-
1
-
-
4644324186
-
NF-kappaB functions as a tumour promoter in inflammation-associated cancer
-
Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S, et al. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 2004;431:461-6.
-
(2004)
Nature
, vol.431
, pp. 461-466
-
-
Pikarsky, E.1
Porat, R.M.2
Stein, I.3
Abramovitch, R.4
Amit, S.5
Kasem, S.6
-
2
-
-
77954297744
-
Nuclear factor kappaB transcription factors are coexpressed and convey a poor outcome in ovarian cancer
-
Annunziata CM, Stavnes HT, Kleinberg L, Berner A, Hernandez LF, Birrer MJ, et al. Nuclear factor kappaB transcription factors are coexpressed and convey a poor outcome in ovarian cancer. Cancer 2010;116:3276-84.
-
(2010)
Cancer
, vol.116
, pp. 3276-3284
-
-
Annunziata, C.M.1
Stavnes, H.T.2
Kleinberg, L.3
Berner, A.4
Hernandez, L.F.5
Birrer, M.J.6
-
3
-
-
77952808420
-
Activation of NF-kappaB signaling by inhibitor of NF-kappaB kinase beta increases aggressiveness of ovarian cancer
-
Hernandez L, Hsu SC, Davidson B, Birrer MJ, Kohn EC, Annunziata CM. Activation of NF-kappaB signaling by inhibitor of NF-kappaB kinase beta increases aggressiveness of ovarian cancer. Cancer Res 2010;70:4005-14.
-
(2010)
Cancer Res
, vol.70
, pp. 4005-4014
-
-
Hernandez, L.1
Hsu, S.C.2
Davidson, B.3
Birrer, M.J.4
Kohn, E.C.5
Annunziata, C.M.6
-
4
-
-
9344249569
-
Inhibition of inhibitor of nuclear factor-kappaB phosphorylation increases the efficacy of paclitaxel in in vitro and in vivo ovarian cancer models
-
Mabuchi S, Ohmichi M, Nishio Y, Hayasaka T, Kimura A, Ohta T, et al. Inhibition of inhibitor of nuclear factor-kappaB phosphorylation increases the efficacy of paclitaxel in in vitro and in vivo ovarian cancer models. Clin Cancer Res 2004;10:7645-54.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 7645-7654
-
-
Mabuchi, S.1
Ohmichi, M.2
Nishio, Y.3
Hayasaka, T.4
Kimura, A.5
Ohta, T.6
-
5
-
-
4544342570
-
Nuclear factor-kappaB: The enemy within
-
Aggarwal BB. Nuclear factor-kappaB: the enemy within. Cancer Cell 2004;6:203-8.
-
(2004)
Cancer Cell
, vol.6
, pp. 203-208
-
-
Aggarwal, B.B.1
-
6
-
-
0021879340
-
The antitumour effect of doxycycline on a T-cell leukaemia in the rat
-
van den Bogert C, Dontje BH, Kroon AM. The antitumour effect of doxycycline on a T-cell leukaemia in the rat. Leuk Res 1985;9: 617-23.
-
(1985)
Leuk Res
, vol.9
, pp. 617-623
-
-
Van Den Bogert, C.1
Dontje, B.H.2
Kroon, A.M.3
-
7
-
-
77953226760
-
Activation of c-Jun N-terminal kinase is essential for mitochondrial membrane potential change and apoptosis induced by doxycycline in melanoma cells
-
Shieh JM, Huang TF, Hung CF, Chou KH, Tsai YJ,WuWB. Activation of c-Jun N-terminal kinase is essential for mitochondrial membrane potential change and apoptosis induced by doxycycline in melanoma cells. Br J Pharmacol 2010;160:1171-84.
-
(2010)
Br J Pharmacol
, vol.160
, pp. 1171-1184
-
-
Shieh, J.M.1
Huang, T.F.2
Hung, C.F.3
Chou, K.H.4
Tsai, Y.J.5
Wu, W.B.6
-
8
-
-
0022640113
-
Arrest of the proliferation of renal and prostate carcinomas of human origin by inhibition of mitochondrial protein synthesis
-
van den Bogert C, Dontje BH, Holtrop M, Melis TE, Romijn JC, van Dongen JW, et al. Arrest of the proliferation of renal and prostate carcinomas of human origin by inhibition of mitochondrial protein synthesis. Cancer Res 1986;46:3283-9.
-
(1986)
Cancer Res
, vol.46
, pp. 3283-3289
-
-
Van Den Bogert, C.1
Dontje, B.H.2
Holtrop, M.3
Melis, T.E.4
Romijn, J.C.5
Van Dongen, J.W.6
-
9
-
-
0035109570
-
Influence of chemically modified tetracyclines on proliferation, invasion and migration properties of MDA-MB-468 human breast cancer cells
-
Meng Q, Xu J, Goldberg ID, Rosen EM, Greenwald RA, Fan S. Influence of chemically modified tetracyclines on proliferation, invasion and migration properties of MDA-MB-468 human breast cancer cells. Clin Exp Metastasis 2000;18:139-46.
-
(2000)
Clin Exp Metastasis
, vol.18
, pp. 139-146
-
-
Meng, Q.1
Xu, J.2
Goldberg, I.D.3
Rosen, E.M.4
Greenwald, R.A.5
Fan, S.6
-
10
-
-
84884213782
-
Minocycline inhibits malignant ascites of ovarian cancer through targeting multiple signaling pathways
-
Pourgholami MH, Ataie-Kachoie P, Badar S, Morris DL. Minocycline inhibits malignant ascites of ovarian cancer through targeting multiple signaling pathways. Gynecol Oncol 2013;129:113-9.
-
(2013)
Gynecol Oncol
, vol.129
, pp. 113-119
-
-
Pourgholami, M.H.1
Ataie-Kachoie, P.2
Badar, S.3
Morris, D.L.4
-
12
-
-
84875967041
-
Minocycline suppresses interleukine-6, its receptor system and signaling pathways and impairs migration, invasion and adhesion capacity of ovarian cancer cells: In vitro and in vivo studies
-
Ataie-Kachoie P, Morris DL, Pourgholami MH. Minocycline suppresses interleukine-6, its receptor system and signaling pathways and impairs migration, invasion and adhesion capacity of ovarian cancer cells: in vitro and in vivo studies. PLoS ONE 2013;8: e60817.
-
(2013)
PLoS ONE
, vol.8
-
-
Ataie-Kachoie, P.1
Morris, D.L.2
Pourgholami, M.H.3
-
13
-
-
77953496625
-
The NF-kappaB family of transcription factors and its regulation
-
Oeckinghaus A, Ghosh S. The NF-kappaB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol 2009;1: a000034.
-
(2009)
Cold Spring Harb Perspect Biol
, vol.1
-
-
Oeckinghaus, A.1
Ghosh, S.2
-
14
-
-
77951624380
-
Constitutive association of TGF-beta-activated kinase 1 with the IkappaB kinase complex in the nucleus and cytoplasm of human neutrophils and its impact on downstream processes
-
Ear T, Fortin CF, Simard FA, McDonald PP. Constitutive association of TGF-beta-activated kinase 1 with the IkappaB kinase complex in the nucleus and cytoplasm of human neutrophils and its impact on downstream processes. J Immunol 2010;184:3897-906.
-
(2010)
J Immunol
, vol.184
, pp. 3897-3906
-
-
Ear, T.1
Fortin, C.F.2
Simard, F.A.3
McDonald, P.P.4
-
15
-
-
84866731086
-
Targeting of TAK1 in inflammatory disorders and cancer
-
Sakurai H. Targeting of TAK1 in inflammatory disorders and cancer. Trends Pharmacol Sci 2012;33:522-30.
-
(2012)
Trends Pharmacol Sci
, vol.33
, pp. 522-530
-
-
Sakurai, H.1
-
16
-
-
80052245462
-
Modulating microtubule stability enhances the cytotoxic response of cancer cells to Paclitaxel
-
Ahmed AA, Wang X, Lu Z, Goldsmith J, Le XF, Grandjean G, et al. Modulating microtubule stability enhances the cytotoxic response of cancer cells to Paclitaxel. Cancer Res 2011;71:5806-17.
-
(2011)
Cancer Res
, vol.71
, pp. 5806-5817
-
-
Ahmed, A.A.1
Wang, X.2
Lu, Z.3
Goldsmith, J.4
Le, X.F.5
Grandjean, G.6
-
17
-
-
0028049074
-
The NF-kappa B transcription factor and cancer: High expression of NFkappa B- and i kappa B-related proteins in tumor cell lines
-
Bours V, Dejardin E, Goujon-Letawe F, Merville MP, Castronovo V. The NF-kappa B transcription factor and cancer: high expression of NFkappa B- and I kappa B-related proteins in tumor cell lines. Biochem Pharmacol 1994;47:145-9.
-
(1994)
Biochem Pharmacol
, vol.47
, pp. 145-149
-
-
Bours, V.1
Dejardin, E.2
Goujon-Letawe, F.3
Merville, M.P.4
Castronovo, V.5
-
18
-
-
0034854288
-
Activation of pRL-TK by 12S E1A oncoprotein: Drawbacks of using an internal reference reporter in transcription assays
-
Thavathiru E, Das GM. Activation of pRL-TK by 12S E1A oncoprotein: drawbacks of using an internal reference reporter in transcription assays. Biotechniques 2001;31:528-30.
-
(2001)
Biotechniques
, vol.31
, pp. 528-530
-
-
Thavathiru, E.1
Das, G.M.2
-
19
-
-
33645661534
-
Albendazole: A potent inhibitor of vascular endothelial growth factor and malignant ascites formation in OVCAR-3 tumor-bearing nude mice
-
Pourgholami MH, Yan Cai Z, Lu Y, Wang L, Morris DL. Albendazole: a potent inhibitor of vascular endothelial growth factor and malignant ascites formation in OVCAR-3 tumor-bearing nude mice. Clin Cancer Res 2006;12:1928-35.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 1928-1935
-
-
Pourgholami, M.H.1
Yan Cai, Z.2
Lu, Y.3
Wang, L.4
Morris, D.L.5
-
20
-
-
59449085264
-
Targeting inflammatory pathways for prevention and therapy of cancer: Short-term friend, longterm foe
-
Aggarwal BB, Vijayalekshmi RV, Sung B. Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, longterm foe. Clin Cancer Res 2009;15:425-30.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 425-430
-
-
Aggarwal, B.B.1
Vijayalekshmi, R.V.2
Sung, B.3
-
21
-
-
2442429408
-
Transient and selective NF-kappa B p65 serine 536 phosphorylation induced by T cell costimulation is mediated by i kappa B kinase beta and controls the kinetics of p65 nuclear import
-
Mattioli I, Sebald A, Bucher C, Charles RP, Nakano H, Doi T, et al. Transient and selective NF-kappa B p65 serine 536 phosphorylation induced by T cell costimulation is mediated by I kappa B kinase beta and controls the kinetics of p65 nuclear import. J Immunol 2004;172: 6336-44.
-
(2004)
J Immunol
, vol.172
, pp. 6336-6344
-
-
Mattioli, I.1
Sebald, A.2
Bucher, C.3
Charles, R.P.4
Nakano, H.5
Doi, T.6
-
22
-
-
44749088134
-
Crosstalk via the NF-kappaB signaling system
-
Basak S, Hoffmann A. Crosstalk via the NF-kappaB signaling system. Cytokine Growth Factor Rev 2008;19:187-97.
-
(2008)
Cytokine Growth Factor Rev
, vol.19
, pp. 187-197
-
-
Basak, S.1
Hoffmann, A.2
-
23
-
-
0031748618
-
Differential regulation of endothelial cell adhesion molecule expression by nitric oxide donors and antioxidants
-
Spiecker M, Darius H, Kaboth K, Hubner F, Liao JK. Differential regulation of endothelial cell adhesion molecule expression by nitric oxide donors and antioxidants. J Leukoc Biol 1998;63: 732-9.
-
(1998)
J Leukoc Biol
, vol.63
, pp. 732-739
-
-
Spiecker, M.1
Darius, H.2
Kaboth, K.3
Hubner, F.4
Liao, J.K.5
-
24
-
-
14844295421
-
Critical roles of threonine 187 phosphorylation in cellular stressinduced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2
-
Singhirunnusorn P, Suzuki S, Kawasaki N, Saiki I, Sakurai H. Critical roles of threonine 187 phosphorylation in cellular stressinduced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2. J Biol Chem 2005; 280:7359-68.
-
(2005)
J Biol Chem
, vol.280
, pp. 7359-7368
-
-
Singhirunnusorn, P.1
Suzuki, S.2
Kawasaki, N.3
Saiki, I.4
Sakurai, H.5
-
25
-
-
0036402140
-
TAK1- TAB1 fusion protein: A novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways
-
Sakurai H, Nishi A, Sato N, Mizukami J, Miyoshi H, Sugita T. TAK1- TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways. Biochem Biophys Res Commun 2002;297: 1277-81.
-
(2002)
Biochem Biophys Res Commun
, vol.297
, pp. 1277-1281
-
-
Sakurai, H.1
Nishi, A.2
Sato, N.3
Mizukami, J.4
Miyoshi, H.5
Sugita, T.6
-
26
-
-
33750564444
-
TAK1-binding protein 1 is a pseudophosphatase
-
Conner SH, Kular G, Peggie M, Shepherd S, Schuttelkopf AW, Cohen P, et al. TAK1-binding protein 1 is a pseudophosphatase. Biochem J 2006;399:427-34.
-
(2006)
Biochem J
, vol.399
, pp. 427-434
-
-
Conner, S.H.1
Kular, G.2
Peggie, M.3
Shepherd, S.4
Schuttelkopf, A.W.5
Cohen, P.6
-
27
-
-
0346243941
-
Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling
-
Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K. Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. EMBO J 2003;22:6277-88.
-
(2003)
EMBO J
, vol.22
, pp. 6277-6288
-
-
Ishitani, T.1
Takaesu, G.2
Ninomiya-Tsuji, J.3
Shibuya, H.4
Gaynor, R.B.5
Matsumoto, K.6
-
28
-
-
40449092814
-
Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factorkappaB activation during breast cancer progression
-
Neil JR, Schiemann WP. Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factorkappaB activation during breast cancer progression. Cancer Res 2008;68:1462-70.
-
(2008)
Cancer Res
, vol.68
, pp. 1462-1470
-
-
Neil, J.R.1
Schiemann, W.P.2
-
29
-
-
84875880772
-
Minocycline selectively inhibits M1 polarization of microglia
-
Kobayashi K, Imagama S, Ohgomori T, Hirano K, Uchimura K, Sakamoto K, et al. Minocycline selectively inhibits M1 polarization of microglia. Cell Death Dis 2013;4:e525.
-
(2013)
Cell Death Dis
, vol.4
-
-
Kobayashi, K.1
Imagama, S.2
Ohgomori, T.3
Hirano, K.4
Uchimura, K.5
Sakamoto, K.6
-
30
-
-
84872708384
-
Minocycline blocks asthma-associated inflammation in part by interfering with the t cell receptor-nuclear factor kappaB-GATA-3-IL-4 axis without a prominent effect on poly(ADP-ribose) polymerase
-
Naura AS, Kim H, Ju J, Rodriguez PC, Jordan J, Catling AD, et al. Minocycline blocks asthma-associated inflammation in part by interfering with the t cell receptor-nuclear factor kappaB-GATA-3-IL-4 axis without a prominent effect on poly(ADP-ribose) polymerase. J Biol Chem 2013;288:1458-68.
-
(2013)
J Biol Chem
, vol.288
, pp. 1458-1468
-
-
Naura, A.S.1
Kim, H.2
Ju, J.3
Rodriguez, P.C.4
Jordan, J.5
Catling, A.D.6
-
31
-
-
0037422858
-
TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway
-
Takaesu G, Surabhi RM, Park KJ, Ninomiya-Tsuji J, Matsumoto K, Gaynor RB. TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway. J Mol Biol 2003;326: 105-15.
-
(2003)
J Mol Biol
, vol.326
, pp. 105-115
-
-
Takaesu, G.1
Surabhi, R.M.2
Park, K.J.3
Ninomiya-Tsuji, J.4
Matsumoto, K.5
Gaynor, R.B.6
-
32
-
-
77957783934
-
TAK1 lysine 158 is required for TGF-beta-induced TRAF6-mediated Smad-independent IKK/NF-kappaB and JNK/AP-1 activation
-
Mao R, Fan Y, Mou Y, Zhang H, Fu S, Yang J. TAK1 lysine 158 is required for TGF-beta-induced TRAF6-mediated Smad-independent IKK/NF-kappaB and JNK/AP-1 activation. Cell Signal 2011; 23:222-7.
-
(2011)
Cell Signal
, vol.23
, pp. 222-227
-
-
Mao, R.1
Fan, Y.2
Mou, Y.3
Zhang, H.4
Fu, S.5
Yang, J.6
-
33
-
-
77949316183
-
Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NFkappaB and JNK/AP-1 activation
-
Fan Y, Yu Y, Shi Y, Sun W, Xie M, Ge N, et al. Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NFkappaB and JNK/AP-1 activation. J Biol Chem 2010;285: 5347-60.
-
(2010)
J Biol Chem
, vol.285
, pp. 5347-5360
-
-
Fan, Y.1
Yu, Y.2
Shi, Y.3
Sun, W.4
Xie, M.5
Ge, N.6
-
34
-
-
84857775368
-
Epithelial transforming growth factor beta-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species
-
Omori E, Inagaki M, Mishina Y, Matsumoto K, Ninomiya-Tsuji J. Epithelial transforming growth factor beta-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species. Proc Natl Acad Sci U S A 2012;109:3365-70.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 3365-3370
-
-
Omori, E.1
Inagaki, M.2
Mishina, Y.3
Matsumoto, K.4
Ninomiya-Tsuji, J.5
-
35
-
-
0029940355
-
TAB1: An activator of the TAK1 MAPKKK in TGF-beta signal transduction
-
Shibuya H, Yamaguchi K, Shirakabe K, Tonegawa A, Gotoh Y, Ueno N, et al. TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. Science 1996;272:1179-82.
-
(1996)
Science
, vol.272
, pp. 1179-1182
-
-
Shibuya, H.1
Yamaguchi, K.2
Shirakabe, K.3
Tonegawa, A.4
Gotoh, Y.5
Ueno, N.6
-
36
-
-
69249131695
-
Transforming growth factor-beta (TGF-beta1) activates TAK1 via TAB1-mediated autophosphorylation, independent of TGF-beta receptor kinase activity in mesangial cells
-
Kim SI, Kwak JH, Na HJ, Kim JK, Ding Y, Choi ME. Transforming growth factor-beta (TGF-beta1) activates TAK1 via TAB1-mediated autophosphorylation, independent of TGF-beta receptor kinase activity in mesangial cells. J Biol Chem 2009;284: 22285-96.
-
(2009)
J Biol Chem
, vol.284
, pp. 22285-22296
-
-
Kim, S.I.1
Kwak, J.H.2
Na, H.J.3
Kim, J.K.4
Ding, Y.5
Choi, M.E.6
-
38
-
-
77449135866
-
Changes in expression, and/or mutations in TGF-beta receptors (TGF-beta RI and TGFbeta RII) andSmad4 in human ovarian tumors
-
Antony ML, Nair R, Sebastian P, Karunagaran D. Changes in expression, and/or mutations in TGF-beta receptors (TGF-beta RI and TGFbeta RII) andSmad4 in human ovarian tumors. J Cancer Res Clin Oncol 2010;136:351-61.
-
(2010)
J Cancer Res Clin Oncol
, vol.136
, pp. 351-361
-
-
Antony, M.L.1
Nair, R.2
Sebastian, P.3
Karunagaran, D.4
-
39
-
-
34347226354
-
Loss of betaglycan expression in ovarian cancer: Role in motility and invasion
-
Hempel N, How T, Dong M, Murphy SK, Fields TA, Blobe GC. Loss of betaglycan expression in ovarian cancer: role in motility and invasion. Cancer Res 2007;67:5231-8.
-
(2007)
Cancer Res
, vol.67
, pp. 5231-5238
-
-
Hempel, N.1
How, T.2
Dong, M.3
Murphy, S.K.4
Fields, T.A.5
Blobe, G.C.6
-
40
-
-
84884211557
-
TGF-beta and NF-kappaB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers
-
Freudlsperger C, Bian Y, Contag Wise S, Burnett J, Coupar J, Yang X, et al. TGF-beta and NF-kappaB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers. Oncogene 2013;32:1549-59.
-
(2013)
Oncogene
, vol.32
, pp. 1549-1559
-
-
Freudlsperger, C.1
Bian, Y.2
Contag Wise, S.3
Burnett, J.4
Coupar, J.5
Yang, X.6
-
41
-
-
77957109672
-
Transforming growth factor-beta1-mediated activation of NF-kappaB contributes to enhanced ADAM-12 expression in mammary carcinoma cells
-
Ray A, Dhar S, Ray BK. Transforming growth factor-beta1-mediated activation of NF-kappaB contributes to enhanced ADAM-12 expression in mammary carcinoma cells. Mol Cancer Res 2010;8:1261-70.
-
(2010)
Mol Cancer Res
, vol.8
, pp. 1261-1270
-
-
Ray, A.1
Dhar, S.2
Ray, B.K.3
|