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Volumn 154, Issue 11, 2013, Pages 4058-4067

Testosterone protects against glucotoxicity-induced apoptosis of pancreatic β-cells (INS-1) and male mouse pancreatic islets

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; ADENOSINE TRIPHOSPHATASE (CALCIUM); ANDROGEN RECEPTOR; CASPASE 3; CASPASE 7; FLUTAMIDE; GLUCOSE; TESTOSTERONE;

EID: 84886561445     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2013-1351     Document Type: Article
Times cited : (24)

References (35)
  • 1
    • 0842284799 scopus 로고    scopus 로고
    • β-Cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes
    • Robertson RP, Harmon J, Tran PO, Poitout V. β-Cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes. 2004;53(suppl 1):S119-S124.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 1
    • Robertson, R.P.1    Harmon, J.2    Tran, P.O.3    Poitout, V.4
  • 2
    • 0033034807 scopus 로고    scopus 로고
    • Hyperglycemia-induced β-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes
    • Donath MY, Gross DJ, Cerasi E, Kaiser N. Hyperglycemia-induced β-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes. Diabetes. 1999;48: 738-744.
    • (1999) Diabetes , vol.48 , pp. 738-744
    • Donath, M.Y.1    Gross, D.J.2    Cerasi, E.3    Kaiser, N.4
  • 3
    • 0030814657 scopus 로고    scopus 로고
    • Impaired development of pancreatic β-cell mass is a primary event during the progression to diabetes in the GK rat
    • Movassat J, Saulnier C, Serradas P, Portha B. Impaired development of pancreatic β-cell mass is a primary event during the progression to diabetes in the GK rat. Diabetologia. 1997;40: 916-925.
    • (1997) Diabetologia , vol.40 , pp. 916-925
    • Movassat, J.1    Saulnier, C.2    Serradas, P.3    Portha, B.4
  • 4
    • 0037219411 scopus 로고    scopus 로고
    • β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes
    • Butler A, Janson J, Bonner-Weir S, Ritzel R, Rizza R, Butler P. β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes. Diabetes. 2003;52: 102-110.
    • (2003) Diabetes , vol.52 , pp. 102-110
    • Butler, A.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.5    Butler, P.6
  • 5
    • 39149104320 scopus 로고    scopus 로고
    • The role for endoplasmic reticulum stress in diabetes mellitus
    • Eizirik DL, Cardozo AK, Cnop M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev. 2008;29: 42-61.
    • (2008) Endocr Rev , vol.29 , pp. 42-61
    • Eizirik, D.L.1    Cardozo, A.K.2    Cnop, M.3
  • 6
    • 2942755868 scopus 로고    scopus 로고
    • Signaling the unfolded protein response from the endoplasmic reticulum
    • Zhang K, Kaufman R. Signaling the unfolded protein response from the endoplasmic reticulum. J Biol Chem. 2004;279: 25935-25938.
    • (2004) J Biol Chem , vol.279 , pp. 25935-25938
    • Zhang, K.1    Kaufman, R.2
  • 7
    • 52049110715 scopus 로고    scopus 로고
    • Identification and characterization of endoplasmic reticulum stress-induced apoptosis in vivo
    • Zhang K, Kaufman R. Identification and characterization of endoplasmic reticulum stress-induced apoptosis in vivo. Methods Enzymol. 2008;442: 395-419.
    • (2008) Methods Enzymol , vol.442 , pp. 395-419
    • Zhang, K.1    Kaufman, R.2
  • 8
    • 33847677975 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress contributes to β cell apoptosis in type 2 diabetes
    • Laybutt D, Preston A, Akerfeldt M, et al. Endoplasmic reticulum stress contributes to β cell apoptosis in type 2 diabetes. Diabetologia. 2007;50: 752-763.
    • (2007) Diabetologia , vol.50 , pp. 752-763
    • Laybutt, D.1    Preston, A.2    Akerfeldt, M.3
  • 10
    • 25844442320 scopus 로고    scopus 로고
    • Diabetes mellitus is associated with subnormal serum levels of free testosterone in men
    • Rhoden EL, Ribeiro EP, Teloken C, Souto CA. Diabetes mellitus is associated with subnormal serum levels of free testosterone in men. BJU Int. 2005;96: 867-870.
    • (2005) BJU Int , vol.96 , pp. 867-870
    • Rhoden, E.L.1    Ribeiro, E.P.2    Teloken, C.3    Souto, C.A.4
  • 12
    • 33745684473 scopus 로고    scopus 로고
    • Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes
    • Kapoor D, Goodwin E, Channer KS, Jones TH. Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes. Eur J Endocrinol. 2006;154: 899-906.
    • (2006) Eur J Endocrinol , vol.154 , pp. 899-906
    • Kapoor, D.1    Goodwin, E.2    Channer, K.S.3    Jones, T.H.4
  • 13
    • 34547672768 scopus 로고    scopus 로고
    • Testosterone deficiency impairs glucose oxidation through defective insulin and its receptor gene expression in target tissues of adult male rats
    • Muthusamy T, Dhevika S, Murugesan P, Balasubramanian K. Testosterone deficiency impairs glucose oxidation through defective insulin and its receptor gene expression in target tissues of adult male rats. Life Sci. 2007;81: 534-542.
    • (2007) Life Sci , vol.81 , pp. 534-542
    • Muthusamy, T.1    Dhevika, S.2    Murugesan, P.3    Balasubramanian, K.4
  • 14
    • 77649268137 scopus 로고    scopus 로고
    • The protective effect of testosterone on streptozotocin-induced apoptosis in β cells is sex specific
    • Palomar-Morales M, Morimoto S, Mendoza-Rodriguez C, Cerbon M. The protective effect of testosterone on streptozotocin-induced apoptosis in β cells is sex specific. Pancreas. 2010;39: 193-200.
    • (2010) Pancreas , vol.39 , pp. 193-200
    • Palomar-Morales, M.1    Morimoto, S.2    Mendoza-Rodriguez, C.3    Cerbon, M.4
  • 15
    • 0014042613 scopus 로고
    • Method for the isolation of intact islets of Langerhans from the rat pancreas
    • Lacy PE, Kostianovsky M. Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes. 1967;16: 35-39.
    • (1967) Diabetes , vol.16 , pp. 35-39
    • Lacy, P.E.1    Kostianovsky, M.2
  • 17
    • 56049099074 scopus 로고    scopus 로고
    • Upregulation of GRP78 and caspase-12 in diastolic failing heart
    • Sun Y, Liu G, Song T, et al. Upregulation of GRP78 and caspase-12 in diastolic failing heart. Acta Biochim Pol. 2008;55: 511-516.
    • (2008) Acta Biochim Pol , vol.55 , pp. 511-516
    • Sun, Y.1    Liu, G.2    Song, T.3
  • 18
    • 47349119906 scopus 로고    scopus 로고
    • Androgen receptor: A new player associated with apoptosis and proliferation of pancreatic β-cell in type 1 diabetes mellitus
    • Li R, Qiu S, Wang H, Tian H, Wang L, Huo Y. Androgen receptor: a new player associated with apoptosis and proliferation of pancreatic β-cell in type 1 diabetes mellitus. Apoptosis. 2008;13(8): 959-971.
    • (2008) Apoptosis , vol.13 , Issue.8 , pp. 959-971
    • Li, R.1    Qiu, S.2    Wang, H.3    Tian, H.4    Wang, L.5    Huo, Y.6
  • 19
    • 0036098197 scopus 로고    scopus 로고
    • High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H(2) receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endothelial cells
    • Zou M, Shi C, Cohen R. High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H(2) receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endothelial cells. Diabetes. 2002;51: 198-203.
    • (2002) Diabetes , vol.51 , pp. 198-203
    • Zou, M.1    Shi, C.2    Cohen, R.3
  • 20
    • 0033564289 scopus 로고    scopus 로고
    • Protein modification during biological aging: Selective tyrosine nitration of the SERCA2a isoform of the sarcoplasmic reticulum Ca2+-ATPase in skeletal muscle
    • Viner RI, Ferrington DA, Williams TD, Bigelow DJ, Schöneich C. Protein modification during biological aging: selective tyrosine nitration of the SERCA2a isoform of the sarcoplasmic reticulum Ca2+-ATPase in skeletal muscle. Biochem J. 1999;340: 657-669.
    • (1999) Biochem J , vol.340 , pp. 657-669
    • Viner, R.I.1    Ferrington, D.A.2    Williams, T.D.3    Bigelow, D.J.4    Schöneich, C.5
  • 21
    • 0242426631 scopus 로고    scopus 로고
    • Effects of peroxynitrite on sarco/ endoplasmic reticulum Ca2+ pump isoforms SERCA2b and SERCA3a
    • Grover A, Kwan C, Samson S. Effects of peroxynitrite on sarco/ endoplasmic reticulum Ca2+ pump isoforms SERCA2b and SERCA3a. Am J Physiol Cell Physiol. 2003;285:C1537-C1543.
    • (2003) Am J Physiol Cell Physiol , vol.285
    • Grover, A.1    Kwan, C.2    Samson, S.3
  • 22
    • 19944432792 scopus 로고    scopus 로고
    • Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic β-cells
    • Cardozo A, Ortis F, Storling J, et al. Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic β-cells. Diabetes. 2005;54: 452-461.
    • (2005) Diabetes , vol.54 , pp. 452-461
    • Cardozo, A.1    Ortis, F.2    Storling, J.3
  • 23
    • 46949094048 scopus 로고    scopus 로고
    • Hormesis: Why it is important to toxicology and toxicologists
    • Calabrese E. Hormesis: why it is important to toxicology and toxicologists. Environ Toxicol Chem. 2008;27: 1451-1474.
    • (2008) Environ Toxicol Chem , vol.27 , pp. 1451-1474
    • Calabrese, E.1
  • 24
    • 33748740924 scopus 로고    scopus 로고
    • Elevated testosterone induces apoptosis in neuronal cells
    • Estrada M, Varshney A, Ehrlich B. Elevated testosterone induces apoptosis in neuronal cells. J Biol Chem. 2006;281: 25492-25501.
    • (2006) J Biol Chem , vol.281 , pp. 25492-25501
    • Estrada, M.1    Varshney, A.2    Ehrlich, B.3
  • 25
    • 5644248079 scopus 로고    scopus 로고
    • Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet β cells in diabetes
    • Robertson RP. Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet β cells in diabetes. J Biol Chem. 2004;279: 42351-42354.
    • (2004) J Biol Chem , vol.279 , pp. 42351-42354
    • Robertson, R.P.1
  • 26
    • 33750502270 scopus 로고    scopus 로고
    • Oxidative stress and impaired insulin secretion in type 2 diabetes
    • Robertson RP. Oxidative stress and impaired insulin secretion in type 2 diabetes. Curr Opin Pharmacol. 2006;6: 615-619.
    • (2006) Curr Opin Pharmacol , vol.6 , pp. 615-619
    • Robertson, R.P.1
  • 27
    • 0028229043 scopus 로고
    • Defective glucose-dependent endoplasmic reticulum Ca2+ sequestration in diabetic mouse islets of Langerhans
    • Roe MW, Philipson LH, Frangakis CJ, et al. Defective glucose-dependent endoplasmic reticulum Ca2+ sequestration in diabetic mouse islets of Langerhans. J Biol Chem. 1994;269: 18279-18282.
    • (1994) J Biol Chem , vol.269 , pp. 18279-18282
    • Roe, M.W.1    Philipson, L.H.2    Frangakis, C.J.3
  • 28
    • 0029849162 scopus 로고    scopus 로고
    • Isoforms of endoplasmic reticulum Ca(2+)-ATPase are differentially expressed in normal and diabetic islets of Langerhans
    • Váradi A, Molnár E, Ostenson CG, Ashcroft SJ. Isoforms of endoplasmic reticulum Ca(2+)-ATPase are differentially expressed in normal and diabetic islets of Langerhans. Biochem J. 1996;319: 521-527.
    • (1996) Biochem J , vol.319 , pp. 521-527
    • Váradi, A.1    Molnár, E.2    Ostenson, C.G.3    Ashcroft, S.J.4
  • 29
    • 0032523059 scopus 로고    scopus 로고
    • Apoptosis in insulin-secreting cells. Evidence for the role of intracellular Ca2+ stores and arachidonic acid metabolism
    • Zhou YP, Teng D, Dralyuk F, et al. Apoptosis in insulin-secreting cells. Evidence for the role of intracellular Ca2+ stores and arachidonic acid metabolism. J Clin Invest. 1998;101: 1623-1632.
    • (1998) J Clin Invest , vol.101 , pp. 1623-1632
    • Zhou, Y.P.1    Teng, D.2    Dralyuk, F.3
  • 30
    • 2542535432 scopus 로고    scopus 로고
    • Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+- ATPase (SERCA)-2b and -3
    • Kulkarni R, Roper M, Dahlgren G, et al. Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+- ATPase (SERCA)-2b and -3. Diabetes. 2004;53: 1517-1525.
    • (2004) Diabetes , vol.53 , pp. 1517-1525
    • Kulkarni, R.1    Roper, M.2    Dahlgren, G.3
  • 31
    • 84870873590 scopus 로고    scopus 로고
    • Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic β cell death
    • Bartolome A, Guillen C, Benito M. Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic β cell death. Autophagy. 2012;8: 1757-1768.
    • (2012) Autophagy , vol.8 , pp. 1757-1768
    • Bartolome, A.1    Guillen, C.2    Benito, M.3
  • 32
    • 0035144493 scopus 로고    scopus 로고
    • Gadd153 sensitizes cells to endoplasmic reticulum stress by downregulating Bcl2 and perturbing the cellular redox state
    • McCullough K, Martindale J, Klotz L, Aw T, Holbrook N. Gadd153 sensitizes cells to endoplasmic reticulum stress by downregulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol. 2001;21: 1249-1259.
    • (2001) Mol Cell Biol , vol.21 , pp. 1249-1259
    • McCullough, K.1    Martindale, J.2    Klotz, L.3    Aw, T.4    Holbrook, N.5
  • 33
    • 77955286961 scopus 로고    scopus 로고
    • Androgen excess produces systemic oxidative stress and predisposes to β-cell failure in female mice
    • Liu S, Navarro G, Mauvais-Jarvis F. Androgen excess produces systemic oxidative stress and predisposes to β-cell failure in female mice. PLoS One. 2010;5:e11302.
    • (2010) PLoS One , vol.5
    • Liu, S.1    Navarro, G.2    Mauvais-Jarvis, F.3
  • 35
    • 43249128538 scopus 로고    scopus 로고
    • Low testosterone levels are common and associated with insulin resistance in men with diabetes
    • Grossmann M, Thomas M, Panagiotopoulos S, et al. Low testosterone levels are common and associated with insulin resistance in men with diabetes. J Clin Endocrinol Metab. 2008;93: 1834-1840.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 1834-1840
    • Grossmann, M.1    Thomas, M.2    Panagiotopoulos, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.