Extending the environmental risk assessment for oseltamivir (Tamiflu®) under pandemic use conditions to the coastal marine compartment

Environment International

Volumn 35, Issue 6, 2009, Pages 931-936

  Hutchinson, Thomas H ^a   Beesley, Amanda ^a   Frickers, Patricia E ^a   Readman, James W ^a   Shaw, Jenny P ^a   Straub, Jürg Oliver ^b  

^a PLYMOUTH MARINE LABORATORY   (United Kingdom)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Ecotoxicology; Environmental fate; Environmental risk assessment; Marine; Oseltamivir; Pandemic; Tamiflu

Indexed keywords

SEWAGE; WATER;

ECO-TOXICOLOGY; ENVIRONMENTAL FATE; ENVIRONMENTAL RISK ASSESSMENT; MARINE; OSELTAMIVIR; PANDEMIC; TAMIFLU;

RISK ASSESSMENT;

OSELTAMIVIR;

AVIAN INFLUENZA; BIOACCUMULATION; COASTAL WATER; CONCENTRATION (COMPOSITION); DOSE-RESPONSE RELATIONSHIP; ECOTOXICOLOGY; ENVIRONMENTAL IMPACT ASSESSMENT; ENVIRONMENTAL RISK; EPIDEMIC; GROWTH RESPONSE; INHIBITION; INVERTEBRATE; MARINE ENVIRONMENT; MEDICINE; RISK ASSESSMENT;

ANIMAL EXPERIMENT; ARTICLE; COASTAL WATERS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG UTILIZATION; ECOTOXICITY; EMBRYO; ENVIRONMENTAL IMPACT; GROWTH INHIBITION; MARINE SPECIES; MICROALGA; NONHUMAN; PANDEMIC; PRIORITY JOURNAL; RISK ASSESSMENT; TOXICITY TESTING; WATER POLLUTION;

ANNELIDA; AVES; ECHINODERMATA; HAPTOPHYCEAE; INVERTEBRATA; ISOCHRYSIS GALBANA; MOLLUSCA; MYTILUS EDULIS; PARACENTROTUS LIVIDUS; POMATOCEROS TRIQUETER; SKELETONEMA COSTATUM;

EID: 67349136512     PISSN: 01604120     EISSN: 18736750     Source Type: Journal    
DOI: 10.1016/j.envint.2009.04.001     Document Type: Article

References (32)

1. Accinelli C., Barra Caracciolo A., and Grenni P. Degradation of the antiviral drug oseltamivir carboxylate in surface water samples. Int J Environ Anal Chem 87 (2007) 579-587
2. Anderson S.L., Hose J.E., and Knezovich J. Genotoxic and developmental effects in sea urchins are sensitive indicators of effects of genotoxic chemicals. Environ Toxicol Chem 13 (1994) 1033-1041
3. Arizzi Novelli A., Argese E., Tagliapietra D., Bettiol C., and Volpi Ghirardini A. Toxicity of tributyltin and triphenyltin to early life stages of Paracentrotus lividus (Echinodermata: Echinoidea). Environ Toxicol Chem 21 (2002) 859-864
4. ASTM. Standard guide for conducting static acute toxicity tests starting with embryos of four species of saltwater bivalve molluscs, E-724-89 (1997), American Society for Testing of Materials, Philadelphia, PA
5. Bartels P., and von Tümpling W. The environmental fate of the antiviral drug oseltamivir carboxylate in different waters. Sci Total Environ 405 (2008) 215-225
6. Dixon D.R., Wilson J.T., Pascoe P.L., and Parry J.M. Anaphase aberrations in the embryos of the marine tubeworm Pomatoceros lamarckii (Polychaeta: Serpulidae): a new in vivo test assay for detecting aneugens and clastogens in the marine environment. Mutagenesis 14 (1999) 375-383
7. EMEA. Note for Guidance on Environmental Risk Assessment of Medicinal Products for Human Use. CPMP/SWP/4447/00. London: EMEA; 2006. http://www.emea.europa.eu/pdfs/human/swp/444700en.pdf, accessed April 2009.
8. Hayward P.J., and Ryland J.S. Handbook of the Marine Fauna of North-West Europe (2006), Oxford University Press, Oxford, UK
9. His E., Beiras R., and Seaman M.N.L. The assessment of marine pollution bioassays with bivalve embryos and larvae. Adv Mar Biol 37 (1999) 1-178
10. Hutchinson T.H. Realizing the potential benefits of small animal models for the aquatic hazard assessment of human pharmaceuticals: a conceptual approach. In: Kümmerer K. (Ed). Pharmaceuticals in the Environment. Sources, Fate, Effects and Risks (2008), Springer, Berlin 245-255
11. In: Kümmerer K. (Ed). Pharmaceuticals in the Environment. Sources, Fate, Effects and Risks (2008), Springer, Berlin viii + 521 pp.
12. Lienert J., Güdel K., and Escher B.I. Screening method for ecotoxicological hazard assessment of 42 pharmaceuticals considering human metabolism and excretory routes. Environ Sci Technol 41 (2007) 4471-4478
13. Lindegårdh N., Hien T.T., Farrar J., Singhasivanon P., White N.J., and Day N.J.J. A simple and rapid liquid chromatographic assay for evaluation of potentially counterfeit Tamiflu. J Pharm Biomed Anal 42 (2006) 430-433
14. Marin A., Montoya S., Vita R., Marín-Guirao L., Lloret J., and Aguado F. Utility of sea urchin embryo-larval bioassays for assessing the environmental impact of marine fishcage farming. Aquaculture 271 (2007) 286-297
15. McDougall C., Chen W.-C., Shimeld S.M., and Ferrier D.E.K. The development of the larval nervous system, musculature and ciliary bands of Pomatoceros lamarckii (Annelida): heterochrony in polychaetes. Front Zool 3 (2006) 1-16 10.1186/1742-9994-3-16
16. Pagano G., de Biase A., Deeva I.B., Degan P., Doronin Y.K., Laccarino M., et al. The role of oxidative stress in developmental and reproductive toxicity of tamoxifen. Life Sci 68 (2001) 1735-1749
17. Roche. Safety data sheet; Oseltamivir phosphate (2007), F. Hoffmann-La Roche Ltd, Basle, Switzerland. http://www.roche.com/corporate_responsibility/environment/safety_data_sheets.htm 04.01, http://www.roche.com/corporate_responsibility/environment/safety_data_sheets.htm, accessed Nov 2008
18. Roepke T.A., Snyder M.J., and Cherr G.N. Estradiol and endocrine disrupting compounds adversely affect development of sea urchin embryos at environmentally relevant concentrations. Aquat Toxicol 71 (2005) 155-173
19. Saccà M.L., Accinelli C., Fick J., Lindberg R., and Olsen B. Environmental fate of the antiviral drug Tamiflu in two aquatic ecosystems. Chemosphere 75 (2009) 28-33
20. Satoh A., Vudikaria L.Q., Kurano N., and Miyachi S. Evaluation of the sensitivity of marine microalgal strains to the heavy metals, Cu, As, Sb, Pb and Cd. Environ Int 31 (2005) 713-722
21. Schipper C.A., Dubbeldam M., Feist S.W., Rietjens Y.M.C.M., and Murk A.T. Cultivation of the heart urchin Echinocardium cordatum and validation of its use in marine toxicity testing for environmental risk assessment. J Exp Mar Biol Ecol 364 (2008) 11-18
22. Segrove F. The development of the serpulid Pomatoceros triqueter L. Q J Microsc Sci 82 (1941) 467-540
23. Singer A.C., Nunn M.A., Gould E.A., and Johnson A.C. Potential risks associated with the proposed widespread use of Tamiflu. Environ Health Perspect 115 (2007) 102-106
24. Singer A.C., Howard B.M., Johnson A.C., Knowles C.J., Jackman S., Accinelli C., et al. Meeting Report: Risk assessment of Tamiflu use under pandemic conditions. Environ Health Perspect 116 (2008) 1563-1567 10.1289/ehp.11310
25. Singer A.C., Johnson A.C., Anderson P.D., and Snyder S.A. Reassessing the risks of Tamiflu use during a pandemic to the Lower Colorado River. Environ Health Perspect 116 (2008) A285-A286
26. Straub J.O. Environmental risk assessment for new human pharmaceuticals in the European Union according to the draft guideline/discussion paper of January 2001. Toxicol Lett 135 (2002) 231-237
27. ®) for sewage works and surface waters under seasonal influenza and pandemic use conditions. Ecotoxicol Environ Safety, 2009. in press.
28. TDG. Technical Guidance Document in support of Commission Directive 93/67/EEC on risk assessment of new notified chemicals and Commission Regulation (EC) No. 1488/94 on risk assessment of existing chemicals (1996) (2003), Office for Official Publications of the European Communities, Luxembourg. http://ecb.jrc.ec.europa.eu/home.php?CONTENU=/DOCUMENTS/TECHNICAL_GUIDANCE_DOCUMENT/EDITION_2/ http://ecb.jrc.ec.europa.eu/home.php?CONTENU=/DOCUMENTS/TECHNICAL_GUIDANCE_DOCUMENT/EDITION_2/, accessed Nov 2008
29. UNEP. GEO Data Portal (2006), United Nations Environment Programme, Switzerland, Geneva. http://geodata.grid.unep.ch/ http://geodata.grid.unep.ch/, accessed Nov 2008
30. US EPA. Short-term Methods for Estimating the Chronic Toxicity of Effluents and Receiving Waters to Marine and Estuarine Organisms. Fourth Edition (2002), US Environmental Protection Agency, Office of Water, Washington DC. http://www.epa.gov/waterscience/methods/wet/disk1/ Reference EPA-821-R-02-014. http://www.epa.gov/waterscience/methods/wet/disk1/, accessed Nov 2008
31. Volpi Ghirardini A., Arizzi Novelli A., and Tagliapietra D. Sediment toxicity assessment in the Lagoon of Venice (Italy) using Paracentrotus lividus (Echinodermata: Echinoidea) fertilization and embryo bioassays. Environ Int 31 (2005) 1065-1077
32. Young C.M. Larval ecology of marine invertebrates: a sesquicentennial history. Ophelia 32 (1990) 1-48