A tunable micro filter modulated by pneumatic pressure for cell separation

Sensors and Actuators, B: Chemical

Volumn 142, Issue 1, 2009, Pages 389-399

  Huang, Song Bin ^a   Wu, Min Hsien ^b   Lee, Gwo Bin ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Cell separation; Filter; Microfluidic; Micropumps; Pneumatic

Indexed keywords

CELL SEPARATION; CELL VIABILITY; CHONDROCYTES; FILTER; FILTER ZONES; FILTRATION RATES; FLUID CHANNELS; LIQUID HANDLING; MICRO FILTERS; MICRO PUMP; MICROBEADS; MICROPUMPS; OPERATING MODES; PNEUMATIC PRESSURE; POLYDIMETHYLSILOXANE PDMS; SAMPLE CELL; SEPARATION MECHANISM; SEPARATION PERFORMANCE; UNIQUE FEATURES; VOID SPACE;

CYTOLOGY; MICROFILTRATION; MICROFLUIDICS; ORGANIC POLYMERS; PNEUMATICS; POROUS MATERIALS; PUMPS; SILICONES; SIZE SEPARATION;

CELL MEMBRANES;

EID: 70349230784     PISSN: 09254005     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.snb.2009.07.046     Document Type: Article

References (46)

1. Macdonald J.C., Duffy D.C., Anderson J.R., Chiu D.T., Wu H., Schueller O.J.A., and Whitesides G.M. Fabrication of microfluidic systems in poly(dimethylsiloxane). Electrophoresis 21 (2000) 27-40
2. van Reis R., and Zydney A. Membrane separations in biotechnology. Curr. Opin. Biotechnol. 12 (2001) 208-211
3. Stressmann M., and Moresoil C. Effect of pore size, shear rate, and harvest time during the constant permeate flux microfiltration of CHO cell culture supernatant. Biotechnol. Prog. 24 (2008) 890-897
4. Roush D.J., and Lu Y. Advances in primary recovery: centrifugation and membrane technology. Biotechnol. Prog. 24 (2008) 488-495
5. Wu M.H., Huang S.B., Cui Z.F., Cui Z., and Lee G.B. Development of perfusion-based micro 3-D cell culture platform and its application for high throughput drug testing. Sens. Actuators B 129 (2008) 231-240
6. Wu M.H., Urban J.P.G., Cui Z., and Cui Z.F. Development of PDMS microbioreactor with well-defined and homogenous culture environment for chondrocyte 3-D culture. Biomed. Microdevices 8 (2006) 331-340
7. Lee P.J., Hung P.J., Rao V.M., and Lee L.P. Nanoliter scale microbioreactor array for quantitative cell biology. Biotechnol. Bioeng. 94 (2005) 5-14
8. Matsubara Y., Murakami Y., Kobayashi M., Morita Y., and Tamiya E. Application of on-chip cell cultures for the detection of allergic response. Biosens. Bioelectron. 19 (2004) 741-747
9. Do J., Lee S., Han J., Kai J., Hong C.C., Gao C., Nevin J.H., Beaucage G., and Ahn C.H. Development of functional lab-on-a-chip on polymer for point-of-care testing of metabolic parameters. Lab Chip 8 (2008) 2113-2120
10. Fiedler S., Shirley S., Schnelle T., and Fuhr G. Dielectrophoretic sorting of particles and cells in a microsystem. Anal. Chem. 70 (1998) 1909-1915
11. Markx G., Huang Y., Zhou X., and Pethig R. Dielectrophoretic characterization and separation of microorganisms. Microbiology 140 (1994) 585-591
12. Wang X., Yang J., Huang Y., Vykoukal J., Becker F., and Gascoyne P. Cell separation by dielectrophoretic field-flow-fractionation. Anal. Chem. 72 (2000) 832-839
13. Huang Y., Joo S., Duhon M., Heller M., Wallace B., and Xu X. Dielectrophoretic cell separation and gene expression profiling on microelectronic chip arrays. Anal. Chem. 74 (2002) 3362-3371
14. Huang Y., Ewalt K., Tirado M., Haigis R., Forster A., Ackley D., Heller M., O'Connell J., and Krihak M. Electric manipulation of bioparticles and macromolecules on microfabricated electrodes. Anal. Chem. 73 (2001) 1549-1559
15. Hawkes J.J., and Coakley W.T. Force field particle filter, combining ultrasound standing waves and laminar flow. Sens. Actuators B Chem. 75 (2001) 213-222
16. Johnson A.D., and Feke D.L. Methodology for fractionating suspended particles using ultrasonic standing wave and divided flow fields. Sep. Technol. 5 (1995) 251-258
17. Yasuda K., Umemura S., and Takeda K. Studies on particle separation by acoustic radiation force and electrostatic force. Jpn. J. Appl. Phys. 1 (1996) 3295-3299
18. Laurell T., Petersson F., and Nilsson A. Chip integrated strategies for acoustic separation and manipulation of cells and particles. Chem. Soc. Rev. 36 (2007) 492-506
19. Petersson F., Aberg L., Sward-Nilsson A.M., and Laurell T. Free flow acoustophoresis: microfluidic-based mode of particle and cell separation. Anal. Chem. 79 (2007) 5117-5123
20. Rong R., Choi J.W., and Ahn C.H. An on-chip magnetic bead separator for biocell sorting. J. Micromech. Microeng. 16 (2006) 2783-2790
21. Lin Y.A., Wong T.S., Bhardwaj U., Chen J.M., McCabe E., and Ho C.M. Formation of high electromagnetic gradients through a particle-based microfluidic approach. J. Micromech. Microeng. 17 (2007) 1299-1306
22. Lien K.Y., Liu C.J., Lin Y.C., Kuo P.L., and Lee G.B. Extraction of genomic DNA and detection of single nucleotide polymorphism genotyping utilizing an integrated magnetic bead-based microfluidic platform. Microfluid. Nanofluid. 6 (2009) 539-555
23. Yamada M., and Seki M. Microfluidic particle sorter employing flow splitting and recombining. Anal. Chem. 78 (2006) 1357-1362
24. Yamada M., Kano K., Tsuda Y., Kobayashi J., Yamato M., Seki M., and Okano T. Microfluidic devices for size-dependent separation of liver cells. Biomed. Microdevices 9 (2007) 637-645
25. VanDelinder V., and Groisman A. Perfusion in microfluidic cross-flow: separation of white blood cells from whole blood and exchange of medium in a continuous flow. Anal. Chem. 79 (2007) 2023-2030
26. Chang W.C., Lee L.P., and Liepmann D. Biomimetic technique for adhesion-based collection and separation of cells in a microfluidic channel. Lab Chip 5 (2005) 64-73
27. Huh D., Bahng J.H., Ling Y., Wei H.H., Kripfgans O.D., Fowlkes J.B., Grotberg J.B., and Takayama S. Gravity-driven microfluidic particle sorting device with hydrodynamic separation amplification. Anal. Chem. 79 (2007) 1369-1376
28. Choi S., Song S., Choi C., and Park J.K. Continuous blood cell separation by hydrophoretic filtration. Lab Chip 7 (2007) 1532-1538
29. Yamada M., Nakashima M., and Seki M. Pinched flow fractionation: continuous size separation of particles utilizing a laminar flow profile in a pinched microchannel. Anal. Chem. 76 (2004) 5465-5471
30. Takagi J., Yamada M., Yasuda M., and Seki M. Continuous particle separation in a microchannel having asymmetrically arranged multiple branches. Lab Chip 5 (2005) 778-784
31. Andersson H., van der Wijngaart W., and Stemme G. Micromachined filter-chamber array with passive valves for biochemical assays on beads. Electrophoresis 22 (2001) 249-257
32. Ji H.M., Samper V., Chen Y., Heng C.K., Lim T.M., and Yobas L. Silicon-based microfilters for whole blood cell separation. Biomed. Microdevices 10 (2008) 251-257
33. Zheng S., Lin H., Liu J.Q., Balic M., Datar R., Cote R.J., and Tai Y.C. Membrane microfilter device for selective capture, electrolysis and genomic analysis of human circulating tumor cells. J. Chromatogr. A 1162 (2007) 154-161
34. Huang S.B., Wu M.H., Cui Z.F., Cui Z., and Lee G.B. A membrane-based serpentine-shape pneumatic micropump with pumping performance modulated by fluidic resistance. J. Micromech. Microeng. 18 (2008) 045008 (12 pp.)
35. Unger M.A., Chou H.P., Thorsen T., Scherer A., and Quake S.R. Monolithic microfabricated valves and pumps by multilayer soft lithography. Science 288 (2000) 113-116
36. Wang C.H., and Lee G.B. Automatic bio-sampling chips integrated with micro-pumps and micro-valves for disease detection. Biosens. Bioelectron. 21 (2005) 419-425
37. Wang C.H., and Lee G.B. Pneumatically driven peristaltic micropumps utilizing serpentine-shape channels. J. Micromech. Microeng. 16 (2006) 341-348
38. Huang C.W., Huang S.B., and Lee G.B. Pneumatic micropumps with serially connected actuation chambers. J. Micromech. Microeng. 16 (2006) 2265-2272
39. Liu C.J., Lien K.Y., Weng C.Y., Shin J.W., Chang T.Y., and Lee G.B. Magnetic-bead-based microfluidic system for ribonucleic acid extraction and reverse transcription processes. Biomed. Microdevices 11 (2009) 339-350
40. Yang S.Y., Lien K.Y., Huang K.J., Lei H.Y., and Lee G.B. Micro flow cytometry utilizing a magnetic bead-based immunoassay for rapid virus detection. Biosens. Bioelectron. 24 (2008) 855-862
41. Cheryan M. Ultrafiltration and microfiltration. 1st ed. (1998), Technomic Publishing Company, Lancaster, PA, USA pp. 4-6, 245-263
42. Mugnier N., Howell J.A., and Ruf M. Optimisation of a back-flush sequence for zeolite microfiltration. J. Membr. Sci. 175 (2000) 149-161
43. Jacobs E.P., Bradshaw S.M., Botes J.P., and Pillay V.L. Reverse-pressure back-flush in pilot scale, dead-end ultrafiltration of surface water. J. Membr. Sci. 252 (2005) 51-63
44. Ohya H., Kim J.J., Chinen A., Aihara M., Semenova S.I., Negishi Y., Mori O., and Yasuda M. Effects of pore size on separation mechanisms of microfiltration of oily water, using porous glass tubular membrane. J. Membr. Sci. 145 (1998) 1-14
45. Wu M.H., Urban J.P.G., Cui Z.F., Cui Z., and Xu X. Effect of extracellular pH on matrix synthesis by chondrocytes in 3D agarose gel. Biotechnol. Prog. 23 (2007) 430-434
46. Xu X., Urban J.P.G., Tirlapur U., Wu M.H., Cui Z., and Cui Z.F. Influence of perfusion on metabolism and matrix production by bovine articular chondrocytes in hydrogel scaffolds. Biotechnol. Bioeng. 93 (2006) 1103-1111