Immunosuppressant therapeutic drug monitoring by LC-MS/MS: Workflow optimization through automated processing of whole blood samples

Clinical Biochemistry

Volumn 46, Issue 16-17, 2013, Pages 1723-1727

  Marinova, Mariela ^a   Artusi, Carlo ^a   Brugnolo, Laura ^a   Antonelli, Giorgia ^b   Zaninotto, Martina ^a   Plebani, Mario ^a,b  

^a UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

Automation; Immunosuppressants; LC MS MS; Routine application; TDM; Whole blood

Indexed keywords

EVEROLIMUS; RAPAMYCIN; TACROLIMUS;

ACCURACY; ARTICLE; BLOOD SAMPLING; CALIBRATOR; DRUG BLOOD LEVEL; DRUG MONITORING; HUMAN; LABORATORY AUTOMATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; WORKLOAD;

AUTOMATION; COEFFICIENT OF VARIATION; CV; ELECTROSPRAY IONIZATION INTERFACE; ESI; EVE; EVEROLIMUS; FK-506; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HPLC; IMMUNOSUPPRESSANTS; INTERNAL STANDARD; IS; LC-MS/MS; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LLOQ; LOD; LOWER LIMIT OF QUANTIFICATION; MASS SPECTROMETRY; MRM; MS; MS/MS; MULTIPLE-REACTION MONITORING; QC; QUALITY CONTROL; ROUTINE APPLICATION; SD; SIR; SIROLIMUS; SOLID PHASE EXTRACTION; SPE; STANDARD DEVIATION; TACROLIMUS; TANDEM MASS; TDM; THERAPEUTIC DRUG MONITORING; WHOLE BLOOD;

AUTOMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG MONITORING; HUMANS; IMMUNOSUPPRESSIVE AGENTS; IONS; MASS SPECTROMETRY; ONLINE SYSTEMS; WORKFLOW;

EID: 84886415271     PISSN: 00099120     EISSN: 18732933     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2013.08.013     Document Type: Article

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