Can we decrease the skin reaction in breast cancer patients using hyaluronic acid during radiation therapy? Results of phase III randomised trial

Radiotherapy and Oncology

Volumn 100, Issue 2, 2011, Pages 205-209

  Kirova, Youlia M ^a   Fromantin, Isabelle ^a   De Rycke, Yann ^a   Fourquet, Alain ^a   Morvan, Esra ^a   Padiglione, Solene ^a   Falcou, Marie Christine ^a   Campana, Francois ^a   Bollet, Marc A ^a  

^a INSTITUT CURIE   (France)

Author keywords

Breast cancer; Dermatitis; Emollient; Hyaluronic acid; Radiotherapy

Indexed keywords

EMOLLIENT AGENT; HYALURONIC ACID; LALUSET; PLACEBO; TOPICREM; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BODY MASS; BREAST CANCER; CANCER PATIENT; CANCER RADIOTHERAPY; CLINICAL EVALUATION; COLORIMETRY; CONTROLLED STUDY; DRUG EFFICACY; DRUG TREATMENT FAILURE; DRUG WITHDRAWAL; FEMALE; HUMAN; MAJOR CLINICAL STUDY; PAIN ASSESSMENT; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; QUALITY OF LIFE; RADIATION DERMATITIS; RANDOMIZED CONTROLLED TRIAL;

ACUTE DISEASE; ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; DERMATITIS; EMOLLIENTS; FEMALE; HUMANS; HYALURONIC ACID; MIDDLE AGED; RADIATION INJURIES; RADIOTHERAPY;

EID: 80052296798     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2011.05.014     Document Type: Article

References (24)

1. K.R. Trott, and J. Kummermehr Radiation effects in skin E. Scherer, C. Streffer, K.R. Trott, Radiopathology of organs and tissues 1991 Springer Verlag Berlin 33 66
2. H.D. Thames, and J.H. Hendry Fractionation in radiotherapy 1987 Taylor and Francis London
3. J.H. Hendry Biological response modifiers and normal tissue injury after irradiation Semin Radiat Oncol 4 1994 123 132 (Pubitemid 24116951)
4. C. Chargari, I. Fromantin, and Y.M. Kirova Importance of local skin treatments during radiotherapy for prevention and treatment of radio-induced epithelitis Cancer Radiother 13 2009 259 266
5. J. Fisher, C. Scott, and R. Stevens Randomized phase III study comparing Best Supportive Care to Biafine as a prophylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: Radiation Therapy Oncology Group (RTOG) 97-13 Int J Radiat Oncol Biol Phys 48 2000 1307 1310
6. M.C. Leonardi, S. Gariboldi, and G.B. Ivaldi A double-blind, randomised, vehicle-controlled clinical study to evaluate the efficacy of MAS065D in limiting the effects of radiation on the skin: interim analysis Eur J Dermatol 18 2008 317 321 (Pubitemid 351821237)
7. N.K. Aaronson, S. Ahmedzai, and B. Bergman European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology J Natl Cancer Inst 85 1993 365 376 (Pubitemid 23073154)
8. F. Campana, Y.M. Kirova, and J.C. Rosenwald Breast radiotherapy in the lateral decubitus position: A technique to prevent lung and heart irradiation Int J Radiat Oncol Biol Phys 61 2005 1348 1354 (Pubitemid 40470414)
9. Y.M. Kirova, N. Fournier-Bidoz, and V. Servois How to boost the breast tumor bed? A multidisciplinary approach in eight steps Int J Radiat Oncol Biol Phys 72 2008 494 500
10. Y.M. Kirova, F. Campana, and N. Fournier-Bidoz Postmastectomy electron beam chest wall irradiation in women with breast cancer: a clinical step toward conformal electron therapy Int J Radiat Oncol Biol Phys 69 2007 1139 1144 (Pubitemid 47625855)
11. Y.M. Kirova, V. Servois, and F. Campana CT-scan based localization of the internal mammary chain and supra clavicular nodes for breast cancer radiation therapy planning Radiother Oncol 79 2006 310 315 (Pubitemid 44109910)
12. P. Castro Pena, Y.M. Kirova, and F. Campana Anatomical, clinical and radiological delineation of target volumes in breast cancer radiotherapy planning: individual variability, questions and answers Br J Radiol 82 2009 595 599
13. Y.M. Kirova, P. Castro Pena, and R. Dendale Definition of nodal volumes in breast cancer treatment and segmentation guidelines. [Article in French] J Radiol 90 2009 747 751
14. D. Moher, K.F. Schulz, and D.G. Altman The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials Lancet 357 2001 1191 1194 (Pubitemid 32378696)
15. A. Bolderston, N.S. Lloyd, and R.K. Wong The prevention and management of acute skin reactions related to radiation therapy: a systematic review and practice guideline Support Care Cancer 14 2006 802 817 (Pubitemid 44060993)
16. S. Heggie, G.P. Bryant, and L. Tripcony A Phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue Cancer Nurs 25 2002 442 451 (Pubitemid 35424054)
17. T.E. Merchant, C. Bosley, and J. Smith A phase III trial comparing an anionic phospholipid-based cream and aloe vera-based gel in the prevention of radiation dermatitis in pediatric patients Radiat Oncol 2 2007 45
18. P. Pommier, F. Gomez, M.P. Sunyach, A. D'Hombres, C. Carrie, and X. Montbarbon Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer J Clin Oncol 22 2004 1447 1453 (Pubitemid 41103627)
19. V. Liguori, C. Guillemin, G.F. Pesce, R.O. Mirimanoff, and J. Bernier Double-blind, randomized clinical study comparing hyaluronic acid cream to placebo in patients treated with radiotherapy Radiother Oncol 42 1997 155 161 (Pubitemid 27132744)
20. G. Primavera, M. Carrera, E. Berardesca, P. Pinnaró, M. Messina, and G. Arcangeli A double-blind, vehicle-controlled clinical study to evaluate the efficacy of MAS065D (XClair), a hyaluronic acid-based formulation, in the management of radiation-induced dermatitis Cutan Ocul Toxicol 25 2006 165 171 (Pubitemid 44410610)
21. A. Boström, H. Lindman, C. Swartling, B. Berne, and J. Bergh Potent corticosteroid cream (mometasone furoate) significantly reduces acute radiation dermatitis: results from a double-blind, randomized study Radiother Oncol 59 2001 257 265 (Pubitemid 32429573)
22. P.N. Shukla, M. Gairola, B.K. Mohanti, and G.K. Rath Prophylactic beclomethasone spray to the skin during postoperative radiotherapy of carcinoma breast: a prospective randomized study Indian J Cancer 43 2006 180 184
23. P. Vavassis, M. Gelinas, J. Chabot Tr, and P.F. Nguyen-Tân Phase 2 study of silver leaf dressing for treatment of radiation-induced dermatitis in patients receiving radiotherapy to the head and neck J Otolaryngol Head Neck Surg 37 2008 124 129
24. M. Wells, M. Macmillan, and G. Raab Does aqueous or sucralfate cream affect the severity of erythematous radiation skin reactions? A randomised controlled trial Radiother Oncol 73 2004 153 162 (Pubitemid 39470154)