Implementing fluorescence anisotropy screening and crystallographic analysis to define PKA isoform-selective activation by cAMP analogs

ACS Chemical Biology

Volumn 8, Issue 10, 2013, Pages 2164-2172

  Brown, Simon H J ^a,e   Cheng, Cecilia Y ^a   Saldanha, S Adrian ^a   Wu, Jian ^a   Cottam, Howard B ^c   Sankaran, Banumathi ^d   Taylor, Susan S ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^e UNIVERSITY OF WOLLONGONG   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; ISOPROTEIN;

ANISOTROPY; ARTICLE; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME STRUCTURE; FLUORESCENCE ANALYSIS; HYDROPHOBICITY; PRIORITY JOURNAL; SECOND MESSENGER; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; FLUORESCENCE POLARIZATION; METABOLISM; X RAY DIFFRACTION;

CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; FLUORESCENCE POLARIZATION; MODELS, MOLECULAR; PROTEIN ISOFORMS; SUBSTRATE SPECIFICITY; X-RAY DIFFRACTION;

EID: 84886527653     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb400247t     Document Type: Article

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