A clogging-free microfluidic platform with an incorporated pneumatically driven membrane-based active valve enabling specific membrane capacitance and cytoplasm conductivity characterization of single cells

Sensors and Actuators, B: Chemical

Volumn 190, Issue , 2014, Pages 928-936

  Huang, Song Bin ^a   Zhao, Yang ^b   Chen, Deyong ^b   Lee, Hsin Chieh ^a   Luo, Yana ^b   Chiu, Tzu Keng ^a   Wang, Junbo ^b   Chen, Jian ^b   Wu, Min Hsien ^a  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b INSTITUTE OF ELECTRONICS   (China)

Author keywords

Active valve; Cellular electrical property characterization; Constriction microchannel; Microfluidics; Single cell analysis

Indexed keywords

ACTIVE VALVES; ELECTRICAL PROPERTY CHARACTERIZATION; LUNG CANCER CELLS; MEMBRANE CAPACITANCES; MICROFLUIDIC PLATFORMS; PNEUMATIC PRESSURE; POLYSTYRENE BEADS; SINGLECELL ANALYSIS;

CAPACITANCE; CELLS; CYTOLOGY; MEMBRANES; MICROCHANNELS;

MICROFLUIDICS;

EID: 84886458992     PISSN: 09254005     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.snb.2013.09.070     Document Type: Article

References (36)

1. S. Suresh Biomechanics and biophysics of cancer cells Acta Biomater. 3 2007 413 438 (Pubitemid 46865787)
2. D.E. Ingber Mechanobiology and diseases of mechanotransduction Ann. Med. 35 2003 564 577 (Pubitemid 38005314)
3. A. Fritsch, M. Hockel, T. Kiessling, K.D. Nnetu, F. Wetzel, M. Zink, and J.A. Kas Are biomechanical changes necessary for tumour progression? Nat. Phys. 6 2010 730 732
4. C. Moraes, Y. Sun, and C.A. Simmons (Micro)managing the mechanical microenvironment Integr. Biol. 3 2011 959 971
5. M.J. Rosenbluth, W.A. Lam, and D.A. Fletcher Analyzing cell mechanics in hematologic diseases with microfluidic biophysical flow cytometry Lab Chip 8 2008 1062 1070 (Pubitemid 351904828)
6. S. Gabriele, A.M. Benoliel, P. Bongrand, and O. Théodoly Microfluidic investigation reveals distinct roles for actin cytoskeleton and myosin II activity in capillary leukocyte trafficking Biophys. J. 96 2009 4308 4318
7. J. Chen, M. Abdelgawad, L. Yu, N. Shakiba, W.Y. Chien, Z. Lu, W.R. Geddie, M.A.S. Jewett, and Y. Sun Electrodeformation for single cell mechanical characterization J. Micromech. Microeng. 21 2011 054012
8. J. Chen, Y. Zheng, Q. Tan, Y.L. Zhang, J. Li, W.R. Geddie, M.A.S. Jewett, and Y. Sun A microfluidic device for simultaneous electrical and mechanical measurements on single cells Biomicrofluidics 5 2011 014113
9. Y. Zheng, J. Nguyen, Y. Weia, and Y. Sun Recent advances in microfluidic techniques for single-cell biophysical characterization Lab Chip 2013 10.1039/C3LC50355K
10. H. Morgan, T. Sun, D. Holmes, S. Gawad, and N.G. Green Single cell dielectric spectroscopy J. Phys. D: Appl. Phys. 40 2007 61 70 (Pubitemid 46485626)
11. A. Valero, T. Braschler, and P. Renaud A unified approach to dielectric single cell analysis: impedance and dielectrophoretic force spectroscopy Lab Chip 10 2010 2216 2225
12. J. Chen, Y. Zheng, Q. Tan, E. Shojaei-Baghini, Y.L. Zhang, J. Li, P. Prasad, L. You, X.Y. Wu, and Y. Sun Classification of cell types using a microfluidic device for mechanical and electrical measurement on single cells Lab Chip 11 2011 3174 8181
13. L. Duncan, H. Shelmerdine, M.P. Hughes, H.M. Coley, Y. Hübner, and F.H. Labeed Dielectrophoretic analysis of changes in cytoplasmic ion levels due to ion channel blocker action reveals underlying differences between drug-sensitive and multidrug-resistant leukaemic cells Phys. Med. Biol. 53 2008 N1 N7
14. Y. Cho, H.S. Kim, A.B. Frazier, Z.G. Chen, D.M. Shin, and A. Han Whole-cell impedance analysis for highly and poorly metastatic cancer cells J. Microelectromech. S. 18 2009 808 817
15. Y. Zhao, D. Chen, H. Li, Y. Luo, B. Deng, S.B. Huang, T.K. Chiu, M.H. Wu, R. Long, H. Hu, J. Wang, and J. Chen A microfluidic system enabling continuous characterization of specific membrane capacitance and cytoplasm conductivity of single cells in suspension Biosens. Bioelectron. 43 2013 304 307
16. Y. Zhao, D. Chen, Y. Luo, H. Li, B. Deng, S.B. Huang, T.K. Chiu, M.H. Wu, R. Long, H. Hu, X. Zhao, W. Yue, J. Wang, and J. Chen A microfluidic system for cell type classification based on cellular size-independent electrical properties Lab Chip 13 2013 2272 2277
17. C. Ionescu-Zanetti, R.M. Shaw, J.G. Seo, Y.N. Jan, L.Y. Jan, and L.P. Lee Mammalian electrophysiology on a microfluidic platform Proc. Natl. Acad. Sci. U. S. A. 102 2005 9112 9117 (Pubitemid 40923525)
18. K.C. Tang, J. Reboud, Y.L. Kwok, S.L. Peng, and L. Yobas Lateral patch-clamping in a standard 1536-well microplate format Lab Chip 10 2010 1044 1050
19. F.F. Becker, X.B. Wang, Y. Huang, R. Pethig, J. Vykoukal, and P.R.C. Gascoyne Separation of human breast-cancer cells from blood by differential dielectric affinity Proc. Natl. Acad. Sci. U. S. A. 92 1995 860 864
20. Q. Tan, G.A. Ferrier, B.K. Chen, C. Wang, and Y. Sun Quantification of the specific membrane capacitance of single cells using a microfluidic device and impedance spectroscopy measurement Biomicrofluidics 6 2012 034112
21. D.R. Gossett, H.T. Tse, S.A. Lee, Y. Ying, A.G. Lindgren, O.O. Yang, J. Rao, A.T. Clark, and D.D. Carlo Hydrodynamic stretching of single cells for large population mechanical phenotyping Proc. Natl. Acad. Sci. U. S. A. 109 2012 7630 7635
22. T. Sun, and H. Morgan Single-cell microfluidic impedance cytometry: a review Microfluid. Nanofluid. 8 2010 423 443
23. S. Gawad, L. Schild, and P. Renaud Micromachined impedance spectroscopy flow cytometer for cell analysis and particle sizing Lab Chip 1 2001 76 82
24. K. Cheung, S. Gawad, and P. Renaud Impedance spectroscopy flow cytometry: on-chip label-free cell differentiation Cytom. Part A 65 2005 124 132 (Pubitemid 40726864)
25. D.H. Holmes Morgan, single cell impedance cytometry for identification and counting of CD4 T-cells in human blood using impedance labels Anal. Chem. 82 2010 1455 1461
26. D. Holmes, D. Pettigrew, C.H. Reccius, J.D. Gwyer, C. van Berkel, J. Holloway, D.E. Davies, and H. Morgan Leukocyte analysis and differentiation using high speed microfluidic single cell impedance cytometry Lab Chip 9 2009 2881 2889
27. Y. Zheng, E. Shojaei-Baghini, A. Azad, C. Wang, and Y. Sun High-throughput biophysical measurement of human red blood cells Lab Chip 12 2012 2560 2567
28. S.B. Huang, M.H. Wu, and G.B. Lee Microfluidic device utilizing pneumatic micro-vibrators to generate alginate microbeads for microencapsulation of cells Sens. Actuators B: Chem. 147 2010 755 764
29. M.H. Wu, S.B. Huang, Z. Cui, and G.B. Lee Development of perfusion-based micro 3-D cell culture platform and its application for high throughput drug testing Sens. Actuators B: Chem. 129 2008 231 240
30. A. Nisar, N. Afzulpurkar, B. Mahaisavariya, and A. Tuantranont MEMS-based micropumps in drug delivery and biomedical applications Sens. Actuators B: Chem. 130 2008 917 942 (Pubitemid 351444729)
31. W.B. Lee, Y.H. Chen, H.I. Lin, S.C. Shiesh, and G.B. Lee An integrated microfluidic system for fast, automatic detection of C-reactive protein Sens. Actuators B: Chem. 157 2011 710 721
32. H.Y. Tan, W.K. Loke, and N.T. Nguyen A reliable method for bonding polydimethylsiloxane (PDMS) to polymethylmethacrylate (PMMA) and its application in micropumps Sens. Actuators B: Chem. 151 2010 133 139
33. S.B. Huang, M.H. Wu, and G.B. Lee A tunable micro filter modulated by pneumatic pressure for cell separation Sens. Actuators B: Chem. 142 2009 389 399
34. J.C. Yoo, H.J. Her, C.J. Kang, and Y.S. Kim Polydimethylsiloxane microfluidic system with in-channel structure for integrated electrochemical detector Sens. Actuators B: Chem. 130 2008 65 69 (Pubitemid 351380387)
35. M. Patrascu, J. Gonzalo-Ruiz, M. Goedbloed, S.H. Brongersma, and M. Crego-Calama Flexible electrostatic microfluidic actuators based on thin film fabrication Sens. Actuators A: Phys. 186 2012 249 256
36. R. Schellin, G. Hess, W. Kühnel, C. Thielemann, D. Trost, J. Wacker, and R. Steinmann Measurements of the mechanical behaviour of micromachined silicon and silicon-nitride membranes for microphones, pressure sensors and gas flow meters Sens. Actuators A: Phys. 41 1994 287 292