-
1
-
-
4344668661
-
Drug repositioning: Identifying and developing new uses for existing drugs
-
Drug Discovery
-
Ashburn, T.T., Thor, K.B. (2004). Drug repositioning: Identifying and developing new uses for existing drugs. Nature Reviews. Drug Discovery, 3, 673.
-
(2004)
Nature Reviews
, vol.3
, pp. 673
-
-
Ashburn, T.T.1
Thor, K.B.2
-
2
-
-
65649112521
-
The value of drug repositioning in the current pharmaceutical market
-
Tobinick, E.L. (2009). The value of drug repositioning in the current pharmaceutical market. Drug News & Perspectives, 22, 119.
-
(2009)
Drug News & Perspectives
, vol.22
, pp. 119
-
-
Tobinick, E.L.1
-
3
-
-
65649114787
-
Drug repositioning summit: Finding new routes to success
-
Campas, C. (2009). Drug repositioning summit: Finding new routes to success. Drug News & Perspectives, 22, 126.
-
(2009)
Drug News & Perspectives
, vol.22
, pp. 126
-
-
Campas, C.1
-
4
-
-
78951480503
-
Pharmaceutical innovation in the 21st century: New drug approvals in the first decade
-
Kaitin, K.I., DiMasi, J.A. (2011). Pharmaceutical innovation in the 21st century: New drug approvals in the first decade, 2000 - 2009. Clinical Pharmacology and Therapeutics, 89, 183.
-
(2011)
2000-2009. Clinical Pharmacology and Therapeutics
, vol.89
, pp. 183
-
-
Kaitin, K.I.1
DiMasi, J.A.2
-
5
-
-
77149155968
-
Trends in risks associated with new drug development: Success rates for investigational drugs
-
DiMasi, J.A., Feldman, L., Seckler, A., Wilson, A. (2010). Trends in risks associated with new drug development: Success rates for investigational drugs. Clinical Pharmacology and Therapeutics, 87, 272.
-
(2010)
Clinical Pharmacology and Therapeutics
, vol.87
, pp. 272
-
-
DiMasi, J.A.1
Feldman, L.2
Seckler, A.3
Wilson, A.4
-
6
-
-
84886494864
-
-
CMR International 2010 Global R & D Performance Metrics Programme
-
CMR International 2010 Global R & D Performance Metrics Programme. http:// cmr.thomsonreuters.com/services/programs/randd/.
-
-
-
-
7
-
-
84886509411
-
-
CMR International 2011 Pharmaceutical Fact Book
-
CMR International 2011 Pharmaceutical Fact Book. http://cmr.thomsonreuters.com/.
-
-
-
-
8
-
-
84886498521
-
-
IMS Institute for Healthcare Informatics The Global Use of Medicines: Outlook through 2015; May 2011
-
IMS Institute for Healthcare Informatics (2011) The Global Use of Medicines: Outlook through 2015; May 2011
-
(2011)
-
-
-
9
-
-
84886513952
-
Beyond the Patent Cliff
-
EvaluatePharmaWorld preview 2016 (June, 2011)
-
EvaluatePharma World preview 2016 " Beyond the Patent Cliff " (June, 2011)
-
-
-
-
10
-
-
73449101512
-
Lessons from 60 years of pharmaceutical innovation
-
Munos, B. (2009). Lessons from 60 years of pharmaceutical innovation. Nature Reviews. Drug Discovery, 8, 959.
-
(2009)
Nature Reviews. Drug Discovery
, vol.8
, pp. 959
-
-
Munos, B.1
-
11
-
-
84886450684
-
-
Food and Drug Administration (FDA) Drug and Biologic Approval Reports
-
Food and Drug Administration (FDA) Drug and Biologic Approval Reports. http://www.fda.gov/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/DrugandBiologicApprovalReports/ default.htm
-
-
-
-
12
-
-
79551575056
-
Trial watch phase III and submission failures: 2007-2010
-
Arrowsmith, J. (2011). Trial watch phase III and submission failures: 2007 - 2010. Nature Reviews. Drug Discovery, 10 (1), 87.
-
(2011)
Nature Reviews. Drug Discovery
, vol.10
, Issue.1
, pp. 87
-
-
Arrowsmith, J.1
-
13
-
-
79960241809
-
Changing end points in breast - cancer drug approval - The avastin story
-
D'Agostino, R.B. (2011). Changing end points in breast - cancer drug approval - The avastin story. The New England journal of medicine, 365, e2.
-
(2011)
The New England journal of medicine
, vol.365
-
-
D'Agostino, R.B.1
-
14
-
-
84886467559
-
-
Food and Drug Administration (FDA) Drug and Biologic Approval Reports
-
Food and Drug Administration (FDA) Drug and Biologic Approval Reports. http:// www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/ Guidances/ucm071590.pdf
-
-
-
-
16
-
-
84886571204
-
-
Food and Drug Administration (FDA) Drug and Biologic Approval Reports
-
Food and Drug Administration (FDA) Drug and Biologic Approval Reports. http://www.fda.gov/downloads/Drugs/ScienceResearch/ResearchAreas/ Pharmacogenetics/ucm085575.pdf
-
-
-
-
17
-
-
84886533758
-
-
Food and Drug Administration (FDA) Drug and Biologic Approval Reports
-
Food and Drug Administration (FDA) Drug and Biologic Approval Reports. http:// www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/ucm215089.htm
-
-
-
-
18
-
-
84886552716
-
-
Food and Drug Administration (FDA) Drug and Biologic Approval Reports
-
Food and Drug Administration (FDA) Drug and Biologic Approval Reports. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/ WC500003517.pdf
-
-
-
-
19
-
-
33244494235
-
Teaching an old drug new tricks
-
Jarvis, L. (2006). Teaching an old drug new tricks. Chemical and Engineering News, 84, 52.
-
(2006)
Chemical and Engineering News
, vol.84
, pp. 52
-
-
Jarvis, L.1
-
20
-
-
33747584123
-
One drug, six men, disaster
-
Bhattacharya, S., Coghlan, A. (2006). One drug, six men, disaster. New scientist (1971), Mar 25 - 31; 189 (2544), 10 - 11.
-
(2006)
New scientist (1971), Mar 25-31;
, vol.189
, Issue.2544
, pp. 10-11
-
-
Bhattacharya, S.1
Coghlan, A.2
-
21
-
-
0037291745
-
Thalidomide: A review of approved and investigational uses
-
Matthews, S.J., McCoy, C. (2003). Thalidomide: A review of approved and investigational uses. Clinical Therapeutics, 25, 342.
-
(2003)
Clinical Therapeutics
, vol.25
, pp. 342
-
-
Matthews, S.J.1
McCoy, C.2
-
22
-
-
61549099680
-
Application of drug repositioning strategy to TOFISOPAM. Current Medicinal Chemistry
-
Bernard, P., Dufresne - Favetta, C., Favetta, P., Do, Q.T., Himbert, F., Zubrzycki, S., Scior, T., Lugnier, C.P. (2008). Application of drug repositioning strategy to TOFISOPAM. Current Medicinal Chemistry, 15, 3196.
-
(2008)
, vol.15
, pp. 3196
-
-
Bernard, P.1
Dufresne-Favetta, C.2
Favetta, P.3
Do, Q.T.4
Himbert, F.5
Zubrzycki, S.6
Scior, T.7
Lugnier, C.P.8
-
23
-
-
34547522758
-
-
Bisson, W.H., Cheltsov, A.V., Bruey-Sedano, N., Lin, B., Chen, J., Goldberger, N., May, L.T., Christopoulos, A., Dalton, J.T., Sexton, P.M., Zhang, X.K., Abagyan, R. (2007). Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs. Proceedings of the National Academy of Sciences of the United States of America, 104, 11927.
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, pp. 11927
-
-
Bisson, W.H.1
Cheltsov, A.V.2
Bruey-Sedano, N.3
Lin, B.4
Chen, J.5
Goldberger, N.6
May, L.T.7
Christopoulos, A.8
Dalton, J.T.9
Sexton, P.M.10
Zhang, X.K.11
Abagyan, R.12
-
24
-
-
77953387346
-
Drug repositioning using in silico compound profiling
-
Dubus, E., Ijjaali, I., Barberan, O., Petitet, F. (2009). Drug repositioning using in silico compound profiling. Future Medicinal Chemistry, 1, 1723.
-
(2009)
Future Medicinal Chemistry
, vol.1
, pp. 1723
-
-
Dubus, E.1
Ijjaali, I.2
Barberan, O.3
Petitet, F.4
-
25
-
-
77954266960
-
SMAP - WS: A parallel web service for structural proteome - wide ligand - binding site comparison
-
Ren, J.Y., Xie, L., Li, W.W., Bourne, P.E. (2010). SMAP - WS: A parallel web service for structural proteome - wide ligand - binding site comparison. Nucleic Acids Research, 38, W441.
-
(2010)
Nucleic Acids Research
, vol.38
-
-
Ren, J.Y.1
Xie, L.2
Li, W.W.3
Bourne, P.E.4
-
26
-
-
78649231963
-
Computational modeling of kinase inhibitor selectivity
-
Subramanian, G., Sud, M. (2010). Computational modeling of kinase inhibitor selectivity. ACS Medicinal Chemistry Letters, 1, 395.
-
(2010)
ACS Medicinal Chemistry Letters
, vol.1
, pp. 395
-
-
Subramanian, G.1
Sud, M.2
-
27
-
-
45349090195
-
In vitro activity of artemisinin in combination with clotrimazole or heat - treated amphotericin B against Plasmodium falciparum
-
Bhattacharya, A., Mishra, L.C., Bhasin, V.K. (2008). In vitro activity of artemisinin in combination with clotrimazole or heat - treated amphotericin B against Plasmodium falciparum. The American Journal of Tropical Medicine and Hygiene, 78, 721.
-
(2008)
The American Journal of Tropical Medicine and Hygiene
, vol.78
, pp. 721
-
-
Bhattacharya, A.1
Mishra, L.C.2
Bhasin, V.K.3
-
28
-
-
77957044703
-
Discovery of drug mode of action and drug repositioning from transcriptional responses
-
Iorio, F., Bosotti, R., Scacheri, E., Belcastro, V., Mithbaokar, P., Ferriero, R., Murino, L., Tagliaferri, R., Brunetti-Pierri, N., Isacchi, A., Di Bernardo, D. (2010). Discovery of drug mode of action and drug repositioning from transcriptional responses. Proceedings of the National Academy of Sciences of the United States of America, 107, 14621.
-
(2010)
Proceedings of the National Academy of Sciences of the United States of America
, vol.107
, pp. 14621
-
-
Iorio, F.1
Bosotti, R.2
Scacheri, E.3
Belcastro, V.4
Mithbaokar, P.5
Ferriero, R.6
Murino, L.7
Tagliaferri, R.8
Brunetti-Pierri, N.9
Isacchi, A.10
Di Bernardo, D.11
-
29
-
-
68249144628
-
Drug discovery using chemical systems biology: Repositioning the safe medicine Comtan to treat multi - drug and extensively drug resistant tuberculosis
-
Kinnings, S.L., Liu, N., Buchmeier, N., Tonge, P.J., Xie, L., Bourne, P.E. (2009). Drug discovery using chemical systems biology: Repositioning the safe medicine Comtan to treat multi - drug and extensively drug resistant tuberculosis. PLoS Computational Biology, 5, e1000423.
-
(2009)
PLoS Computational Biology
, vol.5
-
-
Kinnings, S.L.1
Liu, N.2
Buchmeier, N.3
Tonge, P.J.4
Xie, L.5
Bourne, P.E.6
-
30
-
-
33750132664
-
Complementary new approaches enable repositioning of failed drug candidates
-
Tartaglia, L.A. (2006). Complementary new approaches enable repositioning of failed drug candidates. Expert Opinion on Investigational Drugs, 15, 1295.
-
(2006)
Expert Opinion on Investigational Drugs
, vol.15
, pp. 1295
-
-
Tartaglia, L.A.1
-
31
-
-
77956040787
-
Exploiting drug repositioning for discovery of a novel HIV combination therapy
-
Clouser, C.L., Patterson, S.E., Mansky, L.M. (2010). Exploiting drug repositioning for discovery of a novel HIV combination therapy. Journal of Virology, 84, 9301.
-
(2010)
Journal of Virology
, vol.84
, pp. 9301
-
-
Clouser, C.L.1
Patterson, S.E.2
Mansky, L.M.3
-
32
-
-
38049093745
-
Nelfinavir, a new anti - cancer drug with pleiotropic effects and many paths to autophagy
-
Gills, J.J., LoPiccolo, J., Dennis, P.A. (2008). Nelfinavir, a new anti - cancer drug with pleiotropic effects and many paths to autophagy. Autophagy, 4, 107.
-
(2008)
Autophagy
, vol.4
, pp. 107
-
-
Gills, J.J.1
LoPiccolo, J.2
Dennis, P.A.3
-
33
-
-
84886516630
-
A drug candidate for type II diabetes with a novel molecular target discovered by using an in vivo drug repositioning approach
-
CINF 14 - MLR - 1023
-
Saporito, M.S. et al. (2007). CINF 14 - MLR - 1023: A drug candidate for type II diabetes with a novel molecular target discovered by using an in vivo drug repositioning approach. Abstracts of Papers of the American Chemical Society, 234, 14.
-
(2007)
Abstracts of Papers of the American Chemical Society
, vol.234
, pp. 14
-
-
Saporito, M.S.1
-
34
-
-
33746584053
-
Sildenafil: From angina to erectile dysfunction to pulmonary hypertension and beyond
-
Ghofrani, H.A., Osterloh, I.H., Grimminger, F. (2006). Sildenafil: From angina to erectile dysfunction to pulmonary hypertension and beyond. Nature Reviews. Drug Discovery, 5 (8), 689 - 702.
-
(2006)
Nature Reviews. Drug Discovery
, vol.5
, Issue.8
, pp. 689-702
-
-
Ghofrani, H.A.1
Osterloh, I.H.2
Grimminger, F.3
-
35
-
-
84870812983
-
U.S., National Library of, Medicine
-
U.S. National Library of Medicine. http://ghr.nlm.nih.gov/condition/muckle - wells -syndrome
-
-
-
-
36
-
-
66649102432
-
Canakinumab in CAPS Study Group Use of canakinumab in the cryopyrin - associated periodic syndrome
-
Lachmann, H.J., Kone - Paut, I., Kuemmerle - Deschner, J.B., Leslie, K.S., Hachulla, E., Quartier, P., Gitton, X., Widmer, A., Patel, N., Hawkins, P.N.; Canakinumab in CAPS Study Group (2009). Use of canakinumab in the cryopyrin - associated periodic syndrome. The New England Journal of Medicine, 360 (23), 2416 - 2425.
-
(2009)
The New England Journal of Medicine
, vol.360
, Issue.23
, pp. 2416-2425
-
-
Lachmann, H.J.1
Kone-Paut, I.2
Kuemmerle-Deschner, J.B.3
Leslie, K.S.4
Hachulla, E.5
Quartier, P.6
Gitton, X.7
Widmer, A.8
Patel, N.9
Hawkins, P.N.10
-
37
-
-
34347250504
-
Targeting human epidermal growth factor receptor 2 It is time to kill kinase death human epidermal growth factor receptor 3
-
Menendez, J.A., Lupu, R. (2007). Targeting human epidermal growth factor receptor 2: It is time to kill kinase death human epidermal growth factor receptor 3. Journal of Clinical Oncology, 25 (17), 2496 - 2498.
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.17
, pp. 2496-2498
-
-
Menendez, J.A.1
Lupu, R.2
-
38
-
-
84886468218
-
-
Roche
-
Roche. http://www.roche.com/med - cor - 2010 - 12 - 10
-
-
-
-
39
-
-
36949061827
-
Toxicity and teratogenicity of optical isomers of thalidomide
-
Fabro, S., Smith, R.L., Williams, R.T. (1967). Toxicity and teratogenicity of optical isomers of thalidomide. Nature, 215 (5098), 296.
-
(1967)
Nature
, vol.215
, Issue.5098
, pp. 296
-
-
Fabro, S.1
Smith, R.L.2
Williams, R.T.3
-
40
-
-
0035985945
-
Thalidomide, an antiangiogenic agent with clinical activity in cancer
-
Ng, S.S., Brown, M., Figg, W.D. (2002). Thalidomide, an antiangiogenic agent with clinical activity in cancer. Biomed Pharmacother, 56 (4), 194 - 199.
-
(2002)
Biomed Pharmacother
, vol.56
, Issue.4
, pp. 194-199
-
-
Ng, S.S.1
Brown, M.2
Figg, W.D.3
-
41
-
-
59349085516
-
-
DiPersio, J.F., Uy, G.L., Yasothan, U., Kirkpatrick, P. (2009). Plerixafor. Nature Reviews. Drug Discovery, 8, 105.
-
(2009)
Plerixafor. Nature Reviews. Drug Discovery
, vol.8
, pp. 105
-
-
DiPersio, J.F.1
Uy, G.L.2
Yasothan, U.3
Kirkpatrick, P.4
-
42
-
-
84886555007
-
-
Drugs. com
-
Drugs.com. http://www.drugs.com/new - indications.html
-
-
-
-
43
-
-
84886521048
-
-
Food and Drug Administration (FDA) Drug and Biologic Approval Reports
-
Food and Drug Administration (FDA) Drug and Biologic Approval Reports. http://www.accessdata.fda.gov/scripts/opdlisting/oopd/index.cfm
-
-
-
|