID: 46749115093     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-008-9793-6     Document Type: Article

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