Application of a resazurin-based high-throughput screening assay for the identification and progression of new treatments for human african trypanosomiasis

International Journal for Parasitology: Drugs and Drug Resistance

Volumn 2, Issue , 2012, Pages 262-270

  Bowling, Tana ^a   Mercer, Luke ^a   Don, Robert ^b   Jacobs, Robert ^a   Nare, Bakela ^a  

^a SCYNEXIS Inc   (United States)

^b Drugs for Neglected Diseases Initiative DNDi   (Switzerland)

Author keywords

High throughput screening; Hit to lead; Time to kill; Trypanosoma brucei brucei

Indexed keywords

AMIDOXIME; AMINOKETONE; AMINOOXAZOLE; ANTITRYPANOSOMAL AGENT; ARYLAZOLE; HETEROCYCLIC KETONE; OXAZOLE DERIVATIVE; PENTAMIDINE; PUROMYCIN; PYRAMIDOXIME; PYRROLE DERIVATIVE; RESAZURIN; SULFANILIDE; SURAMIN; UNCLASSIFIED DRUG;

AFRICAN TRYPANOSOMIASIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DEVELOPMENT; DRUG IDENTIFICATION; FEMALE; FIBROBLAST; HIGH THROUGHPUT SCREENING; IC 50; IN VITRO STUDY; MAMMAL CELL; MOLECULAR LIBRARY; MOUSE; NONHUMAN; PARASITE VIABILITY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TITRIMETRY; TRYPANOSOMA BRUCEI;

EID: 84886541727     PISSN: 22113207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpddr.2012.02.002     Document Type: Article

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