Mass balance of anti-influenza drugs discharged into the Yodo River system, Japan, under an influenza outbreak

Chemosphere

Volumn 93, Issue 9, 2013, Pages 1672-1677

  Azuma, Takashi ^a   Nakada, Norihide ^a   Yamashita, Naoyuki ^a   Tanaka, Hiroaki ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Environmental fate; Oseltamivir carboxylate; Relenza; River basin; Tamiflu; Zanamivir

Indexed keywords

AMINES; ANTIVIRAL AGENTS; CARBOXYLATION; CATCHMENTS; EFFLUENTS; METABOLITES; SEWAGE TREATMENT PLANTS;

ENVIRONMENTAL FATE; OSELTAMIVIR CARBOXYLATE; RELENZA; RIVER BASINS; TAMIFLU; ZANAMIVIR;

RIVERS;

4 ACETAMIDO 5 AMINO 3 (1 ETHYLPROPOXY) 1 CYCLOHEXENE 1 CARBOXYLIC ACID; AMANTADINE; OSELTAMIVIR; RIVER WATER; ZANAMIVIR;

CATCHMENT; DISEASE SPREAD; DRUG; INFLUENZA; MASS BALANCE; POLLUTION CONTROL; RIVER POLLUTION; RIVER SYSTEM; SAMPLING;

AQUATIC ENVIRONMENT; ARTICLE; CATCHMENT; CONTROLLED STUDY; DRUG CONTAMINATION; DRUG DISPOSITION; EFFLUENT STANDARD; EPIDEMIC; GLACIAL MASS BALANCE; HOME; HUMAN; INFLUENZA; JAPAN; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MASS SPECTROMETRY; MEASUREMENT; METABOLITE; RIVER ECOSYSTEM; SEWAGE TREATMENT PLANT; URBAN AREA; WATER CONTAMINATION; WATER SAMPLING;

JAPAN;

ENVIRONMENTAL FATE; OSELTAMIVIR CARBOXYLATE; RELENZA; RIVER BASIN; TAMIFLU; ZANAMIVIR;

AMANTADINE; ANTIVIRAL AGENTS; DISEASE OUTBREAKS; ENVIRONMENTAL MONITORING; HUMANS; INFLUENZA, HUMAN; JAPAN; OSELTAMIVIR; RIVERS; WATER POLLUTANTS, CHEMICAL;

EID: 84886443367     PISSN: 00456535     EISSN: 18791298     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2013.05.025     Document Type: Article

References (38)

1. Accinelli C., Saccà Maria L., Fick J., Mencarelli M., Lindberg R., Olsen B. Dissipation and removal of oseltamivir (Tamiflu) in different aquatic environments. Chemosphere 2010, 79:891-897.
2. Andreozzi R., Raffaele M., Nicklas P. Pharmaceuticals in STP effluents and their solar photodegradation in aquatic environment. Chemosphere 2003, 50:1319-1330.
3. Azuma T., Nakada N., Yamashita N., Tanaka H. Synchronous dynamics of observed and predicted values of anti-influenza drugs in environmental waters during a seasonal influenza outbreak. Environ. Sci. Technol. 2012, 46:12873-12881.
4. Bartels P., von Tümpling W. The environmental fate of the antiviral drug oseltamivir carboxylate in different waters. Sci. Total Environ. 2008, 405:215-225.
5. Besaratinia A., Synold T.W., Xi B., Pfeifer G.P. G-to-T transversions and smalltandem base deletions are the hallmark of mutations induced by ultraviolet radiation in mammalian cells. Biochemistry 2004, 43:8169-8177.
6. Chugai Pharmaceutical Co., L. Interview form for Tamiflu (in Japanse). (accessed 17.11.2012). http://www.tamiflu-j.com/tamiflu-j/02/0201.html.
7. Darwish I., Khedr A., Askal H., Mahmoud R. Simple and sensitive spectrophotometric methods for determination of amantadine hydrochloride. J. Appl. Spectrosc. 2006, 73:792-797.
8. Daughton C.G. Cradle-to-cradle stewardship of drugs for minimizing their environmental disposition while promoting human health. I. Rationale for and avenues toward a green pharmacy. Environ. Health Perspect. 2002, 111:775-785.
9. Ellis J.B. Antiviral pandemic risk assessment for urban receiving waters. Water Sci. Technol. 2010, 61:879-884.
10. Fick J., Lindberg R.H., Tysklind M., Haemig P.D., Waldenström J., Wallensten A., Olsen B. Antiviral oseltamivir is not removed or degraded in normal sewage water treatment: Implications for development of resistance by influenza A virus. PLoS One 2007, 2:e986.
11. George H., Joseph M., Penelope W. Clinical pharmacokinetics of the prodrug Oseltamivir and its active metabolite Ro 64-0802. Clin. Pharmacokinet. 1999, 37:471-484.
12. Ghosh G.C., Nakada N., Yamashita N., Tanaka H. Occurrence and fate of oseltamivir carboxylate (Tamiflu) and amantadine in sewage treatment plants. Chemosphere 2010, 81:13-17.
13. Ghosh G.C., Nakada N., Yamashita N., Tanaka H. Oseltamivir carboxylate, the active metabolite of oseltamivir phosphate (Tamiflu), detected in sewage discharge and river water in Japan. Environ. Health Perspect. 2010, 118:103-107.
14. GlaxoSmithKline, 2006. Zanamivir. Safety data sheet. Ver.13, 1-8.
15. Gonçalves C., Peirez S., Osorio V., Petrovic M., Alpendurada M.F., Barceloi D. Photofate of oseltamivir (Tamiflu) and oseltamivir carboxylate under natural and simulated solar irradiation: Kinetics, identification of the transformation products, and environmental occurrence. Environ. Sci. Technol. 2011, 45:4307-4314.
16. Hanamoto S., Nakada N., Yamashita N., Tanaka H. Occurrence of pharmaceuticals and personal care products at Yodo River system (in Japanese). Environ. Eng. Res. 2010, 47:423-432.
17. Hoffmann-La Roche Inc. Nutley, NJ, 2005. Roche research report; Pediatric advisory committee executive summary for Tamiflu. 1-22.
18. Hutchinson T.H., Beesley A., Frickers P.E., Readman J.W., Shaw J.P., Straub J.O. Extending the environmental risk assessment for oseltamivir (Tamiflu®) under pandemic use conditions to the coastal marine compartment. Environ. Int. 2009, 35:931-936.
19. Infectious Disease Surveillance Center, J. Infectious Diseases Weekly Report (IDWR) (in Japanase). (accessed 17.11.2012). http://idsc.nih.go.jp/index-j.html.
20. Japan Sewage Works Association, 2010. Statistics of sewerage (in Japanese).
21. Järhult J.D., Muradrasoli S., Wahlgren J., Söderström H., Orozovic G., Gunnarsson G., Bröjer C., Latorre-Margalef N., Fick J., Grabic R., Lennerstrand J., Waldenström J., Lundkvist Å., Olsen B. Environmental levels of the antiviral oseltamivir induce development of resistance mutation H274Y in influenza A/H1N1 virus in mallards. PLoS One 2011, 6:e24742.
22. Kolpin D.W., Furlong E.T., Meyer M.T., Thurman E.M., Zaugg S.D., Barber L.B., Buxton H.T. Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams, 1999-2000: a national reconnaissance. Environ. Sci. Technol. 2002, 36:1202-1211.
23. Kumar V., Nakada N., Yasojima M., Yamashita N., Johnson A.C., Tanaka H. Rapid determination of free and conjugated estrogen in different water matrices by liquid chromatography-tandem mass spectrometry. Chemosphere 2009, 77:1440-1446.
24. Kumar V., Nakada N., Yamashita N., Johnson A.C., Tanaka H. How seasonality affects the flow of estrogens and their conjugates in one of Japan's most populous catchments. Environ. Pollut. 2011, 159:2906-2912.
25. Leknes H., Sturtzel I.E., Dye C. Environmental release of oseltamivir from a Norwegian sewage treatment plant during the 2009 influenza A (H1N1) pandemic. Sci. Total Environ. 2012, 414:632-638.
26. Malipatil S.M., Jahan K., Deepthi M. Spectrophotometric determination of oseltamivir phosphate in bulk drug and in pharmaceutical formulation. Res. J. Pharm. Biol. Chem. Sci. 2011, 1:933-942.
27. Okuda T., Yamashita N., Tanaka H., Matsukawa H., Tanabe K. Development of extraction method of pharmaceuticals and their occurrences found in Japanese wastewater treatment plants. Environ. Int. 2009, 35:815-820.
28. Prasse C., Schlüsener M.P., Schulz R., Ternes T.A. Antiviral drugs in wastewater and surface waters: A new pharmaceutical class of environmental relevance?. Environ. Sci. Technol. 2010, 44:1728-1735.
29. Renner R. Tamiflu survives sewage treatment. Environ. Sci. Technol. 2007, 41:7591.
30. Roche Laboratories Inc. Newjersy, 2008. Tamiflu® (oseltamivir phosphate) capsules and for oral suspension. Complete production, information. 1-23.
31. Saccà M., Ludovica Accinelli C., Fick J., Lindberg R., Olsen B. Environmental fate of the antiviral drug Tamiflu in two aquatic ecosystems. Chemosphere 2009, 75:28-33.
32. Singer A.C., Nunn M.A., Gould E.A., Johnson A.C. Potential risks associated with the proposed widespread use of Tamiflu. Environ. Health Perspect. 2007, 115:102-106.
33. Söderström H., Järhult J.D., Olsen B., Lindberg R.H., Tanaka H., Fick J. Detection of the antiviral drug Oseltamivir in aquatic environments. PLoS One 2009, 4:e6064.
34. Straub J.O. An environmental risk assessment for oseltamivir (Tamiflu®) for sewage works and surface waters under seasonal-influenza- and pandemic-use conditions. Ecotoxicol. Environ. Saf. 2009, 72:1625-1634.
35. Takanami R., Ozaki H., Giri Rabindra R., Taniguchi S., Hayashi S. Detection of antiviral drugs oseltamivir phosphate and oseltamivir carboxylate in Neya river, Osaka. Jpn. J. Wat. Environ. Technol. 2010, 8:363-372.
36. Tore Lunestad B., Samuelsen O.B., Fjelde S., Ervik A. Photostability of eight antibacterial agents in seawater. Aquaculture 1995, 134:217-225.
37. WHO Pandemic influenza preparedness and response: a WHO guidance document. (accessed 17.11.2012). http://www.who.int/en/.
38. Yamamoto H., Nakamura Y., Moriguchi S., Nakamura Y., Honda Y., Tamura I., Hirata Y., Hayashi A., Sekizawa J. Persistence and partitioning of eight selected pharmaceuticals in the aquatic environment: laboratory photolysis, biodegradation, and sorption experiments. Water Res. 2009, 43:351-362.