메뉴 건너뛰기




Volumn 180, Issue 4, 2013, Pages 414-421

EGFR-inhibition enhances apoptosis in irradiated human head and neck xenograft tumors independent of effects on DNA repair

Author keywords

[No Author keywords available]

Indexed keywords

CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3;

EID: 84886480919     PISSN: 00337587     EISSN: 19385404     Source Type: Journal    
DOI: 10.1667/RR3349.2     Document Type: Article
Times cited : (9)

References (39)
  • 1
    • 0037115674 scopus 로고    scopus 로고
    • Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma
    • Ang KK, Berkey BA, Tu X, Zhang HZ, Katz R, Hammond EH, et al. Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma. Cancer Res 2002; 62: 7350-6.
    • (2002) Cancer Res , vol.62 , pp. 7350-7356
    • Ang, K.K.1    Berkey, B.A.2    Tu, X.3    Zhang, H.Z.4    Katz, R.5    Hammond, E.H.6
  • 3
    • 59649123356 scopus 로고    scopus 로고
    • High rate of severe radiation dermatitis during radiation therapy with concurrent cetuximab in head and neck cancer: Results of a survey in EORTC institutes
    • Giro C, Berger B, Bolke E, Ciernik IF, Duprez F, Locati L, et al. High rate of severe radiation dermatitis during radiation therapy with concurrent cetuximab in head and neck cancer: results of a survey in EORTC institutes. Radiother Oncol 2009; 90: 166-71.
    • (2009) Radiother Oncol , vol.90 , pp. 166-171
    • Giro, C.1    Berger, B.2    Bolke, E.3    Ciernik, I.F.4    Duprez, F.5    Locati, L.6
  • 5
    • 78651368497 scopus 로고    scopus 로고
    • Toxicity of cetuximab versus cisplatin concurrent with radiotherapy in locally advanced head and neck squamous cell cancer (LAHNSCC)
    • Walsh L, Gillham C, Dunne M, Fraser I, Hollywood D, Armstrong J, et al. Toxicity of cetuximab versus cisplatin concurrent with radiotherapy in locally advanced head and neck squamous cell cancer (LAHNSCC). Radiother Oncol 2011; 98: 38-41.
    • (2011) Radiother Oncol , vol.98 , pp. 38-41
    • Walsh, L.1    Gillham, C.2    Dunne, M.3    Fraser, I.4    Hollywood, D.5    Armstrong, J.6
  • 6
    • 77956268839 scopus 로고    scopus 로고
    • Understanding resistance to EGFR inhibitors-impact on future treatment strategies
    • Wheeler DL, Dunn EF, Harari PM, Understanding resistance to EGFR inhibitors-impact on future treatment strategies. Nat Rev Clin Oncol 2010; 7: 493-507.
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 493-507
    • Wheeler, D.L.1    Dunn, E.F.2    Harari, P.M.3
  • 7
    • 42049116522 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells
    • Fuchs BC, Fujii T, Dorfman JD, Goodwin JM, Zhu AX, Lanuti M, et al. Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells. Cancer Res 2008; 68: 2391-9.
    • (2008) Cancer Res , vol.68 , pp. 2391-2399
    • Fuchs, B.C.1    Fujii, T.2    Dorfman, J.D.3    Goodwin, J.M.4    Zhu, A.X.5    Lanuti, M.6
  • 8
    • 77953960942 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition and cmyc expression are the determinants of cetuximab-induced enhancement of squamous cell carcinoma radioresponse
    • Skvortsova I, Skvortsov S, Raju U, Stasyk T, Riesterer O, Schottdorf EM, et al. Epithelial-to-mesenchymal transition and cmyc expression are the determinants of cetuximab-induced enhancement of squamous cell carcinoma radioresponse. Radiother Oncol 2010; 96: 108-15.
    • (2010) Radiother Oncol , vol.96 , pp. 108-115
    • Skvortsova, I.1    Skvortsov, S.2    Raju, U.3    Stasyk, T.4    Riesterer, O.5    Schottdorf, E.M.6
  • 9
    • 65349189958 scopus 로고    scopus 로고
    • American society of clinical oncology provisional clinical opinion: Testing for kras gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy
    • Allegra CJ, Jessup JM, Somerfield MR, Hamilton SR, Hammond EH, Hayes DF, et al. American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy. J Clin Oncol 2009; 27: 2091-6.
    • (2009) J Clin Oncol , vol.27 , pp. 2091-2096
    • Allegra, C.J.1    Jessup, J.M.2    Somerfield, M.R.3    Hamilton, S.R.4    Hammond, E.H.5    Hayes, D.F.6
  • 10
    • 74949117339 scopus 로고    scopus 로고
    • Somatic EGFR mutation and gene copy gain as predictive biomarkers for response to tyrosine kinase inhibitors in non-small cell lung cancer
    • Dahabreh IJ, Linardou H, Siannis F, Kosmidis P, Bafaloukos D, Murray S. Somatic EGFR mutation and gene copy gain as predictive biomarkers for response to tyrosine kinase inhibitors in non-small cell lung cancer. Clin Cancer Res 2010; 16: 291-303.
    • (2010) Clin Cancer Res , vol.16 , pp. 291-303
    • Dahabreh, I.J.1    Linardou, H.2    Siannis, F.3    Kosmidis, P.4    Bafaloukos, D.5    Murray, S.6
  • 11
    • 84880544985 scopus 로고    scopus 로고
    • Recommendations from the EGAPP Working Group: Can testing of tumor tissue for mutations in EGFR pathway downstream effector genes in patients with metastatic colorectal cancer improve health outcomes by guiding decisions regarding anti-EGFR therapy?
    • Calonge N, Fisher NL, Berg AO, Campos-Outcalt D, Djulbegovic B, Ganiats TG, et al. Recommendations from the EGAPP Working Group: can testing of tumor tissue for mutations in EGFR pathway downstream effector genes in patients with metastatic colorectal cancer improve health outcomes by guiding decisions regarding anti-EGFR therapy? Genet Med 2013.
    • (2013) Genet Med
    • Calonge, N.1    Fisher, N.L.2    Berg, A.O.3    Campos-Outcalt, D.4    Djulbegovic, B.5    Ganiats, T.G.6
  • 12
    • 29144520704 scopus 로고    scopus 로고
    • Low incidence of mutations in EGFR kinase domain in Caucasian patients with head and neck squamous cell carcinoma
    • Loeffler-Ragg J, Witsch-Baumgartner M, Tzankov A, Hilbe W, Schwentner I, Sprinzl GM, et al. Low incidence of mutations in EGFR kinase domain in Caucasian patients with head and neck squamous cell carcinoma. Eur J Cancer 2006; 42: 109-11.
    • (2006) Eur J Cancer , vol.42 , pp. 109-111
    • Loeffler-Ragg, J.1    Witsch-Baumgartner, M.2    Tzankov, A.3    Hilbe, W.4    Schwentner, I.5    Sprinzl, G.M.6
  • 13
    • 77951961432 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and K-RAS status in two cohorts of squamous cell carcinomas
    • Van Damme N, Deron P, Van Roy N, Demetter P, Bols A, Van Dorpe J, et al. Epidermal growth factor receptor and K-RAS status in two cohorts of squamous cell carcinomas. BMC Cancer 2010; 10, 189.
    • (2010) BMC Cancer , vol.10 , pp. 189
    • Van Damme, N.1    Deron, P.2    Van Roy, N.3    Demetter, P.4    Bols, A.5    Van Dorpe, J.6
  • 16
    • 66149094649 scopus 로고    scopus 로고
    • Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells
    • Golding SE, Morgan RN, Adams BR, Hawkins AJ, Povirk LF, Valerie K. Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells. Cancer Biol Ther 2009; 8: 730-8.
    • (2009) Cancer Biol Ther , vol.8 , pp. 730-738
    • Golding, S.E.1    Morgan, R.N.2    Adams, B.R.3    Hawkins, A.J.4    Povirk, L.F.5    Valerie, K.6
  • 17
    • 77955277480 scopus 로고    scopus 로고
    • The epidermal growth factor receptor modulates DNA double-strand break repair by regulating nonhomologous end-joining
    • Kriegs M, Kasten-Pisula U, Rieckmann T, Holst K, Saker J, Dahm-Daphi J, et al. The epidermal growth factor receptor modulates DNA double-strand break repair by regulating nonhomologous end-joining. DNA Repair (Amst) 2010; 9: 889-97.
    • (2010) DNA Repair (Amst) , vol.9 , pp. 889-897
    • Kriegs, M.1    Kasten-Pisula, U.2    Rieckmann, T.3    Holst, K.4    Saker, J.5    Dahm-Daphi, J.6
  • 18
    • 36849032852 scopus 로고    scopus 로고
    • Radiation-induced EGFR-signaling and control of DNA-damage repair
    • Rodemann HP, Dittmann K, Toulany M. Radiation-induced EGFR-signaling and control of DNA-damage repair. Int J Radiat Biol 2007; 83: 781-91.
    • (2007) Int J Radiat Biol , vol.83 , pp. 781-791
    • Rodemann, H.P.1    Dittmann, K.2    Toulany, M.3
  • 19
    • 33746088022 scopus 로고    scopus 로고
    • Blockage of epidermal growth factor receptorphosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair
    • Toulany M, Kasten-Pisula U, Brammer I, Wang S, Chen J, Dittmann K, et al. Blockage of epidermal growth factor receptorphosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair. Clin Cancer Res 2006; 12: 4119-26.
    • (2006) Clin Cancer Res , vol.12 , pp. 4119-4126
    • Toulany, M.1    Kasten-Pisula, U.2    Brammer, I.3    Wang, S.4    Chen, J.5    Dittmann, K.6
  • 20
    • 40749094856 scopus 로고    scopus 로고
    • Activation of the PI3- K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer
    • Bussink J, van der Kogel AJ, Kaanders JH. Activation of the PI3- K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer. Lancet Oncol 2008; 9, 288-96.
    • (2008) Lancet Oncol , vol.9 , pp. 288-296
    • Bussink, J.1    Van Der Kogel, A.J.2    Kaanders, J.H.3
  • 21
    • 24744449739 scopus 로고    scopus 로고
    • Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase
    • Dittmann K, Mayer C, Fehrenbacher B, Schaller M, Raju U, Milas L, et al. Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase. J Biol Chem 2005; 280: 31182-9.
    • (2005) J Biol Chem , vol.280 , pp. 31182-31189
    • Dittmann, K.1    Mayer, C.2    Fehrenbacher, B.3    Schaller, M.4    Raju, U.5    Milas, L.6
  • 22
    • 28444453967 scopus 로고    scopus 로고
    • Inhibition of radiationinduced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity
    • Dittmann K, Mayer C, Rodemann HP. Inhibition of radiationinduced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity. Radiother Oncol 2005; 76: 157-61.
    • (2005) Radiother Oncol , vol.76 , pp. 157-161
    • Dittmann, K.1    Mayer, C.2    Rodemann, H.P.3
  • 23
    • 29244437908 scopus 로고    scopus 로고
    • The role of double-strand break repair - Insights from human genetics
    • O'Driscoll M, Jeggo PA. The role of double-strand break repair - insights from human genetics. Nat Rev Genet 2006; 7: 45-54.
    • (2006) Nat Rev Genet , vol.7 , pp. 45-54
    • O'Driscoll, M.1    Jeggo, P.A.2
  • 24
    • 17144371349 scopus 로고    scopus 로고
    • Mechanisms of enhanced radiation response following epidermal growth factor receptor signaling inhibition by erlotinib (Tarceva)
    • Chinnaiyan P, Huang S, Vallabhaneni G, Armstrong E, Varambally S, Tomlins SA, et al. Mechanisms of enhanced radiation response following epidermal growth factor receptor signaling inhibition by erlotinib (Tarceva). Cancer Res 2005; 65: 3328-35.
    • (2005) Cancer Res , vol.65 , pp. 3328-3335
    • Chinnaiyan, P.1    Huang, S.2    Vallabhaneni, G.3    Armstrong, E.4    Varambally, S.5    Tomlins, S.A.6
  • 25
    • 56449098784 scopus 로고    scopus 로고
    • Erlotinib attenuates homologous recombinational repair of chromosomal breaks in human breast cancer cells
    • Li L, Wang H, Yang ES, Arteaga CL, Xia F. Erlotinib attenuates homologous recombinational repair of chromosomal breaks in human breast cancer cells. Cancer Res 2008; 68: 9141-6.
    • (2008) Cancer Res , vol.68 , pp. 9141-9146
    • Li, L.1    Wang, H.2    Yang, E.S.3    Arteaga, C.L.4    Xia, F.5
  • 26
    • 80655127846 scopus 로고    scopus 로고
    • In tumor cells regulation of DNA double strand break repair through EGF receptor involves both NHEJ and HR and is independent of p53 and K-Ras status
    • Myllynen L, Rieckmann T, Dahm-Daphi J, Kasten-Pisula U, Petersen C, Dikomey E, et al. In tumor cells regulation of DNA double strand break repair through EGF receptor involves both NHEJ and HR and is independent of p53 and K-Ras status. Radiother Oncol 2011; 101: 147-51.
    • (2011) Radiother Oncol , vol.101 , pp. 147-151
    • Myllynen, L.1    Rieckmann, T.2    Dahm-Daphi, J.3    Kasten-Pisula, U.4    Petersen, C.5    Dikomey, E.6
  • 27
    • 3142587028 scopus 로고    scopus 로고
    • Tumor microenvironmental physiology and its implications for radiation oncology
    • Vaupel P. Tumor microenvironmental physiology and its implications for radiation oncology. Semin Radiat Oncol 2004; 14: 198-206.
    • (2004) Semin Radiat Oncol , vol.14 , pp. 198-206
    • Vaupel, P.1
  • 28
    • 4544324453 scopus 로고    scopus 로고
    • Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells
    • Bindra RS, Schaffer PJ, Meng A, Woo J, Maseide K, Roth ME, et al. Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells. Mol Cell Biol 2004; 24: 8504-18.
    • (2004) Mol Cell Biol , vol.24 , pp. 8504-8518
    • Bindra, R.S.1    Schaffer, P.J.2    Meng, A.3    Woo, J.4    Maseide, K.5    Roth, M.E.6
  • 29
    • 39049163047 scopus 로고    scopus 로고
    • Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance
    • Chan N, Koritzinsky M, Zhao H, Bindra R, Glazer PM, Powell S, et al. Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance. Cancer Res 2008; 68: 605-14.
    • (2008) Cancer Res , vol.68 , pp. 605-614
    • Chan, N.1    Koritzinsky, M.2    Zhao, H.3    Bindra, R.4    Glazer, P.M.5    Powell, S.6
  • 30
    • 84876146036 scopus 로고    scopus 로고
    • Predictive value of hypoxia, proliferation and tyrosine kinase receptors for EGFR-inhibition and radiotherapy sensitivity in head and neck cancer models
    • Stegeman H, Kaanders JH, van der Kogel AJ, Iida M, Wheeler DL, Span PN, et al. Predictive value of hypoxia, proliferation and tyrosine kinase receptors for EGFR-inhibition and radiotherapy sensitivity in head and neck cancer models. Radiother Oncol 2013; 106: 383-89.
    • (2013) Radiother Oncol , vol.106 , pp. 383-389
    • Stegeman, H.1    Kaanders, J.H.2    Van Der Kogel, A.J.3    Iida, M.4    Wheeler, D.L.5    Span, P.N.6
  • 31
    • 34548803430 scopus 로고    scopus 로고
    • Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer
    • Franovic A, Gunaratnam L, Smith K, Robert I, Patten D, Lee S. Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer. Proc Natl Acad Sci U S A 2007; 104: 13092-7.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 13092-13097
    • Franovic, A.1    Gunaratnam, L.2    Smith, K.3    Robert, I.4    Patten, D.5    Lee, S.6
  • 32
    • 77954370385 scopus 로고    scopus 로고
    • HIF-2falphag-mediated activation of the epidermal growth factor receptor potentiates head and neck cancer cell migration in response to hypoxia
    • Wang X, Schneider A. HIF-2falphag-mediated activation of the epidermal growth factor receptor potentiates head and neck cancer cell migration in response to hypoxia. Carcinogenesis 2010; 31: 1202-10.
    • (2010) Carcinogenesis , vol.31 , pp. 1202-1210
    • Wang, X.1    Schneider, A.2
  • 33
    • 77953009791 scopus 로고    scopus 로고
    • The distribution of the therapeutic monoclonal antibodies cetuximab and trastuzumab within solid tumors
    • Lee CM, Tannock IF. The distribution of the therapeutic monoclonal antibodies cetuximab and trastuzumab within solid tumors. BMC Cancer 2010; 10: 255.
    • (2010) BMC Cancer , vol.10 , pp. 255
    • Lee, C.M.1    Tannock, I.F.2
  • 34
    • 80051783228 scopus 로고    scopus 로고
    • Residual DNA double strand breaks in perfused but not in unperfused areas determine different radiosensitivity of tumours
    • Menegakis A, Eicheler W, Yaromina A, Thames HD, Krause M, Baumann M. Residual DNA double strand breaks in perfused but not in unperfused areas determine different radiosensitivity of tumours. Radiother Oncol 2011; 100: 137-44.
    • (2011) Radiother Oncol , vol.100 , pp. 137-144
    • Menegakis, A.1    Eicheler, W.2    Yaromina, A.3    Thames, H.D.4    Krause, M.5    Baumann, M.6
  • 35
    • 0942278942 scopus 로고    scopus 로고
    • Phosphorylation of histone H2AX as a measure of radiosensitivity
    • Olive PL, Banath JP. Phosphorylation of histone H2AX as a measure of radiosensitivity. Int J Radiat Oncol Biol Phys 2004; 58: 331-5.
    • (2004) Int J Radiat Oncol Biol Phys , vol.58 , pp. 331-335
    • Olive, P.L.1    Banath, J.P.2
  • 36
    • 84858119890 scopus 로고    scopus 로고
    • Chronic hypoxia compromises repair of DNA double-strand breaks to drive genetic instability
    • Kumareswaran R, Ludkovski O, Meng A, Sykes J, Pintilie M, Bristow RG. Chronic hypoxia compromises repair of DNA double-strand breaks to drive genetic instability. J Cell Sci 2012; 125: 189-99.
    • (2012) J Cell Sci , vol.125 , pp. 189-199
    • Kumareswaran, R.1    Ludkovski, O.2    Meng, A.3    Sykes, J.4    Pintilie, M.5    Bristow, R.G.6
  • 37
    • 28444478320 scopus 로고    scopus 로고
    • Hypoxia down-regulates DNA double strand break repair gene expression in prostate cancer cells
    • Meng AX, Jalali F, Cuddihy A, Chan N, Bindra RS, Glazer PM, et al. Hypoxia down-regulates DNA double strand break repair gene expression in prostate cancer cells. Radiother Oncol 2005; 76: 168-76.
    • (2005) Radiother Oncol , vol.76 , pp. 168-176
    • Meng, A.X.1    Jalali, F.2    Cuddihy, A.3    Chan, N.4    Bindra, R.S.5    Glazer, P.M.6
  • 38
    • 2942530310 scopus 로고    scopus 로고
    • ERK and p38 MAPK-activated protein kinases: A family of protein kinases with diverse biological functions
    • Roux PP, Blenis J, ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev 2004; 68, 320-44.
    • (2004) Microbiol Mol Biol Rev , vol.68 , pp. 320-344
    • Roux, P.P.1    Blenis, J.2
  • 39
    • 65649093367 scopus 로고    scopus 로고
    • The role of apoptosis in radiation oncology
    • Meyn RE, Milas L, Ang KK. The role of apoptosis in radiation oncology. Int J Radiat Biol 2009; 85: 107-15.
    • (2009) Int J Radiat Biol , vol.85 , pp. 107-115
    • Meyn, R.E.1    Milas, L.2    Ang, K.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.