Nonagenarians from the Swedish NONA Immune Study have increased plasma antioxidant capacity and similar levels of DNA damage in peripheral blood mononuclear cells compared to younger control subjects

Experimental Gerontology

Volumn 37, Issue 2-3, 2002, Pages 465-473

  Hyland, Paul ^a   Duggan, Orla ^a   Turbitt, Julie ^a   Coulter, James ^a   Wikby, Anders ^b   Johansson, Boo ^b   Tompa, Andrea ^b   Barnett, Christopher ^a   Barnett, Yvonne ^a  

^a UNIVERSITY OF ULSTER   (United Kingdom)

^b JÖNKÖPING UNIVERSITY   (Sweden)

Author keywords

Antioxidant capacity; Ferric reducing ability of plasma assay; Immunosenescence; NONA Immune Study; Nonagenarians; Oxidative DNA damage; Peripheral blood mononuclear cells

Indexed keywords

ANTIOXIDANT;

AGED; ARTICLE; ASSAY; BLOOD; CELL DAMAGE; CELL FUNCTION; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; ENZYME MODIFICATION; FEMALE; HUMAN; HUMAN EXPERIMENT; IMMUNE SYSTEM; IN VIVO STUDY; LONGEVITY; MALE; MONONUCLEAR CELL; NORMAL HUMAN; PRIORITY JOURNAL; SWEDEN; T LYMPHOCYTE;

ADULT; AGED; AGED, 80 AND OVER; AGING; ANTIOXIDANTS; DNA DAMAGE; FEMALE; FERRIC COMPOUNDS; FERROUS COMPOUNDS; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; OXIDATION-REDUCTION; SWEDEN;

EID: 0037012017     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(01)00216-9     Document Type: Article

References (35)

1. Mutagenesis and carcinogenesis: Endogenous and exogenous factors
2. Oxidants, antioxidants, and the degenerative diseases of ageing
3. Purification and characterization of Escherichia coli endonuclease III from the cloned nth gene
4. DNA damage and mutation: Contributors to the age-related alterations in T cell-mediated immune responses?
5. An investigation of in vivo antioxidant status, mutation and DNA repair capacity in human lymphocytes as a function of age
6. Age-related increases in DNA damage and mutations in T cells in vivo and in vitro: Contributors to alterations in T cell mediated immune responses?
7. Absolute peripheral blood lymphocyte count and subsequent mortality of elderly men. The Baltimore Longitudinal Study of Aging
8. An automated, specific, spectrophotometric method for measuring ascorbic acid in plasma (EFTSA)
9. The ferric reducing ability of plasma FRAP as a measure of antioxidant power: The FRAP assay
10. Substrate specificity of the Escherichia coli FPG protein formamidopyrimidine-DNA glycosylase: Excision of purine lesions in DNA produced by ionising radiation or photosensitisation
11. Free radicals, antioxidants and ageing
12. Direct enzymatic detection of endogenous oxidative base damage in human lymphocyte DNA
13. Immune parameters in a longitudinal study of a very old population of Swedish people: A comparison between survivors and non-survivors
14. The immunology of exceptional individuals: The lesson of centenarians
15. Aging: A theory based on free radical and radiation chemistry
16. The effects of carnosine on oxidative DNA damage levels and in vitro lifespan in human peripheral derived CD4 + T cell clones
17. Age-related accumulation of oxidative DNA damage and alterations in levels of p16INK4a/CDKN2a, p21WAF1/CIP1/SDI1 and p27KIP1 in human CD4 + T cell clones in vitro
18. An investigation of mutation as a function of age in humans
19. In vivo antioxidant status, DNA damage, mutation and DNA repair capacity in cultured lymphocytes from healthy 75-80 year old humans
20. Instability and decay of the primary structure of DNA
21. Specific spectrophotometry of ascorbic-acid in serum or plasma by use of ascorbate oxidase
22. Plasma antioxidants and longevity: A study on healthy centenarians
23. Association of lack of mitogen induced lymphocyte proliferation with increased mortality in the elderly
24. Selection protocols does not influence the CD4 and CD8 T cell phenotypes in the elderly: The Swedish longitudinal NONA Immune Study
25. Age-related change in peripheral blood T-lymphocyte sub-populations and cytomegalovirus infection in the very old: The Swedish longitudinal OCTO immune study
26. T cells and Ageing
27. Ageing, immune response and mortality
28. T lymphocyte proliferative capability to defined stimuli and co-stimulatory CD28 pathway is not impaired in healthy centenarians
29. Review: Reactive oxygen species and biological aging - A mechanistic approach
30. A simple technique for quantification of low levels of DNA damage in individual cells
31. Immunology of centenarians
32. Cell-mediated immunity as a predictor of morbidity and mortality in subjects over 60
33. Age-related changes in immune parameters in a very old population of Swedish people: A longitudinal study
34. Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: The Swedish longitudinal OCTO-immune study
35. Somatic mutation and ageing: Cause or effect?